Dynamic longitudinal exposome trajectories in cardiovascular and metabolic non-communicable diseases

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Тoolbox and platforms for data analysis and (re)use

Тoolbox for data analysis, the metadata and the procedure to access the LONGITOOLS platform for data analysis and (re)use will be demonstrated via the website

Science connecting - policy workshop 1

Summary report of the first workshop connecting the scientific objectives of LONGITOOLS and the policy and regulation agendas

Policy briefing

A policy briefing will be published online in the Longitools website

Final science connecting - policy workshop

Summary report of the final workshop connecting the scientific objectives of LONGITOOLS and the policy and regulation agendas

Report 7 Updated Dissemination and Communication strategy - LONGITOOLS/EXIMIOUS

Update of Joint dissemination and communication activities for the network.

Findability catalogue

A publicly available metadata of LONGITOOLS cohorts - the metadata will be published on the LONGITOOLS website, the cluster website and CORDIS

Innovation platform

A public event to launch LONGITOOLS innovation platform organised alongside the second General Assembly of LONGITOOLS

LONGITOOLS website

LONGITOOLS website launched

Pubblicazioni

Risk factors for positive and negative COVID-19 tests: a cautious and in- depth analysis of UK biobank data

Autori: Marc Chadeau-Hyam, Barbara Bodinier, Joshua Elliott, Matthew D Whitaker, Ioanna Tzoulaki, Roel Vermeulen, Michelle Kelly-Irving, Cyrille Delpierre, Paul Elliott
Pubblicato in: International Journal of Epidemiology, Numero 49(5), 2020, Pagina/e 1454-1467, ISSN 0300-5771
Editore: Oxford University Press
DOI: 10.1093/ije/dyaa134

Blood DNA methylation profiling identifies cathepsin Z dysregulation in pulmonary arterial hypertension

Autori: Anna Ulrich, Yukyee Wu, Harmen Draisma, John Wharton, Emilia M. Swietlik, Inês Cebola, Eleni Vasilaki, Zhanna Balkhiyarova, Marjo-Riitta Jarvelin, Juha Auvinen, Karl-Heinz Herzig, J. Gerry Coghlan, James Lordan, Colin Church, Luke S. Howard, Joanna Pepke-Zaba, Mark Toshner, Stephen J. Wort, David G. Kiely, Robin Condliffe, Allan Lawrie, Stefan Gräf, Nicholas W. Morrell, Martin R. Wilkins, Inga P
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-44683-0

Variant-specific symptoms of COVID-19 in a study of 1,542,510 adults in England

Autori: Whitaker M, Elliott J, Bodinier B, Barclay W, Ward H, Cooke G, Donnelly CA, Chadeau-Hyam M, Elliott P
Pubblicato in: Nature Communications, Numero 13 (6856), 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-34244-2

Towards an Interoperable Ecosystem of Research Cohort and Real-world Data Catalogues Enabling Multi-center Studies

Autori: Morris Swertz, Esther van Enckevort, José Luis Oliveira, Isabel Fortier, Julie Bergeron, Nicolas H. Thurin, Eleanor Hyde, Alexander Kellmann, Romin Pahoueshnja, Miriam Sturkenboom, Marianne Cunnington, Anne-Marie Nybo Andersen, Yannick Marcon, Gonçalo Gonçalves, Rosa Gini
Pubblicato in: Yearbook of Medical Informatics, Numero 31(01), 2022, Pagina/e 262-272, ISSN 2364-0502
Editore: Thieme Group
DOI: 10.1055/s-0042-1742522

Effects of prenatal exposure to the 1944–45 Dutch famine and glucocorticoid receptor polymorphisms on later life PTSD susceptibility

Autori: Kayleigh D Gultig, Susanne R. de Rooij, Charlotte E Hilberdink, Miranda Olff, Tessa J. Roseboom, Mirjam van Zuiden
Pubblicato in: European Journal of Psychotraumatology, Numero 14(2), 2023, Pagina/e 2219075, ISSN 2000-8066
Editore: Taylor & Francis
DOI: 10.1080/20008066.2023.2219075

Epigenome-Wide Meta-analysis Reveals Associations Between Dietary Glycemic Index and Glycemic Load and DNA Methylation in Children and Adolescents of Different Body Sizes

Autori: Raffael Ott, Robert Stein, Helena H. Hauta-alus, Justiina Ronkainen, Sílvia Fernández-Barrés, Ulrike Spielau, Holger Kirsten, Tanja Poulain, Phillip E. Melton, Leanne K. Küpers, Hatim Azaryah, Marco Colombo, Kathrin Landgraf, Elmar W. Tobi, Therese O’Sullivan, Rae-Chi Huang, Cristina Campoy, Christiane Winkler, Jesus Vioque, Martine Vrijheid, Wieland Kiess, Antje Körner, Sylvain Sebert, Mar
Pubblicato in: Diabetes Care, Numero 46, 2023, Pagina/e 2067-2075, ISSN 0149-5992
Editore: American Diabetes Association
DOI: 10.2337/dc23-0474

Maternal and infant prediction of the child BMI trajectories; studies across two generations of Northern Finland birth cohorts

Autori: Rozenn Nedelec, Jouko Miettunen, Minna Männikkö, Marjo-Riitta Järvelin, Sylvain Sebert
Pubblicato in: International Journal of Obesity, Numero 45/2, 2021, Pagina/e 404-414, ISSN 0307-0565
Editore: Nature Publishing Group
DOI: 10.1038/s41366-020-00695-0

Defining type 2 diabetes polygenic risk scores through colocalization and network-based clustering of metabolic trait genetic associations

Autori: Samuel Ghatan; Jeroen van Rooij; Mandy van Hoek; Cindy G. Boer; Janine F. Felix; Maryam Kavousi; Vincent W. Jaddoe; Eric J. G. Sijbrands; Carolina Medina-Gomez; Fernando Rivadeneira; Ling Oei
Pubblicato in: Genome Medicine, Numero 16(1), 2024, Pagina/e 1-15, ISSN 1756-994X
Editore: BioMed Central
DOI: 10.1186/s13073-023-01255-7

Measurement invariance testing of the patient health questionnaire-9 (PHQ-9) across people with and without diabetes mellitus from the NHANES, EMHS and UK Biobank datasets

Autori: Arie Nouwen, Sonya S.Deschênes, Zhanna Balkhiyarova, Juan R.Albertorio-Díaz, Inga Prokopenko, Norbert Schmitz
Pubblicato in: Journal of Affective Disorders, Numero 292, 2021, Pagina/e 311-318, ISSN 0165-0327
Editore: Elsevier BV
DOI: 10.1016/j.jad.2021.05.031

Ultra-processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study: a mediation analysis

