Descripción del proyecto
Un dispositivo fotónico portátil y de bajo coste podría mejorar el diagnóstico temprano de la enfermedad cardiovascular
Según la Organización Mundial de la Salud, las enfermedades cardiovasculares son la primera causa de muerte mundial, y se le atribuyen aproximadamente 18 millones de muertes anuales. Al igual que con muchas otras afecciones, diagnosticarlas y actuar cuanto antes puede salvar vidas. Los cambios en el flujo sanguíneo pueden indicar anomalías en la forma que el corazón se contrae para bombear la sangre, además de cambios en el diámetro arterial o la elasticidad, todos ellos factores precursores de las enfermedades cardiovasculares. El proyecto InSiDe, financiado con fondos europeos, está desarrollando un interferómetro láser Doppler portátil que aprovecha la fotónica del silicio y unos algoritmos eficaces para proporcionar un análisis de la señal en tiempo real de determinados parámetros cardiovasculares. Este dispositivo de supervisión de alta tecnología y bajo coste satisfará una necesidad no cubierta, con importantes implicaciones para los pacientes y los sistemas sanitarios.
Objetivo
The rationale for Medtronic and partners to propose the InSiDe project is the unmet need of the medical community for reliable, non-invasive, cheap and easy-to-use tools able to identify and characterize different stages of cardiovascular diseases. Solving this need ensures the early adoption of the appropriate therapies, dramatically reduces healthcare costs and importantly, improves patient outcome.
In fact, monitoring arterial stiffness by measurement of the aortic pulse wave velocity has been demonstrated to be a crucial need for the management of hypertensive patients and it is recommended in the European Society of Cardiology Guidelines. In addition, the early identification of arterial stenosis and cardiac contraction abnormalities can be used to drive earlier therapy adoption and to improve patient’s response in cardiac (valvular) disease.
Building on the realizations of the successful CARDIS (H2020-ICT-644798) project, the objective of InSiDe is to accelerate access to a new diagnostic device, based on silicon photonics technology, able to monitor cardiovascular diseases and to prove its efficacy in driving a timely therapy institution and its related follow-up.
We will:
-Develop an efficient miniaturized laser Doppler interferometer supported by a manufacturable package with integrated imaging optics and by electronics for control of the laser interferometer with onboard near-real time signal processing capability.
-Develop algorithms for translation of the interferometer signals to beat-to-beat measurement results relevant for monitoring and diagnosis of selected cardiovascular parameters.
-Prove the device efficacy in multiple clinical feasibility studies inside and outside the consortium.
-Outline a path to industrialization and manufacturability.
In this way InSiDe will realize a low-cost handheld, robust diagnostic tool, manufacturable in high-volumes. The diagnostic tool gives immediate results for physician’s interpretation.
Ámbito científico
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsignal processing
- medical and health sciencesclinical medicinecardiologycardiovascular diseases
- natural scienceschemical sciencesinorganic chemistrymetalloids
- natural sciencesphysical sciencesopticslaser physics
Palabras clave
Programa(s)
Convocatoria de propuestas
Consulte otros proyectos de esta convocatoriaConvocatoria de subcontratación
H2020-ICT-2019-2
Régimen de financiación
IA - Innovation actionCoordinador
3001 Leuven
Bélgica