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Disentangling the stringent response to engineer novel anti-persister drugs

Project description

Novel mechanistic insight into antibiotic resistance

Antibiotic-resistant bacteria are a growing health concern worldwide with many healthcare implications. Emerging evidence indicates that dormant bacteria subpopulations which are difficult to eradicate with conventional means are the primary source of antibiotic resistance. The EU-funded DiStRes project is investigating the RelA/SpoT (RSH) proteins that promote the stringent response in bacteria and modulate cell metabolism through the (p)ppGpp. Through a combined microbiology and structural biology approach, researchers will focus on the molecular mechanisms of ppGpp synthesis and hydrolysis. DiStRes will not only shed light on the mechanism of drug resistance, but also help design and screen novel drug candidates that target the stringent response in persistent bacteria.

Call for proposal

ERC-2019-COG
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Host institution

UNIVERSITE LIBRE DE BRUXELLES
Address
Avenue Franklin Roosevelt 50
1050 Bruxelles
Belgium
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 000 000

Beneficiaries (1)

UNIVERSITE LIBRE DE BRUXELLES
Belgium
EU contribution
€ 2 000 000
Address
Avenue Franklin Roosevelt 50
1050 Bruxelles
Activity type
Higher or Secondary Education Establishments