Dynamic longitudinal exposome trajectories in cardiovascular and metabolic non-communicable diseases

Deliverables

Documents, reports (1)

Science connecting - policy workshop 1

Summary report of the first workshop connecting the scientific objectives of LONGITOOLS and the policy and regulation agendas

Other (2)

Innovation platform

A public event to launch LONGITOOLS innovation platform organised alongside the second General Assembly of LONGITOOLS

LONGITOOLS website

LONGITOOLS website launched

Publications

Peer reviewed articles (64)

Risk factors for positive and negative COVID-19 tests: a cautious and in- depth analysis of UK biobank data

Author(s): Marc Chadeau-Hyam, Barbara Bodinier, Joshua Elliott, Matthew D Whitaker, Ioanna Tzoulaki, Roel Vermeulen, Michelle Kelly-Irving, Cyrille Delpierre, Paul Elliott
Published in: International Journal of Epidemiology, 49(5), 2020, Page(s) 1454-1467, ISSN 0300-5771
Publisher: Oxford University Press
DOI: 10.1093/ije/dyaa134

Variant-specific symptoms of COVID-19 in a study of 1,542,510 adults in England

Author(s): Whitaker M, Elliott J, Bodinier B, Barclay W, Ward H, Cooke G, Donnelly CA, Chadeau-Hyam M, Elliott P
Published in: Nature Communications, 13 (6856), 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-34244-2

Maternal and infant prediction of the child BMI trajectories; studies across two generations of Northern Finland birth cohorts

Author(s): Rozenn Nedelec, Jouko Miettunen, Minna Männikkö, Marjo-Riitta Järvelin, Sylvain Sebert
Published in: International Journal of Obesity, 45/2, 2021, Page(s) 404-414, ISSN 0307-0565
Publisher: Nature Publishing Group
DOI: 10.1038/s41366-020-00695-0

Measurement invariance testing of the patient health questionnaire-9 (PHQ-9) across people with and without diabetes mellitus from the NHANES, EMHS and UK Biobank datasets

Author(s): Arie Nouwen, Sonya S.Deschênes, Zhanna Balkhiyarova, Juan R.Albertorio-Díaz, Inga Prokopenko, Norbert Schmitz
Published in: Journal of Affective Disorders, 292, 2021, Page(s) 311-318, ISSN 0165-0327
Publisher: Elsevier BV
DOI: 10.1016/j.jad.2021.05.031

Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes

Author(s): Natalia Pervjakova; Gunn-Helen Moen; Maria-Carolina Borges; Teresa Ferreira; James P Cook; Catherine Allard; Robin N Beaumont; Mickaël Canouil; Gad Hatem; Anni Heiskala; Anni Joensuu; Ville Karhunen; Soo Heon Kwak; Frederick T J Lin; Jun Liu; Sheryl Rifas-Shiman; Claudia H Tam; Wing Hung Tam; Gudmar Thorleifsson; Toby Andrew; Juha Auvinen; Bishwajit Bhowmik; Amélie Bonnefond; Fabien Delahaye; Ay
Published in: Human Molecular Genetics, 31(19), 2022, Page(s) 3377-3391, ISSN 0964-6906
Publisher: Oxford University Press
DOI: 10.1093/hmg/ddac050

Cord blood leptin level and a common variant of its receptor as determinants of the BMI trajectory: the EDEN mother-child cohort

Author(s): Aminata H. Cissé, Marion Taine, Muriel Tafflet, Blandine de Lauzon-Guillain, Karine Clément, Olfa Khalfallah, Laetitia Davidovic, Sandrine Lioret, Marie A. Charles, Barbara Heude
Published in: Pediatric Obesity, 2022, ISSN 2047-6310
Publisher: Wiley-Blackwell for the International Association for the Study of Obesity
DOI: 10.1111/ijpo.12955

Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

Author(s): Thomas W. Winkler*, Humaira Rasheed, Lifelines Cohort Study, DiscovEHR/MyCode study, VA Million Veteran Program, Alexander Teumer, Mathias Gorski, Bryce X. Rowan, Kira J. Stanzick, Laurent F. Thomas, Adrienne Tin, Anselm Hoppmann, Audrey Y. Chu, Bamidele Tayo, Chris H.L. Thio, Daniele Cusi, Jin Fang Chai, Karsten B. Sieber, Katrin Horn, Man Li, Markus Scholz, Massimiliano Cocca, Matthias Wuttke, P
Published in: Communications Biology, 5(580), 2022, ISSN 2399-3642
Publisher: Springer Nature
DOI: 10.1038/s42003-022-03448-z

Maternal Mediterranean diet in pregnancy and newborn DNA methylation: a meta-analysis in the PACE Consortium

Author(s): Leanne K. Küpers; Sílvia Fernández-Barrés; Aayah Nounu; Chloe Friedman; Ruby Fore; Giulia Mancano; Dana Dabelea; Sheryl L. Rifas-Shiman; Rosa H. Mulder; Emily Oken; Laura Johnson; Mariona Bustamante; Vincent W.V. Jaddoe; Marie-France Hivert; Anne P. Starling; Jeanne H.M. de Vries; Gemma C. Sharp; Martine Vrijheid; Janine F. Felix
Published in: Epigenetics, 2022, Page(s) 1-13, ISSN 1559-2308
Publisher: Taylor & Francis Group
DOI: 10.1080/15592294.2022.2038412