Autori: Fernanda Morales-Berstein, Carine Biessy, Vivian Viallon, Ana Goncalves-Soares, Corinne Casagrande, Bertrand Hémon, Nathalie Kliemann, Manon Cairat, Jessica Blanco Lopez, Aline Al Nahas, Kiara Chang, Eszter Vamos, Fernanda Rauber, Renata Bertazzi Levy, Diana Barbosa Cunha, Paula Jakszyn, Pietro Ferrari, Paolo Vineis, Giovanna Masala, Alberto Catalano, Emily Sonestedt, Yan Borné, Verena Katzke, R
Pubblicato in: European Journal of Nutrition, Numero 63, 2023, Pagina/e 377-396, ISSN 1436-6207
Editore: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00394-023-03270-1

Animal and plant protein intake during infancy and childhood DNA methylation: a meta-analysis in the NutriPROGRAM consortium

Autori: Mohammed El Sharkawy,Janine F. Felix,Veit Grote,Trudy Voortman,Vincent W. V. Jaddoe,Berthold Koletzko &Leanne K. Küpers
Pubblicato in: Epigenetics, 2024, ISSN 1559-2308
Editore: Taylor & Francis
DOI: 10.1080/15592294.2023.2299045

52-year follow-up of a birth cohort reveals a high pneumonia incidence among young men

Autori: Pia Holma, Paula Pesonen, Olli Mustonen, Marjo-Riitta Järvelin, Heikki Kauma, Juha Auvinen, Timo Hautala
Pubblicato in: ERJ Open Research, Numero 8, 2025, Pagina/e 00707-2021, ISSN 2312-0541
Editore: European Respiratory Society (ERS)
DOI: 10.1183/23120541.00707-2021

Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes

Autori: Natalia Pervjakova; Gunn-Helen Moen; Maria-Carolina Borges; Teresa Ferreira; James P Cook; Catherine Allard; Robin N Beaumont; Mickaël Canouil; Gad Hatem; Anni Heiskala; Anni Joensuu; Ville Karhunen; Soo Heon Kwak; Frederick T J Lin; Jun Liu; Sheryl Rifas-Shiman; Claudia H Tam; Wing Hung Tam; Gudmar Thorleifsson; Toby Andrew; Juha Auvinen; Bishwajit Bhowmik; Amélie Bonnefond; Fabien Delahaye; Ay
Pubblicato in: Human Molecular Genetics, Numero 31(19), 2022, Pagina/e 3377-3391, ISSN 0964-6906
Editore: Oxford University Press
DOI: 10.1093/hmg/ddac050

Automated calibration of consensus weighted distance-based clustering approaches using sharp

Autori: Barbara Bodinier, Dragana Vuckovic, Sabrina Rodrigues, Sarah Filippi, Julien Chiquet, Marc Chadeau-Hyam
Pubblicato in: Bioinformatics, Numero 39(11), 2023, ISSN 1367-4811
Editore: Oxford University Press
DOI: 10.1093/bioinformatics/btad635

Green spaces and respiratory, cardiometabolic, and neurodevelopmental outcomes: An individual-participant data meta-analysis of >35.000 European children

Autori: Amanda Fernandes, Demetris Avraam, Tim Cadman, Payam Dadvand, Mònica Guxens, Anne-Claire Binter, Angela Pinot de Moira, Mark Nieuwenhuijsen, Liesbeth Duijts, Jordi Julvez, Montserrat De Castro, Serena Fossati, Sandra Márquez, Tanja Vrijkotte, Ahmed Elhakeem, Rosemary McEachan, Tiffany Yang, Marie Pedersen, Johan Vinther, Johanna Lepeule, Martine Vrijheid
Pubblicato in: Environment International, Numero 190, 2024, ISSN 0160-4120
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2024.108853

Cord blood leptin level and a common variant of its receptor as determinants of the BMI trajectory: the EDEN mother-child cohort

Autori: Aminata H. Cissé, Marion Taine, Muriel Tafflet, Blandine de Lauzon-Guillain, Karine Clément, Olfa Khalfallah, Laetitia Davidovic, Sandrine Lioret, Marie A. Charles, Barbara Heude
Pubblicato in: Pediatric Obesity, 2022, ISSN 2047-6310
Editore: Wiley-Blackwell for the International Association for the Study of Obesity
DOI: 10.1111/ijpo.12955

Investigating childhood maltreatment as a modifier of genetic risk for cardiovascular diseases in the UK Biobank

Autori: Helena Urquijo, Ana Gonçalves Soares, Abigail Fraser, Laura D. Howe, Alice R. Carter
Pubblicato in: PLOS One, 2023, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0285258

Examining associations of air pollution and green space with depressive symptoms in adults: A LongITools cross-cohort analysis

Autori: Irina Motoc, Bigina N.R. Ginos, Ana Goncalves Soares, Ahmed Elhakeem, Trudy Voortman, Maryam Kavousi, Annemarie I. Luik, Tessa J. Roseboom, Susanne R. de Rooij
Pubblicato in: Environmental Research, Numero 264, 2025, Pagina/e 120321, ISSN 0013-9351
Editore: Academic Press
DOI: 10.1016/j.envres.2024.120321

Associations of low levels of air pollution with cardiometabolic outcomes and the role of diet quality in individuals with obesity

Autori: Healy, Darren R; Kårlund, Anna; Mikkonen, Santtu; Puhakka, Soile; Karhunen, Leila; Kolehmainen, Marjukka
Pubblicato in: Environmental Research, Numero 242, 2024, Pagina/e 117637, ISSN 0013-9351
Editore: Academic Press
DOI: 10.1016/j.envres.2023.117637

Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

Autori: Thomas W. Winkler*, Humaira Rasheed, Lifelines Cohort Study, DiscovEHR/MyCode study, VA Million Veteran Program, Alexander Teumer, Mathias Gorski, Bryce X. Rowan, Kira J. Stanzick, Laurent F. Thomas, Adrienne Tin, Anselm Hoppmann, Audrey Y. Chu, Bamidele Tayo, Chris H.L. Thio, Daniele Cusi, Jin Fang Chai, Karsten B. Sieber, Katrin Horn, Man Li, Markus Scholz, Massimiliano Cocca, Matthias Wuttke, P
Pubblicato in: Communications Biology, Numero 5(580), 2022, ISSN 2399-3642
Editore: Springer Nature
DOI: 10.1038/s42003-022-03448-z

Maternal caffeine consumption during pregnancy and offspring cord blood DNA methylation: an epigenome-wide association study meta-analysis

Autori: Laura Schellhas*, Giulietta S. Monasso, Janine F. Felix, Vincent Wv Jaddoe, Peiyuan Huang, Sílvia Fernández-Barrés, Martine Vrijheid, Giancarlo Pesce, Isabella Annesi-Maesano, Christian M. Page, Anne Lise Brantsæter, Mona Bekkhus, Siri E. Håberg, Stephanie J. London, Marcus R. Munafò, Luisa Zuccolo, Gemma C. Sharp
Pubblicato in: Epigenomics, Numero 15(22), 2023, ISSN 1750-1911
Editore: Future Medicine Ltd.
DOI: 10.2217/epi-2023-0263

