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BioInspired Clicked Siderophore-Antibiotics

Project description

A Trojan horse strategy for killing bacteria

The rapid increase in antibiotic resistance poses a global healthcare threat. According to the World Health Organisation, the development of novel drugs against Mycobacterium tuberculosis and Gram-negative nosocomial infections constitutes a top priority. To enhance drug uptake by bacteria, the EU-funded ANTIBIOCLICKS project is working on a Trojan horse-like approach whereby the antibiotic gets conjugated to iron-chelating microbial siderophores used to transport iron across cell membranes. Scientists will employ a simple yet powerful click chemistry strategy to couple siderophores to antibiotics or other molecules and evaluate their antibiotic and diagnostic potential. The new bioinspired conjugation chemistry will serve as the stepping stone for the future development of novel bacterial therapeutics and diagnostics.

Field of science

  • /natural sciences/biological sciences/microbiology/bacteriology
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance
  • /medical and health sciences/clinical medicine/pneumology/tuberculosis

Call for proposal

ERC-2019-COG
See other projects for this call

Funding Scheme

ERC-COG - Consolidator Grant

Host institution

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Address
Rue De Tolbiac 101
75654 Paris
France
Activity type
Research Organisations
EU contribution
€ 2 000 000

Beneficiaries (1)

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 2 000 000
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations