Deliverables Documents, reports (1) Science connecting - policy workshop 1 Summary report of the first workshop connecting the scientific objectives of LONGITOOLS and the policy and regulation agendas Other (2) Innovation platform A public event to launch LONGITOOLS innovation platform organised alongside the second General Assembly of LONGITOOLS LONGITOOLS website LONGITOOLS website launched Publications Peer reviewed articles (76) Risk factors for positive and negative COVID-19 tests: a cautious and in- depth analysis of UK biobank data Author(s): Marc Chadeau-Hyam, Barbara Bodinier, Joshua Elliott, Matthew D Whitaker, Ioanna Tzoulaki, Roel Vermeulen, Michelle Kelly-Irving, Cyrille Delpierre, Paul Elliott Published in: International Journal of Epidemiology, Issue 49(5), 2020, Page(s) 1454-1467, ISSN 0300-5771 Publisher: Oxford University Press DOI: 10.1093/ije/dyaa134 Variant-specific symptoms of COVID-19 in a study of 1,542,510 adults in England Author(s): Whitaker M, Elliott J, Bodinier B, Barclay W, Ward H, Cooke G, Donnelly CA, Chadeau-Hyam M, Elliott P Published in: Nature Communications, Issue 13 (6856), 2022, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-022-34244-2 Maternal and infant prediction of the child BMI trajectories; studies across two generations of Northern Finland birth cohorts Author(s): Rozenn Nedelec, Jouko Miettunen, Minna Männikkö, Marjo-Riitta Järvelin, Sylvain Sebert Published in: International Journal of Obesity, Issue 45/2, 2021, Page(s) 404-414, ISSN 0307-0565 Publisher: Nature Publishing Group DOI: 10.1038/s41366-020-00695-0 Measurement invariance testing of the patient health questionnaire-9 (PHQ-9) across people with and without diabetes mellitus from the NHANES, EMHS and UK Biobank datasets Author(s): Arie Nouwen, Sonya S.Deschênes, Zhanna Balkhiyarova, Juan R.Albertorio-Díaz, Inga Prokopenko, Norbert Schmitz Published in: Journal of Affective Disorders, Issue 292, 2021, Page(s) 311-318, ISSN 0165-0327 Publisher: Elsevier BV DOI: 10.1016/j.jad.2021.05.031 Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes Author(s): Natalia Pervjakova; Gunn-Helen Moen; Maria-Carolina Borges; Teresa Ferreira; James P Cook; Catherine Allard; Robin N Beaumont; Mickaël Canouil; Gad Hatem; Anni Heiskala; Anni Joensuu; Ville Karhunen; Soo Heon Kwak; Frederick T J Lin; Jun Liu; Sheryl Rifas-Shiman; Claudia H Tam; Wing Hung Tam; Gudmar Thorleifsson; Toby Andrew; Juha Auvinen; Bishwajit Bhowmik; Amélie Bonnefond; Fabien Delahaye; Ay Published in: Human Molecular Genetics, Issue 31(19), 2022, Page(s) 3377-3391, ISSN 0964-6906 Publisher: Oxford University Press DOI: 10.1093/hmg/ddac050 Cord blood leptin level and a common variant of its receptor as determinants of the BMI trajectory: the EDEN mother-child cohort Author(s): Aminata H. Cissé, Marion Taine, Muriel Tafflet, Blandine de Lauzon-Guillain, Karine Clément, Olfa Khalfallah, Laetitia Davidovic, Sandrine Lioret, Marie A. Charles, Barbara Heude Published in: Pediatric Obesity, 2022, ISSN 2047-6310 Publisher: Wiley-Blackwell for the International Association for the Study of Obesity DOI: 10.1111/ijpo.12955 Investigating childhood maltreatment as a modifier of genetic risk for cardiovascular diseases in the UK Biobank Author(s): Helena Urquijo, Ana Gonçalves Soares, Abigail Fraser, Laura D. Howe, Alice R. Carter Published in: PLOS One, 2023, ISSN 1932-6203 Publisher: Public Library of Science DOI: 10.1371/journal.pone.0285258 Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals Author(s): Thomas W. Winkler*, Humaira Rasheed, Lifelines