Maternal Mediterranean diet in pregnancy and newborn DNA methylation: a meta-analysis in the PACE Consortium

Autori: Leanne K. Küpers; Sílvia Fernández-Barrés; Aayah Nounu; Chloe Friedman; Ruby Fore; Giulia Mancano; Dana Dabelea; Sheryl L. Rifas-Shiman; Rosa H. Mulder; Emily Oken; Laura Johnson; Mariona Bustamante; Vincent W.V. Jaddoe; Marie-France Hivert; Anne P. Starling; Jeanne H.M. de Vries; Gemma C. Sharp; Martine Vrijheid; Janine F. Felix
Pubblicato in: Epigenetics, 2022, Pagina/e 1-13, ISSN 1559-2308
Editore: Taylor & Francis Group
DOI: 10.1080/15592294.2022.2038412

Prenatal Urban Environment and Blood Pressure Trajectories From Childhood to Early Adulthood

Autori: Ana Gonçalves Soares, Susana Santos, Emie Seyve, Rozenn Nedelec, Soile Puhakka, Aino-Maija Eloranta, Santtu Mikkonen, Wen Lun Yuan, Deborah A Lawlor, Jon Heron, Martine Vrijheid, Johanna Lepeule, Mark Nieuwenhuijsen, Serena Fossati, Vincent W V Jaddoe, Timo Lakka, Sylvain Sebert, Barbara Heude, Janine F Felix, Ahmed Elhakeem, Nicholas J Timpson
Pubblicato in: JACC: Advances, Numero 3(2), 2024, Pagina/e 100808, ISSN 2772-963X
Editore: Elsevier B.V
DOI: 10.1101/2023.03.31.23288002

A bidirectional Mendelian randomisation study to evaluate the relationship between body constitution and hearing loss

Autori: Yiyan He; Ville Karhunen; Anna Pulakka; Marko Kantomaa; Sylvain Sebert
Pubblicato in: Scientific Reports, Numero 13(1), 2023, Pagina/e 1-10, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-023-44735-x

Epigenetic signature of very low birth weight in young adult life

Autori: Juho Kuula, Darina Czamara, Helena Hauta-alus, Jari Lahti, Petteri Hovi, Maija E. Miettinen, Justiina Ronkainen, Johan G. Eriksson, Sture Andersson, Marjo-Riitta Järvelin, Sylvain Sebert, Katri Räikkönen, Elisabeth B. Binder, Eero Kajantie
Pubblicato in: Pediatric Research, 2024, ISSN 0031-3998
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1038/s41390-024-03354-6

comorbidPGS: an R package assessing shared predisposition between Phenotypes using Polygenic Scores

Autori: Vincent Pascat, Liudmila Zudina, Anna Ulrich, Jared G. Maina, Marika Kaakinen, Igor Pupko, Amélie Bonnefond, Ayşe Demirkan, Zhanna Balkhiyarova, Philippe Froguel, Inga Prokopenko
Pubblicato in: Human Heredity, Numero 89(1), 2024, Pagina/e 60-70, ISSN 0001-5652
Editore: S. Karger AG
DOI: 10.1159/000539325

Paternal body mass index and offspring DNA methylation: findings from the PACE consortium

Autori: Gemma C Sharp, Rossella Alfano, Akram Ghantous, Jose Urquiza, Sheryl L Rifas-Shiman, Christian M Page, Jianping Jin, Silvia Fernández-Barrés, Gillian Santorelli, Gwen Tindula, Gemma C Sharp, Rossella Alfano, Akram Ghantous, Jose Urquiza, Sheryl L Rifas-Shiman, Christian M Page, Jianping Jin, Silvia Fernández-Barrés, Gillian Santorelli, Gwen Tindula, Paul Yousefi, Leanne Kupers, Carlos Ruiz-Are
Pubblicato in: International Journal of Epidemiology, 2021, ISSN 0300-5771
Editore: Oxford University Press
DOI: 10.1093/ije/dyaa267

Abdominal obesity is a more important causal risk factor for pancreatic cancer than overall obesity

Autori: Jared G. Maina; Vincent Pascat; Liudmila Zudina; Anna Ulrich; Igor Pupko; Amélie Bonnefond; Zhanna Balkhiyarova; Marika Kaakinen; Philippe Froguel; Inga Prokopenko
Pubblicato in: European Journal of Human Genetics, Numero 31, 2023, Pagina/e 962-966, ISSN 1018-4813
Editore: Natue Publishing Group
DOI: 10.1038/s41431-023-01301-3

The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice

Autori: Francesca Forzano, Olga Antonova, Angus Clarke, Guido de Wert, Sabine Hentze, Yalda Jamshidi, Yves Moreau, Markus Perola, Inga Prokopenko, Andrew Read, Alexandre Reymond, Vigdis Stefansdottir, Carla van El & Maurizio Genuardi, on behalf of the Executive Committee of the European Society of Human Genetics & the Public and Professional Policy Committee of the European Society of Human Genetics
Pubblicato in: The European Journal of Human Genetics, 2021, ISSN 1018-4813
Editore: Natue Publishing Group
DOI: 10.1038/s41431-021-01000-x

Post-weight loss changes in fasting appetite- and energy balance-related hormone concentrations and the effect of the macronutrient content of a weight maintenance diet: a randomised controlled trial

Autori: Mari Näätänen, Marjukka Kolehmainen, David E. Laaksonen, Karl-Heinz Herzig, Kaisa Poutanen, Leila Karhunen
Pubblicato in: European Journal of Nutrition, 2020, ISSN 1436-6207
Editore: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00394-020-02438-3

Determinants of body mass index during early life: findings from an exposome-wide association study with follow-up replication and Mendelian randomization analyses

Autori: Jie V Zhao, Ana Goncalves Soares, Demetris Avraam, Tim Cadman, Marie Aline Charles, Barbara Heude, Vincent Jaddoe, Yannis Manios, George Moschonis, Anne-Marie Nybo Andersen, Lorenzo Richiardi, Justiina Ronkainen, Sylvain Sebert, Morris Swertz, Evangelia Tzorovili, Martine Vrijheid, Wen Lun Yuan, Deborah A Lawlor, Ahmed Elhakeem
Pubblicato in: Exposome, Numero 5, 2025, ISSN 2635-2265
Editore: Oxford University Press (OUP)
DOI: 10.1093/exposome/osaf004

Metabolic profiles reflect weight loss maintenance and the composition of diet after very-low-energy diet

Autori: Mari Näätänen; Anna Kårlund; Santtu Mikkonen; Anton Klåvus; Otto Savolainen; Marko Lehtonen; Leila Karhunen; Kati Hanhineva; Marjukka Kolehmainen
Pubblicato in: Clinical Nutrition, Numero 42(7), 2023, Pagina/e 1126-1141, ISSN 0261-5614
Editore: Churchill Livingstone
DOI: 10.1016/j.clnu.2023.05.011

