DevelOpmeNt of Cancer RNA TherapEutics

Informazioni relative al progetto

cONCReTE

ID dell’accordo di sovvenzione: 872391

DOI

10.3030/872391

Progetto concluso il 27 Agosto 2024

Data della firma CE 2 Marzo 2020

Data di avvio 1 Maggio 2020

Data di completamento 31 Ottobre 2025

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 2 060 800,00

Contributo UE

€ 2 060 800,00

Coordinato da

UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II
Italy

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (11)

Developing a morphology-based RNAi-screening assay for the detection of EMT or MET

External server set up and access for all RISE-cONCReTE participants

Characterizing the roles of ncRNAs involved in EMT

Methods for the identification of non-coding RNA modulated by histone modification

colon and breast cancer cell lines are used

Methods for identification of RNA binders

Identify the molecular map of RNA binders and ncRNAs and identify new target for personalized cancer therapies Characterize the role in tumor cell biology of the identified RNA binders ncRNAs

ncRNAs involved in hypoxia and, CAIX in glioma

Characterize the relationship between ncRNAs, hypoxia and, CAIX in glioma and identification of a non-coding RNA signatures. Characterize the role of ncRNAs regulating hypoxia cascade in tumor cell biology

Content for network wide events approved by Director of TOK

Appointment of Project Monitor

Identification of ncRNAs implicated in exosome-mediated tumor/stroma communication

Identification of non coding RNA loci modulated by DNA methylation that could represent novel therapeutical target

two sources of human malignancies are used cancer cell lines and primary tumors

Gender equality monitoring

Pubblicazioni

Peer reviewed articles (31)

Practical tips and new trends in electrochemical biosensing of cancer-related extracellular vesicles

Autori: Patrick Severin Sfragano, Serena Pillozzi, Gerolama Condorelli, Ilaria Palchetti
Pubblicato in: Analytical and bioanalytical chemistry., 2023, Pagina/e 1-20, ISSN 1618-2650
Editore: Springer
DOI: 10.1007/s00216-023-04530-z

Exploiting the Natural Properties of Extracellular Vesicles in Targeted Delivery towards Specific Cells and Tissues

Autori: Pablo Lara, Alan B. Chan, Luis J. Cruz, Andrew F. G. Quest, Marcelo J. Kogan
Pubblicato in: Pharmaceutics, Numero 12/11, 2020, Pagina/e 1022, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12111022

Urinary Dickkopf-3 and Contrast-Associated Kidney Damage

Autori: Giuseppina Roscigno, Cristina Quintavalle, Giuseppe Biondi-Zoccai, Francesca De Micco, Giacomo Frati, Alessandra Affinito, Silvia Nuzzo, Gerolama Condorelli, Carlo Briguori
Pubblicato in: Journal of the American College of Cardiology, Numero 77/21, 2021, Pagina/e 2667-2676, ISSN 0735-1097
Editore: Elsevier BV
DOI: 10.1016/j.jacc.2021.03.330

IL-6/STAT3 signaling in tumor cells restricts the expression of frameshift-derived neoantigens by SMG1 induction

Autori: Daniel Meraviglia-Crivelli; Helena Villanueva; Angelina Zheleva; María Villalba-Esparza; Beatriz Moreno; Ashwathi Puravankara Menon; Alfonso Calvo; Javier Cebollero; Martin Barainka; Igor Ruiz de los Mozos; Carlos Huesa-Berral; Fernando Pastor
Pubblicato in: Molecular Cancer,, Numero 12, 2022, Pagina/e Vol 21, Iss 1, Pp 1-24, ISSN 1476-4598
Editore: BioMed Central
DOI: 10.1186/s12943-022-01679-6

Zinc-Phthalocyanine-Loaded Extracellular Vesicles Increase Efficacy and Selectivity of Photodynamic Therapy in Co-Culture and Preclinical Models of Colon Cancer

Autori: Pablo Lara, Ruben V. Huis in ‘t Veld, Carla Jorquera-Cordero, Alan B. Chan, Ferry Ossendorp, Luis J. Cruz
Pubblicato in: Pharmaceutics, Numero 13/10, 2021, Pagina/e 1547, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13101547