Cohort Study, DiscovEHR/MyCode study, VA Million Veteran Program, Alexander Teumer, Mathias Gorski, Bryce X. Rowan, Kira J. Stanzick, Laurent F. Thomas, Adrienne Tin, Anselm Hoppmann, Audrey Y. Chu, Bamidele Tayo, Chris H.L. Thio, Daniele Cusi, Jin Fang Chai, Karsten B. Sieber, Katrin Horn, Man Li, Markus Scholz, Massimiliano Cocca, Matthias Wuttke, P Published in: Communications Biology, Issue 5(580), 2022, ISSN 2399-3642 Publisher: Springer Nature DOI: 10.1038/s42003-022-03448-z Maternal Mediterranean diet in pregnancy and newborn DNA methylation: a meta-analysis in the PACE Consortium Author(s): Leanne K. Küpers; Sílvia Fernández-Barrés; Aayah Nounu; Chloe Friedman; Ruby Fore; Giulia Mancano; Dana Dabelea; Sheryl L. Rifas-Shiman; Rosa H. Mulder; Emily Oken; Laura Johnson; Mariona Bustamante; Vincent W.V. Jaddoe; Marie-France Hivert; Anne P. Starling; Jeanne H.M. de Vries; Gemma C. Sharp; Martine Vrijheid; Janine F. Felix Published in: Epigenetics, 2022, Page(s) 1-13, ISSN 1559-2308 Publisher: Taylor & Francis Group DOI: 10.1080/15592294.2022.2038412 Paternal body mass index and offspring DNA methylation: findings from the PACE consortium Author(s): Gemma C Sharp, Rossella Alfano, Akram Ghantous, Jose Urquiza, Sheryl L Rifas-Shiman, Christian M Page, Jianping Jin, Silvia Fernández-Barrés, Gillian Santorelli, Gwen Tindula, Gemma C Sharp, Rossella Alfano, Akram Ghantous, Jose Urquiza, Sheryl L Rifas-Shiman, Christian M Page, Jianping Jin, Silvia Fernández-Barrés, Gillian Santorelli, Gwen Tindula, Paul Yousefi, Leanne Kupers, Carlos Ruiz-Are Published in: International Journal of Epidemiology, 2021, ISSN 0300-5771 Publisher: Oxford University Press DOI: 10.1093/ije/dyaa267 The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice Author(s): Francesca Forzano, Olga Antonova, Angus Clarke, Guido de Wert, Sabine Hentze, Yalda Jamshidi, Yves Moreau, Markus Perola, Inga Prokopenko, Andrew Read, Alexandre Reymond, Vigdis Stefansdottir, Carla van El & Maurizio Genuardi, on behalf of the Executive Committee of the European Society of Human Genetics & the Public and Professional Policy Committee of the European Society of Human Genetics Published in: The European Journal of Human Genetics, 2021, ISSN 1018-4813 Publisher: Natue Publishing Group DOI: 10.1038/s41431-021-01000-x Post-weight loss changes in fasting appetite- and energy balance-related hormone concentrations and the effect of the macronutrient content of a weight maintenance diet: a randomised controlled trial Author(s): Mari Näätänen, Marjukka Kolehmainen, David E. Laaksonen, Karl-Heinz Herzig, Kaisa Poutanen, Leila Karhunen Published in: European Journal of Nutrition, 2020, ISSN 1436-6207 Publisher: Dr. Dietrich Steinkopff Verlag DOI: 10.1007/s00394-020-02438-3 Maternal plasma fatty acid patterns in mid-pregnancy and offspring epigenetic gestational age at birth Author(s): Giulietta S. Monasso, Trudy Voortman, Janine F. Felix Published in: Epigenetics, 2022, ISSN 1559-2294 Publisher: Landes Bioscience DOI: 10.1080/15592294.2022.2076051 Cohort profile:46 years of follow-up of the Northern Finland Birth Cohort 1966 (NFBC1966) Author(s): Nordström, T. (Tanja); Miettunen, J. (Jouko); Auvinen, J. (Juha); Ala-Mursula, L. (Leena); Keinänen-Kiukaanniemi, S. (Sirkka); Veijola, J. (Juha); Järvelin, M.