Spatio-Temporal Regulation of Inflammation and Tissue Regeneration: Studying the immune system - tissue - microbiota communication to develop targeted therapies for immune-mediated diseases and cancer

Project Information

REpAIR

Grant agreement ID: 865466

DOI

10.3030/865466

EC signature date 7 February 2020

Start date 1 October 2020

End date 30 September 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 999 687,00

EU contribution

€ 1 999 687,00

Coordinated by

UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (13)

Efferocytosis fuels malignant pleural effusion through TIMP1

Author(s): Lilan Zhao; Lilan Zhao; Anastasios D. Giannou; Yang Xu; Ahmad Mustafa Shiri; Imke Liebold; Imke Liebold; Babett Steglich; Babett Steglich; Tanja Bedke; Tao Zhang; Jöran Lücke; Pasquale Scognamiglio; Jan Kempski; Anna Woestemeier; Jing Chen; Theodora Agalioti; Dimitra E. Zazara; Diana Lindner; Diana Lindner; Melanie Janning; Melanie Janning; Melanie Janning; Jan K. Hennigs; Rajesh Jagirdar; Ouran
Published in: Science Advances, Issue 1, 2021, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abd6734

T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis

Author(s): Daria Briukhovetska, Javier Suarez-Gosalvez, Cornelia Voigt, Anamarija Markota, Anastasios D. Giannou, Maryam Schübel, Jakob Jobst, Tao Zhang, Janina Dörr, Florian Märkl, Lina Majed, Philipp Jie Müller, Peter May, Adrian Gottschlich, Nicholas Tokarew, Jöran Lücke, Arman Oner, Melanie Schwerdtfeger, David Andreu-Sanz, Ruth Grünmeier, Matthias Seifert, Stefanos Michaelides, Michael Hristov, L
Published in: Immunity, 2023, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2022.12.010

IL-22BP controls the progression of liver metastasis in colorectal cancer

Author(s): Anastasios D. Giannou, Jan Kempski, Tao Zhang, Jöran Lücke, Ahmad Mustafa Shiri, Dimitra E. Zazara, Ioannis Belios, Andres Machicote, Philipp Seeger, Theodora Agalioti, Joseph Tintelnot, Adrian Sagebiel, Miriam Tomczak, Lennart Bauditz, Tanja Bedke, Lorenz Kocheise, Baris Mercanoglu, Mohammad Fard-Aghaie, Emmanouil Giorgakis, Panagis M. Lykoudis, Anastasia Pikouli, Julia-Kristin Grass, Ramez Wah
Published in: Frontiers in Oncology, Issue 13, 2023, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2023.1170502

CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis

Author(s): Tao Zhang, Ramez Wahib, Dimitra E. Zazara, Jöran Lücke, Ahmad Mustafa Shiri, Jan Kempski, Lilan Zhao, Theodora Agalioti, Andres Pablo Machicote, Olympia Giannou, Ioannis Belios, Rongrong Jia, Siwen Zhang, Joseph Tintelnot, Hannes Seese, Julia Kristin Grass, Baris Mercanoglu, Louisa Stern, Pasquale Scognamiglio, Mohammad Fard-Aghaie, Philipp Seeger, Jonas Wakker, Marius Kemper, Benjamin Brunswig,
Published in: OncoImmunology, Issue 12, 2024, ISSN 2162-402X
Publisher: Informa UK Limited
DOI: 10.1080/2162402x.2023.2269634

DiSCERN - Deep Single Cell Expression ReconstructioN for improved cell clustering and cell subtype and state detection

Author(s): Fabian Hausmann, Can Ergen-Behr, Robin Khatri, Mohamed Marouf, Sonja Hänzelmann, Nicola Gagliani, Samuel Huber, Pierre Machart, Stefan Bonn
Published in: Genome Biology, Issue 24, 2024, Page(s) 212 (2023), ISSN 1474-760X
Publisher: BioMed Central
DOI: 10.1101/2022.03.09.483600

The good and the bad about separation anxiety: roles of IL-22 and IL-22BP in liver pathologies.

Author(s): Jöran Lücke; Morsal Sabihi; Tao Zhang; Lennart Fynn Bauditz; Ahmad Mustafa Shiri; Anastasios D. Giannou; Samuel Huber
Published in: Seminars in Immunopathology, Issue 1, 2021, ISSN 1863-2297
Publisher: Springer Verlag
DOI: 10.1007/s00281-021-00854-z

Extension of the Segatella copri complex to 13 species with distinct large extrachromosomal elements and associations with host conditions

