Decoding protein persulfidation signaling

Informazioni relative al progetto

SULFAGING

ID dell’accordo di sovvenzione: 864921

DOI

10.3030/864921

Data della firma CE 23 Giugno 2020

Data di avvio 1 Ottobre 2020

Data di completamento 28 Febbraio 2027

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 999 905,00

Contributo UE

€ 1 999 905,00

Coordinato da

UNIVERSITY OF GLASGOW
United Kingdom

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Open Research Data Pilot (1)

Data Management Plan

The DMP provides an analysis of the main elements of the data management policy .

Pubblicazioni

Peer reviewed articles (9)

The Role of Protein Persulfidation in Brain Aging and Neurodegeneration

Autori: Dunja Petrovic, Emilia Kouroussis, Thibaut Vignane, Milos R. Filipovic
Pubblicato in: Frontiers in Aging Neuroscience, Numero 13, 2021, ISSN 1663-4365
Editore: Frontiers Research Foundation
DOI: 10.3389/fnagi.2021.674135

PTPRK regulates glycolysis and de novo lipogenesis to promote hepatocyte metabolic reprogramming in obesity

Autori: Eduardo H. Gilglioni, Ao Li, Wadsen St-Pierre-Wijckmans, Tzu-Keng Shen, Israel Pérez-Chávez, Garnik Hovhannisyan, Michela Lisjak, Javier Negueruela, Valerie Vandenbempt, Julia Bauzá-Martinez, Jose M. Herranz, Daria Ezeriņa, Stéphane Demine, Zheng Feng, Thibaut Vignane, Lukas Otero Sanchez, Flavia Lambertucci, Alena Prašnická, Jacques Devière, David C. Hay, Jose A. Encinar, Sumeet Pal Singh
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-53733-0

Neurobehavioral dysfunction in a mouse model of Down syndrome: upregulation of cystathionine β-synthase, H2S overproduction, altered protein persulfidation, synaptic dysfunction, endoplasmic reticulum stress, and autophagy

Autori: Theodora Panagaki, Lucia Janickova, Dunja Petrovic, Karim Zuhra, Tamás Ditrói, Eszter P. Jurányi, Olivier Bremer, Kelly Ascenção, Thilo M. Philipp, Péter Nagy, Milos R. Filipovic, Csaba Szabo
Pubblicato in: GeroScience, Numero 46, 2024, Pagina/e 4275-4314, ISSN 2509-2723
Editore: Springer
DOI: 10.1007/s11357-024-01146-8

Hypoxia sensing requires H2S dependent persulfidation of olfactory receptor 78

Autori: Ying-Jie Peng, Jayasri Nanduri, Ning Wang, Ganesh K. Kumar, Vytautas Bindokas,Bindu D. Paul, Xuanmao Chen, Aaron P. Fox, Thibaut Vignane, Milos R. Filipovic, Nanduri R. Prabhakar
Pubblicato in: Science Advances, Numero 9(27), 2023, ISSN 2375-2548
Editore: American Association for the Advancement of Science
DOI: 10.1126/sciadv.adf3026

Hydrogen sulfide is neuroprotective in Alzheimer’s disease by sulfhydrating GSK3β and inhibiting Tau hyperphosphorylation

Autori: Daniel Giovinazzo, Biljana Bursac, Juan I. Sbodio, Sumedha Nalluru, Thibaut Vignane, Adele M. Snowman, Lauren M. Albacarys, Thomas W. Sedlak, Roberta Torregrossa, Matthew Whiteman, Milos R. Filipovic, Solomon H. Snyder, Bindu D. Paul
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 118/4, 2021, Pagina/e e2017225118, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2017225118

ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1.

Autori: Cyril Statzer, Jin Meng, Richard Venz, Monet Bland, Stacey Robida-Stubbs, Krina Patel, Dunja Petrovic, Raffaella Emsley, Pengpeng Liu, Ianessa Morantte, Cole Haynes, William B. Mair, Alban Longchamp, Milos R. Filipovic, T. Keith Blackwell & Collin Y. Ewald
Pubblicato in: Nature Communications, Numero 13, 967 (2022), 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-28599-9

Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation

Autori: Dunja Petrovic, Luke Slade, Yiorgos Paikopoulos, Davide D’Andrea, Nevena Savic, Ana Stancic, Jan Lj Miljkovic, Thibaut Vignane, Maria Kyriaki Drekolia, Dusan Mladenovic, Nikola Sutulovic, Alice Refeyton, Milica Kolakovic, Vladimir M. Jovanovic, Jasmina Zivanovic, Marko Miler, Valentina Vellecco, Vincenzo Brancaleone, Mariarosaria Bucci, Alva M. Casey, ChakShun Yu, Siva Swapna Kasarla, Karl Willi
Pubblicato in: Cell Metabolism, Numero 37, 2025, Pagina/e 542-556.e14, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2024.12.008

Emerging Chemical Biology of Protein Persulfidation

Autori: Thibaut Vignane, Milos R. Filipovic
Pubblicato in: Antioxidants & Redox Signaling, Numero 39(1-3), 2023, Pagina/e 19-39, ISSN 1523-0864
Editore: Mary Ann Liebert Inc.
DOI: 10.1089/ars.2023.0352

Persulfidation protects from oxidative stress under nonphotorespiratory conditions in Arabidopsis

Autori: Margarita García-Calderón, Thibaut Vignane, Milos R. Filipovic, M. Teresa Ruiz, Luis C. Romero, Antonio J. Márquez, Cecilia Gotor, Angeles Aroca
Pubblicato in: New Phytologist, 2023, ISSN 0028-646X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/nph.18838

Other (1)

Protein thiol alterations drive aberrant phase separation in aging

Autori: Thibaut Vignane, Martín Hugo, Christian Hoffmann, Antionia Katsouda, Jovan Petric, Han Wang, Marko Miler, Ferran Comas, Dunja Petrovic, Suyuan Chen, Jan Lj. Miljkovic, Jordan L Morris, Suvagata Roy Chowdhury, Julien Prudent, Natalija Polovic, Michael P. Murphy, Andreas Papapetropoulos, Dragomir Milovanovic, Milos R. Filipovic
Pubblicato in: bioRxiv preprint, 2023
Editore: Cold Spring Harbor Laboratory (CSHL)
DOI: 10.1101/2023.11.07.566021

Book chapters (1)

Detection of protein persulfidation in plants by the dimedone switch method

Autori: Angeles Aroca; Ana Jurado-Flores; Milos R. Filipovic; Cecilia Gotor; Luis C. Romero
Pubblicato in: Methods in Enzymology, Numero 676, 2022, Pagina/e 385-402, ISBN 9780323955614
Editore: Academic Press
DOI: 10.1016/bs.mie.2022.07.024