-R. (Marjo-Riitta); Sebert, S. (Sylvain); Männikkö, M. (Minna) Published in: International Journal of Epidemiology, Issue 50(6), 2021, Page(s) 1786-1787, ISSN 0300-5771 Publisher: Oxford University Press DOI: 10.1093/ije/dyab109 Identification and distribution of sterols, bile acids, and acylcarnitines by LC-MS/MS in humans, mice, and pigs – A qualitative analysis Author(s): Ambrin Farizah Babu, Ville Mikael Koistinen, Soile Turunen, Gloria Solano-Aguilar, Joseph F. Urban, Jr., Iman Zarei and Kati Hanhineva Published in: Metabolites, Issue 12(1), 2022, Page(s) 49, ISSN 2218-1989 Publisher: MDPI DOI: 10.3390/metabo12010049 Maternal iron status in early pregnancy and DNA methylation in offspring: an epigenome-wide meta-analysis Author(s): M. J. Taeubert, P. de Prado-Bert, M. L. Geurtsen, G. Mancano, M. J. Vermeulen, I. K. M. Reiss, D. Caramaschi, J. Sunyer, G. C. Sharp, J. Julvez, M. U. Muckenthaler & J. F. Felix Published in: Clinical Epigenetics, Issue 14(59), 2022, ISSN 1868-7083 Publisher: BioMed Central DOI: 10.1186/s13148-022-01276-w Heterogeneous Effects of Calorie Content and Nutritional Components Underlie Dietary Influence on Pancreatic Cancer Susceptibility Author(s): James Dooley, Vasiliki Lagou, Jermaine Goveia, Anna Ulrich, Katerina Rohlenova, Nathalie Heirman, Tobias Karakach, Yulia Lampi, Shawez Khan, Jun Wang, Tom Dresselaers, Uwe Himmelreich, Marc J. Gunter, Inga Prokopenko, Peter Carmeliet, Adrian Liston Published in: Cell Reports, Issue 32/2, 2020, Page(s) 107880, ISSN 2211-1247 Publisher: Cell Press DOI: 10.1016/j.celrep.2020.107880 Epigenome-wide contributions to individual differences in childhood phenotypes: a GREML approach Author(s): Alexander Neumann, Jean-Baptiste Pingault, Janine F. Felix, Vincent W. V. Jaddoe, Henning Tiemeier, Charlotte Cecil & Esther Walton Published in: Clinical Epigenetics, Issue 14(1), 2022, Page(s) 53, ISSN 1868-7083 Publisher: BioMed Central Ltd DOI: 10.1186/s13148-022-01268-w Relationship between glucose homeostasis and obesity in early life—a study of Italian children and adolescents Author(s): Zhanna Balkhiyarova, Rosa Luciano, Marika Kaakinen, Anna Ulrich, Aleksey Shmeliov, Marzia Bianchi, Laura Chioma, Bruno Dallapiccola, Inga Prokopenko, Melania Manco Published in: Human Molecular Genetics, Issue 09646906, 2022, Page(s) 816-826, ISSN 0964-6906 Publisher: Oxford University Press DOI: 10.1093/hmg/ddab287 DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures Author(s): Monica del C. Gomez-Alonso, Anja Kretschmer, Rory Wilson, Liliane Pfeiffer, Ville Karhunen, Ilkka Seppälä, Weihua Zhang, Kirstin Mittelstraß, Simone Wahl, Pamela R. Matias-Garcia, Holger Prokisch, Sacha Horn, Thomas Meitinger, Luis R. Serrano-Garcia, Sylvain Sebert, Olli Raitakari, Marie Loh, Wolfgang Rathmann, Martina Müller-Nurasyid, Christian Herder, Michael Roden, Mikko Hurme, Marjo-Riitta Published in: Clinical Epigenetics, Issue 13/1, 2021, ISSN 1868-7075 Publisher: Springer Verlag DOI: 10.1186/s13148-020-00957-8 Associations of Hair Cortisol Concentrations With Cardiometabolic Risk Factors in Childhood Author(s): Florianne O L Vehmeijer, Susana Santos, Yolanda B de Rijke, Erica L T van den Akker, Janine F Felix, Elisabeth F C van Rossum, Vincent W V Jaddoe Published in: The Journal of Clinical Endocrinology & Metabolism, 2021, ISSN 0021-972X Publisher: The Endocrine Society DOI: 10.1210/clinem/dgab379 Associations of green and blue space exposure in pregnancy with epigenetic gestational age acceleration Author(s): Marques I, Santos S, Monasso G, Fossati S, Vrijheid M, Nieuwenhuijsen M, Jaddoe VWV, Felix JF Published in: Epigenetics, 2023, ISSN 1559-2308 Publisher: Taylor & Francis DOI: 10.1080/15592294.2023.2165321 Infant weight growth patterns, childhood BMI and arterial health at age 10 years Author(s): Giulietta S. Monasso, Carolina C.V. Silva, Susana