How the Fulani people can help fight malaria
Numbering at least 25 million, the Fulani people are one of the largest ethnic groups in West Africa, widely scattered across the region. They are also more resistant to malaria, a life-threatening disease caused by a parasite transmitted by mosquitoes. The reason the Fulani are less susceptible to malaria infections remains unknown. The QuinADAR1 project will test the hypothesis that reduced rates of A-to-I editing of RNA in the Fulani following infection enables them to mount a more effective innate immune response to malaria. This contributes to their relative protection from the disease. The results of the research may lead to new strategies to boost effective immune response to malaria.