Paternal body mass index and offspring DNA methylation: findings from the PACE consortium

Author(s): Gemma C Sharp, Rossella Alfano, Akram Ghantous, Jose Urquiza, Sheryl L Rifas-Shiman, Christian M Page, Jianping Jin, Silvia Fernández-Barrés, Gillian Santorelli, Gwen Tindula, Gemma C Sharp, Rossella Alfano, Akram Ghantous, Jose Urquiza, Sheryl L Rifas-Shiman, Christian M Page, Jianping Jin, Silvia Fernández-Barrés, Gillian Santorelli, Gwen Tindula, Paul Yousefi, Leanne Kupers, Carlos Ruiz-Are
Published in: International Journal of Epidemiology, 2021, ISSN 0300-5771
Publisher: Oxford University Press
DOI: 10.1093/ije/dyaa267

The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice

Author(s): Francesca Forzano, Olga Antonova, Angus Clarke, Guido de Wert, Sabine Hentze, Yalda Jamshidi, Yves Moreau, Markus Perola, Inga Prokopenko, Andrew Read, Alexandre Reymond, Vigdis Stefansdottir, Carla van El & Maurizio Genuardi, on behalf of the Executive Committee of the European Society of Human Genetics & the Public and Professional Policy Committee of the European Society of Human Genetics
Published in: The European Journal of Human Genetics, 2021, ISSN 1018-4813
Publisher: Natue Publishing Group
DOI: 10.1038/s41431-021-01000-x

Post-weight loss changes in fasting appetite- and energy balance-related hormone concentrations and the effect of the macronutrient content of a weight maintenance diet: a randomised controlled trial

Author(s): Mari Näätänen, Marjukka Kolehmainen, David E. Laaksonen, Karl-Heinz Herzig, Kaisa Poutanen, Leila Karhunen
Published in: European Journal of Nutrition, 2020, ISSN 1436-6207
Publisher: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00394-020-02438-3

Maternal plasma fatty acid patterns in mid-pregnancy and offspring epigenetic gestational age at birth

Author(s): Giulietta S. Monasso, Trudy Voortman, Janine F. Felix
Published in: Epigenetics, 2022, ISSN 1559-2294
Publisher: Landes Bioscience
DOI: 10.1080/15592294.2022.2076051

Cohort profile:46 years of follow-up of the Northern Finland Birth Cohort 1966 (NFBC1966)

Author(s): Nordström, T. (Tanja); Miettunen, J. (Jouko); Auvinen, J. (Juha); Ala-Mursula, L. (Leena); Keinänen-Kiukaanniemi, S. (Sirkka); Veijola, J. (Juha); Järvelin, M.-R. (Marjo-Riitta); Sebert, S. (Sylvain); Männikkö, M. (Minna)
Published in: International Journal of Epidemiology, 50(6), 2021, Page(s) 1786-1787, ISSN 0300-5771
Publisher: Oxford University Press
DOI: 10.1093/ije/dyab109

Identification and distribution of sterols, bile acids, and acylcarnitines by LC-MS/MS in humans, mice, and pigs – A qualitative analysis 

Author(s): Ambrin Farizah Babu, Ville Mikael Koistinen, Soile Turunen, Gloria Solano-Aguilar, Joseph F. Urban, Jr., Iman Zarei and Kati Hanhineva
Published in: Metabolites, 12(1), 2022, Page(s) 49, ISSN 2218-1989
Publisher: MDPI
DOI: 10.3390/metabo12010049

Maternal iron status in early pregnancy and DNA methylation in offspring: an epigenome-wide meta-analysis

Author(s): M. J. Taeubert, P. de Prado-Bert, M. L. Geurtsen, G. Mancano, M. J. Vermeulen, I. K. M. Reiss, D. Caramaschi, J. Sunyer, G. C. Sharp, J. Julvez, M. U. Muckenthaler & J. F. Felix
Published in: Clinical Epigenetics, 14(59), 2022, ISSN 1868-7083
Publisher: BioMed Central
DOI: 10.1186/s13148-022-01276-w

Heterogeneous Effects of Calorie Content and Nutritional Components Underlie Dietary Influence on Pancreatic Cancer Susceptibility

Author(s): James Dooley, Vasiliki Lagou, Jermaine Goveia, Anna Ulrich, Katerina Rohlenova, Nathalie Heirman, Tobias Karakach, Yulia Lampi, Shawez Khan, Jun Wang, Tom Dresselaers, Uwe Himmelreich, Marc J. Gunter, Inga Prokopenko, Peter Carmeliet, Adrian Liston
Published in: Cell Reports, 32/2, 2020, Page(s) 107880, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.107880

Epigenome-wide contributions to individual differences in childhood phenotypes: a GREML approach

