CAPTURING THE PHYSICS OF LIFE ON 3D-TRAFFICKING SUBCELLULAR NANOSYSTEMS

Información del proyecto

CAPTUR3D

Identificador del acuerdo de subvención: 866127

DOI 10.3030/866127

Fecha de la firma de la CE 16 Marzo 2020

Fecha de inicio 1 Marzo 2021

Fecha de finalización 28 Febrero 2026

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total € 1 985 750,00

Aportación de la UE € 1 985 750,00

Coordinado por

SCUOLA NORMALE SUPERIORE
Italy

Publicaciones

Peer reviewed articles (9)

Mechanistic Insights into the Superior DNA Delivery Efficiency of Multicomponent Lipid Nanoparticles: An In Vitro and In Vivo Study

Autores: Erica Quagliarini; Junbiao Wang; Serena Renzi; Lishan Cui; Luca Digiacomo; Gianmarco Ferri; Luca Pesce; Valentina De Lorenzi; Giulia Matteoli; Heinz Amenitsch; Laura Masuelli; Roberto Bei; Daniela Pozzi; Augusto Amici; Francesco Cardarelli; Cristina Marchini; Giulio Caracciolo
Publicado en: ACS Applied Materials and Interfaces, 2022, ISSN 1944-8244
Editor: American Chemical Society
DOI: 10.1021/acsami.2c20019

β-Cell Pathophysiology: A Review of Advanced Optical Microscopy Applications

Autores: Gianmarco Ferri; Luca Pesce; Marta Tesi; Piero Marchetti; Francesco Cardarelli
Publicado en: International Journal of Molecular Sciences, Edición 14220067, 2021, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms222312820

Unveiling nanoscale optical signatures of cytokine‑induced β‑cell dysfunction

Autores: Licia Anna Pugliese, Valentina De Lorenzi, Mario Bernardi, Samuele Ghignoli, Marta Tesi, Piero Marchetti, Luca Pesce, Francesco Cardarelli
Publicado en: Scientific Reports, 2023, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-023-40272-9

Fluorescence Lifetime Nanoscopy of Liposomal Irinotecan Onivyde: From Manufacturing to Intracellular Processing

Autores: Mario Bernardi, Giovanni Signore, Aldo Moscardini, Licia Anna Pugliese, Luca Pesce, Fabio Beltram, Francesco Cardarelli
Publicado en: ACS Applied Bio Materials, 2023, ISSN 2576-6422
Editor: American Chemical Society
DOI: 10.1021/acsabm.3c00478

Single-cell imaging of α and β cell metabolic response to glucose in living human Langerhans islets

Autores: Fabio Azzarello, Luca Pesce, Valentina De Lorenzi, Gianmarco Ferri, Marta Tesi, Silvia Del Guerra, Piero Marchetti, Francesco Cardarelli
Publicado en: Communications Biology, 2022, ISSN 2399-3642
Editor: Nature Publishing Group
DOI: 10.1038/s42003-022-04215-w

Spatiotemporal Correlation Spectroscopy Reveals a Protective Effect of Peptide-Based GLP-1 Receptor Agonism against Lipotoxicity on Insulin Granule Dynamics in Primary Human β-Cells.

Autores: Gianmarco Ferri; Marta Tesi; Luca Pesce; Marco Bugliani; Francesca Grano; Margherita Occhipinti; Mara Suleiman; Carmela De Luca; Lorella Marselli; Piero Marchetti; Francesco Cardarelli
Publicado en: Pharmaceutics, Edición 19994923, 2021, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13091403

Probing Structural and Dynamic Properties of Trafficking Subcellular Nanostructures by Spatiotemporal Fluctuation Spectroscopy

Autores: Gianmarco Ferri, Fabio Azzarello, Francesca D'Autilia, Francesco Cardarelli
Publicado en: Journal of Visualized Experiments, Edición 1940087X, 2021, ISSN 1940-087X
Editor: MYJoVE Corporation
DOI: 10.3791/62790

Investigating the mechanism of action of DNA-loaded PEGylatedlipid nanoparticles

Autores: Luca Digiacomo, Serena Renzi, Erica Quagliarini, Daniela Pozzi, Heinz Amenitsch, Gianmarco Ferri, Luca Pesce, Valentina De Lorenzi, Giulia Matteoli, Francesco Cardarelli, Giulio Caracciolo
Publicado en: Nanomedicine: Nanotechnology, Biology, and Medicine, 2023, ISSN 1549-9634
Editor: Elsevier BV
DOI: 10.1016/j.nano.2023.102697

Measuring molecular diffusion in dynamic subcellular nanostructures by fast Raster Image Correlation Spectroscopy and 3D orbital tracking

Autores: Filippo Begarani; Francesca D’Autilia; Gianmarco Ferri; Luca Pesce; Fabio Azzarello; Valentina De Lorenzi; William Durso; Ambra Del Grosso; Marco Cecchini; Francesco Cardarelli
Publicado en: International Journal of Molecular Sciences, Edición 14220067, 2022, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23147623

Conference proceedings (2)

Single-cell-resolution imaging of alpha/beta cell metabolic response to glucose stimulation in living human-derived Langerhans islets

Autores: Francesco Cardarelli, Fabio Azzarello, Luca Pesce, Valentina De Lorenzi, Gianmarco Ferri, Marta Tesi, Silvia Del Guerra, Piero Marchetti
Publicado en: DIABETOLOGIA - ISSN: 1432-0428, 2022, Página(s) S18-S19
Editor: SPRINGER
DOI: 10.1007/s00125-022-05755-w

Direct optical nanoscopy unveils signatures of cytokine-induced β-cell structural and functional stress

Autores: Licia Anna Pugliese, Valentina De Lorenzi, Mario Bernardi, Samuele Ghignoli, Marta Tesi, Piero Marchetti, Luca Pesce, Francesco Cardarelli
Publicado en: DIABETOLOGIA - ISSN: 1432-0428, 2023
Editor: Springer
DOI: 10.1007/s00125-023-05969-6

Other (2)

Phasor Identifier: A Cloud-based Analysis of Phasor-FLIM Data on Python Notebooks

Autores: Mario Bernardi, Francesco Cardarelli
Publicado en: Biorxiv, 2023
Editor: Cold Spring Harbor
DOI: 10.1101/2023.08.30.555392

Direct optical nanoscopy unveils signatures of cytokine-induced β-cell structural and functional stress

Autores: Licia Anna Pugliese, Valentina De Lorenzi, Mario Bernardi, Samuele Ghignoli, Marta Tesi, Piero Marchetti, Francesco Cardarelli, Luca Pesce
Publicado en: BiorXiv, 2023
Editor: Cold Spring Harbor
DOI: 10.1101/2023.02.20.529190