Quantifying the spread of P. falciparum malaria

Informations projet

QUANTUM

N° de convention de subvention: 864180

DOI

10.3030/864180

Projet clôturé

Date de signature de la CE 15 Juin 2020

Date de début 1 Juillet 2020

Date de fin 30 Juin 2025

Financé au titre de

• EXCELLENT SCIENCE - European Research Council (ERC)

Coût total

€ 2 000 000,00

Contribution de l’UE

€ 2 000 000,00

Coordonné par

STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Netherlands

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Open Research Data Pilot (1)

Open Research Data Pilot

To be discussed with project officer

Publications

Peer reviewed articles (37)

The effect of anticoagulants in blood collection tubes on Plasmodium falciparum transmission in direct membrane feeding assays

Auteurs: Wouter Graumans, Kjerstin Lanke, Geert-Jan van Gemert, Manon Alkema, Marga van de Vegte-Bolmer, Teun Bousema, Katharine A Collins
Publié dans: Transactions of The Royal Society of Tropical Medicine and Hygiene, 2021, ISSN 0035-9203
Éditeur: Royal Society of Tropical Medicine and Hygiene
DOI: 10.1093/trstmh/trab095

Naturally acquired antibodies to gametocyte antigens are associated with reduced transmission of Plasmodium vivax gametocytes to Anopheles arabiensis mosquitoes

Auteurs: Tebeje SK, Chali W, Hailemeskel E, Ramjith J, Gashaw A, Ashine T, Nebret D, Esayas E, Emiru T, Tsegaye T, Teelen K, Lanke K, Takashima E, Tsuboi T, Salinas ND, Tolia NH, Narum D, Drakeley C, Witkowski B, Vantaux A, Jore MM, Stone WJR, Hansen IS, Tadesse FG, Bousema T.
Publié dans: Front Cell Infect Microbiol, 2023, ISSN 2235-2988
Éditeur: Frontiers Media S. A.
DOI: 10.3389/fcimb.2022.1106369

Pyronaridine–artesunate or dihydroartemisinin–piperaquine combined with single low-dose primaquine to prevent Plasmodium falciparum malaria transmission in Ouélessébougou, Mali: a four-arm, single-blind, phase 2/3, randomised trial

Auteurs: Stone W, Mahamar A, Sanogo K, Sinaba Y, Niambele SM, Sacko A, Keita S, Youssouf A, Diallo M, Soumare HM, Kaur H, Lanke K, Ter Heine R, Bradley J, Issiaka D, Diawara H, Traore SF, Bousema T, Drakeley C, Dicko A.
Publié dans: Lancet Microbe, 2022, ISSN 2666-5247
Éditeur: The Lancet Publishing Group
DOI: 10.1016/s2666-5247(21)00192-0

Plasmodium falciparum adapts its investment into replication versus transmission according to the host environment.

Auteurs: Abdi AI, Achcar F, Sollelis L, Silva-Filho JL, Mwikali K, Muthui M, Mwangi S, Kimingi HW, Orindi B, Andisi Kivisi C, Alkema M, Chandrasekar A, Bull PC, Bejon P, Modrzynska K, Bousema T, Marti M.
Publié dans: Elife, 2023, ISSN 2050-084X
Éditeur: eLife Sciences Publications
DOI: 10.7554/elife.85140

Safety, tolerability, and Plasmodium falciparum transmission-reducing activity of monoclonal antibody TB31F: a single-centre, open-label, first-in-human, dose-escalation, phase 1 trial in healthy malaria-naive adults.