Author(s): Alexander Neumann, Jean-Baptiste Pingault, Janine F. Felix, Vincent W. V. Jaddoe, Henning Tiemeier, Charlotte Cecil & Esther Walton
Published in: Clinical Epigenetics, 14(1), 2022, Page(s) 53, ISSN 1868-7083
Publisher: BioMed Central Ltd
DOI: 10.1186/s13148-022-01268-w

Relationship between glucose homeostasis and obesity in early life—a study of Italian children and adolescents

Author(s): Zhanna Balkhiyarova, Rosa Luciano, Marika Kaakinen, Anna Ulrich, Aleksey Shmeliov, Marzia Bianchi, Laura Chioma, Bruno Dallapiccola, Inga Prokopenko, Melania Manco
Published in: Human Molecular Genetics, 09646906, 2022, Page(s) 816-826, ISSN 0964-6906
Publisher: Oxford University Press
DOI: 10.1093/hmg/ddab287

DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures

Author(s): Monica del C. Gomez-Alonso, Anja Kretschmer, Rory Wilson, Liliane Pfeiffer, Ville Karhunen, Ilkka Seppälä, Weihua Zhang, Kirstin Mittelstraß, Simone Wahl, Pamela R. Matias-Garcia, Holger Prokisch, Sacha Horn, Thomas Meitinger, Luis R. Serrano-Garcia, Sylvain Sebert, Olli Raitakari, Marie Loh, Wolfgang Rathmann, Martina Müller-Nurasyid, Christian Herder, Michael Roden, Mikko Hurme, Marjo-Riitta
Published in: Clinical Epigenetics, 13/1, 2021, ISSN 1868-7075
Publisher: Springer Verlag
DOI: 10.1186/s13148-020-00957-8

Associations of Hair Cortisol Concentrations With Cardiometabolic Risk Factors in Childhood

Author(s): Florianne O L Vehmeijer, Susana Santos, Yolanda B de Rijke, Erica L T van den Akker, Janine F Felix, Elisabeth F C van Rossum, Vincent W V Jaddoe
Published in: The Journal of Clinical Endocrinology & Metabolism, 2021, ISSN 0021-972X
Publisher: The Endocrine Society
DOI: 10.1210/clinem/dgab379

Infant weight growth patterns, childhood BMI and arterial health at age 10 years

Author(s): Giulietta S. Monasso, Carolina C.V. Silva, Susana Santos, Romy Goncalvez, Romy Gaillard, Janine F. Felix, Vincent W.V. Jaddoe
Published in: Obesity, 30(3), 2022, Page(s) 770-778, ISSN 1930-7381
Publisher: Wiley-Blackwell
DOI: 10.1002/oby.23376

Defining the Scope of Exposome Studies and Research Needs from a Multidisciplinary Perspective.

Author(s): Pei Zhang; Pei Zhang; Pei Zhang; Christopher Carlsten; Romanas Chaleckis; Romanas Chaleckis; Kati Hanhineva; Kati Hanhineva; Kati Hanhineva; Mengna Huang; Tomohiko Isobe; Ville M. Koistinen; Ville M. Koistinen; Isabel Meister; Isabel Meister; Stefano Papazian; Kalliroi Sdougkou; Hongyu Xie; Jonathan W. Martin; Stephen M. Rappaport; Hiroshi Tsugawa; Douglas I. Walker; Tracey J. Woodruff; Robert O.
Published in: Environmental Science & Technology Letters, 8(10), 2021, Page(s) 839-852, ISSN 2328-8930
Publisher: ACS Publications
DOI: 10.1021/acs.estlett.1c00648

Body fat, pericardial fat, liver fat and arterial health at age 10 years

Author(s): Giulietta S. Monasso, Susana Santos, Carolina C. V. Silva, Madelon L. Geurtsen, Edwin Oei, Romy Gaillard, Janine F. Felix, Vincent W. V. Jaddoe
Published in: Pediatric Obesity, 2022, ISSN 2047-6310
Publisher: Wiley-Blackwell for the International Association for the Study of Obesity
DOI: 10.1111/ijpo.12926

Expression Quantitative Trait Locus Mapping in Pulmonary Arterial Hypertension

Author(s): Anna Ulrich, Pablo Otero-Núñez, John Wharton, Emilia M. Swietlik, Stefan Gräf, Nicholas W. Morrell, Dennis Wang, Allan Lawrie, Martin R. Wilkins, Inga Prokopenko, Christopher J. Rhodes, UK PAH Cohort Study Consortium
Published in: Genes, 11/11, 2020, Page(s) 1247, ISSN 2073-4425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes11111247

Longitudinal associations of DNA methylation and sleep in children: a meta-analysis

Author(s): Sara Sammallahti, M. Elisabeth Koopman-Verhoeff, Anne-Claire Binter, Rosa H. Mulder, Alba Cabré-Riera, Tuomas Kvist, Anni L. K. Malmberg, Giancarlo Pesce, Sabine Plancoulaine, Jonathan A. Heiss, Sheryl L. Rifas-Shiman, Stefan W. Röder, Anne P. Starling, Rory Wilson, Kathrin Guerlich, Kristine L. Haftorn, Christian M. Page, Annemarie I. Luik, Henning Tiemeier, Janine F. Felix, Katri Raikkonen, Ja
Published in: Clinical Epigenetics, 14(83), 2022, ISSN 1868-7083
Publisher: BioMed Central
DOI: 10.1186/s13148-022-01298-4

