Disentangling the stringent response to engineer novel anti-persister drugs

Informazioni relative al progetto

DiStRes

ID dell’accordo di sovvenzione: 864311

DOI

10.3030/864311

Progetto chiuso

Data della firma CE 6 Marzo 2020

Data di avvio 1 Dicembre 2020

Data di completamento 30 Novembre 2025

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 000 000,00

Contributo UE

€ 2 000 000,00

Coordinato da

UNIVERSITE LIBRE DE BRUXELLES
Belgium

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (15)

Nonhydrolysable Analogues of (p)ppGpp and (p)ppApp Alarmone Nucleotides as Novel Molecular Tools

Autori: Mojr, Viktor;Roghanian, Mohammad;Tamman, Hedvig ;Do Pham, Duy Dinh;Petrová, Magdalena;Pohl, Radek;Takada, Hiraku;Van Nerom, Katleen ;Ainelo, Hanna ;Caballero Montes, Julien ;Jimmy, Steffi;Garcia-Pino, Abel ;Hauryliuk, Vasili;Rejman, Dominik
Pubblicato in: A C S Chemical Biology, 2021, ISSN 1554-8929
Editore: American Chemical Society
DOI: 10.1021/acschembio.1c00398

The structural basis of hyperpromiscuity in a core combinatorial network of type II toxin–antitoxin and related phage defense systems

Autori: Karin Ernits Chayan Kumar Saha Tetiana Brodiazhenko Bhanu Chouhan Aditi Shenoy Jessica A Buttress Julián J Duque-Pedraza Veda Bojar Jose A Nakamoto Tatsuaki Kurata Artyom A Egorov Lena Shyrokova Marcus J O Johansson Toomas Mets Aytan Rustamova Jelisaveta Džigurski Tanel Tenson Abel Garcia-Pino Henrik Strahl Arne Elofsson Vasili Hauryliuk Gemma C Atkinson
Pubblicato in: Proc Natl Acad Sci U S A ., 2023, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2305393120

A polyamine acetyltransferase regulates the motility and biofilm formation of Acinetobacter baumannii

Autori: Armalytė J, Čepauskas A, Šakalytė G, Martinkus J, Skerniškytė J, Martens C, Sužiedėlienė E, Garcia-Pino A, Jurėnas D.
Pubblicato in: Nature Communications, Numero 14, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-39316-5

Toxic small alarmone synthetase FaRel2 inhibits translation by pyrophosphorylating tRNA ^Gly and tRNA ^Thr

Autori: Tatsuaki Kurata, Masaki Takegawa, Takayuki Ohira, Egor A. Syroegin, Gemma C. Atkinson, Marcus J.O. Johansson, Yury S. Polikanov, Abel Garcia-Pino, Tsutomu Suzuki, Vasili Hauryliuk
Pubblicato in: Science Advances, Numero 10, 2024, ISSN 2375-2548
Editore: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/sciadv.adr9624

Mechanism of phage sensing and restriction by toxin-antitoxin-chaperone systems

Autori: Mets, Toomas; Kurata, Tatsuaki; Ernits, Karin; Johansson, Marcus J.O.; Craig, Sophie Z.; Evora, Gabriel Medina; Buttress, Jessica A.; Odai, Roni; Wallant, Kyo Coppieters‘t; Nakamoto, Jose A.; Shyrokova, Lena; Egorov, Artyom A.; Doering, Christopher Ross; Brodiazhenko, Tetiana; Laub, Michael T.; Tenson, Tanel; Strahl, Henrik; Martens, Chloe; Harms, Alexander; id_orcid0000-0003-2106-1286; Garcia-P
Pubblicato in: Cell Host & Microbe, 32 (7), Numero 2, 2024, ISSN 1934-6069
Editore: Elsevier
DOI: 10.3929/ethz-b-000682805

The structure of DarB in complex with RelNTD reveals nonribosomal activation of Rel stringent factors

Autori: Ainelo A, Caballero-Montes J, Bulvas O, Ernits K, Coppieters 't Wallant K, Takada H, Craig SZ, Mazzucchelli G, Zedek S, Pichová I, Atkinson GC, Talavera A, Martens C, Hauryliuk V, Garcia-Pino A.
Pubblicato in: Science Advances, Numero 9, 2023, ISSN 2375-2548
Editore: American Association for the Advancement of Science
DOI: 10.1126/sciadv.ade4077

Ribosome association primes the stringent factor Rel for tRNA-dependent locking in the A-site and activation of (p)ppGpp synthesis