Overview and Future Perspectives on Tumor-Targeted Positron Emission Tomography and Fluorescence Imaging of Pancreatic Cancer in the Era of Neoadjuvant Therapy

Autori: Martijn A. van Dam; Floris A. Vuijk; Judith A. Stibbe; Ruben D. Houvast; Saskia A. C. Luelmo; Stijn Crobach; Shirin Shahbazi Feshtali; Lioe-Fee de Geus-Oei; Bert A. Bonsing; Cornelis F. M. Sier; Peter J. K. Kuppen; Rutger-Jan Swijnenburg; Albert D. Windhorst; Jacobus Burggraaf; Alexander L. Vahrmeijer; J. Sven D. Mieog
Pubblicato in: Cancers, Numero 13, 2021, Pagina/e 13(23), ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13236088

Effect of the Addition of Alginate and/or Tetracycline on Brushite Cement Properties

Autori: Claudia Morilla, Elianis Perdomo, Ana Karla Hernández, Ramcy Regalado, Amisel Almirall, Gastón Fuentes, Yaima Campos Mora, Timo Schomann, Alan Chan, Luis J. Cruz
Pubblicato in: Molecules, Numero 26/11, 2021, Pagina/e 3272, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26113272

Extracellular Vesicles from M1-Polarized Macrophages Combined with Hyaluronic Acid and a β-Blocker Potentiate Doxorubicin’s Antitumor Activity by Downregulating Tumor-Associated Macrophages in Breast Cancer

Autori: Carla Jorquera-Cordero, Pablo Lara , Luis J Cruz , Timo Schomann , Anna van Hofslot, Thaís Gomes de Carvalho , Paulo Marcos Da Matta Guedes, Laura Creemers, Roman I Koning, Alan B Chan, Raimundo Fernandes de Araujo Junior
Pubblicato in: Pharmaceutics, Numero 14(5), 2022, Pagina/e 1068, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14051068

Exosomal microRNAs synergistically trigger stromal fibroblasts in breast cancer

Autori: Iolanda Scognamiglio, Lorenza Cocca, Ilaria Puoti, Francesco Palma, Francesco Ingenito, Cristina Quintavalle, Alessandra Affinito, Giuseppina Roscigno, Silvia Nuzzo, Rosario Vincenzo Chianese, Stefania Belli, Guglielmo Thomas, Timo Schomann, Alan Chan, Maria Patrizia Stoppelli, Gerolama Condorelli
Pubblicato in: Molecular therapy. Nucleic acids, Numero vol. 28, 2022, Pagina/e 17-31, ISSN 2162-2531
Editore: Nature Publishing Group
DOI: 10.1016/j.omtn.2022.02.013

Chemical, Antioxidant, and Antimicrobial Properties of the Peel and Male Flower By-Products of Four Varieties of Punica granatum L. Cultivated in the Marche Region for Their Use in Cosmetic Products

Autori: Maria Rosa Gigliobianco; Manuela Cortese; Samanta Nannini; Lucrezia Di Nicolantonio; Dolores Vargas Peregrina; Giulio Lupidi; Luca Agostino Vitali; Elena Bocchietto; Piera Di Martino; Roberta Censi
Pubblicato in: Antioxidants, Numero 11, 2022, Pagina/e 768, ISSN 2076-3921
Editore: Basel, Switzerland
DOI: 10.3390/antiox11040768

Prognostic and Clinicopathological Significance of MiR-155 in Breast Cancer: A Systematic Review

Autori: Anna Maria Grimaldi, Silvia Nuzzo, Gerolama Condorelli, Marco Salvatore, Mariarosaria Incoronato
Pubblicato in: International Journal of Molecular Sciences, Numero 21/16, 2020, Pagina/e 5834, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21165834

The Incorporation of Etanercept into a Porous Tri-Layer Scaffold for Restoring and Repairing Cartilage Tissue

Autori: Campos, Yaima; Fuentes, Gastón; Almirall, Amisel; Que, Ivo; Schomann, Timo; Chung, Chih Kit; Jorquera Cordero, Carla; Quintanilla Sierra, Luis; Rodríguez Cabello, José Carlos; Chan, Alan; Cruz, Luis
Pubblicato in: Pharmaceutics, Numero 1, 2022, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14020282