Maternal plasma fatty acid patterns in mid-pregnancy and offspring epigenetic gestational age at birth

Autori: Giulietta S. Monasso, Trudy Voortman, Janine F. Felix
Pubblicato in: Epigenetics, 2022, ISSN 1559-2294
Editore: Landes Bioscience
DOI: 10.1080/15592294.2022.2076051

Cohort profile:46 years of follow-up of the Northern Finland Birth Cohort 1966 (NFBC1966)

Autori: Nordström, T. (Tanja); Miettunen, J. (Jouko); Auvinen, J. (Juha); Ala-Mursula, L. (Leena); Keinänen-Kiukaanniemi, S. (Sirkka); Veijola, J. (Juha); Järvelin, M.-R. (Marjo-Riitta); Sebert, S. (Sylvain); Männikkö, M. (Minna)
Pubblicato in: International Journal of Epidemiology, Numero 50(6), 2021, Pagina/e 1786-1787, ISSN 0300-5771
Editore: Oxford University Press
DOI: 10.1093/ije/dyab109

Cardiometabolic Risk Estimation Using Exposome Data and Machine Learning

Autori: Angélica Atehortúa; Polyxeni Gkontra; Marina Camacho; Oliver Diaz; Maria Bulgheroni; Valentina Simonetti; Marc Chadeau-Hyam; Janine F. Felix; Sylvain Sebert; Karim Lekadir
Pubblicato in: International Journal of Medical Informatics, Numero 179, 2023, ISSN 1386-5056
Editore: Elsevier BV
DOI: 10.2139/ssrn.4367352

Tissue-wide metabolomics reveals wide impact of gut microbiota on mice metabolite composition

Autori: Iman Zarei, Ville M. Koistinen, Marietta Kokla, Anton Klåvus, Ambrin Farizah Babu, Marko Lehtonen, Seppo Auriola & Kati Hanhineva
Pubblicato in: Scientific Reports, Numero 12, 2022, Pagina/e 15018, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-022-19327-w

Identification and distribution of sterols, bile acids, and acylcarnitines by LC-MS/MS in humans, mice, and pigs – A qualitative analysis

Autori: Ambrin Farizah Babu, Ville Mikael Koistinen, Soile Turunen, Gloria Solano-Aguilar, Joseph F. Urban, Jr., Iman Zarei and Kati Hanhineva
Pubblicato in: Metabolites, Numero 12(1), 2022, Pagina/e 49, ISSN 2218-1989
Editore: MDPI
DOI: 10.3390/metabo12010049

Maternal iron status in early pregnancy and DNA methylation in offspring: an epigenome-wide meta-analysis

Autori: M. J. Taeubert, P. de Prado-Bert, M. L. Geurtsen, G. Mancano, M. J. Vermeulen, I. K. M. Reiss, D. Caramaschi, J. Sunyer, G. C. Sharp, J. Julvez, M. U. Muckenthaler & J. F. Felix
Pubblicato in: Clinical Epigenetics, Numero 14(59), 2022, ISSN 1868-7083
Editore: BioMed Central
DOI: 10.1186/s13148-022-01276-w

Association of Exposure to Second-Hand Smoke During Childhood with Blood DNA Methylation

Autori: Marta Cosin-Tomas, Thanh Hoang, Cancan Qi, Giulietta S. Monasso, Ryan Langdon, Simon Kebede Meri, Lucinda Calas, Paula de Prado-Bert, Rebecca C. Richmond, Vincent W.V. Jaddoe, Liesbeth Duijts, John Wright, Isabella Annesi-Maesano, Regina Gražulevičienė, Marianna Karachaliou, Gerard Koppelman, Erik Melén, Olena Gruzieva, Martine Virjheid, Paul D. Yousefi, Janine F. Felix, Stephanie J. Londo
Pubblicato in: Environmental Epigenetics, 2024, ISSN 2058-5888
Editore: Oxford University Press
DOI: 10.2139/ssrn.4944259

Timing based clustering of childhood BMI trajectories reveals differential maturational patterns; Study in the Northern Finland Birth Cohorts 1966 and 1986

Autori: Anni Heiskala, J. Derek Tucker, Priyanka Choudhary, Rozenn Nedelec, Justiina Ronkainen, Olli Sarala, Marjo-Riitta Järvelin, Mikko J. Sillanpää, Sylvain Sebert
Pubblicato in: International Journal of Obesity, Numero 49, 2025, Pagina/e 872-880, ISSN 0307-0565
Editore: Nature Publishing Group
DOI: 10.1038/s41366-025-01714-8

Heterogeneous Effects of Calorie Content and Nutritional Components Underlie Dietary Influence on Pancreatic Cancer Susceptibility

Autori: James Dooley, Vasiliki Lagou, Jermaine Goveia, Anna Ulrich, Katerina Rohlenova, Nathalie Heirman, Tobias Karakach, Yulia Lampi, Shawez Khan, Jun Wang, Tom Dresselaers, Uwe Himmelreich, Marc J. Gunter, Inga Prokopenko, Peter Carmeliet, Adrian Liston
Pubblicato in: Cell Reports, Numero 32/2, 2020, Pagina/e 107880, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2020.107880

Women exposed to famine in early gestation have increased mortality up to age 76 years

Autori: Aline Marileen Wiegersma, Tessa J. Roseboom, Susanne R. de Rooij
Pubblicato in: Paediatric and Perinatal Epidemiology, Numero 39, 2025, Pagina/e 236-241, ISSN 0269-5022
Editore: Blackwell Publishing Inc.
DOI: 10.1111/ppe.13131

MOLGENIS Armadillo: a lightweight server for federated analysis using DataSHIELD

Autori: Tim Cadman, Mariska K Slofstra, Marije A van der Geest, Demetris Avraam, Tom R P Bishop, Tommy de Boer, Liesbeth Duijts, Sido Haakma, Eleanor Hyde, Vincent Jaddoe, Tarik Karramass, Fleur Kelpin, Yannick Marcon, Angela Pinot de Moira, Dick Postma, Clemens Tolboom, Ruben L Veenstra, Stuart Wheater, Marieke Welten, Rebecca C Wilson, Erik Zwart, Morris Swertz
Pubblicato in: Bioinformatics, Numero 41, 2025, ISSN 1367-4811
Editore: Oxford University Press (OUP)
DOI: 10.1093/bioinformatics/btae726

A framework for conducting GWAS using repeated measures data with an application to childhood BMI

Autori: Kimberley Burrows, Anni Heiskala, Jonathan P. Bradfield, Zhanna Balkhiyarova, Lijiao Ning, Mathilde Boissel, Yee-Ming Chan, Philippe Froguel, Amelie Bonnefond, Hakon Hakonarson, Alexessander Couto Alves, Deborah A. Lawlor, Marika Kaakinen, Marjo-Riitta Järvelin, Struan F. A. Grant, Kate Tilling, Inga Prokopenko, Sylvain Sebert, Mickaël Canouil, Nicole M. Warrington
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-53687-3

