Rhesus diseases of HDN (Hemolytic disease of the newborn) is caused when a woman with Rh negative blood is pregnant from a male Rh positive, having a baby Rh positive. In this case, the mother starts to produce antibodies to attack the fetal red blood cells ending with severe consequences: stillbirth, newborn death, severe jaundice and brain damage. Despite being this disease eradicated from the developed world, it still continues in much of Africa, Asia and Eastern Europe due to the lack of preventive tools and lab settings particularly in rural areas (e.g. around 300,000 cases are reported annually in these regions). Since this disease can be easily eliminated by screening the Rh group of pregnant women and prophylaxis (if it is needed), we have developed ABOPEN (renamed as Rhesus Stick) a user-friendly off-the-lab test to identify the RhD factor type in just 1 minute and a single-step procedure. The device can be stored for up to 24 months at 37ºC, can be used by anyone in anywhere (at home, clinics, rural dispensaries) and have a fair priced (€4), which represents a good opportunity to be adopted as women Rh screening routine in developing countries.