Santos, Romy Goncalvez, Romy Gaillard, Janine F. Felix, Vincent W.V. Jaddoe Published in: Obesity, Issue 30(3), 2022, Page(s) 770-778, ISSN 1930-7381 Publisher: Wiley-Blackwell DOI: 10.1002/oby.23376 Defining the Scope of Exposome Studies and Research Needs from a Multidisciplinary Perspective. Author(s): Pei Zhang; Pei Zhang; Pei Zhang; Christopher Carlsten; Romanas Chaleckis; Romanas Chaleckis; Kati Hanhineva; Kati Hanhineva; Kati Hanhineva; Mengna Huang; Tomohiko Isobe; Ville M. Koistinen; Ville M. Koistinen; Isabel Meister; Isabel Meister; Stefano Papazian; Kalliroi Sdougkou; Hongyu Xie; Jonathan W. Martin; Stephen M. Rappaport; Hiroshi Tsugawa; Douglas I. Walker; Tracey J. Woodruff; Robert O. Published in: Environmental Science & Technology Letters, Issue 8(10), 2021, Page(s) 839-852, ISSN 2328-8930 Publisher: ACS Publications DOI: 10.1021/acs.estlett.1c00648 Body fat, pericardial fat, liver fat and arterial health at age 10 years Author(s): Giulietta S. Monasso, Susana Santos, Carolina C. V. Silva, Madelon L. Geurtsen, Edwin Oei, Romy Gaillard, Janine F. Felix, Vincent W. V. Jaddoe Published in: Pediatric Obesity, 2022, ISSN 2047-6310 Publisher: Wiley-Blackwell for the International Association for the Study of Obesity DOI: 10.1111/ijpo.12926 Expression Quantitative Trait Locus Mapping in Pulmonary Arterial Hypertension Author(s): Anna Ulrich, Pablo Otero-Núñez, John Wharton, Emilia M. Swietlik, Stefan Gräf, Nicholas W. Morrell, Dennis Wang, Allan Lawrie, Martin R. Wilkins, Inga Prokopenko, Christopher J. Rhodes, UK PAH Cohort Study Consortium Published in: Genes, Issue 11/11, 2020, Page(s) 1247, ISSN 2073-4425 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/genes11111247 Longitudinal associations of DNA methylation and sleep in children: a meta-analysis Author(s): Sara Sammallahti, M. Elisabeth Koopman-Verhoeff, Anne-Claire Binter, Rosa H. Mulder, Alba Cabré-Riera, Tuomas Kvist, Anni L. K. Malmberg, Giancarlo Pesce, Sabine Plancoulaine, Jonathan A. Heiss, Sheryl L. Rifas-Shiman, Stefan W. Röder, Anne P. Starling, Rory Wilson, Kathrin Guerlich, Kristine L. Haftorn, Christian M. Page, Annemarie I. Luik, Henning Tiemeier, Janine F. Felix, Katri Raikkonen, Ja Published in: Clinical Epigenetics, Issue 14(83), 2022, ISSN 1868-7083 Publisher: BioMed Central DOI: 10.1186/s13148-022-01298-4 Dynamic longitudinal exposome trajectories in cardiovascular and metabolic noncommunicable diseases Author(s): Ronkainen, Justiina; Nedelec, Rozenn; Atehortua, Angelica; Balkhiyarova, Zhanna; Cascarano, Anna; Ngoc Dang, Vien; Elhakeem, Ahmed; van Enckevort, Esther; Goncalves Soares, Ana; Haakma, Sido; Halonen, Miia; Heil, Katharina F; Heiskala, Anni; Hyde, Eleanor; Jacquemin, Bénédicte; Keikkala, Elina; Kerckhoffs, Jules; Klåvus, Anton; Kopinska, Joanna A; Lepeule, Johanna; Marazzi, Francesca; Motoc, Ir Published in: Environmental Epidemiology, Issue 6(1), 2022, Page(s) e184, ISSN 2474-7882 Publisher: Wolters Kluwer Health Inc DOI: 10.1097/ee9.0000000000000184 Bifidobacterium Is Enriched in Gut Microbiome of Kashmiri Women with Polycystic Ovary Syndrome Author(s): Saqib Hassan, Marika A. Kaakinen, Harmen Draisma, Liudmila Zudina, Mohd A. Ganie, Aafia Rashid, Zhanna Balkhiyarova, George S. Kiran, Paris Vogazianos, Christos Shammas, Joseph Selvin, Athos Antoniades, Ayse Demirkan and Inga Prokopenko Published in: Genes, Issue 13(2), 2022, Page(s) 379, ISSN 2073-4425 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/genes13020379 Mediators of the association between childhood body mass index and educational attainment: