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Gene Therapy to restore lymphatic flow lymphedema

Project description

Novel gene therapy approach to treat lymphedema

Lymphedema is a disabling condition of localised accumulation of fluid in a tissue caused by a compromised lymphatic system. It is an incurable disease that affects millions of people worldwide and is most often a consequence of cancer treatment. The main objective of the EU-funded TheraLymph project is to develop treatment to ameliorate this condition using a non-integrative gene therapy approach. The project consortium's translational research programme brings together scientists and physicians from 5 European countries and will be focused on patients who developed lymphedema after breast cancer. Research will determine risk factors for lymphedema and key molecular players involved in the lymphatic dysfunction. The project goal is to validate the best molecule combination for gene therapy and to finalise phase I/II clinical trials at the affiliated hospital.

Call for proposal

H2020-SC1-BHC-2018-2020

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Sub call

H2020-SC1-2019-Single-Stage-RTD

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Net EU contribution
€ 1 475 531,25
Address
Rue De Tolbiac 101
75654 Paris
France

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Participants (10)

HELSINGIN YLIOPISTO
Finland
Net EU contribution
€ 1 046 198,75
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto

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Region
Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITE DE LAUSANNE
Switzerland
Net EU contribution
€ 868 185,00
Address
Quartier Unil-centre Bâtiment Unicentre
1015 Lausanne

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Region
Schweiz/Suisse/Svizzera Région lémanique Vaud
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UPPSALA UNIVERSITET
Sweden
Net EU contribution
€ 455 000,00
Address
Von Kraemers Alle 4
751 05 Uppsala

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Region
Östra Sverige Östra Mellansverige Uppsala län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
DE DUVE INSTITUTE AISBL
Belgium
Net EU contribution
€ 608 335,00
Address
Avenue Hippocrate 75/50
1200 Bruxelles

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Region
Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
Activity type
Research Organisations
Non-EU contribution
€ 0,00
UNIVERSITE DE LIEGE
Belgium
Net EU contribution
€ 706 250,00
Address
Place Du 20 Aout 7
4000 Liege

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Region
Région wallonne Prov. Liège Arr. Liège
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
Net EU contribution
€ 317 287,50
Address
Rue Michel Ange 3
75794 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
UNIVERZITA KARLOVA
Czechia
Net EU contribution
€ 293 750,00
Address
Ovocny Trh 560/5
116 36 Praha 1

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Region
Praha Hlavní město Praha
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE
France
Net EU contribution
€ 947 000,00
Address
Rue Viguerie 2 Hotel Dieu Saint Jacques
31052 Toulouse Cedex 3

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Region
Occitanie Midi-Pyrénées Haute-Garonne
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
FLASH THERAPEUTICS
France
Net EU contribution
€ 1 132 908,50
Address
3 Avenue Hubert Curien
31100 Toulouse

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Occitanie Midi-Pyrénées Haute-Garonne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
INSERM TRANSFERT SA
France
Net EU contribution
€ 214 500,00
Address
Rue Watt 7
75013 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00