Design and Implementation of a National SARS-CoV-2 Monitoring Program in England: REACT-1 Study

Autori: Paul Elliott, Matthew Whitaker, David Tang, Oliver Eales, Nicholas Steyn, Barbara Bodinier, Haowei Wang, Joshua Elliott, Christina Atchison, Deborah Ashby, Wendy Barclay, Graham Taylor, Ara Darzi, Graham S. Cooke, Helen Ward, Christl A. Donnelly, Steven Riley, Marc Chadeau-Hyam
Pubblicato in: American Journal of Public Health, Numero 113, 2023, Pagina/e 545-554, ISSN 0090-0036
Editore: American Public Health Association
DOI: 10.2105/ajph.2023.307230

Epigenome-wide contributions to individual differences in childhood phenotypes: a GREML approach

Autori: Alexander Neumann, Jean-Baptiste Pingault, Janine F. Felix, Vincent W. V. Jaddoe, Henning Tiemeier, Charlotte Cecil & Esther Walton
Pubblicato in: Clinical Epigenetics, Numero 14(1), 2022, Pagina/e 53, ISSN 1868-7083
Editore: BioMed Central Ltd
DOI: 10.1186/s13148-022-01268-w

Sex inequalities in cardiovascular risk prediction

Autori: Joshua Elliott, Barbara Bodinier, Matthew Whitaker, Rin Wada, Graham Cooke, Helen Ward, Ioanna Tzoulaki, Paul Elliott, Marc Chadeau-Hyam
Pubblicato in: Cardiovascular Research, 2024, ISSN 0008-6363
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Maternal Diet Quality During Pregnancy and Offspring Hepatic Fat in Early Childhood: The Healthy Start Study

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Autori: Daniela Polessa Paula, Marina Camacho, Odaleia Barbosa, Larissa Marques, Rosane Harter Griep, Maria Jesus Mendes da Fonseca, Sandhi Barreto, Karim Lekadir
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Infant weight growth patterns, childhood BMI and arterial health at age 10 years

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Associations between dietary intake and glucose tolerance in clinical and metabolomics-based metabotypes

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Shaping the risk for late-life neurodegenerative disease: A systematic review on prenatal risk factors for Alzheimer's disease-related volumetric brain biomarkers

Autori: Amber Boots, Aline Marileen Wiegersma, Yasaman Vali, Malon van den Hof, Miranda W Langendam, Jacqueline Limpens, Ellen V Backhouse, Susan D Shenkin, Joanna M Wardlaw, Tessa J Roseboom, Susanne R de Rooij
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Prenatal exposure to undernutrition is associated with a specific lipid profile predicting future brain aging

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Prenatal Exposure to the 1944-45 Dutch Famine and Risk for Dementia up to Age 75: An Analysis of Primary Care Data

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OMICs Signatures Linking Persistent Organic Pollutants to Cardiovascular Disease in the Swedish Mammography Cohort

Autori: Tessa Schillemans, Yingxiao Yan, Anton Ribbenstedt, Carolina Donat-Vargas, Christian H. Lindh, Hannu Kiviranta, Panu Rantakokko, Alicja Wolk, Rikard Landberg, Agneta Åkesson, Carl Brunius
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Expression Quantitative Trait Locus Mapping in Pulmonary Arterial Hypertension

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Are active school transport and leisure-time physical activity associated with performance and wellbeing at secondary school? A population-based study

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Longitudinal associations of DNA methylation and sleep in children: a meta-analysis

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Dynamic longitudinal exposome trajectories in cardiovascular and metabolic noncommunicable diseases

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Bifidobacterium Is Enriched in Gut Microbiome of Kashmiri Women with Polycystic Ovary Syndrome

Autori: Saqib Hassan, Marika A. Kaakinen, Harmen Draisma, Liudmila Zudina, Mohd A. Ganie, Aafia Rashid, Zhanna Balkhiyarova, George S. Kiran, Paris Vogazianos, Christos Shammas, Joseph Selvin, Athos Antoniades, Ayse Demirkan and Inga Prokopenko
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Machine and deep learning for longitudinal biomedical data: a review of methods and applications

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Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence

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Automated calibration for stability selection in penalised regression and graphical models

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Associations of Arterial Thickness, Stiffness, and Blood Pressure With Brain Morphology in Early Adolescence: A Prospective Population-Based Study

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Exposure to fine particulate matter in adults is associated with immune cell gene expression related to inflammation, the electron transport chain, and cell cycle regulation

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GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification

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Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth

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The Adverse Influence of Maternal Glycaemia During Pregnancy on Offspring's Cardiometabolic Health Profiles

Autori: Wen Lun Yuan, Aminata H. Cissé, Muriel Tafflet, Elissa El Khoury, Olfa Khalfallah, Laetitia Davidovic, Marie Aline Charles, Barbara Heude
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Fetal and childhood exposure to parental tobacco smoking and arterial health at age 10 years

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Air pollution exposure is associated with gene expression in children

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Maternal Glycemic Dysregulation During Pregnancy and Neonatal Blood DNA Methylation: Meta-analyses of Epigenome-Wide Association Studies

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Sex-specific effects of prenatal undernutrition on resting-state functional connectivity in the human brain at age 68

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A framework for assessing selection and misclassification bias in Mendelian randomization studies: An illustrative example between body mass index and COVID-19

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NMR metabolomic modeling of age and lifespan: A multicohort analysis

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Resveratrol and 3,3′-Diindolylmethane Differentially Regulate Aryl Hydrocarbon Receptor and Estrogen Receptor Alpha Activity through Multiple Transcriptomic Targets in MCF-7 Human Breast Cancer Cells

Autori: Siddhartha Das,Venkata S. Somisetty,Stine M. Ulven and Jason Matthews
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Associations of maternal night shift work during pregnancy with DNA methylation in offspring: a meta-analysis in the PACE consortium

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A novel approach to risk exposure and epigenetics—the use of multidimensional context to gain insights into the early origins of cardiometabolic and neurocognitive health

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The impact of adversities across the lifespan on psychological symptom profiles in late adulthood: a latent profile analysis

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Identifying Key Predictors of Mid‐Childhood Obesity in a Population‐Based Cohort Study: An Evidence Synthesis and Predictive Modeling Study

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Genetic Correlation and Causal Relationships between Cardio-Metabolic Traits and Lung Function Impairment

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Early exposure to social disadvantages and later life body mass index beyond genetic predisposition in three generations of Finnish birth cohorts

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Prenatal Smoking Exposures and Epigenome-wide Methylation in Newborn Blood

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Vitamin B12, folate and homocysteine concentrations during pregnancy and early signs of atherosclerosis at school-age

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Machine Learning-Based DNA Methylation Score for Fetal Exposure to Maternal Smoking: Development and Validation in Samples Collected from Adolescents and Adults

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Cardiovascular Health at Age 5 Years: Distribution, Determinants, and Association With Neurodevelopment

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Cohort profile: the Dutch famine birth cohort (DFBC)- a prospective birth cohort study in the Netherlands.