Auteurs: van der Boor SC, Smit MJ, van Beek SW, Ramjith J, Teelen K, van de Vegte-Bolmer M, van Gemert GJ, Pickkers P, Wu Y, Locke E, Lee SM, Aponte J, King CR, Birkett AJ, Miura K, Ayorinde MA, Sauerwein RW, Ter Heine R, Ockenhouse CF, Bousema T, Jore MM, McCall MBB.
Publié dans: Lancet Infect Dis, 2022, ISSN 1473-3099
Éditeur: The Lancet Publishing Group
DOI: 10.1016/s1473-3099(22)00428-5

Plasmodium falciparum gametocyte production correlates with genetic markers of parasite replication but is not influenced by experimental exposure to mosquito biting

Auteurs: Sara Lynn Blanken, Aissata Barry, Kjerstin Lanke, Moussa Guelbeogo, Alphonse Ouedraogo, Issiaka Soulama, Sam Aboubacar Coulibaly, Karina Teelen, Wouter Graumans, Elin Dumont, Will Stone, Jordache Ramjith, Matthias Marti, Carolina M. Andrade, Chris Drakeley, Katharine Collins, Alfred Tiono, Teun Bousema
Publié dans: eBioMedicine, Numéro 105, 2024, Page(s) 105190, ISSN 2352-3964
Éditeur: Elsevier BV
DOI: 10.1016/j.ebiom.2024.105190

Flexible time-to-event models for double-interval-censored infectious disease data with clearance of the infection as a competing risk

Auteurs: Ramjith, J.; Andolina, C.; Bousema, T.; Jonker, M.A.
Publié dans: Frontiers in Applied Mathematics and Statistics, 2022, ISSN 2297-4687
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fams.2022.1035393

Asymptomatic School-Aged Children Are Important Drivers of Malaria Transmission in a High Endemicity Setting in Uganda

Auteurs: Rek J, Blanken SL, Okoth J, Ayo D, Onyige I, Musasizi E, Ramjith J, Andolina C, Lanke K, Arinaitwe E, Olwoch P, Collins KA, Kamya MR, Dorsey G, Drakeley C, Staedke SG, Bousema T, Conrad MD.
Publié dans: The Journal of Infectious Diseases, 2022, ISSN 0022-1899
Éditeur: University of Chicago Press
DOI: 10.1093/infdis/jiac169

Dynamics of asymptomatic Plasmodium falciparum and Plasmodium vivax infections and their infectiousness to mosquitoes in a low transmission setting of Ethiopia: a longitudinal observational study

Auteurs: Elifaged Hailemeskel, Surafel K. Tebeje, Jordache Ramjith, Temesgen Ashine, Kjerstin Lanke, Sinknesh W. Behaksra, Tadele Emiru, Tizita Tsegaye, Abrham Gashaw, Soria Kedir, Wakweya Chali, Endashaw Esayas, Temesgen Tafesse, Haile Abera, Mikiyas Gebremichael Bulto, Girma Shumie, Beyene Petros, Hassen Mamo, Chris Drakeley, Endalamaw Gadisa, Teun Bousema, Fitsum G. Tadesse
Publié dans: International Journal of Infectious Diseases, Numéro 143, 2024, Page(s) 107010, ISSN 1201-9712
Éditeur: Elsevier BV
DOI: 10.1016/j.ijid.2024.107010

Comparative analysis of glass and Hemotek membrane feeding systems for malaria transmission research

Auteurs: Graumans W, Schinkel M, van Gemert GJ, Spitzen J, Bousema T, Miesen P.
Publié dans: Transactions of The Royal Society of Tropical Medicine and Hygiene, 2023, ISSN 0035-9203
Éditeur: Royal Society of Tropical Medicine and Hygiene
DOI: 10.1093/trstmh/trac135

Quantification of sporozoite expelling by Anopheles mosquitoes infected with laboratory and naturally circulating P. falciparum gametocytes.

Auteurs: Andolina C, Graumans W, Guelbeogo M, van Gemert GJ, Ramijth J, Harouna S, Soumanaba Z, Stoter R, Vegte-Bolmer M, Pangos M, Sinnis P, Collins K, Staedke SG, Tiono AB, Drakeley C, Lanke K, Bousema T.
Publié dans: Elife, 2024, Page(s) 12:RP90989, ISSN 2050-084x
Éditeur: eLife Sciences Publications
DOI: 10.7554/elife.90989

Monoclonal antibodies block transmission of genetically diverse Plasmodium falciparum strains to mosquitoes

