DevelOpmeNt of Cancer RNA TherapEutics

Informations projet

cONCReTE

N° de convention de subvention: 872391

DOI

10.3030/872391

Projet clôturé le 27 Août 2024

Date de signature de la CE 2 Mars 2020

Date de début 1 Mai 2020

Date de fin 31 Octobre 2025

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total

€ 2 060 800,00

Contribution de l’UE

€ 2 060 800,00

Coordonné par

UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II
Italy

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (11)

Developing a morphology-based RNAi-screening assay for the detection of EMT or MET

External server set up and access for all RISE-cONCReTE participants

Characterizing the roles of ncRNAs involved in EMT

Methods for the identification of non-coding RNA modulated by histone modification

colon and breast cancer cell lines are used

Methods for identification of RNA binders

Identify the molecular map of RNA binders and ncRNAs and identify new target for personalized cancer therapies Characterize the role in tumor cell biology of the identified RNA binders ncRNAs

ncRNAs involved in hypoxia and, CAIX in glioma

Characterize the relationship between ncRNAs, hypoxia and, CAIX in glioma and identification of a non-coding RNA signatures. Characterize the role of ncRNAs regulating hypoxia cascade in tumor cell biology

Content for network wide events approved by Director of TOK

Appointment of Project Monitor

Identification of ncRNAs implicated in exosome-mediated tumor/stroma communication

Identification of non coding RNA loci modulated by DNA methylation that could represent novel therapeutical target

two sources of human malignancies are used cancer cell lines and primary tumors

Gender equality monitoring

Publications

Peer reviewed articles (31)

Practical tips and new trends in electrochemical biosensing of cancer-related extracellular vesicles

Auteurs: Patrick Severin Sfragano, Serena Pillozzi, Gerolama Condorelli, Ilaria Palchetti
Publié dans: Analytical and bioanalytical chemistry., 2023, Page(s) 1-20, ISSN 1618-2650
Éditeur: Springer
DOI: 10.1007/s00216-023-04530-z

Exploiting the Natural Properties of Extracellular Vesicles in Targeted Delivery towards Specific Cells and Tissues

Auteurs: Pablo Lara, Alan B. Chan, Luis J. Cruz, Andrew F. G. Quest, Marcelo J. Kogan
Publié dans: Pharmaceutics, Numéro 12/11, 2020, Page(s) 1022, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12111022

Urinary Dickkopf-3 and Contrast-Associated Kidney Damage

Auteurs: Giuseppina Roscigno, Cristina Quintavalle, Giuseppe Biondi-Zoccai, Francesca De Micco, Giacomo Frati, Alessandra Affinito, Silvia Nuzzo, Gerolama Condorelli, Carlo Briguori
Publié dans: Journal of the American College of Cardiology, Numéro 77/21, 2021, Page(s) 2667-2676, ISSN 0735-1097
Éditeur: Elsevier BV
DOI: 10.1016/j.jacc.2021.03.330

IL-6/STAT3 signaling in tumor cells restricts the expression of frameshift-derived neoantigens by SMG1 induction

Auteurs: Daniel Meraviglia-Crivelli; Helena Villanueva; Angelina Zheleva; María Villalba-Esparza; Beatriz Moreno; Ashwathi Puravankara Menon; Alfonso Calvo; Javier Cebollero; Martin Barainka; Igor Ruiz de los Mozos; Carlos Huesa-Berral; Fernando Pastor
Publié dans: Molecular Cancer,, Numéro 12, 2022, Page(s) Vol 21, Iss 1, Pp 1-24, ISSN 1476-4598
Éditeur: BioMed Central
DOI: 10.1186/s12943-022-01679-6

Zinc-Phthalocyanine-Loaded Extracellular Vesicles Increase Efficacy and Selectivity of Photodynamic Therapy in Co-Culture and Preclinical Models of Colon Cancer

Auteurs: Pablo Lara, Ruben V. Huis in ‘t Veld, Carla Jorquera-Cordero, Alan B. Chan, Ferry Ossendorp, Luis J. Cruz
Publié dans: Pharmaceutics, Numéro 13/10, 2021, Page(s) 1547, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13101547