Analysis of a UK prospective cohort study Author(s): Kirsty Bowman, Tim Cadman, Ana Goncalves Soares, Oliver Robinson, Amanda Hughes, Jon Heron, Alexa Blair Segal, Maria Carmen Huerta, Laura D. Howe Published in: Pediatric Obesity, Issue 18(5), 2023, Page(s) e13014, ISSN 2047-6310 Publisher: Wiley-Blackwell for the International Association for the Study of Obesity DOI: 10.1111/ijpo.13014 Machine and deep learning for longitudinal biomedical data: a review of methods and applications Author(s): Cascarano, Anna; Mur-Petit, Jordi; Hernández-González, Jerónimo; Camacho, Marina; de Toro Eadie, Nina; Gkontra, Polyxeni; Chadeau-Hyam, Marc; Vitria, Jordi; Lekadir, Karim Published in: Artificial Intelligence Review, Issue 44, 2023, ISSN 1573-7462 Publisher: Springer Nature DOI: 10.1007/s10462-023-10561-w Automated calibration for stability selection in penalised regression and graphical models Author(s): Barbara Bodinier, Sarah Filippi, Therese Haugdahl Nøst, Julien Chiquet, Marc Chadeau-Hyam Published in: Journal of the Royal Statistical Socety Series C: Applied Statistics, 2023, ISSN 0035-9254 Publisher: Blackwell Publishing Inc. DOI: 10.1093/jrsssc/qlad058 Effect of common pregnancy and perinatal complications on offspring metabolic traits across the life-course: a multi-cohort study Author(s): Ahmed Elhakeem, Justiina Roinkainen, Toby Mansell, Tuija Mikkola, Binisha Mishra, Rama Wahab, Tim Cadman, Tiffany Yang, David Burgner, Johan G. Eriksson, Marjo-Riitta Järvelin, Romy Gaillard, Vincent W V Jaddoe, Terho Lehtimäki, Olli T Raitakari, Richard Saffrey, Melissa Wake, John Wright, Sylvain P Sebert, Deborah A Lawlor Published in: BMC Medicine, Issue 21(23), 2023, ISSN 1741-7015 Publisher: BioMed Central DOI: 10.1101/2022.04.05.22273388 Depression, cardiometabolic disease, and their co-occurrence after childhood maltreatment: an individual participant data meta-analysis including over 200,000 participants Author(s): Camille Souama, Femke Lamers, Yuri Milaneschi, Christiaan H. Vinkers, Serena Defina, Linda Garvert, Frederike Stein, Tom Woofenden, Katharina Brosch, Udo Dannlowski, Henrike Galenkamp, Ron de Graaf, Vincent W. V. Jaddoe, Anja Lok, Bas B. van Rijn, Henry Völzke, Charlotte A. M. Cecil, Janine F. Felix, Hans J. Grabe, Tilo Kircher, Karim Lekadir, Margreet ten Have, Esther Walton & Brenda W. J. H. Pe Published in: BMC Medicine, Issue 21 (93), 2023, ISSN 1741-7015 Publisher: BioMed Central DOI: 10.1186/s12916-023-02769-y Fetal and childhood exposure to parental tobacco smoking and arterial health at age 10 years Author(s): Giulietta S Monasso, Janine F Felix, Romy Gaillard, Vincent W V Jaddoe Published in: American Journal of Hypertension, Issue 35(10), 2022, Page(s) 867-874, ISSN 1941-7225 Publisher: Oxford University Press DOI: 10.1093/ajh/hpac084 Maternal Glycemic Dysregulation During Pregnancy and Neonatal Blood DNA Methylation: Meta-analyses of Epigenome-Wide Association Studies Author(s): Elmar W. Tobi; Diana L. Juvinao-Quintero; Justiina Ronkainen; Raffael Ott; Rossella Alfano; Mickaël Canouil; Madelon L. Geurtsen; Amna Khamis; Leanne K. Küpers; Ives Y. Lim; Patrice Perron; Giancarlo Pesce; Johanna Tuhkanen; Anne P. Starling; Toby Andrew; Elisabeth Binder; Robert Caiazzo; Jerry K.Y. Chan; Romy Gaillard; Peter D. Gluckman; Elina Keikkala; Neerja Karnani; Sanna Mustaniemi; Tim S. Published in: Diabetes Care, Issue 6, 2022, ISSN 0149-5992 Publisher: American Diabetes Association DOI: 10.2337/dc21-1701 Sex-specific effects of prenatal undernutrition on resting-state functional connectivity in the human brain at