Auteurs: Roos M. de Jong, Lisette Meerstein-Kessel, Dari F. Da, Sandrine Nsango, Joseph D. Challenger, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Elias Duarte, Noam Teyssier, Robert W. Sauerwein, Thomas S. Churcher, Roch K. Dabire, Isabelle Morlais, Emily Locke, Martijn A. Huynen, Teun Bousema & Matthijs M. Jore
Publié dans: npj Vaccines, 2021, ISSN 2059-0105
Éditeur: Springer Nature
DOI: 10.1038/s41541-021-00366-9

AlbuMAX supplemented media induces the formation of transmission-competent P. falciparum gametocytes

Auteurs: Wouter Graumans, Alex van der Starre, Rianne Stoter, Geert-Jan van Gemert, Chiara Andolina, Jordache Ramjith, Taco Kooij, Teun Bousema, Nicholas Proellochs
Publié dans: Molecular and Biochemical Parasitology, Numéro 259, 2024, Page(s) 111634, ISSN 0166-6851
Éditeur: Elsevier BV
DOI: 10.1016/j.molbiopara.2024.111634

Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230.

Auteurs: Ivanochko D, Fabra-García A, Teelen K, van de Vegte-Bolmer M, van Gemert GJ, Newton J, Semesi A, de Bruijni M, Bolscher J, Ramjith J, Szabat M, Vogt S, Kraft L, Duncan S, Lee SM, Kamya MR, Feeney ME, Jagannathan P, Greenhouse B, Sauerwein RW, Richter King C, MacGill RS, Bousema T, Jore MM, Julien JP.
Publié dans: Immunity, 2023, ISSN 1074-7613
Éditeur: Cell Press
DOI: 10.1016/j.immuni.2023.01.013

Plasmodium falciparum gametocyte production in longitudinally monitored incident infections is associated with duration of infection and human host factors

Auteurs: Chiara Andolina; Jordache Ramjith; John Rek; Kjerstin Lanke; Joseph Okoth; Lynn Grignard; Emmanuel Arinaitwe; Jessica Briggs; Jeffrey Bailey; Ozkan Aydemir; Moses R Kamya; Bryan Greenhouse; Grant Dorsey; Sarah G Staedke; Chris Drakeley; Marianne Jonker; Teun Bousema
Publié dans: Scientific Report, Numéro 1, 2023, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.21203/rs.3.rs-2158355/v1

Plasmodium malariae infections as a cause of febrile disease in an area of high Plasmodium falciparum transmission intensity in Eastern Uganda

Auteurs: Daniel Ayo, Bakar Odongo, Joseph Omara, Chiara Andolina, Ole Mulder, Sarah G. Staedke & Teun Bousema
Publié dans: Malaria Journal, 2021, ISSN 1475-2875
Éditeur: BioMed Central
DOI: 10.1186/s12936-021-03962-1

Maintaining Plasmodium falciparum gametocyte infectivity during blood collection and transport for mosquito feeding assays in the field

Auteurs: Harouna M. Soumare, Wamdaogo Moussa Guelbeogo, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Zongo Soumanaba, Alphonse Ouedraogo, Maurice S. Ouattara, Ahmad Abdullahi, Lamin Jadama, Muhammed M. Camara, Pa Modou Gaye, Michael Mendy, Nwakanma Davis, Alfred B. Tiono, Umberto D’Alessandro, Chris Drakeley, Teun Bousema, Marta Moreno, Katharine A. Collins
Publié dans: Malaria Journal, Numéro 20/1, 2021, ISSN 1475-2875
Éditeur: BioMed Central
DOI: 10.1186/s12936-021-03725-y

Assessment of the transmission blocking activity of antimalarial compounds by membrane feeding assays using natural Plasmodium falciparum gametocyte isolates from West-Africa.

