Protection from malaria in the Fulani ethnic group of West Africa involves reduced levels of A-to-I RNA editing by ADAR1

Project description

How the Fulani people can help fight malaria

Numbering at least 25 million, the Fulani people are one of the largest ethnic groups in West Africa, widely scattered across the region. They are also more resistant to malaria, a life-threatening disease caused by a parasite transmitted by mosquitoes. The reason the Fulani are less susceptible to malaria infections remains unknown. The QuinADAR1 project will test the hypothesis that reduced rates of A-to-I editing of RNA in the Fulani following infection enables them to mount a more effective innate immune response to malaria. This contributes to their relative protection from the disease. The results of the research may lead to new strategies to boost effective immune response to malaria.

Fields of science

• medical and health sciences › health sciences › infectious diseases › malaria
• medical and health sciences › basic medicine › immunology
• natural sciences › biological sciences › genetics › RNA
• social sciences › political sciences › government systems

Programme(s)

• H2020-EU.4. - SPREADING EXCELLENCE AND WIDENING PARTICIPATION Main Programme

Topic(s)

• WF-01-2018 - Widening Fellowships

Call for proposal

H2020-WF-2018-2020

See other projects for this call

Sub call

H2020-WF-01-2018

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

Masarykova univerzita

Net EU contribution

€ 144 980,64

Address

Zerotinovo Namesti 9
601 77 Brno
Czechia

Region

Jihovýchod › Jihomoravský kraj

Activity type

Higher or Secondary Education Establishments

Links

Non-EU contribution

€ 0,00