Author(s): Aitor Blanco-Míguez, Eric J.C. Gálvez, Edoardo Pasolli, Francesca De Filippis, Lena Amend, Kun D. Huang, Paolo Manghi, Till-Robin Lesker, Thomas Riedel, Linda Cova, Michal Punčochář, Andrew Maltez Thomas, Mireia Valles-Colomer, Isabel Schober, Thomas C.A. Hitch, Thomas Clavel, Sarah E. Berry, Richard Davies, Jonathan Wolf, Tim D. Spector, Jörg Overmann, Adrian Tett, Danilo Ercolini, Nicola S
Published in: Cell Host & Microbe, Issue 31, 2024, Page(s) 1804-1819.e9, ISSN 1931-3128
Publisher: Cell Press
DOI: 10.1016/j.chom.2023.09.013

A Critical Role of the IL-22–IL-22 Binding Protein Axis in Hepatocellular Carcinoma

Author(s): Anastasios D. Giannou; Jöran Lücke; Dörte Kleinschmidt; Ahmad Mustafa Shiri; Babett Steglich; Mikolaj Nawrocki; Tao Zhang; Dimitra E. Zazara; Jan Kempski; Lilan Zhao; Olympia Giannou; Theodora Agalioti; Leonie Brockmann; Franziska Bertram; Morsal Sabihi; Marius Böttcher; Florian Ewald; Kornelius Schulze; Johann von Felden; Andres Machicote; Ioannis C. Maroulis; Petra C. Arck; Julia-Kristin Gra
Published in: Cancers; Volume 14; Issue 24; Pages: 6019, Issue 1, 2022, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14246019

Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer

Author(s): Joseph Tintelnot, Yang Xu, Till R. Lesker, Martin Schönlein, Leonie Konczalla, Anastasios D. Giannou, , Penelope Pelczar, Dominik Kylies, Victor G. Puelles, Agata A. Bielecka, Manuela Peschka, Filippo Cortesi, Kristoffer Riecken, Maximilian Jung, Lena Amend, Tobias S. Bröring, Marija Trajkovic-Arsic, Jens T. Siveke, Thomas Renné, Danmei Zhang, Stefan Boeck, Till Strowig, Faik G. Uzunoglu, Cena
Published in: Nature, 2023, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-023-05728-y

IL-10 dampens antitumor immunity and promotes liver metastasis via PD-L1 induction

Author(s): Ahmad Mustafa Shiri, Tao Zhang, Tanja Bedke, Dimitra E. Zazara, Lilan Zhao, Jöran Lücke, Morsal Sabihi, Antonella Fazio, Siwen Zhang, Daniele V.F. Tauriello, Eduard Batlle, Babett Steglich, Jan Kempski, Theodora Agalioti, Mikołaj Nawrocki, Yang Xu, Kristoffer Riecken, Imke Liebold, Leonie Brockmann, Leonie Konczalla, Lidia Bosurgi, Baris Mercanoglu, Philipp Seeger, Natalie Küsters, Panagis M.
Published in: Journal of Hepatology, Issue 80, 2024, Page(s) 634-644, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2023.12.015

Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22

Author(s): Anastasios D. Giannou, Jan Kempski, Ahmad Mustafa Shiri, Jöran Lücke, Tao Zhang, Lilan Zhao, Dimitra E. Zazara, Filippo Cortesi, Kristoffer Riecken, Maria Carolina Amezcua Vesely, Jun Siong Low, Hao Xu, Eleanna Kaffe, Laura Garcia-Perez, Theodora Agalioti, Yoshito Yamada, Wolfgang Jungraithmayr, Ehud Zigmond, Karl-Frederick Karstens, Babett Steglich, Jonas Wagner, Leonia Konczalla, Antonella Car
Published in: Immunity, Issue 56, 2023, Page(s) 125-142.e12, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2022.12.014

Induction of IL-22-Producing CD4+ T Cells by Segmented Filamentous Bacteria Independent of Classical Th17 Cells

Author(s): Urmi Roy, Romulo S. de Oliveira, Eric J. C. Galvez, Achim Gronow, Marijana Basic, Laura Garcia Perez, Nicola Gagliani, Andre Bleich, Samuel Huber, Till Strowig
Published in: Frontiers in Immunology, 2021, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2021.671331

MetaPhlAn 4 profiling of unknown species-level genome bins improves the characterization of diet-associated microbiome changes in mice

Author(s): Paolo Manghi, Aitor Blanco-Míguez, Serena Manara, Amir NabiNejad, Fabio Cumbo, Francesco Beghini, Federica Armanini, Davide Golzato, Kun D. Huang, Andrew M. Thomas, Gianmarco Piccinno, Michal Punčochář, Moreno Zolfo, Till R. Lesker, Marius Bredon, Julien Planchais, Jeremy Glodt, Mireia Valles-Colomer, Omry Koren, Edoardo Pasolli, Francesco Asnicar, Till Strowig, Harry Sokol, Nicola Segata
Published in: Cell Reports, Issue 42, 2025, Page(s) 112464, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2023.112464