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Spatio-Temporal Regulation of Inflammation and Tissue Regeneration: Studying the immune system - tissue - microbiota communication to develop targeted therapies for immune-mediated diseases and cancer

Project description

Colorectal cancer may result from too much of a good thing

Tissue repair is regulated by a complex interplay among the immune system, injured tissue and microbiota. To make matters more complicated, inflammation can play a positive or a negative role. The molecular mechanisms underlying the interactions are largely unknown. Inflammatory bowel disease and colorectal cancer provide an opportunity to investigate the relationships among inflammation, immunity, microbiota, tissue repair and signalling pathways gone awry. The EU-funded project REpAIR is studying interleukin-22 (IL-22) and its inhibitor in these disease processes. IL-22, produced by immune cells, acts on intestinal epithelial cells to modulate microbiota composition and promote tissue regeneration. However, it can also promote chronic inflammation and cancer. Outcomes will shed light on how the same pathways can lead to either a physiological repair response or to disease and point to targeted therapies for immune-related diseases and cancer.

Host institution

UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Net EU contribution
€ 1 356 125,00
Address
Martinistrasse 52
20251 Hamburg
Germany

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Beneficiaries (2)

UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Germany
Net EU contribution
€ 1 356 125,00
Address
Martinistrasse 52
20251 Hamburg

See on map

Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH
Germany
Net EU contribution
€ 643 562,00
Address
Inhoffenstrasse 7
38124 Braunschweig

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Region
Niedersachsen Braunschweig Braunschweig, Kreisfreie Stadt
Activity type
Research Organisations
Non-EU contribution
€ 0,00