Selection of RNA aptamers targeting hypoxia in cancer

Autori: Nuzzo S, Iaboni M, Ibba ML, Rienzo A, Musumeci D, Franzese M, Roscigno G, Affinito A, Petrillo G, Quintavalle C, Ciccone G, Esposito CL, Catuogno S
Pubblicato in: Frontiers in molecular biosciences, Numero 2296889X, 2022, ISSN 2296-889X
Editore: Lausanne : Frontiers Media S.A
DOI: 10.3389/fmolb.2022.956935

Gastric Ulcer Healing Property of Bryophyllum pinnatum Leaf Extract in Chronic Model In Vivo and Gastroprotective Activity of Its Major Flavonoid

Autori: Edilane Rodrigues Dantas De Araújo; Gerlane Coelho Bernardo Guerra; Anderson Wilbur Lopes Andrade; Júlia Morais Fernandes; Valéria Costa Da Silva; Emanuella De Aragão Tavares; Aurigena Antunes De Araújo; Raimundo Fernandes de Araújo Júnior; Raimundo Fernandes de Araújo Júnior; Raimundo Fernandes de Araújo Júnior; Raimundo Fernandes de Araújo Júnior; Silvana Maria Zucolotto; Silvana Ma
Pubblicato in: Frontiers in Pharmacology, Numero 12, 2021, Pagina/e Vol 12, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fphar.2021.744192

The Role of RNA and DNA Aptamers in Glioblastoma Diagnosis and Therapy: A Systematic Review of the Literature

Autori: Silvia Nuzzo, Valentina Brancato, Alessandra Affinito, Marco Salvatore, Carlo Cavaliere, Gerolama Condorelli
Pubblicato in: Cancers, Numero 12/8, 2020, Pagina/e 2173, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12082173

Analysis of Differentially Expressed Genes, MMP3 and TESC, and Their Potential Value in Molecular Pathways in Colon Adenocarcinoma: A Bioinformatics Approach

Autori: Constantin Busuioc; Andreea Nutu; Cornelia Braicu; Oana Zanoaga; Monica Trif; Ioana Berindan-Neagoe
Pubblicato in: BioMedInformatics, Numero 12, 2022, Pagina/e 474-491, ISSN 2673-7426
Editore: MDPI
DOI: 10.3390/biomedinformatics2030030

Combinatorial therapeutic approaches of photodynamic therapy and immune checkpoint blockade for colon cancer treatment

Autori: Yang Hao, Chih Kit Chung, Zili Gu, Timo Schomann, Xiaoxu Dong, Ruben V Huis In 't Veld, Marcel G M Camps, Peter Ten Dijke, Ferry A Ossendorp, Luis J Cruz
Pubblicato in: Molecular biomedicine, 2022, ISSN 2662-8651
Editore: Singapore : Springer Singapore, [2020]-
DOI: 10.1186/s43556-022-00086-z

MCT4-driven CAF-mediated metabolic reprogramming in breast cancer microenvironment is a vulnerability targetable by miR-425-5p

Autori: Alessandra Affinito, Cristina Quintavalle, Rosario Vincenzo Chianese, Giuseppina Roscigno, Danilo Fiore, Valeria D’Argenio, Guglielmo Thomas, Alessia Savarese, Francesco Ingenito, Lorenza Cocca, Silvia Nuzzo, Maxim V. Berezovski, Maria Patrizia Stoppelli, Gerolama Condorelli
Pubblicato in: Cell Death Discovery, Numero 10, 2024, ISSN 2058-7716
Editore: CDD Press
DOI: 10.1038/s41420-024-01910-x

Functionalized Nanoparticles Targeting Tumor-Associated Macrophages as Cancer Therapy.