Dynamic longitudinal exposome trajectories in cardiovascular and metabolic noncommunicable diseases

Author(s): Ronkainen, Justiina; Nedelec, Rozenn; Atehortua, Angelica; Balkhiyarova, Zhanna; Cascarano, Anna; Ngoc Dang, Vien; Elhakeem, Ahmed; van Enckevort, Esther; Goncalves Soares, Ana; Haakma, Sido; Halonen, Miia; Heil, Katharina F; Heiskala, Anni; Hyde, Eleanor; Jacquemin, Bénédicte; Keikkala, Elina; Kerckhoffs, Jules; Klåvus, Anton; Kopinska, Joanna A; Lepeule, Johanna; Marazzi, Francesca; Motoc, Ir
Published in: Environmental Epidemiology, 6(1), 2022, Page(s) e184, ISSN 2474-7882
Publisher: Wolters Kluwer Health Inc
DOI: 10.1097/ee9.0000000000000184

Bifidobacterium Is Enriched in Gut Microbiome of Kashmiri Women with Polycystic Ovary Syndrome

Author(s): Saqib Hassan, Marika A. Kaakinen, Harmen Draisma, Liudmila Zudina, Mohd A. Ganie, Aafia Rashid, Zhanna Balkhiyarova, George S. Kiran, Paris Vogazianos, Christos Shammas, Joseph Selvin, Athos Antoniades, Ayse Demirkan and Inga Prokopenko
Published in: Genes, 13(2), 2022, Page(s) 379, ISSN 2073-4425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes13020379

Effect of common pregnancy and perinatal complications on offspring metabolic traits across the life-course: a multi-cohort study

Author(s): Ahmed Elhakeem, Justiina Roinkainen, Toby Mansell, Tuija Mikkola, Binisha Mishra, Rama Wahab, Tim Cadman, Tiffany Yang, David Burgner, Johan G. Eriksson, Marjo-Riitta Järvelin, Romy Gaillard, Vincent W V Jaddoe, Terho Lehtimäki, Olli T Raitakari, Richard Saffrey, Melissa Wake, John Wright, Sylvain P Sebert, Deborah A Lawlor
Published in: BMC Medicine, 21(23), 2023, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1101/2022.04.05.22273388

Maternal Glycemic Dysregulation During Pregnancy and Neonatal Blood DNA Methylation: Meta-analyses of Epigenome-Wide Association Studies

Author(s): Elmar W. Tobi; Diana L. Juvinao-Quintero; Justiina Ronkainen; Raffael Ott; Rossella Alfano; Mickaël Canouil; Madelon L. Geurtsen; Amna Khamis; Leanne K. Küpers; Ives Y. Lim; Patrice Perron; Giancarlo Pesce; Johanna Tuhkanen; Anne P. Starling; Toby Andrew; Elisabeth Binder; Robert Caiazzo; Jerry K.Y. Chan; Romy Gaillard; Peter D. Gluckman; Elina Keikkala; Neerja Karnani; Sanna Mustaniemi; Tim S.
Published in: Diabetes Care, 6, 2022, ISSN 0149-5992
Publisher: American Diabetes Association
DOI: 10.2337/dc21-1701

Sex-specific effects of prenatal undernutrition on resting-state functional connectivity in the human brain at age 68

Author(s): AmberBoot, Moriah E.Thomason, Claudia Espinoza-Heredia, Patrick J.Pruitt, Jessica S.Damoiseaux, Tessa J.Roseboom, Susanne R.de Rooij
Published in: Neurobiology of Aging, 112, 2022, Page(s) 129-138, ISSN 0197-4580
Publisher: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2022.01.003

Maternal Dietary Glycemic Index and Glycemic Load in Pregnancy and Offspring Cord Blood DNA Methylation

Author(s): Leanne K. Küpers; Sílvia Fernández-Barrés; Giulia Mancano; Laura Johnson; Raffael Ott; Jesus Vioque; Marco Colombo; Kathrin Landgraf; Elmar W. Tobi; Antje Körner; Romy Gaillard; Jeanne H.M. de Vries; Vincent W.V. Jaddoe; Martine Vrijheid; Gemma C. Sharp; Janine F. Felix
Published in: Diabetes Care, 2022, ISSN 0149-5992
Publisher: American Diabetes Association
DOI: 10.2337/dc21-2662

Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

Author(s): Vasiliki Lagou, Reedik Mägi, Jouke- Jan Hottenga, Harald Grallert, John R. B. Perry, Nabila Bouatia-Naji, Letizia Marullo, Denis Rybin, Rick Jansen, Josine L. Min, Antigone S. Dimas, Anna Ulrich, Liudmila Zudina, Jesper R. Gådin, Longda Jiang, Alessia Faggian, Amélie Bonnefond, Joao Fadista, Maria G. Stathopoulou, Aaron Isaacs, Sara M. Willems, Pau Navarro, Toshiko Tanaka, Anne U. Jackson, May
Published in: Nature Communications, 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-19366-9

