Projektbeschreibung
Neue Studie untersucht Interaktionen, die die Myelinbildung stören
Eine Störung der Myelinbildung in unserem Körper verursacht ernsthafte Erkrankungen wie Multiple Sklerose. Das EU-finanzierte Projekt OLI.VAS wird die molekularen Interaktionen zwischen Blutgefäßen und Oligodendrozyten, Gliazellen, die im zentralen Nervensystem Myelin bilden, untersuchen. Jüngste Forschungsergebnisse deuten darauf hin, dass Blutgefäße nicht nur Sauerstoff und Nährstoffe bereitstellen, sondern auch aktiv die Entwicklung und Funktion der Organe steuern. Diesbezüglich fand die Forschungsgruppe von OLI.VAS heraus, dass die von den Gefäßen ausgehenden Signale direkt die Bildung von Oligodendrozyten-Vorläuferzellen an der sogenannten oglio-vaskulären Schnittstelle steuern. Anhand eines multidisziplinären Ansatzes wollen die Forschenden die molekularen Interaktionen zwischen Blutgefäßen und Oligodendrozyten während der Entwicklung und der Homöostase sowie bei demyelinisierenden Erkrankungen ermitteln.
Ziel
Oligodendrocytes (OLs) are the glia cells that produce myelin in the central nervous system (CNS). Despite the severe outcome of demyelinating diseases, like multiple sclerosis (MS), little is known about the mechanisms by which myelin is disrupted or why remyelination fails in disease. Thus, a substantial advance in the understanding of oligodendrocyte biology and myelin pathology is required in order to develop successful treatments for demyelinating diseases.
Recent research indicates that apart from delivering oxygen and nutrients, blood vessels are active regulators of organ function. Our recent work supports the existence of an oligo-vascular interface where vessels directly control oligodendrogenesis. However, mechanistic insights of the interaction between OLs and the vasculature are lacking. Based on the innovative hypothesis that proper generation and OL functionality depends on active crosstalk with the vasculature, the OLI.VAS project will now tackle the challenge to characterize in depth the interaction between OLs and the vasculature during development and demyelinating diseases.
To achieve this goal, two complementary multidisciplinary research tracks are pursued:
Research track 1: Deconstructing and reconstructing the oligo-vascular interface to unravel the relationship of oligodendrocyte lineage cells with the vasculature
Research track 2: Studying the oligo-vascular interface in white matter lesions. Modulating the vasculature to prevent de-myelination or promote of re-myelination
Both tracks combine cutting edge technology in single cell and spatial transcriptomics, bioinformatics, 3D imaging, in vitro and ex vivo tissue culture, mouse genetics and MS patient samples.
OLI.VAS will deliver new insights into the role of the vasculature as a regulator of oligodendrogenesis and myelination and thus generate major scientific breakthroughs in an area that is highly relevant for diseases such as MS, which affects more than 600000 patients in Europe.
Wissenschaftliches Gebiet
Schlüsselbegriffe
Programm/Programme
Thema/Themen
Finanzierungsplan
ERC-COG - Consolidator GrantGastgebende Einrichtung
53127 Bonn
Deutschland