Auteurs: B Henry N, Soulama I, S Sermé S, Bolscher JM, T G Huijs T, S Coulibaly A, Sombié S, Ouédraogo N, Diarra A, Zongo S, Guelbéogo WM, Nébié I, Sirima SB, Tiono AB, Pietro A, Collins KA, Dechering KJ, Bousema T.
Publié dans: PLoS One, 2023, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0284751

A portfolio of geographically distinct laboratory-adapted Plasmodium falciparum clones with consistent infection rates in Anopheles mosquitoes

Auteurs: van de Vegte-Bolmer M, Graumans W, Stoter R, van Gemert GJ, Sauerwein R, Collins KA, Bousema T.
Publié dans: Malar J., 2021, ISSN 1475-2875
Éditeur: BioMed Central
DOI: 10.1186/s12936-021-03912-x

Reversible host cell surface remodelling limits immune recognition and maximizes survival of Plasmodium falciparum gametocytes

Auteurs: Priscilla Ngotho, Kathleen Dantzler Press, Megan Peedell, William Muasya, Brian Roy Omondi, Stanley E. Otoboh, Jahiro Gomez, Lorena Coronado, Karl B. Seydel, Melissa Kapulu, Miriam Laufer, Terrie Taylor, Teun Bousema, Matthias Marti
Publié dans: PLOS Pathogens, Numéro 21, 2025, Page(s) e1013110, ISSN 1553-7374
Éditeur: Public Library of Science (PLoS)
DOI: 10.1371/journal.ppat.1013110

Quantifying Reductions in Plasmodium falciparum Infectivity to Mosquitos: A Sample Size Calculator to Inform Clinical Trials on Transmission-Reducing Interventions

Auteurs: Ramjith J, Alkema M, Bradley J, Dicko A, Drakeley C, Stone W, Bousema T.
Publié dans: Front. Immunol., 2022, ISSN 1664-3224
Éditeur: Frontiers Media S.A
DOI: 10.3389/fimmu.2022.899615

The acquisition of humoral immune responses targeting Plasmodium falciparum sexual stages in controlled human malaria infections.

Auteurs: de Jong RM, Alkema M, Oulton T, Dumont E, Teelen K, Nakajima R, de Assis RR, Press KWD, Ngotho P, Tetteh KKA, Felgner P, Marti M, Collins KA, Drakeley C, Bousema T, Stone WJR.
Publié dans: Front Immunol., 2022, ISSN 1664-3224
Éditeur: Frontiers
DOI: 10.3389/fimmu.2022.930956

Entomological impact of mass administration of ivermectin and dihydroartemisinin-piperaquine in The Gambia: a cluster-randomized controlled trial

Auteurs: Soumare, H.M., Dabira, E.D., Camara, M.M. et al.
Publié dans: Parasites Vectors, 2022, ISSN 1756-3305
Éditeur: BioMed Central
DOI: 10.1186/s13071-022-05557-4

Evidence for a role of Anopheles stephensi in the spread of drug- and diagnosis-resistant malaria in Africa.

Auteurs: Emiru T, Getachew D, Murphy M, Sedda L, Ejigu LA, Bulto MG, Byrne I, Demisse M, Abdo M, Chali W, Elliott A, Vickers EN, Aranda-Díaz A, Alemayehu L, Behaksera SW, Jebessa G, Dinka H, Tsegaye T, Teka H, Chibsa S, Mumba P, Girma S, Hwang J, Yoshimizu M, Sutcliffe A, Taffese HS, Bayissa GA, Zohdy S, Tongren JE, Drakeley C, Greenhouse B, Bousema T, Tadesse FG.
Publié dans: Nature Medicine, 2023, ISSN 1546-170X
Éditeur: Springer Nature
DOI: 10.1038/s41591-023-02641-9

Single low-dose tafenoquine combined with dihydroartemisinin–piperaquine to reduce Plasmodium falciparum transmission in Ouelessebougou, Mali: a phase 2, single-blind, randomised clinical trial

Auteurs: Stone W, Mahamar A, Smit MJ, Sanogo K, Sinaba Y, Niambele SM, Sacko A, Keita S, Dicko OM, Diallo M, Maguiraga SO, Samake S, Attaher O, Lanke K, Ter Heine R, Bradley J, McCall MBB, Issiaka D, Traore SF, Bousema T, Drakeley C, Dicko A
Publié dans: Lancet Microbe, 2022, ISSN 2666-5247
Éditeur: The Lancet Publishing Group
DOI: 10.1016/s2666-5247(21)00356-6