Autori: Bleker, Laura S; de Rooij, Susanne R; Painter, Rebecca C; Ravelli, Anita CJ; Roseboom, Tessa J
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Integrative genomic analyses in adipocytes implicate DNA methylation in human obesity and diabetes

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Dynamics of competing SARS-CoV-2 variants during the Omicron epidemic in England

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A meta-analysis of epigenome-wide association studies of ultra-processed food consumption with DNA methylation in European children

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Dynamics of SARS-CoV-2 infection hospitalisation and infection fatality ratios over 23 months in England

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Dynamics of a national Omicron SARS-CoV-2 epidemic during January 2022 in England

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Abuse in childhood and cardiometabolic health in early adulthood: evidence from the Avon Longitudinal Study of Parents and Children

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How does childhood maltreatment influence cardiovascular disease? A sequential causal mediation analysis

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Associations of circulating folate, vitamin B12 and homocysteine concentrations in early pregnancy and cord blood with epigenetic gestational age: the Generation R Study

Autori: Giulietta S. Monasso, Leanne K. Küpers, Vincent W. V. Jaddoe, Sandra G. Heil, Janine F. Felix
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Omicron SARS-CoV-2 epidemic in England during February 2022: A series of cross-sectional community surveys

Autori: Chadeau-Hyam, M Tang, D Eales, O Bodinier, B Wang, H Jonnerby, J Whitaker, M Elliott, J Haw, D Walters, CE Atchison, C Diggle, PJ Page, AJ Ashby, D Barclay, W Taylor, G Cooke, G Ward, H Darzi, A Donnelly, CA Elliott, P
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Functional Effects In Silico Prediction for Androgen Receptor Ligand-Binding Domain Novel I836S Mutation

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Brain activity during Stroop task performance at age 74 after exposure to the Dutch famine during early gestation

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Associations of Maternal Educational Level, Proximity to Green Space During Pregnancy, and Gestational Diabetes With Body Mass Index From Infancy to Early Adulthood: A Proof-of-Concept Federated Analysis in 18 Birth Cohorts

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Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude

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Twin peaks: The Omicron SARS-CoV-2 BA.1 and BA.2 epidemics in England

Autori: PAUL ELLIOTT, OLIVER EALES, NICHOLAS STEYN, DAVID TANG, BARBARA BODINIER, HAOWEI WANG, JOSHUA ELLIOTT, MATTHEW WHITAKER, CHRISTINA ATCHISON, PETER J. DIGGLE, ANDREW J. PAGE, ALEXANDER J. TROTTER, DEBORAH ASHBY, WENDY BARCLAY, GRAHAM TAYLOR, HELEN WARD, ARA DARZI GRAHAM S. COOKE, CHRISTL A. DONNELLY, AND MARC CHADEAU-HYAM
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Risk of Recurrent Pregnancy Loss in the Ukrainian Population Using a Combined Effect of Genetic Variants: A Case-Control Study

Autori: Eleni M. Loizidou, Anastasia Kucherenko, Pavlo Tatarskyy, Sergey Chernushyn, Ganna Livshyts, Roman Gulkovskyi, Iryna Vorobiova, Yurii Antipkin, Oleksandra Gorodna, Marika A. Kaakinen, Inga Prokopenko, Ludmila Livshits
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MC3R links nutritional state to childhood growth and the timing of puberty

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Bi-directional Mendelian randomization and multi-phenotype GWAS show causality and shared pathophysiology between depression and type 2 diabetes

Autori: Jared G Maina; Zhanna Balkhiyarova; Arie Nouwen; Igor Pupko; Anna Ulrich; Mathilde Boissel; Amélie Bonnefond; Philippe Froguel; Amna Khamis; Inga Prokopenko; Marika Kaakinen
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Associations of PFAS-related plasma metabolites with cholesterol and triglyceride concentrations

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Proteomic signatures of eosinophilic and neutrophilic asthma from serum and sputum

Autori: Khezia Asamoah, Kian Fan Chung, Nazanin Zounemat Kermani, Barbara Bodinier, Sven-Erik Dahlen, Ratko Djukanovic, Pankaj K. Bhavsar, Ian M. Adcock, Dragana Vuckovic, Marc Chadeau-Hyam
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Association between perinatal factors, genetic susceptibility to obesity and age at adiposity rebound in children of the EDEN mother–child cohort

Autori: Aminata Hallimat Cissé, Sandrine Lioret, Blandine de Lauzon-Guillain, Anne Forhan, Ken K. Ong, Marie Aline Charles, Barbara Heude
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The interplay between inflammatory cytokines and cardiometabolic disease: bi-directional mendelian randomisation study

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COVID-19 mortality in the UK Biobank cohort: revisiting and evaluating risk factors

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Prenatal exposure to the Dutch famine is associated with more self-perceived cognitive problems at 72 years of age

Autori: Aline Marileen Wiegersma, Amber Boots, Tessa J. Roseboom & Susanne R. de Rooij
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Hair-Derived Exposome Exploration of Cardiometabolic Health: Piloting a Bayesian Multitrait Variable Selection Approach

Autori: Rin Wada, Feng-Jiao Peng, Chia-An Lin, Roel Vermeulen, Alba Iglesias-González, Paul Palazzi, Barbara Bodinier, Sylvie Streel, Michèle Guillaume, Dragana Vuckovic, Sonia Dagnino, Julien Chiquet, Brice M. R. Appenzeller, Marc Chadeau-Hyam
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The determinants and longitudinal changes in vitamin D status in middle-age: a Northern Finland Birth Cohort 1966 study

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Editore: Dr. Dietrich Steinkopff Verlag
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The role of lifestyle factors in the association between early-life stress and adolescent psycho-physical health: Moderation analysis in two European birth cohorts

Autori: Defina S, Woofenden T, Baltramonaityte V, Tiemeier H, Fairchild G, Felix JF, Cecil CAM, Walton E
Pubblicato in: Preventive Medicine, Numero 182, 2024, Pagina/e 107926, ISSN 0091-7435
Editore: Academic Press
DOI: 10.1016/j.ypmed.2024.107926

Gestational age at birth and body size from infancy through adolescence: An individual participant data meta-analysis on 253,810 singletons in 16 birth cohort studies

Autori: Johan L. Vinther, Tim Cadman, Demetris Avraam, Claus T. Ekstrøm, Thorkild I. A. Sørensen, Ahmed Elhakeem, Ana C. Santos, Angela Pinot de Moira, Barbara Heude, Carmen Iñiguez, Costanza Pizzi, Elinor Simons, Ellis Voerman, Eva Corpeleijn, Faryal Zariouh, Gilian Santorelli, Hazel M. Inskip, Henrique Barros, Jennie Carson, Jennifer R. Harris, Johanna L. Nader, Justiina Ronkainen, Katrine Strandberg
Pubblicato in: PLOS Medicine, Numero 20, 2023, Pagina/e e1004036, ISSN 1549-1676
Editore: Public Library of Science
DOI: 10.1371/journal.pmed.1004036

