New Reagents for Quantifying the Routing and Kinetics of T-cell Activation

Project Information

KineTic

Grant agreement ID: 865175

DOI

10.3030/865175

EC signature date 12 February 2020

Start date 1 August 2020

End date 31 January 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 000 000,00

EU contribution

€ 2 000 000,00

Coordinated by

UNIVERSITEIT LEIDEN
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (12)

QUAS-R: An SLC1A5-mediated glutamine uptake assay with single-cell resolution reveals metabolic heterogeneity with immune populations

Author(s): Leonard R. Pelgrom, Gavin M. Davis, Simon O’Shaughnessy, Emilie J.M. Wezenberg, Sander I. Van Kasteren, David K. Finlay, Linda V. Sinclair
Published in: Cell Reports, Issue 42, 2024, Page(s) 112828, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2023.112828

Single-cell analysis of regions of interest (SCARI) using a photosensitive tag

Author(s): Anne M. van der Leun, Mirjam E. Hoekstra, Luuk Reinalda, Colinda L. G. J. Scheele, Mireille Toebes, Michel J. van de Graaff, Linda Y. Y. Chen, Hanjie Li, Akhiad Bercovich, Yaniv Lubling, Eyal David, Daniela S. Thommen, Amos Tanay, Jacco van Rheenen, Ido Amit, Sander I. van Kasteren & Ton N. Schumacher
Published in: Nature Chemical biology, Issue 17, 2021, Page(s) 1139-1147, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-021-00839-x

Citrullinated human and murine MOG35-55 display distinct biophysical and biochemical behavior

Author(s): W. Doelman, R.C. Reijnen, N. Dijksman, A.P.A. Janssen, N. van Driel, B.A. ’t Hart, I. Philippens, C. Araman, W. Baron, S.I. van Kasteren
Published in: Journal of Biological Chemistry, 2023, ISSN 1083-351X
Publisher: Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology
DOI: 10.1016/j.jbc.2023.103065

Bioorthogonal Correlative Light-Electron Microscopy of Mycobacterium tuberculosis in Macrophages Reveals the Effect of Antituberculosis Drugs on Subcellular Bacterial Distribution

Author(s): Thomas Bakkum, Matthias T. Heemskerk, Erik Bos, Mirjam Groenewold, Nikolaos Oikonomeas-Koppasis, Kimberley V. Walburg, Suzanne van Veen, Martijn J. C. van der Lienden, Tyrza van Leeuwen, Marielle C. Haks, Tom H. M. Ottenhoff, Abraham J. Koster, and Sander I. van Kasteren
Published in: ACS Central Science, Issue 6,11, 2020, Page(s) 1997–2007, ISSN 2374-7943
Publisher: American Chemical Society
DOI: 10.1021/acscentsci.0c00539

A Lysosome-Targeted Tetrazine for Organelle-Specific Click-to-Release Chemistry in Antigen Presenting Cells

Author(s): Nina A.M. Ligthart, Mark A.R. de Geus, Merel A.T. van de Plassche, Diana Torres García, Marjolein M.E. Isendoorn, Luuk Reinalda, Daniëlle Ofman, Tyrza van Leeuwen, Sander I. van Kasteren
Published in: Journal of the American Chemical Society, Issue 145, 2023, Page(s) 12630-12640, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.3c02139

Probing the metalloproteome: an 8-mercaptoquinoline motif enriches minichromosome maintenance complex components as significant metalloprotein targets in live cells

Author(s): Sean M. McKenna, Bogdan I. Florea, Daniela M. Zisterer, Sander I. van Kasteren, Joanna F. McGouran
Published in: RSC Chemical Biology, Issue 5, 2024, Page(s) 776-786, ISSN 2633-0679
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4cb00053f

Live-cell imaging of sterculic acid - a naturally occurring 1,2-cyclopropene fatty acid - by bioorthogonal reaction with turn-on tetrazine-fluorophore conjugates

Author(s): Kristine Bertheussen; Merel van de Plassche; Thomas Bakkum; Berend Gagestein; Iakovia Ttofi; Alexi J. C. Sarris; Herman S. Overkleeft; Mario van der Stelt; Sander I. van Kasteren
Published in: Angewandte Chemie (International Edition), Issue 1, 2022, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.

Application of a Highly Selective Cathepsin S Two-step Activity-Based Probe in Multicolor Bio-Orthogonal Correlative Light-Electron Microscopy

Author(s): Floris J. van Dalen; Thomas Bakkum; Tyrza van Leeuwen; Mirjam Groenewold; Edgar Deu; Abraham J. Koster; Sander I. van Kasteren; Martijn Verdoes
Published in: Frontiers in Chemistry, Issue 1, 2021, Page(s) 628433, ISSN 2296-2646
Publisher: Frontiers
DOI: 10.3389/fchem.2020.628433

Bioorthogonal Peptide Enrichment From Complex Samples Using a Rink-Amide-Based Catch-and-Release Strategy

Author(s): Tyrza van Leeuwen, Ward Doelman, Robin W.R. van den Kieboom, Bogdan I. Florea, Sander I. van Kasteren
Published in: ChemBioChem, Issue e202300082, 2023, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202300082

Methyltetrazine as a small live-cell compatible bioorthogonal handle for imaging enzyme activities in situ

Author(s): Diana Torres-García; Merel A. T. van de Plassche; Emma van Boven; Tyrza van Leeuwen; Mirjam G. J. Groenewold; Alexi J. C. Sarris; Luuk Klein; Herman S. Overkleeft; Sander I. van Kasteren
Published in: RSC Chemical Biology, Issue 1, 2022, Page(s) 1325-1330, ISSN 2633-0679
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2cb00120a

Single-molecule imaging of glycan–lectin interactions on cells with Glyco-PAINT

Author(s): Roger Riera, Tim P. Hogervorst, Ward Doelman, Yan Ni, Silvia Pujals, Evangelia Bolli, Jeroen D. C. Codée, Sander I. van Kasteren & Lorenzo Albertazzi
Published in: Nature Chemical Biology, Issue 17, 2021, Page(s) 1281-1288, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-021-00896-2

Bioorthogonal protein labelling enables the study of antigen processing of citrullinated and carbamylated auto-antigens

Author(s): Tyrza van Leeuwen; Can Araman; Linda Pieper Pournara; Arieke S. B. Kampstra; Thomas Bakkum; Mikkel H. S. Marqvorsen; Clarissa R. Nascimento; G. J. Mirjam Groenewold; Willemijn van der Wulp; Marcel Camps; George M.C. Janssen; Peter A. van Veelen; Gerard J. P. van Westen; Antonius P A Janssen; Bogdan I. Florea; Herman S. Overkleeft; Ferry Ossendorp; René E. M. Toes; Sander I. van Kasteren
Published in: RSC Chemical Biology, Issue 2, 2021, Page(s) 855-862, ISSN 2633-0679
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1cb00009h