Controlling Activity of Lysogenic Phages by Small Molecule Inducers and Dysregulators

Project description

The human microbiome and its interaction with lysogenic phages

The human microbiome plays a critical role in health and disease. However, the phages infecting these microbiota have not gained sufficient attention. The majority of phages reside integrated in the genome of the microbial host as lysogenic prophages. Certain conditions induce prophages, resulting in the creation of virus particles, the destruction of the host cells and an increased production of virulence factors. The EU-funded CAPSID project aims to uncover the small molecules modulating phage induction. The objective is to isolate and characterise phage-inducing or dysregulating metabolites and identify their molecular targets. The project will apply chemical tools to study the relevant mechanisms and develop synthetic modulators of the phage-microbe systems for specific medical purposes.

Field of science

/natural sciences/biological sciences/microbiology/virology

Funding Scheme

ERC-COG - Consolidator Grant

Host institution

UNIVERSITAT WIEN

Address

Universitatsring 1
1010 Wien
Austria

Activity type

Higher or Secondary Education Establishments

EU contribution

€ 1 992 240

Website

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Beneficiaries (1)

UNIVERSITAT WIEN

Austria