age 68 Author(s): AmberBoot, Moriah E.Thomason, Claudia Espinoza-Heredia, Patrick J.Pruitt, Jessica S.Damoiseaux, Tessa J.Roseboom, Susanne R.de Rooij Published in: Neurobiology of Aging, Issue 112, 2022, Page(s) 129-138, ISSN 0197-4580 Publisher: Elsevier BV DOI: 10.1016/j.neurobiolaging.2022.01.003 Maternal Dietary Glycemic Index and Glycemic Load in Pregnancy and Offspring Cord Blood DNA Methylation Author(s): Leanne K. Küpers; Sílvia Fernández-Barrés; Giulia Mancano; Laura Johnson; Raffael Ott; Jesus Vioque; Marco Colombo; Kathrin Landgraf; Elmar W. Tobi; Antje Körner; Romy Gaillard; Jeanne H.M. de Vries; Vincent W.V. Jaddoe; Martine Vrijheid; Gemma C. Sharp; Janine F. Felix Published in: Diabetes Care, 2022, ISSN 0149-5992 Publisher: American Diabetes Association DOI: 10.2337/dc21-2662 Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability Author(s): Vasiliki Lagou, Reedik Mägi, Jouke- Jan Hottenga, Harald Grallert, John R. B. Perry, Nabila Bouatia-Naji, Letizia Marullo, Denis Rybin, Rick Jansen, Josine L. Min, Antigone S. Dimas, Anna Ulrich, Liudmila Zudina, Jesper R. Gådin, Longda Jiang, Alessia Faggian, Amélie Bonnefond, Joao Fadista, Maria G. Stathopoulou, Aaron Isaacs, Sara M. Willems, Pau Navarro, Toshiko Tanaka, Anne U. Jackson, May Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-020-19366-9 Genetic Correlation and Causal Relationships between Cardio-Metabolic Traits and Lung Function Impairment Author(s): Matthias Wielscher; Andre F.S. Amaral; Diana A van der Plaat; Louise V. Wain; Louise V. Wain; Sylvain Sebert; David Mosen-Ansorena; Juha Auvinen; Karl-Heinz Herzig; Karl-Heinz Herzig; Karl-Heinz Herzig; Abbas Dehghan; Deborah Jarvis; Marjo-Riitta Järvelin Published in: Genome Medicine, Issue 13(104), 2021, ISSN 1756-994X Publisher: BioMed Central DOI: 10.2139/ssrn.3566256 Early exposure to social disadvantages and later life body mass index beyond genetic predisposition in three generations of Finnish birth cohorts Author(s): Estelle Lowry, Nina Rautio, Niko Wasenius, Tom A. Bond, Jari Lahti, Ioanna Tzoulaki, Abbas Dehghan, Anni Heiskala, Leena Ala-Mursula, Jouko Miettunen, Johan Eriksson, Marjo-Riitta Järvelin, Sylvain Sebert Published in: BMC Public Health, Issue 20/1, 2020, ISSN 1471-2458 Publisher: BioMed Central DOI: 10.1186/s12889-020-08763-w Vitamin B12, folate and homocysteine concentrations during pregnancy and early signs of atherosclerosis at school-age Author(s): Giulietta S. Monasso, Janine F. Felix, Sandra G. Heil, Yolanda B. de Rijke, Romy Gaillard, Vincent W.V. Jaddoe Published in: Clinical Nutrition, Issue 40(9), 2021, Page(s) 5133-5140, ISSN 0346-251X Publisher: Pergamon Press Ltd. DOI: 10.1016/j.clnu.2021.08.001 Machine Learning-Based DNA Methylation Score for Fetal Exposure to Maternal Smoking: Development and Validation in Samples Collected from Adolescents and Adults Author(s): Sebastian Rauschert, Phillip E. Melton, Anni Heiskala, Ville Karhunen, Graham Burdge, Jeffrey M. Craig, Keith M. Godfrey, Karen Lillycrop, Trevor A. Mori, Lawrence J. Beilin, Wendy H. Oddy, Craig Pennell, Marjo-Riitta Järvelin, Sylvain Sebert, Rae-Chi Huang Published in: Environmental Health Perspectives, Issue 128/9, 2020, Page(s) 097003, ISSN 0091-6765 Publisher: US Department of Health and Human Services DOI: 10.1289/ehp6076 Cardiovascular Health at Age 5 Years: Distribution, Determinants, and Association With Neurodevelopment Author(s): Rachel E. Climie*, Muriel Tafflet, Thomas van Sloten, Blandine de Lauzon-Guillain, Jonathan Y. Bernard, Patricia Dargent-Molina, Sabine Plancoulaine, Sandrine