Overview and Future Perspectives on Tumor-Targeted Positron Emission Tomography and Fluorescence Imaging of Pancreatic Cancer in the Era of Neoadjuvant Therapy

Auteurs: Martijn A. van Dam; Floris A. Vuijk; Judith A. Stibbe; Ruben D. Houvast; Saskia A. C. Luelmo; Stijn Crobach; Shirin Shahbazi Feshtali; Lioe-Fee de Geus-Oei; Bert A. Bonsing; Cornelis F. M. Sier; Peter J. K. Kuppen; Rutger-Jan Swijnenburg; Albert D. Windhorst; Jacobus Burggraaf; Alexander L. Vahrmeijer; J. Sven D. Mieog
Publié dans: Cancers, Numéro 13, 2021, Page(s) 13(23), ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13236088

Effect of the Addition of Alginate and/or Tetracycline on Brushite Cement Properties

Auteurs: Claudia Morilla, Elianis Perdomo, Ana Karla Hernández, Ramcy Regalado, Amisel Almirall, Gastón Fuentes, Yaima Campos Mora, Timo Schomann, Alan Chan, Luis J. Cruz
Publié dans: Molecules, Numéro 26/11, 2021, Page(s) 3272, ISSN 1420-3049
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26113272

Extracellular Vesicles from M1-Polarized Macrophages Combined with Hyaluronic Acid and a β-Blocker Potentiate Doxorubicin’s Antitumor Activity by Downregulating Tumor-Associated Macrophages in Breast Cancer

Auteurs: Carla Jorquera-Cordero, Pablo Lara , Luis J Cruz , Timo Schomann , Anna van Hofslot, Thaís Gomes de Carvalho , Paulo Marcos Da Matta Guedes, Laura Creemers, Roman I Koning, Alan B Chan, Raimundo Fernandes de Araujo Junior
Publié dans: Pharmaceutics, Numéro 14(5), 2022, Page(s) 1068, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14051068

Exosomal microRNAs synergistically trigger stromal fibroblasts in breast cancer

Auteurs: Iolanda Scognamiglio, Lorenza Cocca, Ilaria Puoti, Francesco Palma, Francesco Ingenito, Cristina Quintavalle, Alessandra Affinito, Giuseppina Roscigno, Silvia Nuzzo, Rosario Vincenzo Chianese, Stefania Belli, Guglielmo Thomas, Timo Schomann, Alan Chan, Maria Patrizia Stoppelli, Gerolama Condorelli
Publié dans: Molecular therapy. Nucleic acids, Numéro vol. 28, 2022, Page(s) 17-31, ISSN 2162-2531
Éditeur: Nature Publishing Group
DOI: 10.1016/j.omtn.2022.02.013

Chemical, Antioxidant, and Antimicrobial Properties of the Peel and Male Flower By-Products of Four Varieties of Punica granatum L. Cultivated in the Marche Region for Their Use in Cosmetic Products

Auteurs: Maria Rosa Gigliobianco; Manuela Cortese; Samanta Nannini; Lucrezia Di Nicolantonio; Dolores Vargas Peregrina; Giulio Lupidi; Luca Agostino Vitali; Elena Bocchietto; Piera Di Martino; Roberta Censi
Publié dans: Antioxidants, Numéro 11, 2022, Page(s) 768, ISSN 2076-3921
Éditeur: Basel, Switzerland
DOI: 10.3390/antiox11040768

Prognostic and Clinicopathological Significance of MiR-155 in Breast Cancer: A Systematic Review

Auteurs: Anna Maria Grimaldi, Silvia Nuzzo, Gerolama Condorelli, Marco Salvatore, Mariarosaria Incoronato
Publié dans: International Journal of Molecular Sciences, Numéro 21/16, 2020, Page(s) 5834, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21165834

The Incorporation of Etanercept into a Porous Tri-Layer Scaffold for Restoring and Repairing Cartilage Tissue

Auteurs: Campos, Yaima; Fuentes, Gastón; Almirall, Amisel; Que, Ivo; Schomann, Timo; Chung, Chih Kit; Jorquera Cordero, Carla; Quintanilla Sierra, Luis; Rodríguez Cabello, José Carlos; Chan, Alan; Cruz, Luis
Publié dans: Pharmaceutics, Numéro 1, 2022, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14020282

