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Translational aspects of the discovery of skull marrow – meninges connections

Project description

Exploiting skull-meninges connections to control brain pathologies

As more and more people around the world are living longer, society is facing growing challenges arising from neurodegenerative diseases affecting millions of people. The recent discovery of the skull-meninges connections (SMCs) that can mediate immune cell trafficking into the brain is extremely promising for new diagnostics and treatments. However, the comprehensive cellular and structural features of the SMCs and the skull/calvaria need further research. The EU-funded CALVARIA project will use advanced experimental technologies of tissue clearing, proteomics and single-cell RNA sequencing to investigate possible exploitation of the discovery for easier access from the skull/calvaria bone marrow, enabling better drug delivery into the brain, control of neuroinflammation and easier detection of brain pathologies.

Call for proposal

ERC-2019-COG
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Host institution

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Address
Ingolstadter Landstrasse 1
85764 Neuherberg
Germany
Activity type
Research Organisations
EU contribution
€ 1 996 900

Beneficiaries (1)

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
EU contribution
€ 1 996 900
Address
Ingolstadter Landstrasse 1
85764 Neuherberg
Activity type
Research Organisations