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Disentangling the stringent response to engineer novel anti-persister drugs

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Publications

Nonhydrolysable Analogues of (p)ppGpp and (p)ppApp Alarmone Nucleotides as Novel Molecular Tools

Author(s): Mojr, Viktor;Roghanian, Mohammad;Tamman, Hedvig ;Do Pham, Duy Dinh;Petrová, Magdalena;Pohl, Radek;Takada, Hiraku;Van Nerom, Katleen ;Ainelo, Hanna ;Caballero Montes, Julien ;Jimmy, Steffi;Garcia-Pino, Abel ;Hauryliuk, Vasili;Rejman, Dominik
Published in: A C S Chemical Biology, 2021, ISSN 1554-8929
Publisher: American Chemical Society
DOI: 10.1021/acschembio.1c00398

(p)ppGpp controls stringent factors by exploiting antagonistic allosteric coupling between catalytic domains

Author(s): Roghanian, Mohammad;Van Nerom, Katleen ;Takada, Hiraku;Caballero Montes, Julien ;Tamman, Hedvig ;Kudrin, Pavel;Talavera Perez, Ariel ;Dzhygyr, Ievgen;Ekström, Simon;Atkinson, Gemma Catherine;Garcia-Pino, Abel ;Hauryliuk, Vasili
Published in: Molecular cell, 81, 16, 2021, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2021.07.026

RelA-SpoT Homolog toxins pyrophosphorylate the CCA end of tRNA to inhibit protein synthesis

Author(s): Kurata, Tatsuaki;Brodiazhenko, Tetiana;Alves Oliveira, Sofia Raquel;Roghanian, Mohammad;Sakaguchi, Yuriko;Turnbull, Kathryn Jane;Bulvas, Ondrej;Takada, Hiraku;Tamman, Hedvig ;Ainelo, Andres;Pohl, Radek;Rejman, Dominik;Tenson, Tanel;Suzuki, Tsutomu;Garcia-Pino, Abel ;Atkinson, Gemma Catherine;Hauryliuk, Vasili
Published in: Molecular cell, 81, 15, 2021, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2021.06.005