Selection of RNA aptamers targeting hypoxia in cancer

Auteurs: Nuzzo S, Iaboni M, Ibba ML, Rienzo A, Musumeci D, Franzese M, Roscigno G, Affinito A, Petrillo G, Quintavalle C, Ciccone G, Esposito CL, Catuogno S
Publié dans: Frontiers in molecular biosciences, Numéro 2296889X, 2022, ISSN 2296-889X
Éditeur: Lausanne : Frontiers Media S.A
DOI: 10.3389/fmolb.2022.956935

Gastric Ulcer Healing Property of Bryophyllum pinnatum Leaf Extract in Chronic Model In Vivo and Gastroprotective Activity of Its Major Flavonoid

Auteurs: Edilane Rodrigues Dantas De Araújo; Gerlane Coelho Bernardo Guerra; Anderson Wilbur Lopes Andrade; Júlia Morais Fernandes; Valéria Costa Da Silva; Emanuella De Aragão Tavares; Aurigena Antunes De Araújo; Raimundo Fernandes de Araújo Júnior; Raimundo Fernandes de Araújo Júnior; Raimundo Fernandes de Araújo Júnior; Raimundo Fernandes de Araújo Júnior; Silvana Maria Zucolotto; Silvana Ma
Publié dans: Frontiers in Pharmacology, Numéro 12, 2021, Page(s) Vol 12, ISSN 1663-9812
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fphar.2021.744192

The Role of RNA and DNA Aptamers in Glioblastoma Diagnosis and Therapy: A Systematic Review of the Literature

Auteurs: Silvia Nuzzo, Valentina Brancato, Alessandra Affinito, Marco Salvatore, Carlo Cavaliere, Gerolama Condorelli
Publié dans: Cancers, Numéro 12/8, 2020, Page(s) 2173, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12082173

Analysis of Differentially Expressed Genes, MMP3 and TESC, and Their Potential Value in Molecular Pathways in Colon Adenocarcinoma: A Bioinformatics Approach

Auteurs: Constantin Busuioc; Andreea Nutu; Cornelia Braicu; Oana Zanoaga; Monica Trif; Ioana Berindan-Neagoe
Publié dans: BioMedInformatics, Numéro 12, 2022, Page(s) 474-491, ISSN 2673-7426
Éditeur: MDPI
DOI: 10.3390/biomedinformatics2030030

Combinatorial therapeutic approaches of photodynamic therapy and immune checkpoint blockade for colon cancer treatment

Auteurs: Yang Hao, Chih Kit Chung, Zili Gu, Timo Schomann, Xiaoxu Dong, Ruben V Huis In 't Veld, Marcel G M Camps, Peter Ten Dijke, Ferry A Ossendorp, Luis J Cruz
Publié dans: Molecular biomedicine, 2022, ISSN 2662-8651
Éditeur: Singapore : Springer Singapore, [2020]-
DOI: 10.1186/s43556-022-00086-z

MCT4-driven CAF-mediated metabolic reprogramming in breast cancer microenvironment is a vulnerability targetable by miR-425-5p

Auteurs: Alessandra Affinito, Cristina Quintavalle, Rosario Vincenzo Chianese, Giuseppina Roscigno, Danilo Fiore, Valeria D’Argenio, Guglielmo Thomas, Alessia Savarese, Francesco Ingenito, Lorenza Cocca, Silvia Nuzzo, Maxim V. Berezovski, Maria Patrizia Stoppelli, Gerolama Condorelli
Publié dans: Cell Death Discovery, Numéro 10, 2024, ISSN 2058-7716
Éditeur: CDD Press
DOI: 10.1038/s41420-024-01910-x

Functionalized Nanoparticles Targeting Tumor-Associated Macrophages as Cancer Therapy.