Lioret, Xavier Jouven, Marie-Alines Charles, Barbara Heude and Jean-Philippe Empana Published in: Frontiers in Pediatrics, 2022, ISSN 2296-2360 Publisher: Frontiers Media S.A. DOI: 10.3389/fped.2022.827525 Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight Author(s): NCD Risk Factor Collaboration (NCD-RisC); Iurilli, Maria LC; Zhou, Bin; Bennett, James E; Carrillo-Larco, Rodrigo M; Sophiea, Marisa K; Rodriguez-Martinez, Andrea; Bixby, Honor; Solomon, Bethlehem D; Taddei, Cristina; Danaei, Goodarz; Di Cesare, Mariachiara; Stevens, Gretchen A; Riley, Leanne M; Savin, Stefan; Cowan, Melanie J; Bovet, Pascal; Damasceno, Albertino; Chirita-Emandi, Adela; Hayes, Ali Published in: "eLife, eLife Sciences Publication, 2021, 10, ⟨10.7554/elife.60060⟩", Issue 2, 2021, ISSN 2050-084X Publisher: eLife Sciences Publications DOI: 10.3929/ethz-b-000478961 Dynamics of competing SARS-CoV-2 variants during the Omicron epidemic in England Author(s): Eales, O Martins, LDO Page, AJ Wang, H Bodinier, B Tang, D Haw, D Jonnerby, J Atchison, C Ashby, D Barclay, W Taylor, G Cooke, G Ward, H Darzi, A Riley, S Elliott, P Donnelly, CA Chadeau-Hyam, M Published in: Nature Communications, Issue 13 (4375), 2022, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-022-32096-4 Dynamics of a national Omicron SARS-CoV-2 epidemic during January 2022 in England Author(s): Paul Elliott; Oliver Eales; Barbara Bodinier; David Tang; Haowei Wang; Jakob Jonnerby; David Haw; Joshua Elliott; Matthew Whitaker; Caroline E. Walters; Christina Atchison; Peter J. Diggle; Andrew J. Page; Alexander J. Trotter; Deborah Ashby; Wendy Barclay; Graham Taylor; Helen Ward; Ara Darzi; Graham S. Cooke; Marc Chadeau-Hyam; Christl A. Donnelly Published in: Nature Communications, Issue 13(4500), 2022, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-022-32121-6 Abuse in childhood and cardiometabolic health in early adulthood: evidence from the Avon Longitudinal Study of Parents and Children Author(s): Ana Luiza Goncalves Soares, Annie Zimmerman, Stanley Zammit, Anke Karl, Sarah L Halligan, Abi Fraser Published in: Journal of the American Heart Association, Issue 10(24), 2021, Page(s) e021701, ISSN 2047-9980 Publisher: Wiley-Blackwell DOI: 10.1161/jaha.121.021701 How does childhood maltreatment influence cardiovascular disease? A sequential causal mediation analysis Author(s): Ana G Soares, Laura D Howe, Jon Heron, Gemma Hammerton, Janet Rich-Edwards, Maria C Magnus, Sarah L Halligan, Abigail Fraser Published in: International Journal of Epidemiology, 2021, ISSN 0300-5771 Publisher: Oxford University Press DOI: 10.1093/ije/dyab085 Associations of circulating folate, vitamin B12 and homocysteine concentrations in early pregnancy and cord blood with epigenetic gestational age: the Generation R Study Author(s): Giulietta S. Monasso, Leanne K. Küpers, Vincent W. V. Jaddoe, Sandra G. Heil, Janine F. Felix Published in: Clinical Epigenetics, Issue 13/1, 2021, Page(s) 95, ISSN 1868-7075 Publisher: Springer Verlag DOI: 10.1186/s13148-021-01065-x Omicron SARS-CoV-2 epidemic in England during February 2022: A series of cross-sectional community surveys Author(s): Chadeau-Hyam, M Tang, D Eales, O Bodinier, B Wang, H Jonnerby, J Whitaker, M Elliott, J Haw, D Walters, CE Atchison, C Diggle, PJ Page, AJ Ashby, D Barclay, W Taylor, G Cooke, G Ward, H Darzi, A Donnelly, CA Elliott, P Published in: The Lancet Regional Health - Europe, Issue 21, 2022, Page(s) 100462, ISSN 2666-7762 Publisher: Elsevier Ltd DOI: 10.1016/j.lanepe.2022.100462 Functional Effects In Silico Prediction for Androgen Receptor Ligand-Binding Domain Novel I836S Mutation Author(s): Alexey Rayevsky, Dmytro Sirokha, Dariia Samofalova, Dmytro Lozhko, Olexandra Gorodna, Inga Prokopenko, Liudmyla Livshits Published in: Life, Issue 11/7, 2021, Page(s) 659, ISSN 2075-1729 Publisher: MDPI DOI: 10.3390/life11070659 Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude Author(s): Latha Kadalayil, Md. 