Disentangling the stringent response to engineer novel anti-persister drugs

Project Information

DiStRes

Grant agreement ID: 864311

DOI

10.3030/864311

Project closed

EC signature date 6 March 2020

Start date 1 December 2020

End date 30 November 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 000 000,00

EU contribution

€ 2 000 000,00

Coordinated by

UNIVERSITE LIBRE DE BRUXELLES
Belgium

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (15)

Nonhydrolysable Analogues of (p)ppGpp and (p)ppApp Alarmone Nucleotides as Novel Molecular Tools

Author(s): Mojr, Viktor;Roghanian, Mohammad;Tamman, Hedvig ;Do Pham, Duy Dinh;Petrová, Magdalena;Pohl, Radek;Takada, Hiraku;Van Nerom, Katleen ;Ainelo, Hanna ;Caballero Montes, Julien ;Jimmy, Steffi;Garcia-Pino, Abel ;Hauryliuk, Vasili;Rejman, Dominik
Published in: A C S Chemical Biology, 2021, ISSN 1554-8929
Publisher: American Chemical Society
DOI: 10.1021/acschembio.1c00398

The structural basis of hyperpromiscuity in a core combinatorial network of type II toxin–antitoxin and related phage defense systems

Author(s): Karin Ernits Chayan Kumar Saha Tetiana Brodiazhenko Bhanu Chouhan Aditi Shenoy Jessica A Buttress Julián J Duque-Pedraza Veda Bojar Jose A Nakamoto Tatsuaki Kurata Artyom A Egorov Lena Shyrokova Marcus J O Johansson Toomas Mets Aytan Rustamova Jelisaveta Džigurski Tanel Tenson Abel Garcia-Pino Henrik Strahl Arne Elofsson Vasili Hauryliuk Gemma C Atkinson
Published in: Proc Natl Acad Sci U S A ., 2023, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2305393120

A polyamine acetyltransferase regulates the motility and biofilm formation of Acinetobacter baumannii

Author(s): Armalytė J, Čepauskas A, Šakalytė G, Martinkus J, Skerniškytė J, Martens C, Sužiedėlienė E, Garcia-Pino A, Jurėnas D.
Published in: Nature Communications, Issue 14, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-39316-5

Toxic small alarmone synthetase FaRel2 inhibits translation by pyrophosphorylating tRNA ^Gly and tRNA ^Thr

Author(s): Tatsuaki Kurata, Masaki Takegawa, Takayuki Ohira, Egor A. Syroegin, Gemma C. Atkinson, Marcus J.O. Johansson, Yury S. Polikanov, Abel Garcia-Pino, Tsutomu Suzuki, Vasili Hauryliuk
Published in: Science Advances, Issue 10, 2024, ISSN 2375-2548
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/sciadv.adr9624

Mechanism of phage sensing and restriction by toxin-antitoxin-chaperone systems

Author(s): Mets, Toomas; Kurata, Tatsuaki; Ernits, Karin; Johansson, Marcus J.O.; Craig, Sophie Z.; Evora, Gabriel Medina; Buttress, Jessica A.; Odai, Roni; Wallant, Kyo Coppieters‘t; Nakamoto, Jose A.; Shyrokova, Lena; Egorov, Artyom A.; Doering, Christopher Ross; Brodiazhenko, Tetiana; Laub, Michael T.; Tenson, Tanel; Strahl, Henrik; Martens, Chloe; Harms, Alexander; id_orcid0000-0003-2106-1286; Garcia-P
Published in: Cell Host & Microbe, 32 (7), Issue 2, 2024, ISSN 1934-6069
Publisher: Elsevier
DOI: 10.3929/ethz-b-000682805

The structure of DarB in complex with RelNTD reveals nonribosomal activation of Rel stringent factors

Author(s): Ainelo A, Caballero-Montes J, Bulvas O, Ernits K, Coppieters 't Wallant K, Takada H, Craig SZ, Mazzucchelli G, Zedek S, Pichová I, Atkinson GC, Talavera A, Martens C, Hauryliuk V, Garcia-Pino A.
Published in: Science Advances, Issue 9, 2023, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.ade4077

Ribosome association primes the stringent factor Rel for tRNA-dependent locking in the A-site and activation of (p)ppGpp synthesis