Auteurs: Yuanyuan He; Raimundo Fernandes de Araújo Júnior; Luis J. Cruz; Christina Eich
Publié dans: Pharmaceutics,, Numéro 13(10), 2021, Page(s) 70, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13101670

Identification of a novel RNA aptamer that selectively targets breast cancer exosomes

Auteurs: Carla Lucia Esposito, Cristina Quintavalle, Francesco Ingenito, Deborah Rotoli, Giuseppina Roscigno, Silvia Nuzzo, Renato Thomas, Silvia Catuogno, Vittorio de Franciscis, Gerolama Condorelli
Publié dans: Molecular Therapy - Nucleic Acids, 2021, ISSN 2162-2531
Éditeur: Nature Publishing Group
DOI: 10.1016/j.omtn.2021.01.012

STAT3 silencing by an aptamer-based strategy hampers the crosstalk between NSCLC cells and cancer-associated fibroblasts

Auteurs: Maria L. Ibba,Giuseppe Ciccone,Deborah Rotoli,Gabriele Coppola,Alfonso Fiorelli, Silvia Catuogno,Carla L. Esposito
Publié dans: Molecular therapy nucleic acid, Numéro 32, 2023, Page(s) 111–126., ISSN 2162-2531
Éditeur: Nature Publishing Group
DOI: 10.1016/j.omtn.2023.03.003

Evaluation of EphB4 as Target for Image-Guided Surgery of Breast Cancer

Auteurs: Cansu de Muijnck, Yoren van Gorkom, Maurice van Duijvenvoorde, Mina Eghtesadi, Geeske Dekker-Ensink, Shadhvi S. Bhairosingh, Alessandra Affinito, Peter J. K. Kuppen, Alexander L. Vahrmeijer, Cornelis F. M. Sier
Publié dans: Pharmaceuticals, Numéro 13/8, 2020, Page(s) 172, ISSN 1424-8247
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph13080172

Nanocarriers as a Tool for the Treatment of Colorectal Cancer

Auteurs: Ana Luiza C. de S. L. Oliveira, Timo Schomann, Lioe-Fee de Geus-Oei, Ellen Kapiteijn, Luis J. Cruz, Raimundo Fernandes de Araújo Junior
Publié dans: Pharmaceutics, Numéro 13/8, 2021, Page(s) 1321, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13081321

Comparative Proteomic Profiling of Secreted Extracellular Vesicles from Breast Fibroadenoma and Malignant Lesions: A Pilot Study

Auteurs: Katia Pane, Cristina Quintavalle, Silvia Nuzzo, Francesco Ingenito, Giuseppina Roscigno, Alessandra Affinito, Iolanda Scognamiglio, Birlipta Pattanayak, Enrico Gallo, Antonella Accardo, Guglielmo Thomas, Zoran Minic, Maxim V Berezovski, Monica Franzese, Gerolama Condorelli
Publié dans: International journal of molecular sciences, Numéro vol. 23, 2022, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23073989

Thermosensitive Injectable Hydrogels for Intra-Articular Delivery of Etanercept for the Treatment of Osteoarthritis

Auteurs: Jomarien García-Couce, Timo Schomann, Chih Kit Chung, Ivo Que, Carla Jorquera-Cordero, Gastón Fuentes, Amisel Almirall, Alan Chan, Luis J Cruz
Publié dans: Gels, Numéro Quarterly, 2022, ISSN 2310-2861
Éditeur: Basel, Switzerland : MDPI AG, [2015]-
DOI: 10.3390/gels8080488

Immunohistochemical Evaluation of Candidate Biomarkers for Fluorescence-Guided Surgery of Myxofibrosarcoma Using an Objective Scoring Method

Auteurs: Zeger Rijs; Esther Belt; Gijsbert M. Kalisvaart; Cornelis F. M. Sier; Peter J. K. Kuppen; Arjen H. G. Cleven; Alexander L. Vahrmeijer; Michiel A. J. van de Sande; Pieter B. A. A. van Driel
Publié dans: Biomedicines,, Numéro 13, 2023, Page(s) Vol 11, Iss 3, p 982, ISSN 2227-9059
Éditeur: MDPI
DOI: 10.3390/biomedicines11030982

Impact of the Interactions between Fragrances and Cosmetic Bases on the Fragrance Olfactory Performance: A Tentative to Correlate SPME-GC/MS Analysis with That of an Experienced Perfumer