Using linear and natural cubic splines, SITAR, and latent trajectory models to characterise nonlinear longitudinal growth trajectories in cohort studies

Autori: Ahmed Elhakeem; Rachael A. Hughes; Kate Tilling; Diana L. Cousminer; Diana L. Cousminer; Jackowski S; Jackowski S; Tim J Cole; Kwong Asf; Kwong Asf; Li Z; Li Z; Struan F.A. Grant; Baxter-Jones A; Babette S. Zemel; Babette S. Zemel; Debbie A Lawlor
Pubblicato in: BMC Medical Research Methodology, Numero 68, 2022, ISSN 1471-2288
Editore: BioMed Central
DOI: 10.1186/s12874-022-01542-8

Epigenome-wide change and variation in DNA methylation in childhood: trajectories from birth to late adolescence

Autori: Rosa H Mulder, Alexander Neumann, Charlotte A M Cecil, Esther Walton, Lotte C Houtepen, Andrew J Simpkin, Jolien Rijlaarsdam, Bastiaan T Heijmans, Tom R Gaunt, Janine F Felix, Vincent W V Jaddoe, Marian J Bakermans-Kranenburg, Henning Tiemeier, Caroline L Relton, Marinus H van IJzendoorn, Matthew Suderman
Pubblicato in: Human Molecular Genetics, Numero 30/1, 2021, Pagina/e 119-134, ISSN 0964-6906
Editore: Oxford University Press
DOI: 10.1093/hmg/ddaa280

Effects of Pre- and Postnatal Early-Life Stress on Internalizing, Adiposity and Their Comorbidity

Autori: Serena Defina, MSc Tom Woofenden, MSc Vilte Baltramonaityte, MSc Carmine M. Pariante, MD, PhD Karim Lekadir, PhD Vincent W.V. Jaddoe, PhD Fadila Serdarevic, MD, PhD Henning Tiemeier, MD, PhD Esther Walton, PhD Janine F. Felix, PhD Charlotte A.M. Cecil, PhD on behalf of theEarlyCause Consortium
Pubblicato in: Journal of the American Academy of Child & Adolescent Psychiatry, 2023, ISSN 0890-8567
Editore: Elsevier BV
DOI: 10.1016/j.jaac.2023.05.034

Epigenome-wide meta-analysis of prenatal maternal stressful life events and newborn DNA methylation

Autori: Anna Kotsakis Ruehlmann, Sara Sammallahti, Andrea P. Cortés Hidalgo, Kelly M. Bakulski, Elisabeth B. Binder, Megan Loraine Campbell, Doretta Caramaschi, Charlotte A.M. Cecil, Elena Colicino, Cristiana Cruceanu, Darina Czamara, Linda Dieckmann, John Dou, Janine F. Felix, Josef Frank, Siri E. Håberg, Gunda Herberth, Thanh T. Hoang, Lotte C. Houtepen, Anke HülsNastassja Koen, Stephanie J. London,
Pubblicato in: Molecular Psychiatry, 2023, ISSN 1359-4184
Editore: Nature Publishing Group
DOI: 10.1038/s41380-023-02010-5

Epigenetic age acceleration and cardiovascular outcomes in school-age children: The Generation R Study.

Autori: Giulietta S Monasso; Vincent W. V. Jaddoe; Leanne K. Küpers; Leanne K. Küpers; Janine F. Felix
Pubblicato in: Clinical Epigenetics, Numero 13(1), 2021, Pagina/e 205, ISSN 1868-7083
Editore: BioMed Central Ltd
DOI: 10.1186/s13148-021-01193-4

Plasma metabolites associated with exposure to perfluoroalkyl substances and risk of type 2 diabetes – A nested case-control study

Autori: Tessa Schillemans, Lin Shi, Carolina Donat-Vargas, Kati Hanhineva, Andreas Tornevi, Ingegerd Johansson, Jani Koponen, Hannu Kiviranta, Olov Rolandsson, Ingvar A. Bergdahl, Rikard Landberg, Agneta Åkesson, Carl Brunius
Pubblicato in: Environment International, Numero 146, 2021, Pagina/e 106180, ISSN 0160-4120
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2020.106180

Harnessing Microbes for Sustainable Development: Food Fermentation as a Tool for Improving the Nutritional Quality of Alternative Protein Sources

Autori: Anna Kårlund, Carlos Gómez-Gallego, Jenni Korhonen, Outi-Maaria Palo-oja, Hani El-Nezami, Marjukka Kolehmainen
Pubblicato in: Nutrients, Numero 12/4, 2020, Pagina/e 1020, ISSN 2072-6643
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu12041020

Keeping it in the family: Consanguinity reveals P4HTM as a novel syndromic obesity gene

Autori: Janine F. Felix and Struan F.A. Grant
Pubblicato in: Diabetes, Numero 72(9), 2023, Pagina/e 1184–1186, ISSN 0012-1797
Editore: American Diabetes Association
DOI: 10.2337/dbi23-0010

Maternal age is related to offspring <scp>DNA</scp> methylation: A meta‐analysis of results from the <scp>PACE</scp> consortium

Autori: Edwina Yeung, Richard J. Biedrzycki, Laura C. Gómez Herrera, Prachand Issarapu, John Dou, Irene Fontes Marques, Sohail Rafik Mansuri, Christian Magnus Page, Justin Harbs, Dennis Khodasevich, Eric Poisel, Zhongzheng Niu, Catherine Allard, Emma Casey, Fernanda Morales Berstein, Giulia Mancano, Hannah R. Elliott, Rebecca Richmond, Yiyan He, Justiina Ronkainen, Sylvain Sebert, Erin M. Bell, Gemma Sh
Pubblicato in: Aging Cell, Numero 23, 2024, ISSN 1474-9718
Editore: Blackwell Publishing Inc.
DOI: 10.1111/acel.14194

Fetal exposure to phthalates and bisphenols and DNA methylation at birth: the Generation R Study

Autori: Chalana M. Sol, Abigail Gaylord, Susana Santos, Vincent W. V. Jaddoe, Janine F. Felix & Leonardo Trasande
Pubblicato in: Clinical Epigenetics, Numero 14(125), 2022, ISSN 1868-7083
Editore: BioMed Central
DOI: 10.1186/s13148-022-01345-0

Genome-wide characterization of circulating metabolic biomarkers

Autori: Minna K. Karjalainen, Savita Karthikeyan, Clare Oliver-Williams, Eeva Sliz, Elias Allara, Wing Tung Fung, Praveen Surendran, Weihua Zhang, Pekka Jousilahti, Kati Kristiansson, Veikko Salomaa, Matt Goodwin, David A. Hughes, Michael Boehnke, Lilian Fernandes Silva, Xianyong Yin, Anubha Mahajan, Matt J. Neville, Natalie R. van Zuydam, Renée de Mutsert, Ruifang Li-Gao, Dennis O. Mook-Kanamori, Ayse D
Pubblicato in: Nature, Numero 628, 2024, Pagina/e 130-138, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-024-07148-y