Autori: Hiraku Takada Mohammad Roghanian Julien Caballero-Montes Katleen Van Nerom Steffi Jimmy Pavel Kudrin Fabio Trebini Rikinori Murayama Genki Akanuma Abel Garcia-Pino Vasili Hauryliuk
Pubblicato in: Nucleic Acids Research, 2021, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkaa1187

Biochemical and X-ray analyses of the players involved in the <i>faRel</i>2/<i>aTfaRel</i>2 toxin–antitoxin operon

Autori: Lucia Dominguez-Molina; Ariel Talavera; Albinas Cepauskas; Tatsuaki Kurata; Dannele Echemendia-Blanco; Vasili Hauryliuk; Abel Garcia-Pino
Pubblicato in: Acta Crystallographica Section F, Numero 1, 2023, ISSN 2053-230X
Editore: John Wiley and Sons Ltd
DOI: 10.1107/s2053230x23007288

A bacterial immunity protein directly senses two disparate phage proteins

Autori: Tong Zhang, Albinas Cepauskas, Anastasiia Nadieina, Aurelien Thureau, Kyo Coppieters ‘t Wallant, Chloé Martens, Daniel C. Lim, Abel Garcia-Pino, Michael T. Laub
Pubblicato in: Nature, Numero 635, 2025, Pagina/e 728-735, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-024-08039-y

Direct activation of a bacterial innate immune system by a viral capsid protein

Autori: Zhang T, Tamman H, Coppieters 't Wallant K, Kurata T, LeRoux M, Srikant S, Brodiazhenko T, Cepauskas A, Talavera A, Martens C, Atkinson GC, Hauryliuk V, Garcia-Pino A, Laub MT.
Pubblicato in: Nature, Numero 612, 2022, Pagina/e 132-140, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41586-022-05444-z

Structure of SpoT reveals evolutionary tuning of catalysis via conformational constraint

Autori: Tamman H, Ernits K, Roghanian M, Ainelo A, Julius C, Perrier A, Talavera A, Ainelo H, Dugauquier R, Zedek S, Thureau A, Pérez J, Lima-Mendez G, Hallez R, Atkinson GC, Hauryliuk V, Garcia-Pino A.
Pubblicato in: Nature Chemical Biology, Numero 19, 2022, Pagina/e 334–345, ISSN 1552-4450
Editore: Nature Publishing Group
DOI: 10.1038/s41589-022-01198-x

(p)ppGpp controls stringent factors by exploiting antagonistic allosteric coupling between catalytic domains

Autori: Roghanian, Mohammad;Van Nerom, Katleen ;Takada, Hiraku;Caballero Montes, Julien ;Tamman, Hedvig ;Kudrin, Pavel;Talavera Perez, Ariel ;Dzhygyr, Ievgen;Ekström, Simon;Atkinson, Gemma Catherine;Garcia-Pino, Abel ;Hauryliuk, Vasili
Pubblicato in: Molecular cell, Numero 81, 16, 2021, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2021.07.026

Dynamic transitions of initiator binding coordinate the replication of the two chromosomes in Vibrio cholerae

Autori: Théophile Niault, Ariel Talavera, Eric Le Cam, Sonia Baconnais, Ole Skovgaard, Florian Fournes, Léa Wagner, Hedvig Tamman, Andrew Thompson, Dannele Echemendia-Blanco, Noa Guzzi, Abel Garcia-Pino, Didier Mazel, Marie-Eve Val
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-55598-9

RelA-SpoT Homolog toxins pyrophosphorylate the CCA end of tRNA to inhibit protein synthesis

Autori: Kurata, Tatsuaki;Brodiazhenko, Tetiana;Alves Oliveira, Sofia Raquel;Roghanian, Mohammad;Sakaguchi, Yuriko;Turnbull, Kathryn Jane;Bulvas, Ondrej;Takada, Hiraku;Tamman, Hedvig ;Ainelo, Andres;Pohl, Radek;Rejman, Dominik;Tenson, Tanel;Suzuki, Tsutomu;Garcia-Pino, Abel ;Atkinson, Gemma Catherine;Hauryliuk, Vasili
Pubblicato in: Molecular cell, Numero 81, 15, 2021, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2021.06.005

Mechanisms of neutralization of toxSAS from toxin–antitoxin modules

Autori: Lucia Dominguez-Molina, Tatsuaki Kurata, Albinas Cepauskas, Dannele Echemendia-Blanco, Safia Zedek, Ariel Talavera-Perez, Gemma C. Atkinson, Vasili Hauryliuk, Abel Garcia-Pino
Pubblicato in: Nature Chemical Biology, Numero 21, 2025, Pagina/e 182-192, ISSN 1552-4450
Editore: Nature Publishing Group
DOI: 10.1038/s41589-024-01630-4