Genetic Correlation and Causal Relationships between Cardio-Metabolic Traits and Lung Function Impairment

Author(s): Matthias Wielscher; Andre F.S. Amaral; Diana A van der Plaat; Louise V. Wain; Louise V. Wain; Sylvain Sebert; David Mosen-Ansorena; Juha Auvinen; Karl-Heinz Herzig; Karl-Heinz Herzig; Karl-Heinz Herzig; Abbas Dehghan; Deborah Jarvis; Marjo-Riitta Järvelin
Published in: Genome Medicine, 13(104), 2021, ISSN 1756-994X
Publisher: BioMed Central
DOI: 10.2139/ssrn.3566256

Early exposure to social disadvantages and later life body mass index beyond genetic predisposition in three generations of Finnish birth cohorts

Author(s): Estelle Lowry, Nina Rautio, Niko Wasenius, Tom A. Bond, Jari Lahti, Ioanna Tzoulaki, Abbas Dehghan, Anni Heiskala, Leena Ala-Mursula, Jouko Miettunen, Johan Eriksson, Marjo-Riitta Järvelin, Sylvain Sebert
Published in: BMC Public Health, 20/1, 2020, ISSN 1471-2458
Publisher: BioMed Central
DOI: 10.1186/s12889-020-08763-w

Vitamin B12, folate and homocysteine concentrations during pregnancy and early signs of atherosclerosis at school-age

Author(s): Giulietta S. Monasso, Janine F. Felix, Sandra G. Heil, Yolanda B. de Rijke, Romy Gaillard, Vincent W.V. Jaddoe
Published in: Clinical Nutrition, 40(9), 2021, Page(s) 5133-5140, ISSN 0346-251X
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.clnu.2021.08.001

Machine Learning-Based DNA Methylation Score for Fetal Exposure to Maternal Smoking: Development and Validation in Samples Collected from Adolescents and Adults

Author(s): Sebastian Rauschert, Phillip E. Melton, Anni Heiskala, Ville Karhunen, Graham Burdge, Jeffrey M. Craig, Keith M. Godfrey, Karen Lillycrop, Trevor A. Mori, Lawrence J. Beilin, Wendy H. Oddy, Craig Pennell, Marjo-Riitta Järvelin, Sylvain Sebert, Rae-Chi Huang
Published in: Environmental Health Perspectives, 128/9, 2020, Page(s) 097003, ISSN 0091-6765
Publisher: US Department of Health and Human Services
DOI: 10.1289/ehp6076

Cardiovascular Health at Age 5 Years: Distribution, Determinants, and Association With Neurodevelopment

Author(s): Rachel E. Climie*, Muriel Tafflet, Thomas van Sloten, Blandine de Lauzon-Guillain, Jonathan Y. Bernard, Patricia Dargent-Molina, Sabine Plancoulaine, Sandrine Lioret, Xavier Jouven, Marie-Alines Charles, Barbara Heude and Jean-Philippe Empana
Published in: Frontiers in Pediatrics, 2022, ISSN 2296-2360
Publisher: Frontiers Media S.A.
DOI: 10.3389/fped.2022.827525

Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight

Author(s): NCD Risk Factor Collaboration (NCD-RisC); Iurilli, Maria LC; Zhou, Bin; Bennett, James E; Carrillo-Larco, Rodrigo M; Sophiea, Marisa K; Rodriguez-Martinez, Andrea; Bixby, Honor; Solomon, Bethlehem D; Taddei, Cristina; Danaei, Goodarz; Di Cesare, Mariachiara; Stevens, Gretchen A; Riley, Leanne M; Savin, Stefan; Cowan, Melanie J; Bovet, Pascal; Damasceno, Albertino; Chirita-Emandi, Adela; Hayes, Ali
Published in: "eLife, eLife Sciences Publication, 2021, 10, ⟨10.7554/elife.60060⟩", 2, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.3929/ethz-b-000478961

Dynamics of competing SARS-CoV-2 variants during the Omicron epidemic in England

Author(s): Eales, O Martins, LDO Page, AJ Wang, H Bodinier, B Tang, D Haw, D Jonnerby, J Atchison, C Ashby, D Barclay, W Taylor, G Cooke, G Ward, H Darzi, A Riley, S Elliott, P Donnelly, CA Chadeau-Hyam, M
Published in: Nature Communications, 13 (4375), 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-32096-4

Dynamics of a national Omicron SARS-CoV-2 epidemic during January 2022 in England

Author(s): Paul Elliott; Oliver Eales; Barbara Bodinier; David Tang; Haowei Wang; Jakob Jonnerby; David Haw; Joshua Elliott; Matthew Whitaker; Caroline E. Walters; Christina Atchison; Peter J. Diggle; Andrew J. Page; Alexander J. Trotter; Deborah Ashby; Wendy Barclay; Graham Taylor; Helen Ward; Ara Darzi; Graham S. Cooke; Marc Chadeau-Hyam; Christl A. Donnelly
Published in: Nature Communications, 13(4500), 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-32121-6

