Spatio-Temporal Regulation of Inflammation and Tissue Regeneration: Studying the immune system - tissue - microbiota communication to develop targeted therapies for immune-mediated diseases and cancer

Informacje na temat projektu

REpAIR

Identyfikator umowy o grant: 865466

DOI 10.3030/865466

Data podpisania przez KE 7 Lutego 2020

Data rozpoczęcia 1 Października 2020

Data zakończenia 31 Marca 2026

Finansowanie w ramach

• EXCELLENT SCIENCE - European Research Council (ERC)

Koszt całkowity € 1 999 687,00

Wkład UE € 1 999 687,00

Koordynowany przez

UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Germany

Publikacje

Peer reviewed articles (6)

Efferocytosis fuels malignant pleural effusion through TIMP1

Autorzy: Lilan Zhao; Lilan Zhao; Anastasios D. Giannou; Yang Xu; Ahmad Mustafa Shiri; Imke Liebold; Imke Liebold; Babett Steglich; Babett Steglich; Tanja Bedke; Tao Zhang; Jöran Lücke; Pasquale Scognamiglio; Jan Kempski; Anna Woestemeier; Jing Chen; Theodora Agalioti; Dimitra E. Zazara; Diana Lindner; Diana Lindner; Melanie Janning; Melanie Janning; Melanie Janning; Jan K. Hennigs; Rajesh Jagirdar; Ouran
Opublikowane w: Science Advances, Numer 1, 2021, ISSN 2375-2548
Wydawca: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abd6734

T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis

Autorzy: Daria Briukhovetska, Javier Suarez-Gosalvez, Cornelia Voigt, Anamarija Markota, Anastasios D. Giannou, Maryam Schübel, Jakob Jobst, Tao Zhang, Janina Dörr, Florian Märkl, Lina Majed, Philipp Jie Müller, Peter May, Adrian Gottschlich, Nicholas Tokarew, Jöran Lücke, Arman Oner, Melanie Schwerdtfeger, David Andreu-Sanz, Ruth Grünmeier, Matthias Seifert, Stefanos Michaelides, Michael Hristov, L
Opublikowane w: Immunity, 2023, ISSN 1074-7613
Wydawca: Cell Press
DOI: 10.1016/j.immuni.2022.12.010

The good and the bad about separation anxiety: roles of IL-22 and IL-22BP in liver pathologies.

Autorzy: Jöran Lücke; Morsal Sabihi; Tao Zhang; Lennart Fynn Bauditz; Ahmad Mustafa Shiri; Anastasios D. Giannou; Samuel Huber
Opublikowane w: Seminars in Immunopathology, Numer 1, 2021, ISSN 1863-2297
Wydawca: Springer Verlag
DOI: 10.1007/s00281-021-00854-z

A Critical Role of the IL-22–IL-22 Binding Protein Axis in Hepatocellular Carcinoma

Autorzy: Anastasios D. Giannou; Jöran Lücke; Dörte Kleinschmidt; Ahmad Mustafa Shiri; Babett Steglich; Mikolaj Nawrocki; Tao Zhang; Dimitra E. Zazara; Jan Kempski; Lilan Zhao; Olympia Giannou; Theodora Agalioti; Leonie Brockmann; Franziska Bertram; Morsal Sabihi; Marius Böttcher; Florian Ewald; Kornelius Schulze; Johann von Felden; Andres Machicote; Ioannis C. Maroulis; Petra C. Arck; Julia-Kristin Gra
Opublikowane w: Cancers; Volume 14; Numer 24; Pages: 6019, Numer 1, 2022, ISSN 2072-6694
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14246019

Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22

Autorzy: Anastasios D. Giannou, Jan Kempski, Ahmad Mustafa Shiri, Jöran Lücke, Tao Zhang, Lilan Zhao, Dimitra E. Zazara, Filippo Cortesi, Kristoffer Riecken, Maria Carolina Amezcua Vesely, Jun Siong Low, Hao Xu, Eleanna Kaffe, Laura Garcia-Perez, Theodora Agalioti, Yoshito Yamada, Wolfgang Jungraithmayr, Ehud Zigmond, Karl-Frederick Karstens, Babett Steglich, Jonas Wagner, Leonia Konczalla, Antonella Car
Opublikowane w: Immunity, Numer 56, 2023, Strona(/y) 125-142.e12, ISSN 1074-7613
Wydawca: Cell Press
DOI: 10.1016/j.immuni.2022.12.014

Induction of IL-22-Producing CD4+ T Cells by Segmented Filamentous Bacteria Independent of Classical Th17 Cells

Autorzy: Urmi Roy, Romulo S. de Oliveira, Eric J. C. Galvez, Achim Gronow, Marijana Basic, Laura Garcia Perez, Nicola Gagliani, Andre Bleich, Samuel Huber, Till Strowig
Opublikowane w: Frontiers in Immunology, 2021, ISSN 1664-3224
Wydawca: Frontiers Media S.A.
DOI: 10.3389/fimmu.2021.671331