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His-Li mouse, the unique humanized mouse model resembling human liver and immune systems

Project description

A mouse model for drug toxicology studies

Nearly 7 in 10 drugs under development fail due to toxicity or issues in metabolism and excretion. Current drug testing models do not faithfully recapitulate human liver physiology and are thus unsuitable for predicting the safety of drugs destined for human use. To address this problem, the EU-funded His-Li mouse project is developing a humanised mouse model that is suitable for preclinical drug testing. The His-Li mouse offers humanised liver and immune system function, allowing for more faithful results regarding drug safety. Following the feasibility study, the project will formulate a marking and supply strategy to introduce the His-Li mouse model into the pharmaceutical industry.

Call for proposal


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Sub call



Net EU contribution
€ 50 000,00
Biopark Le Forum 1 260 Avenue Mari
74160 Arachamps

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Auvergne-Rhône-Alpes Rhône-Alpes Haute-Savoie
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 21 429,00