Autori: Yuanyuan He; Raimundo Fernandes de Araújo Júnior; Luis J. Cruz; Christina Eich
Pubblicato in: Pharmaceutics,, Numero 13(10), 2021, Pagina/e 70, ISSN 2078-2489
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13101670

Identification of a novel RNA aptamer that selectively targets breast cancer exosomes

Autori: Carla Lucia Esposito, Cristina Quintavalle, Francesco Ingenito, Deborah Rotoli, Giuseppina Roscigno, Silvia Nuzzo, Renato Thomas, Silvia Catuogno, Vittorio de Franciscis, Gerolama Condorelli
Pubblicato in: Molecular Therapy - Nucleic Acids, 2021, ISSN 2162-2531
Editore: Nature Publishing Group
DOI: 10.1016/j.omtn.2021.01.012

STAT3 silencing by an aptamer-based strategy hampers the crosstalk between NSCLC cells and cancer-associated fibroblasts

Autori: Maria L. Ibba,Giuseppe Ciccone,Deborah Rotoli,Gabriele Coppola,Alfonso Fiorelli, Silvia Catuogno,Carla L. Esposito
Pubblicato in: Molecular therapy nucleic acid, Numero 32, 2023, Pagina/e 111–126., ISSN 2162-2531
Editore: Nature Publishing Group
DOI: 10.1016/j.omtn.2023.03.003

Evaluation of EphB4 as Target for Image-Guided Surgery of Breast Cancer

Autori: Cansu de Muijnck, Yoren van Gorkom, Maurice van Duijvenvoorde, Mina Eghtesadi, Geeske Dekker-Ensink, Shadhvi S. Bhairosingh, Alessandra Affinito, Peter J. K. Kuppen, Alexander L. Vahrmeijer, Cornelis F. M. Sier
Pubblicato in: Pharmaceuticals, Numero 13/8, 2020, Pagina/e 172, ISSN 1424-8247
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph13080172

Nanocarriers as a Tool for the Treatment of Colorectal Cancer

Autori: Ana Luiza C. de S. L. Oliveira, Timo Schomann, Lioe-Fee de Geus-Oei, Ellen Kapiteijn, Luis J. Cruz, Raimundo Fernandes de Araújo Junior
Pubblicato in: Pharmaceutics, Numero 13/8, 2021, Pagina/e 1321, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13081321

Comparative Proteomic Profiling of Secreted Extracellular Vesicles from Breast Fibroadenoma and Malignant Lesions: A Pilot Study

Autori: Katia Pane, Cristina Quintavalle, Silvia Nuzzo, Francesco Ingenito, Giuseppina Roscigno, Alessandra Affinito, Iolanda Scognamiglio, Birlipta Pattanayak, Enrico Gallo, Antonella Accardo, Guglielmo Thomas, Zoran Minic, Maxim V Berezovski, Monica Franzese, Gerolama Condorelli
Pubblicato in: International journal of molecular sciences, Numero vol. 23, 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23073989

Thermosensitive Injectable Hydrogels for Intra-Articular Delivery of Etanercept for the Treatment of Osteoarthritis

Autori: Jomarien García-Couce, Timo Schomann, Chih Kit Chung, Ivo Que, Carla Jorquera-Cordero, Gastón Fuentes, Amisel Almirall, Alan Chan, Luis J Cruz
Pubblicato in: Gels, Numero Quarterly, 2022, ISSN 2310-2861
Editore: Basel, Switzerland : MDPI AG, [2015]-
DOI: 10.3390/gels8080488

Immunohistochemical Evaluation of Candidate Biomarkers for Fluorescence-Guided Surgery of Myxofibrosarcoma Using an Objective Scoring Method

Autori: Zeger Rijs; Esther Belt; Gijsbert M. Kalisvaart; Cornelis F. M. Sier; Peter J. K. Kuppen; Arjen H. G. Cleven; Alexander L. Vahrmeijer; Michiel A. J. van de Sande; Pieter B. A. A. van Driel
Pubblicato in: Biomedicines,, Numero 13, 2023, Pagina/e Vol 11, Iss 3, p 982, ISSN 2227-9059
Editore: MDPI
DOI: 10.3390/biomedicines11030982

Impact of the Interactions between Fragrances and Cosmetic Bases on the Fragrance Olfactory Performance: A Tentative to Correlate SPME-GC/MS Analysis with That of an Experienced Perfumer