Abuse in childhood and cardiometabolic health in early adulthood: evidence from the Avon Longitudinal Study of Parents and Children

Author(s): Ana Luiza Goncalves Soares, Annie Zimmerman, Stanley Zammit, Anke Karl, Sarah L Halligan, Abi Fraser
Published in: Journal of the American Heart Association, 10(24), 2021, Page(s) e021701, ISSN 2047-9980
Publisher: Wiley-Blackwell
DOI: 10.1161/jaha.121.021701

How does childhood maltreatment influence cardiovascular disease? A sequential causal mediation analysis

Author(s): Ana G Soares, Laura D Howe, Jon Heron, Gemma Hammerton, Janet Rich-Edwards, Maria C Magnus, Sarah L Halligan, Abigail Fraser
Published in: International Journal of Epidemiology, 2021, ISSN 0300-5771
Publisher: Oxford University Press
DOI: 10.1093/ije/dyab085

Associations of circulating folate, vitamin B12 and homocysteine concentrations in early pregnancy and cord blood with epigenetic gestational age: the Generation R Study

Author(s): Giulietta S. Monasso, Leanne K. Küpers, Vincent W. V. Jaddoe, Sandra G. Heil, Janine F. Felix
Published in: Clinical Epigenetics, 13/1, 2021, Page(s) 95, ISSN 1868-7075
Publisher: Springer Verlag
DOI: 10.1186/s13148-021-01065-x

Omicron SARS-CoV-2 epidemic in England during February 2022: A series of cross-sectional community surveys

Author(s): Chadeau-Hyam, M Tang, D Eales, O Bodinier, B Wang, H Jonnerby, J Whitaker, M Elliott, J Haw, D Walters, CE Atchison, C Diggle, PJ Page, AJ Ashby, D Barclay, W Taylor, G Cooke, G Ward, H Darzi, A Donnelly, CA Elliott, P
Published in: The Lancet Regional Health - Europe, 21, 2022, Page(s) 100462, ISSN 2666-7762
Publisher: Elsevier Ltd
DOI: 10.1016/j.lanepe.2022.100462

Functional Effects In Silico Prediction for Androgen Receptor Ligand-Binding Domain Novel I836S Mutation

Author(s): Alexey Rayevsky, Dmytro Sirokha, Dariia Samofalova, Dmytro Lozhko, Olexandra Gorodna, Inga Prokopenko, Liudmyla Livshits
Published in: Life, 11/7, 2021, Page(s) 659, ISSN 2075-1729
Publisher: MDPI
DOI: 10.3390/life11070659

Twin peaks: The Omicron SARS-CoV-2 BA.1 and BA.2 epidemics in England

Author(s): PAUL ELLIOTT, OLIVER EALES, NICHOLAS STEYN, DAVID TANG, BARBARA BODINIER, HAOWEI WANG, JOSHUA ELLIOTT, MATTHEW WHITAKER, CHRISTINA ATCHISON, PETER J. DIGGLE, ANDREW J. PAGE, ALEXANDER J. TROTTER, DEBORAH ASHBY, WENDY BARCLAY, GRAHAM TAYLOR, HELEN WARD, ARA DARZI GRAHAM S. COOKE, CHRISTL A. DONNELLY, AND MARC CHADEAU-HYAM
Published in: Science, 376 (6600), 2022, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abq4411

Risk of Recurrent Pregnancy Loss in the Ukrainian Population Using a Combined Effect of Genetic Variants: A Case-Control Study

Author(s): Eleni M. Loizidou, Anastasia Kucherenko, Pavlo Tatarskyy, Sergey Chernushyn, Ganna Livshyts, Roman Gulkovskyi, Iryna Vorobiova, Yurii Antipkin, Oleksandra Gorodna, Marika A. Kaakinen, Inga Prokopenko, Ludmila Livshits
Published in: Genes, 12/1, 2021, Page(s) 64, ISSN 2073-4425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes12010064

MC3R links nutritional state to childhood growth and the timing of puberty

Author(s): B. Y. H. Lam, A. Williamson, S. Finer, F. R. Day, J. A. Tadross, A. Gonçalves Soares, K. Wade, P. Sweeney, M. N. Bedenbaugh, D. T. Porter, A. Melvin, K. L. J. Ellacott, R. N. Lippert, S. Buller, J. Rosmaninho-Salgado, G. K. C. Dowsett, K. E. Ridley, Z. Xu, I. Cimino, D. Rimmington, K. Rainbow, K. Duckett, S. Holmqvist, A. Khan, Genes & Health Research Team, S. O’Rahilly
Published in: Nature, 599, 2021, Page(s) 436-441, ISSN 0028-0836
Publisher: Nature Publishing Group
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Associations of PFAS-related plasma metabolites with cholesterol and triglyceride concentrations