Sources of persistent malaria transmission in a setting with effective malaria control in eastern Uganda: a longitudinal, observational cohort study

Auteurs: Andolina C, Rek JC, Briggs J, Okoth J, Musiime A, Ramjith J, Teyssier N, Conrad M, Nankabirwa JI, Lanke K, Rodriguez-Barraquer I, Meerstein-Kessel L, Arinaitwe E, Olwoch P, Rosenthal PJ, Kamya MR, Dorsey G, Greenhouse B, Drakeley C, Staedke SG, Bousema T.
Publié dans: Lancet Infect Dis., 2021, ISSN 1473-3099
Éditeur: The Lancet Publishing Group
DOI: 10.1016/s1473-3099(21)00072

Plasmodium falciparum gametocyte carriage in longitudinally monitored incident infections is associated with duration of infection and human host factors.

Auteurs: Andolina C, Ramjith J, Rek J, Lanke K, Okoth J, Grignard L, Arinaitwe E, Briggs J, Bailey J, Aydemir O, Kamya MR, Greenhouse B, Dorsey G, Staedke SG, Drakeley C, Jonker M, Bousema T
Publié dans: Scientific Reports, 2023, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-023-33657-3

Improved Detectability of Plasmodium falciparum Clones with Repeated Sampling in Incident and Chronic Infections in Burkina Faso

Auteurs: Barry A, Awandu S S, Tiono A B, Grignard L, Bousema T, Collins K A
Publié dans: Am J Trop Med Hyg ., 2021, ISSN 1476-1645
Éditeur: Journal of the American Society of Tropical Medicine and Hygeine
DOI: 10.4269/ajtmh.21-0493

Modeling the Impact of a Highly Potent Plasmodium falciparum Transmission-Blocking Monoclonal Antibody in Areas of Seasonal Malaria Transmission

Auteurs: Challenger JD, van Beek SW, Ter Heine R, van der Boor SC, Charles GD, Smit MJ, Ockenhouse C, Aponte JJ, McCall MBB, Jore MM, Churcher TS, Bousema T.
Publié dans: The Journal of Infectious Diseases, 2023, ISSN 1537-6613
Éditeur: Oxfrd University Press
DOI: 10.1093/infdis/jiad101

The acquisition of humoral immune responses targeting Plasmodium falciparum sexual stages in controlled human malaria infections

Auteurs: de Jong RM, Alkema M, Oulton T, Dumont E, Teelen K, Nakajima R, de Assis RR, Press KWD, Ngotho P, Tetteh KKA, Felgner P, Marti M, Collins KA, Drakeley C, Bousema T, Stone WJR. The
Publié dans: Front Immunol, 2022, ISSN 1664-3224
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.930956.ecollection2022

Heterologous Expression and Evaluation of Novel Plasmodium falciparum Transmission Blocking Vaccine Candidates

Auteurs: de Jong RM, Singh SK, Teelen K, van de Vegte-Bolmer M, van Gemert GJ, Stone WJR, Locke E, Plieskatt J, Theisen M, Bousema T, Jore MM.
Publié dans: Front. Immunol, 2022, ISSN 1664-3224
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.909060

Susceptibility of Anopheles gambiae to Natural Plasmodium falciparum Infection: A Comparison between the Well-Established Anopheles gambiae s.s Line and a Newly Established Ugandan Anopheles gambiae s.s. Line

Auteurs: Daniel Ayo, Ismail Onyige, Joseph Okoth, Eric Musasizi, Ambrose Oruni, Jordache Ramjith, Emmanuel Arinaitwe, John C. Rek, Chris Drakeley, Sarah G. Staedke, Martin J. Donnelly, Teun Bousema, Melissa Conrad, Sara Lynn Blanken
Publié dans: The American Journal of Tropical Medicine and Hygiene, Numéro 110, 2024, Page(s) 209-213, ISSN 0002-9637
Éditeur: American Society of Tropical Medicine and Hygiene
DOI: 10.4269/ajtmh.23-0203

Highly potent, naturally acquired human monoclonal antibodies against Pfs48/45 block Plasmodium falciparum transmission to mosquitoes.