Autori: Lucrezia Di Nicolantonio; Maria Rosa Gigliobianco; Dolores Vargas Peregrina; Simone Angeloni; Luca Ilorini; Piera Di Martino; Roberta Censi
Pubblicato in: Cosmetics, Numero 9(4), 2022, Pagina/e 70, ISSN 2079-9284
Editore: MDPI
DOI: 10.3390/cosmetics9040070

The Role of Non-Coding RNAs in Epigenetic Dysregulation in Glioblastoma Development

Autori: Ekaterina Isachesku, Cornelia Braicu,Radu Pirlog,Anja Kocijancic,Constantin Busuioc,Lavinia-Lorena Pruteanu,Deo Prakash Pandey, Ioana Berindan-Neagoe
Pubblicato in: Int J Mol Sci, Numero 24(22), 2023, Pagina/e 16320, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms242216320

Bacterial Cellulose as Drug Delivery System for Optimizing Release of Immune Checkpoint Blocking Antibodies

Autori: Chih Kit Chung; Uwe Beekmann; Dana Kralisch; Katja Bierau; Alan Chan; Ferry Ossendorp; Luis J. Cruz
Pubblicato in: Pharmaceutics, Numero 14, 2022, Pagina/e 1351, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14071351

Cell-Based Tracers as Trojan Horses for Image-Guided Surgery

Autori: Vincent Q. Sier, Margreet R. de Vries, Joost R. van der Vorst, Alexander L. Vahrmeijer, Cornelis van Kooten, Luis J. Cruz, Lioe-Fee de Geus-Oei, Valerie Ferreira, Cornelis F. M. Sier, Frauke Alves, Munitta Muthana
Pubblicato in: International Journal of Molecular Sciences, Numero 22/2, 2021, Pagina/e 755, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22020755

Modulating the Crosstalk between the Tumor and the Microenvironment Using SiRNA: A Flexible Strategy for Breast Cancer Treatment

Autori: Giuseppina Roscigno, Iolanda Scognamiglio, Francesco Ingenito, Rosario Vincenzo Chianese, Francesco Palma, Alan Chan, Gerolama Condorelli
Pubblicato in: Cancers, Numero 12/12, 2020, Pagina/e 3744, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12123744

Other (4)

Introducing Fluorescence-Guided Surgery for Pediatric Ewing, Osteo-, and Rhabdomyosarcomas: A Literature Review

Autori: Rijs, Z.; Jeremiasse, B.; Shifai, N.; Gelderblom, H.; Sier, C.F.M.; Vahrmeijer, A.L.; Leeuwen, F.W.B. van; Steeg, A.F.W. van der; Sande, M.A.J. van de
Pubblicato in: Biomedicines, Numero 9, 2021, Pagina/e VOLUME=9;ISSUE=10, ISSN 2227-9059
Editore: MDPI
DOI: 10.3390/biomedicines9101388

Ethical implications of epigenetics in the eraof personalized medicine

Autori: Josep Santaló1 and María Berdasco2,3*
Pubblicato in: Clinical Epigenetics, Numero 14:44, 2022, ISSN 1868-7083
Editore: BioMed Central
DOI: 10.1186/s13148-022-01263-1

Antifouling Strategies of Nanoparticles for Diagnostic and Therapeutic Application: A Systematic Review of the Literature.

Autori: Paolo Bevilacqua; Silvia Nuzzo; Enza Torino; Gerolama Condorelli; Marco Salvatore; Anna Maria Grimaldi
Pubblicato in: Nanomaterials, Numero 11, 2021, Pagina/e 11(3), 780, ISSN 2079-4991
Editore: MDPI
DOI: 10.3390/nano11030780

Combinatorial Therapeutic Approaches with Nanomaterial-Based Photodynamic Cancer Therapy

Autori: Hao, Y.; Chung, C.K.; Yu, Z.F.; Veld, R.H.I.V. 't; Ossendorp, F.A.; Dijke, P. ten; Cruz, L.J.
Pubblicato in: Pharmaceutics, Numero 14 (1), 2022, Pagina/e 120, ISSN 2078-2489
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14010120