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Raitakari; Andy Ryan; Rui Providência; Stephanie Smith; Julie Taylor; Ther Published in: Robinson , O , Carter , A R , Ala-Korpela , M , Casas , J P , Chaturvedi , N , Engmann , J , Howe , L D , Hughes , A D , Järvelin , M-R , Kähönen , M , Karhunen , V , Kuh , D , Shah , T , Ben-Shlomo , Y , Sofat , R , Lau , C-H E , Lehtimäki , T , Menon , U , Raitakari , O , Ryan , A , Providencia , R , Smith , S , Taylor , J , Tillin , T , Viikari , J , Wong , A , Hingorani , A D , Kivimaki ,, Issue 50(3), 2021, Page(s) 768-782, ISSN 0300-5771 Publisher: Oxford University Press DOI: 10.1093/ije/dyaa188 Epigenome-Wide Association Study Reveals Methylation Loci Associated With Offspring Gestational Diabetes Mellitus Exposure and Maternal Methylome Author(s): Mickaël Canouil; Amna Khamis; Elina Keikkala; Sandra Hummel; Stephane Lobbens; Amélie Bonnefond; Fabien Delahaye; Evangelia Tzala; Sanna Mustaniemi; Marja Vääräsmäki; Marjo-Riitta Jarvelin; Sylvain Sebert; Eero Kajantie; Philippe Froguel; Toby Andrew Published in: Diabetes Care, Issue 44(9), 2021, Page(s) 1992-1999, ISSN 0149-5992 Publisher: American Diabetes Association DOI: 10.2337/dc20-2960 The relationship of life-course patterns of adiposity with type 2 diabetes, depression, and their comorbidity in the Northern Finland Birth Cohort 1966 Author(s): Priyanka Choudhary; Justiina Ronkainen; Rozenn Nedelec; Mimmi Tolvanen; Estelle Lowry; Jouko Miettunen; Marjo-Riitta Jarvelin; Sylvain Sebert Published in: Choudhary , P , Ronkainen , J , Nedelec , R , Tolvanen , M , Lowry , E , Jarvelin , M-R & Sebert , S 2022 , ' The relationship of life-course patterns of adiposity with type 2 diabetes, depression, and their comorbidity in the Northern Finland Birth Cohort 1966 ' , International Journal of Obesity . https://doi.org/10.1038/s41366-022-01134-y, Issue 4, 2022, ISSN 0307-0565 Publisher: Nature Publishing Group DOI: 10.1038/s41366-022-01134-y Towards early risk biomarkers:serum metabolic signature in childhood predicts cardio-metabolic risk in adulthood Author(s): Ojanen, X. (Xiaowei); Cheng, R. (Runtan); Törmäkangas, T. (Timo); Rappaport, N. (Noa); Wilmanski, T. (Tomasz); Wu, N. (Na); Fung, E. (Erik); Nedelec, R. (Rozenn); Sebert, S. (Sylvain); Vlachopoulos, D. (Dimitris); Yan, W. (Wei); Price, N. D. (Nathan D.); Cheng, S. (Sulin); Wiklund, P. (Petri) Published in: eBioMedicine, Issue 72(103611), 2021, ISSN 2352-3964 Publisher: Elsevier BV DOI: 10.1016/j.ebiom.2021.103611 Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation Author(s): Olivia Solomon; Karen Huen; Paul Yousefi; Leanne K. Küpers; Juan R. González; Matthew Suderman; Sarah E. Reese; Christian M. Page; Olena Gruzieva; Peter Rzehak; Lu Gao; Kelly M. Bakulski; Alexei Novoloaca; Catherine Allard; Irene Pappa; Maria Llambrich; Marta Vives; Dereje D. Jima; Tuomas Kvist; Andrea Baccarelli; Cory White; Faisal I. Rezwan; Gemma C. Sharp; Gwen Tindula; Anna Bergström; Veit Published in: Mutation Research/Reviews in Mutation Research, Issue 789, 2022, ISSN 1383-5742 Publisher: Elsevier BV DOI: 10.1016/j.mrrev.2022.108415 Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available
