Spatio-Temporal Regulation of Inflammation and Tissue Regeneration: Studying the immune system - tissue - microbiota communication to develop targeted therapies for immune-mediated diseases and cancer

Project Information

REpAIR

Grant agreement ID: 865466

DOI 10.3030/865466

EC signature date 7 February 2020

Start date 1 October 2020

End date 31 March 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 999 687,00

EU contribution € 1 999 687,00

Coordinated by

UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Germany

Publications

Peer reviewed articles (6)

Efferocytosis fuels malignant pleural effusion through TIMP1

Author(s): Lilan Zhao; Lilan Zhao; Anastasios D. Giannou; Yang Xu; Ahmad Mustafa Shiri; Imke Liebold; Imke Liebold; Babett Steglich; Babett Steglich; Tanja Bedke; Tao Zhang; Jöran Lücke; Pasquale Scognamiglio; Jan Kempski; Anna Woestemeier; Jing Chen; Theodora Agalioti; Dimitra E. Zazara; Diana Lindner; Diana Lindner; Melanie Janning; Melanie Janning; Melanie Janning; Jan K. Hennigs; Rajesh Jagirdar; Ouran
Published in: Science Advances, Issue 1, 2021, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abd6734

T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis

Author(s): Daria Briukhovetska, Javier Suarez-Gosalvez, Cornelia Voigt, Anamarija Markota, Anastasios D. Giannou, Maryam Schübel, Jakob Jobst, Tao Zhang, Janina Dörr, Florian Märkl, Lina Majed, Philipp Jie Müller, Peter May, Adrian Gottschlich, Nicholas Tokarew, Jöran Lücke, Arman Oner, Melanie Schwerdtfeger, David Andreu-Sanz, Ruth Grünmeier, Matthias Seifert, Stefanos Michaelides, Michael Hristov, L
Published in: Immunity, 2023, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2022.12.010

The good and the bad about separation anxiety: roles of IL-22 and IL-22BP in liver pathologies.

Author(s): Jöran Lücke; Morsal Sabihi; Tao Zhang; Lennart Fynn Bauditz; Ahmad Mustafa Shiri; Anastasios D. Giannou; Samuel Huber
Published in: Seminars in Immunopathology, Issue 1, 2021, ISSN 1863-2297
Publisher: Springer Verlag
DOI: 10.1007/s00281-021-00854-z

A Critical Role of the IL-22–IL-22 Binding Protein Axis in Hepatocellular Carcinoma

Author(s): Anastasios D. Giannou; Jöran Lücke; Dörte Kleinschmidt; Ahmad Mustafa Shiri; Babett Steglich; Mikolaj Nawrocki; Tao Zhang; Dimitra E. Zazara; Jan Kempski; Lilan Zhao; Olympia Giannou; Theodora Agalioti; Leonie Brockmann; Franziska Bertram; Morsal Sabihi; Marius Böttcher; Florian Ewald; Kornelius Schulze; Johann von Felden; Andres Machicote; Ioannis C. Maroulis; Petra C. Arck; Julia-Kristin Gra
Published in: Cancers; Volume 14; Issue 24; Pages: 6019, Issue 1, 2022, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14246019

Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22

Author(s): Anastasios D. Giannou, Jan Kempski, Ahmad Mustafa Shiri, Jöran Lücke, Tao Zhang, Lilan Zhao, Dimitra E. Zazara, Filippo Cortesi, Kristoffer Riecken, Maria Carolina Amezcua Vesely, Jun Siong Low, Hao Xu, Eleanna Kaffe, Laura Garcia-Perez, Theodora Agalioti, Yoshito Yamada, Wolfgang Jungraithmayr, Ehud Zigmond, Karl-Frederick Karstens, Babett Steglich, Jonas Wagner, Leonia Konczalla, Antonella Car
Published in: Immunity, Issue 56, 2023, Page(s) 125-142.e12, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2022.12.014

Induction of IL-22-Producing CD4+ T Cells by Segmented Filamentous Bacteria Independent of Classical Th17 Cells

Author(s): Urmi Roy, Romulo S. de Oliveira, Eric J. C. Galvez, Achim Gronow, Marijana Basic, Laura Garcia Perez, Nicola Gagliani, Andre Bleich, Samuel Huber, Till Strowig
Published in: Frontiers in Immunology, 2021, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2021.671331