Decoding protein persulfidation signaling

Project Information

SULFAGING

Grant agreement ID: 864921

DOI

10.3030/864921

EC signature date 23 June 2020

Start date 1 October 2020

End date 28 February 2027

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 999 905,00

EU contribution

€ 1 999 905,00

Coordinated by

UNIVERSITY OF GLASGOW
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management Plan

The DMP provides an analysis of the main elements of the data management policy .

Publications

Peer reviewed articles (9)

The Role of Protein Persulfidation in Brain Aging and Neurodegeneration

Author(s): Dunja Petrovic, Emilia Kouroussis, Thibaut Vignane, Milos R. Filipovic
Published in: Frontiers in Aging Neuroscience, Issue 13, 2021, ISSN 1663-4365
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnagi.2021.674135

PTPRK regulates glycolysis and de novo lipogenesis to promote hepatocyte metabolic reprogramming in obesity

Author(s): Eduardo H. Gilglioni, Ao Li, Wadsen St-Pierre-Wijckmans, Tzu-Keng Shen, Israel Pérez-Chávez, Garnik Hovhannisyan, Michela Lisjak, Javier Negueruela, Valerie Vandenbempt, Julia Bauzá-Martinez, Jose M. Herranz, Daria Ezeriņa, Stéphane Demine, Zheng Feng, Thibaut Vignane, Lukas Otero Sanchez, Flavia Lambertucci, Alena Prašnická, Jacques Devière, David C. Hay, Jose A. Encinar, Sumeet Pal Singh
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-53733-0

Neurobehavioral dysfunction in a mouse model of Down syndrome: upregulation of cystathionine β-synthase, H2S overproduction, altered protein persulfidation, synaptic dysfunction, endoplasmic reticulum stress, and autophagy

Author(s): Theodora Panagaki, Lucia Janickova, Dunja Petrovic, Karim Zuhra, Tamás Ditrói, Eszter P. Jurányi, Olivier Bremer, Kelly Ascenção, Thilo M. Philipp, Péter Nagy, Milos R. Filipovic, Csaba Szabo
Published in: GeroScience, Issue 46, 2024, Page(s) 4275-4314, ISSN 2509-2723
Publisher: Springer
DOI: 10.1007/s11357-024-01146-8

Hypoxia sensing requires H2S dependent persulfidation of olfactory receptor 78

Author(s): Ying-Jie Peng, Jayasri Nanduri, Ning Wang, Ganesh K. Kumar, Vytautas Bindokas,Bindu D. Paul, Xuanmao Chen, Aaron P. Fox, Thibaut Vignane, Milos R. Filipovic, Nanduri R. Prabhakar
Published in: Science Advances, Issue 9(27), 2023, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.adf3026

Hydrogen sulfide is neuroprotective in Alzheimer’s disease by sulfhydrating GSK3β and inhibiting Tau hyperphosphorylation

Author(s): Daniel Giovinazzo, Biljana Bursac, Juan I. Sbodio, Sumedha Nalluru, Thibaut Vignane, Adele M. Snowman, Lauren M. Albacarys, Thomas W. Sedlak, Roberta Torregrossa, Matthew Whiteman, Milos R. Filipovic, Solomon H. Snyder, Bindu D. Paul
Published in: Proceedings of the National Academy of Sciences, Issue 118/4, 2021, Page(s) e2017225118, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2017225118

ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1.

Author(s): Cyril Statzer, Jin Meng, Richard Venz, Monet Bland, Stacey Robida-Stubbs, Krina Patel, Dunja Petrovic, Raffaella Emsley, Pengpeng Liu, Ianessa Morantte, Cole Haynes, William B. Mair, Alban Longchamp, Milos R. Filipovic, T. Keith Blackwell & Collin Y. Ewald
Published in: Nature Communications, Issue 13, 967 (2022), 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-28599-9

Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation

Author(s): Dunja Petrovic, Luke Slade, Yiorgos Paikopoulos, Davide D’Andrea, Nevena Savic, Ana Stancic, Jan Lj Miljkovic, Thibaut Vignane, Maria Kyriaki Drekolia, Dusan Mladenovic, Nikola Sutulovic, Alice Refeyton, Milica Kolakovic, Vladimir M. Jovanovic, Jasmina Zivanovic, Marko Miler, Valentina Vellecco, Vincenzo Brancaleone, Mariarosaria Bucci, Alva M. Casey, ChakShun Yu, Siva Swapna Kasarla, Karl Willi
Published in: Cell Metabolism, Issue 37, 2025, Page(s) 542-556.e14, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2024.12.008

Emerging Chemical Biology of Protein Persulfidation

Author(s): Thibaut Vignane, Milos R. Filipovic
Published in: Antioxidants & Redox Signaling, Issue 39(1-3), 2023, Page(s) 19-39, ISSN 1523-0864
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/ars.2023.0352

Persulfidation protects from oxidative stress under nonphotorespiratory conditions in Arabidopsis

Author(s): Margarita García-Calderón, Thibaut Vignane, Milos R. Filipovic, M. Teresa Ruiz, Luis C. Romero, Antonio J. Márquez, Cecilia Gotor, Angeles Aroca
Published in: New Phytologist, 2023, ISSN 0028-646X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/nph.18838

Other (1)

Protein thiol alterations drive aberrant phase separation in aging

Author(s): Thibaut Vignane, Martín Hugo, Christian Hoffmann, Antionia Katsouda, Jovan Petric, Han Wang, Marko Miler, Ferran Comas, Dunja Petrovic, Suyuan Chen, Jan Lj. Miljkovic, Jordan L Morris, Suvagata Roy Chowdhury, Julien Prudent, Natalija Polovic, Michael P. Murphy, Andreas Papapetropoulos, Dragomir Milovanovic, Milos R. Filipovic
Published in: bioRxiv preprint, 2023
Publisher: Cold Spring Harbor Laboratory (CSHL)
DOI: 10.1101/2023.11.07.566021

Book chapters (1)

Detection of protein persulfidation in plants by the dimedone switch method

Author(s): Angeles Aroca; Ana Jurado-Flores; Milos R. Filipovic; Cecilia Gotor; Luis C. Romero
Published in: Methods in Enzymology, Issue 676, 2022, Page(s) 385-402, ISBN 9780323955614
Publisher: Academic Press
DOI: 10.1016/bs.mie.2022.07.024