Author(s): T. Schillemans; I.A. Bergdahl; K. Hanhineva; L. Shi; C. Donat-Vargas; J. Koponen; H. Kiviranta; R. Landberg; A. Åkesson; C. Brunius
Published in: Environmental Research (0013-9351) vol.216(2023), 216(2), 2023, Page(s) 114570, ISSN 0013-9351
Publisher: Academic Press
DOI: 10.1016/j.envres.2022.114570

COVID-19 mortality in the UK Biobank cohort: revisiting and evaluating risk factors

Author(s): Joshua Elliott, Barbara Bodinier, Matthew Whitaker, Cyrille Delpierre, Roel Vermeulen, Ioanna Tzoulaki, Paul Elliott, Marc Chadeau-Hyam
Published in: European Journal of Epidemiology, 36/3, 2021, Page(s) 299-309, ISSN 0393-2990
Publisher: Kluwer Academic Publishers
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Prenatal exposure to the Dutch famine is associated with more self-perceived cognitive problems at 72 years of age

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Published in: BMC Geriatrics, 22, 2022, Page(s) 176, ISSN 1471-2318
Publisher: BioMed Central
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The determinants and longitudinal changes in vitamin D status in middle-age: a Northern Finland Birth Cohort 1966 study

Author(s): Helmi Ikonen; Johanna Lumme; Jussi Seppälä; Jussi Seppälä; Paula Pesonen; Terhi Piltonen; Terhi Piltonen; Marjo-Riitta Järvelin; Karl-Heinz Herzig; Jouko Miettunen; Jouko Miettunen; Maarit Niinimäki; Maarit Niinimäki; Saranya Palaniswamy; Saranya Palaniswamy; Sylvain Sebert; Marja Ojaniemi; Marja Ojaniemi
Published in: European Journal of Nutrition, 60, 2021, Page(s) 4541–4553, ISSN 1436-6207
Publisher: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00394-021-02606-z

Using linear and natural cubic splines, SITAR, and latent trajectory models to characterise nonlinear longitudinal growth trajectories in cohort studies

Author(s): Ahmed Elhakeem; Rachael A. Hughes; Kate Tilling; Diana L. Cousminer; Diana L. Cousminer; Jackowski S; Jackowski S; Tim J Cole; Kwong Asf; Kwong Asf; Li Z; Li Z; Struan F.A. Grant; Baxter-Jones A; Babette S. Zemel; Babette S. Zemel; Debbie A Lawlor
Published in: BMC Medical Research Methodology, 68, 2022, ISSN 1471-2288
Publisher: BioMed Central
DOI: 10.1186/s12874-022-01542-8

Epigenome-wide change and variation in DNA methylation in childhood: trajectories from birth to late adolescence

Author(s): Rosa H Mulder, Alexander Neumann, Charlotte A M Cecil, Esther Walton, Lotte C Houtepen, Andrew J Simpkin, Jolien Rijlaarsdam, Bastiaan T Heijmans, Tom R Gaunt, Janine F Felix, Vincent W V Jaddoe, Marian J Bakermans-Kranenburg, Henning Tiemeier, Caroline L Relton, Marinus H van IJzendoorn, Matthew Suderman
Published in: Human Molecular Genetics, 30/1, 2021, Page(s) 119-134, ISSN 0964-6906
Publisher: Oxford University Press
DOI: 10.1093/hmg/ddaa280

Epigenetic age acceleration and cardiovascular outcomes in school-age children: The Generation R Study.

Author(s): Giulietta S Monasso; Vincent W. V. Jaddoe; Leanne K. Küpers; Leanne K. Küpers; Janine F. Felix
Published in: Clinical Epigenetics, 13(1), 2021, Page(s) 205, ISSN 1868-7083
Publisher: BioMed Central Ltd
DOI: 10.1186/s13148-021-01193-4

Polycystic ovary syndrome and leukocyte telomere length:cross-sectional and longitudinal changes

Author(s): Pölönen, J. (Johanna); Pinola, P. (Pekka); Ronkainen, J. (Justiina); Blakemore, A. I. (Alex I.); Buxton, J. L. (Jessica L.); Tapanainen, J. S. (Juha S.); Franks, S. (Stephen); Piltonen, T. T. (Terhi T.); Sebert, S. (Sylvain); Morin-Papunen, L. (Laure)
Published in: European Journal of Endocrinology, 187(5), 2022, Page(s) 651-661, ISSN 0804-4643
Publisher: BioScientifica Ltd.
DOI: 10.1530/eje-22-0462

Plasma metabolites associated with exposure to perfluoroalkyl substances and risk of type 2 diabetes – A nested case-control study

Author(s): Tessa Schillemans, Lin Shi, Carolina Donat-Vargas, Kati Hanhineva, Andreas Tornevi, Ingegerd Johansson, Jani Koponen, Hannu Kiviranta, Olov Rolandsson, Ingvar A. Bergdahl, Rikard Landberg, Agneta Åkesson, Carl Brunius
Published in: Environment International, 146, 2021, Page(s) 106180, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
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Harnessing Microbes for Sustainable Development: Food Fermentation as a Tool for Improving the Nutritional Quality of Alternative Protein Sources