Author(s): Hiraku Takada Mohammad Roghanian Julien Caballero-Montes Katleen Van Nerom Steffi Jimmy Pavel Kudrin Fabio Trebini Rikinori Murayama Genki Akanuma Abel Garcia-Pino Vasili Hauryliuk
Published in: Nucleic Acids Research, 2021, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkaa1187

Biochemical and X-ray analyses of the players involved in the <i>faRel</i>2/<i>aTfaRel</i>2 toxin–antitoxin operon

Author(s): Lucia Dominguez-Molina; Ariel Talavera; Albinas Cepauskas; Tatsuaki Kurata; Dannele Echemendia-Blanco; Vasili Hauryliuk; Abel Garcia-Pino
Published in: Acta Crystallographica Section F, Issue 1, 2023, ISSN 2053-230X
Publisher: John Wiley and Sons Ltd
DOI: 10.1107/s2053230x23007288

A bacterial immunity protein directly senses two disparate phage proteins

Author(s): Tong Zhang, Albinas Cepauskas, Anastasiia Nadieina, Aurelien Thureau, Kyo Coppieters ‘t Wallant, Chloé Martens, Daniel C. Lim, Abel Garcia-Pino, Michael T. Laub
Published in: Nature, Issue 635, 2025, Page(s) 728-735, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-024-08039-y

Direct activation of a bacterial innate immune system by a viral capsid protein

Author(s): Zhang T, Tamman H, Coppieters 't Wallant K, Kurata T, LeRoux M, Srikant S, Brodiazhenko T, Cepauskas A, Talavera A, Martens C, Atkinson GC, Hauryliuk V, Garcia-Pino A, Laub MT.
Published in: Nature, Issue 612, 2022, Page(s) 132-140, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-05444-z

Structure of SpoT reveals evolutionary tuning of catalysis via conformational constraint

Author(s): Tamman H, Ernits K, Roghanian M, Ainelo A, Julius C, Perrier A, Talavera A, Ainelo H, Dugauquier R, Zedek S, Thureau A, Pérez J, Lima-Mendez G, Hallez R, Atkinson GC, Hauryliuk V, Garcia-Pino A.
Published in: Nature Chemical Biology, Issue 19, 2022, Page(s) 334–345, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-022-01198-x

(p)ppGpp controls stringent factors by exploiting antagonistic allosteric coupling between catalytic domains

Author(s): Roghanian, Mohammad;Van Nerom, Katleen ;Takada, Hiraku;Caballero Montes, Julien ;Tamman, Hedvig ;Kudrin, Pavel;Talavera Perez, Ariel ;Dzhygyr, Ievgen;Ekström, Simon;Atkinson, Gemma Catherine;Garcia-Pino, Abel ;Hauryliuk, Vasili
Published in: Molecular cell, Issue 81, 16, 2021, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2021.07.026

Dynamic transitions of initiator binding coordinate the replication of the two chromosomes in Vibrio cholerae

Author(s): Théophile Niault, Ariel Talavera, Eric Le Cam, Sonia Baconnais, Ole Skovgaard, Florian Fournes, Léa Wagner, Hedvig Tamman, Andrew Thompson, Dannele Echemendia-Blanco, Noa Guzzi, Abel Garcia-Pino, Didier Mazel, Marie-Eve Val
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-55598-9

RelA-SpoT Homolog toxins pyrophosphorylate the CCA end of tRNA to inhibit protein synthesis

Author(s): Kurata, Tatsuaki;Brodiazhenko, Tetiana;Alves Oliveira, Sofia Raquel;Roghanian, Mohammad;Sakaguchi, Yuriko;Turnbull, Kathryn Jane;Bulvas, Ondrej;Takada, Hiraku;Tamman, Hedvig ;Ainelo, Andres;Pohl, Radek;Rejman, Dominik;Tenson, Tanel;Suzuki, Tsutomu;Garcia-Pino, Abel ;Atkinson, Gemma Catherine;Hauryliuk, Vasili
Published in: Molecular cell, Issue 81, 15, 2021, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2021.06.005

Mechanisms of neutralization of toxSAS from toxin–antitoxin modules

Author(s): Lucia Dominguez-Molina, Tatsuaki Kurata, Albinas Cepauskas, Dannele Echemendia-Blanco, Safia Zedek, Ariel Talavera-Perez, Gemma C. Atkinson, Vasili Hauryliuk, Abel Garcia-Pino
Published in: Nature Chemical Biology, Issue 21, 2025, Page(s) 182-192, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-024-01630-4