Gene Therapy to restore lymphatic flow lymphedema

Deliverables

Intralymphatic injection of Luciferase expressing lentivector in mice
Design and validate probes for CRISPR ON, CRISPR/CAS9, CRISPR/CAS13

Intralymphatic injection of GFP expressing lentivector in mice

Project website

Data Management Plan

Publications

Functional Crosstalk between Human Adipose Tissue and Lymphatic System

Author(s): Zuzana Varaliová
Published in: 2022
Publisher: Univerzita Karlova

Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression

Author(s): Emilia A. Korhonen, Aino Murtomäki, Sawan Kumar Jha, Andrey Anisimov, Anne Pink, Yan Zhang, Simon Stritt, Inam Liaqat, Lukas Stanczuk, Laura Alderfer, Zhiliang Sun, Emmi Kapiainen, Abhishek Singh, Ibrahim Sultan, Anni Lantta, Veli-Matti Leppänen, Lauri Eklund, Yulong He, Hellmut G. Augustin, Kari Vaahtomeri, Pipsa Saharinen, Taija Mäkinen, and Kari Alitalo
Published in: The Journal of Clinical Investigation, Issue 132(15), 2022, Page(s) e155478, ISSN 1558-8238
Publisher: ASCI
DOI: 10.1172/jci155478

Lymphedema alters lipolytic, lipogenic, immune and angiogenic properties of adipose tissue: a hypothesis-generating study in breast cancer survivors

Author(s): Michal Koc, Martin Wald, Zuzana Varaliová, Barbora Ondrůjová, Terezie Čížková, Milan Brychta, Jana Kračmerová, Lenka Beranová, Jan Pala, Veronika Šrámková, Michaela Šiklová, Jan Gojda, Lenka Rossmeislová
Published in: Scientific Reports, Issue 11/1, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-87494-3

The Impact of Estrogen Receptor in Arterial and Lymphatic Vascular Diseases

Author(s): Coralie Fontaine, Florent Morfoisse, Florence Tatin, Audrey Zamora, Rana Zahreddine, Daniel Henrion, Jean-François Arnal, Françoise Lenfant, Barbara Garmy-Susini
Published in: International Journal of Molecular Sciences, Issue 21/9, 2020, Page(s) 3244, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21093244

VEGFC negatively regulates the growth and aggressiveness of medulloblastoma cells

Author(s): Manon Penco-Campillo, Yannick Comoglio, Álvaro Javier Feliz Morel, Rita Hanna, Jérôme Durivault, Magalie Leloire, Bastien Mejias, Marina Pagnuzzi, Amandine Morot, Fanny Burel-Vandenbos, Matthew Selby, Daniel Williamson, Steven C. Clifford, Audrey Claren, Jérôme Doyen, Vincent Picco, Sonia Martial, Gilles Pagès
Published in: Communications Biology, Issue 3/1, 2020, ISSN 2399-3642
Publisher: Nature publishing group
DOI: 10.1038/s42003-020-01306-4

Development and aging of the lymphatic vascular system

Author(s): Alejandra González-Loyola, Tatiana V. Petrova
Published in: Advanced Drug Delivery Reviews, Issue 169, 2021, Page(s) 63-78, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/j.addr.2020.12.005

Lymphatic Malformations: Genetics, Mechanisms and Therapeutic Strategies

Author(s): Taija Mäkinen, Laurence M. Boon, Miikka Vikkula, Kari Alitalo
Published in: Circulation Research, Issue 129/1, 2021, Page(s) 136-154, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.121.318142

Coordinating Effect of VEGFC and Oleic Acid Participates to Tumor Lymphangiogenesis

Author(s): Florent Morfoisse, Fabienne De Toni, Jeremy Nigri, Mohsen Hosseini, Audrey Zamora, Florence Tatin, Françoise Pujol, Jean-Emmanuel Sarry, Dominique Langin, Eric Lacazette, Anne-Catherine Prats, Richard Tomasini, Jean Galitzky, Anne Bouloumié, Barbara Garmy-Susini
Published in: Cancers, Issue 13/12, 2021, Page(s) 2851, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13122851

Interplay of vascular endothelial growth factor receptors in organ-specific vessel maintenance

Author(s): Sinem Karaman, Satu Paavonsalo, Krista Heinolainen, Madeleine H. Lackman, Amanda Ranta, Karthik A. Hemanthakumar, Yoshiaki Kubota, Kari Alitalo
Published in: Journal of experimental medicine, Issue March 7, 219(3à, 2022, Page(s) e20210565, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20210565

Sex Hormones in Lymphedema

Author(s): Florent Morfoisse, Audrey Zamora, Emmanuelle Marchaud, Manon Nougue, Leila H. Diallo, Florian David, Emilie Roussel, Eric Lacazette, Anne-Catherine Prats, Florence Tatin, Barbara Garmy-Susini
Published in: Cancers, Issue 13/3, 2021, Page(s) 530, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13030530

Targeting of the ELR+CXCL/CXCR1/2 Pathway Is a Relevant Strategy for the Treatment of Paediatric Medulloblastomas

Author(s): Manon Penco-Campillo, Clément Molina, Patricia Piris, Nouha Soufi, Manon Carré, Marina Pagnuzzi-Boncompagni, Vincent Picco, Maeva Dufies, Cyril Ronco, Rachid Benhida, Sonia Martial, and Gilles Pagès
Published in: MDPI, Issue Volume 11 Issue 23, 2022, Page(s) 3933, ISSN 2078-2489
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells11233933

Characterization of ANGPT2 mutations associated with primary lymphedema

Author(s): Veli-Matti Leppänen, Pascal Brouillard, Emilia A. Korhonen, Tuomas Sipilä, Sawan Kumar Jha, Nicole Revencu, Veerle Labarque, Elodie Fastré, Matthieu Schlögel, Marie Ravoet, Amihood Singer, Claudia Luzzatto, Donatella Angelone, Giovanni Crichiutti, Angela D’Elia, Jaakko Kuurne, Harri Elamaa, Gou Young Koh, Pipsa Saharinen, Miikka Vikkula, Kari Alitalo
Published in: Science Translational Medicine, Issue 12/560, 2020, Page(s) eaax8013, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aax8013

Deliverables

Publications

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