Author(s): Anna Kårlund, Carlos Gómez-Gallego, Jenni Korhonen, Outi-Maaria Palo-oja, Hani El-Nezami, Marjukka Kolehmainen
Published in: Nutrients, 12/4, 2020, Page(s) 1020, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu12041020

Fetal exposure to phthalates and bisphenols and DNA methylation at birth: the Generation R Study

Author(s): Chalana M. Sol, Abigail Gaylord, Susana Santos, Vincent W. V. Jaddoe, Janine F. Felix & Leonardo Trasande
Published in: Clinical Epigenetics, 14(125), 2022, ISSN 1868-7083
Publisher: BioMed Central
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Metabolic profiles of socio-economic position: a multi-cohort analysis

Author(s): Oliver Robinson; Alice R Carter; Mika Ala-Korpela; Juan P Casas; Juan P Casas; Nishi Chaturvedi; Jorgen Engmann; Laura D Howe; Alun D. Hughes; Marjo-Riitta Järvelin; Mika Kähönen; Ville Karhunen; Diana Kuh; Tina Shah; Yoav Ben-Shlomo; Reecha Sofat; Chung-Ho E Lau; Terho Lehtimäki; Usha Menon; Olli T. Raitakari; Olli T. Raitakari; Andy Ryan; Rui Providência; Stephanie Smith; Julie Taylor; Ther
Published in: Robinson , O , Carter , A R , Ala-Korpela , M , Casas , J P , Chaturvedi , N , Engmann , J , Howe , L D , Hughes , A D , Järvelin , M-R , Kähönen , M , Karhunen , V , Kuh , D , Shah , T , Ben-Shlomo , Y , Sofat , R , Lau , C-H E , Lehtimäki , T , Menon , U , Raitakari , O , Ryan , A , Providencia , R , Smith , S , Taylor , J , Tillin , T , Viikari , J , Wong , A , Hingorani , A D , Kivimaki ,, 50(3), 2021, Page(s) 768-782, ISSN 0300-5771
Publisher: Oxford University Press
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Epigenome-Wide Association Study Reveals Methylation Loci Associated With Offspring Gestational Diabetes Mellitus Exposure and Maternal Methylome

Author(s): Mickaël Canouil; Amna Khamis; Elina Keikkala; Sandra Hummel; Stephane Lobbens; Amélie Bonnefond; Fabien Delahaye; Evangelia Tzala; Sanna Mustaniemi; Marja Vääräsmäki; Marjo-Riitta Jarvelin; Sylvain Sebert; Eero Kajantie; Philippe Froguel; Toby Andrew
Published in: Diabetes Care, 44(9), 2021, Page(s) 1992-1999, ISSN 0149-5992
Publisher: American Diabetes Association
DOI: 10.2337/dc20-2960

The relationship of life-course patterns of adiposity with type 2 diabetes, depression, and their comorbidity in the Northern Finland Birth Cohort 1966

Author(s): Priyanka Choudhary; Justiina Ronkainen; Rozenn Nedelec; Mimmi Tolvanen; Estelle Lowry; Jouko Miettunen; Marjo-Riitta Jarvelin; Sylvain Sebert
Published in: Choudhary , P , Ronkainen , J , Nedelec , R , Tolvanen , M , Lowry , E , Jarvelin , M-R & Sebert , S 2022 , ' The relationship of life-course patterns of adiposity with type 2 diabetes, depression, and their comorbidity in the Northern Finland Birth Cohort 1966 ' , International Journal of Obesity . https://doi.org/10.1038/s41366-022-01134-y, 4, 2022, ISSN 0307-0565
Publisher: Nature Publishing Group
DOI: 10.1038/s41366-022-01134-y

Towards early risk biomarkers:serum metabolic signature in childhood predicts cardio-metabolic risk in adulthood

Author(s): Ojanen, X. (Xiaowei); Cheng, R. (Runtan); Törmäkangas, T. (Timo); Rappaport, N. (Noa); Wilmanski, T. (Tomasz); Wu, N. (Na); Fung, E. (Erik); Nedelec, R. (Rozenn); Sebert, S. (Sylvain); Vlachopoulos, D. (Dimitris); Yan, W. (Wei); Price, N. D. (Nathan D.); Cheng, S. (Sulin); Wiklund, P. (Petri)
Published in: eBioMedicine, 72(103611), 2021, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2021.103611

Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation

Author(s): Olivia Solomon; Karen Huen; Paul Yousefi; Leanne K. Küpers; Juan R. González; Matthew Suderman; Sarah E. Reese; Christian M. Page; Olena Gruzieva; Peter Rzehak; Lu Gao; Kelly M. Bakulski; Alexei Novoloaca; Catherine Allard; Irene Pappa; Maria Llambrich; Marta Vives; Dereje D. Jima; Tuomas Kvist; Andrea Baccarelli; Cory White; Faisal I. Rezwan; Gemma C. Sharp; Gwen Tindula; Anna Bergström; Veit
Published in: Mutation Research/Reviews in Mutation Research, 789, 2022, ISSN 1383-5742
Publisher: Elsevier BV
DOI: 10.1016/j.mrrev.2022.108415