Auteurs: Lucrezia Di Nicolantonio; Maria Rosa Gigliobianco; Dolores Vargas Peregrina; Simone Angeloni; Luca Ilorini; Piera Di Martino; Roberta Censi
Publié dans: Cosmetics, Numéro 9(4), 2022, Page(s) 70, ISSN 2079-9284
Éditeur: MDPI
DOI: 10.3390/cosmetics9040070

The Role of Non-Coding RNAs in Epigenetic Dysregulation in Glioblastoma Development

Auteurs: Ekaterina Isachesku, Cornelia Braicu,Radu Pirlog,Anja Kocijancic,Constantin Busuioc,Lavinia-Lorena Pruteanu,Deo Prakash Pandey, Ioana Berindan-Neagoe
Publié dans: Int J Mol Sci, Numéro 24(22), 2023, Page(s) 16320, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms242216320

Bacterial Cellulose as Drug Delivery System for Optimizing Release of Immune Checkpoint Blocking Antibodies

Auteurs: Chih Kit Chung; Uwe Beekmann; Dana Kralisch; Katja Bierau; Alan Chan; Ferry Ossendorp; Luis J. Cruz
Publié dans: Pharmaceutics, Numéro 14, 2022, Page(s) 1351, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14071351

Cell-Based Tracers as Trojan Horses for Image-Guided Surgery

Auteurs: Vincent Q. Sier, Margreet R. de Vries, Joost R. van der Vorst, Alexander L. Vahrmeijer, Cornelis van Kooten, Luis J. Cruz, Lioe-Fee de Geus-Oei, Valerie Ferreira, Cornelis F. M. Sier, Frauke Alves, Munitta Muthana
Publié dans: International Journal of Molecular Sciences, Numéro 22/2, 2021, Page(s) 755, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22020755

Modulating the Crosstalk between the Tumor and the Microenvironment Using SiRNA: A Flexible Strategy for Breast Cancer Treatment

Auteurs: Giuseppina Roscigno, Iolanda Scognamiglio, Francesco Ingenito, Rosario Vincenzo Chianese, Francesco Palma, Alan Chan, Gerolama Condorelli
Publié dans: Cancers, Numéro 12/12, 2020, Page(s) 3744, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12123744

Other (4)

Introducing Fluorescence-Guided Surgery for Pediatric Ewing, Osteo-, and Rhabdomyosarcomas: A Literature Review

Auteurs: Rijs, Z.; Jeremiasse, B.; Shifai, N.; Gelderblom, H.; Sier, C.F.M.; Vahrmeijer, A.L.; Leeuwen, F.W.B. van; Steeg, A.F.W. van der; Sande, M.A.J. van de
Publié dans: Biomedicines, Numéro 9, 2021, Page(s) VOLUME=9;ISSUE=10, ISSN 2227-9059
Éditeur: MDPI
DOI: 10.3390/biomedicines9101388

Ethical implications of epigenetics in the eraof personalized medicine

Auteurs: Josep Santaló1 and María Berdasco2,3*
Publié dans: Clinical Epigenetics, Numéro 14:44, 2022, ISSN 1868-7083
Éditeur: BioMed Central
DOI: 10.1186/s13148-022-01263-1

Antifouling Strategies of Nanoparticles for Diagnostic and Therapeutic Application: A Systematic Review of the Literature.

Auteurs: Paolo Bevilacqua; Silvia Nuzzo; Enza Torino; Gerolama Condorelli; Marco Salvatore; Anna Maria Grimaldi
Publié dans: Nanomaterials, Numéro 11, 2021, Page(s) 11(3), 780, ISSN 2079-4991
Éditeur: MDPI
DOI: 10.3390/nano11030780

Combinatorial Therapeutic Approaches with Nanomaterial-Based Photodynamic Cancer Therapy

Auteurs: Hao, Y.; Chung, C.K.; Yu, Z.F.; Veld, R.H.I.V. 't; Ossendorp, F.A.; Dijke, P. ten; Cruz, L.J.
Publié dans: Pharmaceutics, Numéro 14 (1), 2022, Page(s) 120, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14010120