Auteurs: Fabra-García A, Hailemariam S, de Jong RM, Janssen K, Teelen K, van de Vegte-Bolmer M, van Gemert GJ, Ivanochko D, Semesi A, McLeod B, Vos MW, de Bruijni MHC, Bolscher JM, Szabat M, Vogt S, Kraft L, Duncan S, Kamya MR, Feeney ME, Jagannathan P, Greenhouse B, Dechering KJ, Sauerwein RW, King CR, MacGill RS, Bousema T, Julien JP, Jore MM.
Publié dans: Immunity, 2023, ISSN 1074-7613
Éditeur: Cell Press
DOI: 10.1016/j.immuni.2023.01.009

Tripartite interactions between viruses, parasites, and mosquitoes

Auteurs: Michelle Schinkel, Teun Bousema, Ronald P van Rij
Publié dans: Current Opinion in Insect Science, Numéro 64, 2024, Page(s) 101222, ISSN 2214-5745
Éditeur: Elsevier BV
DOI: 10.1016/j.cois.2024.101222

The mosquitocidal activity of isoxazoline derivatives afoxolaner, lotilaner and fluralaner are not affected by mosquito sugar or antibiotic treatment

Auteurs: Harouna Soré, Wamdaogo Moussa Guelbeogo, Soumanaba Zongo, Judith M. Bolscher, Nicolas Ouedraogo, Adama Gansane, Teun Bousema, Katharine A. Collins, Koen J. Dechering
Publié dans: Sci Rep, 2025, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.21203/rs.3.rs-5270550/v1

Artemether-lumefantrine with or without single-dose primaquine and sulfadoxine-pyrimethamine plus amodiaquine with or without single-dose tafenoquine to reduce Plasmodium falciparum transmission: a phase 2, single-blind, randomised clinical trial in Ouelessebougou, Mali.

Auteurs: Mahamar A, Smit MJ, Sanogo K, Sinaba Y, Niambele SM, Sacko A, Dicko OM, Diallo M, Maguiraga SO, Sankaré Y, Keita S, Samake S, Dembele A, Lanke K, Ter Heine R, Bradley J, Dicko Y, Traore SF, Drakeley C, Dicko A, Bousema T, Stone W.
Publié dans: Lancet Microbe, 2024, ISSN 2666-5247
Éditeur: Elsevier-Lancet
DOI: 10.1016/s2666-5247(24)00023-5

Effect of weekly fever-screening and treatment and monthly RDT testing and treatment on the infectious reservoir of malaria parasites in Burkina Faso: a cluster-randomised trial

Auteurs: Katharine A Collins, Alphonse Ouedraogo, Wamdaogo Moussa Guelbeogo, Issiaka Soulama, Maurice S Ouattara, Salif Sombie, Nicolas Ouedraogo, Aboubacar S Coulibaly, Apollinaire Nombre, Kjerstin Lanke, Jordache Ramjith, Shehu S Awandu, Samuel S Serme, Noelie Henry, Will Stone, Issa N Ouedraogo, Amidou Diarra, Tobias M Holden, Sodiomon B Sirima, John Bradley, Seyi Soremekun, Prashanth Selvaraj, Jaline G
Publié dans: The Lancet Microbe, Numéro 5, 2024, Page(s) 100891, ISSN 2666-5247
Éditeur: Elsevier
DOI: 10.1016/s2666-5247(24)00114-9

Other (1)

Anopheles mosquito exposure is associated with age, gender and bed net use in areas in Uganda experiencing varying malaria transmission intensity

Auteurs: Sara Lynn Blanken, Maxwell Kilama, Jordache Ramjith, Alex K. Musiime, Kjerstin Lanke, Daniel Ayo, Kristiaan Huijbers, Tom Hofste, Melissa Conrad, Paul Krezanoski, Grant Dorsey, Moses R. Kamya, Emmanuel Arinaitwe, Teun Bousema
Publié dans: MedRxiv, 2024
Éditeur: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.12.12.24318757