A meta-analysis of epigenome-wide association studies on pregnancy vitamin B12 concentrations and offspring DNA methylation

Autori: Giulietta S. Monasso,Thanh T. Hoang, Giulia Mancano, Sílvia Fernández-Barrés,John Dou, Vincent W.V. Jaddoe, Christian M. Page,Laura Johnson, Mariona Bustamante, Kelly M. Bakulski, Siri E. Håberg, Per M. Ueland, Thomas Battram, Simon K. Merid, Erik Melén, Doretta Caramaschi, Leanne K. Küpers, Jordi Sunyer, Wenche Nystad, Sandra G. Heil, Rebecca J. Schmidt, Martine Vrijheid, Gemma C. Sharp,Ste
Pubblicato in: Epigenetics, 2023, ISSN 1559-2308
Editore: Taylor & Francis
DOI: 10.1080/15592294.2023.2202835

Metabolic profiles of socio-economic position: a multi-cohort analysis

Autori: Oliver Robinson; Alice R Carter; Mika Ala-Korpela; Juan P Casas; Juan P Casas; Nishi Chaturvedi; Jorgen Engmann; Laura D Howe; Alun D. Hughes; Marjo-Riitta Järvelin; Mika Kähönen; Ville Karhunen; Diana Kuh; Tina Shah; Yoav Ben-Shlomo; Reecha Sofat; Chung-Ho E Lau; Terho Lehtimäki; Usha Menon; Olli T. Raitakari; Olli T. Raitakari; Andy Ryan; Rui Providência; Stephanie Smith; Julie Taylor; Ther
Pubblicato in: International Journal of Epidemiology, Numero 50(3), 2021, Pagina/e 768-782, ISSN 0300-5771
Editore: Oxford University Press
DOI: 10.1093/ije/dyaa188

Epigenome-Wide Association Study Reveals Methylation Loci Associated With Offspring Gestational Diabetes Mellitus Exposure and Maternal Methylome

Autori: Mickaël Canouil; Amna Khamis; Elina Keikkala; Sandra Hummel; Stephane Lobbens; Amélie Bonnefond; Fabien Delahaye; Evangelia Tzala; Sanna Mustaniemi; Marja Vääräsmäki; Marjo-Riitta Jarvelin; Sylvain Sebert; Eero Kajantie; Philippe Froguel; Toby Andrew
Pubblicato in: Diabetes Care, Numero 44(9), 2021, Pagina/e 1992-1999, ISSN 0149-5992
Editore: American Diabetes Association
DOI: 10.2337/dc20-2960

Integrating multiple lines of evidence to assess the effects of maternal BMI on pregnancy and perinatal outcomes

Autori: Borges MC, Clayton GL, Freathy RM, Felix JF, Fernández-Sanlés A, Soares AG, Kilpi F, Yang Q, McEachan RRC, Richmond RC, Liu X, Skotte L, Irizar A, Hattersley AT, Bodinier B, Scholtens DM, Nohr EA, Bond TA, Hayes MG, West J, Tyrrell J, Wright J, Bouchard L, Murcia M, Bustamante M, Chadeau-Hyam M, Jarvelin MR, Vrijheid M, Perron P, Magnus P, Gaillard R, Jaddoe VWV, Lowe WL Jr, Feenstra B, Hivert M
Pubblicato in: BMC Medicine, Numero 22(1), 2024, Pagina/e 32, ISSN 1741-7015
Editore: BioMed Central
DOI: 10.1186/s12916-023-03167-0

A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation

Autori: Shaobo Li, Natalia Spitz, Akram Ghantous, Sarina Abrishamcar, Brigitte Reimann, Irene Marques, Matt J. Silver, Sofía Aguilar-Lacasaña, Negusse Kitaba, Faisal I. Rezwan, Stefan Röder, Lea Sirignano, Johanna Tuhkanen, Giulia Mancano, Gemma C. Sharp, Catherine Metayer, Libby Morimoto, Dan J. Stein, Heather J. Zar, Rossella Alfano, Tim Nawrot, Congrong Wang, Eero Kajantie, Elina Keikkala, Sanna Mus
Pubblicato in: Communications Biology, Numero 7(6), 2024, ISSN 2399-3642
Editore: Springer Nature
DOI: 10.1038/s42003-023-05698-x

The relationship of life-course patterns of adiposity with type 2 diabetes, depression, and their comorbidity in the Northern Finland Birth Cohort 1966

Autori: Priyanka Choudhary; Justiina Ronkainen; Rozenn Nedelec; Mimmi Tolvanen; Estelle Lowry; Jouko Miettunen; Marjo-Riitta Jarvelin; Sylvain Sebert
Pubblicato in: International Journal of Obesity, Numero 4, 2022, ISSN 0307-0565
Editore: Nature Publishing Group
DOI: 10.1038/s41366-022-01134-y

Towards early risk biomarkers:serum metabolic signature in childhood predicts cardio-metabolic risk in adulthood

Autori: Ojanen, X. (Xiaowei); Cheng, R. (Runtan); Törmäkangas, T. (Timo); Rappaport, N. (Noa); Wilmanski, T. (Tomasz); Wu, N. (Na); Fung, E. (Erik); Nedelec, R. (Rozenn); Sebert, S. (Sylvain); Vlachopoulos, D. (Dimitris); Yan, W. (Wei); Price, N. D. (Nathan D.); Cheng, S. (Sulin); Wiklund, P. (Petri)
Pubblicato in: eBioMedicine, Numero 72(103611), 2021, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/j.ebiom.2021.103611

Gestational epigenetic age and ADHD symptoms in childhood: a prospective, multi-cohort study

Autori: Salontaji K, Haftorn KL, Sanders F, Page CM, Walton E, Felix JF, Bekkhus M, Bohlin J, Tiemeier H, Cecil CAM
Pubblicato in: Molecular Psychiatry, 2024, ISSN 1359-4184
Editore: Nature Publishing Group
DOI: 10.1038/s41380-024-02544-2

Participant engagement and involvement in longitudinal cohort studies: qualitative insights from a selection of pregnancy and birth, twin, and family-based population cohort studies

Autori: Isabelle Budin-Ljøsne, Nanna A. G. Fredheim, Charlotte Alison Jevne, Bojana Milanovic Kleven, Marie Aline Charles, Janine F. Felix, Robin Flaig, María Paz García, Alexandra Havdahl, Shahid Islam, Shona M. Kerr, Inger Kristine Meder, Lynn Molloy, Susan M. B. Morton, Costanza Pizzi, Aamnah Rahman, Gonneke Willemsen, Diane Wood, Jennifer R. Harris
Pubblicato in: BMC Medical Research Methodology, Numero 24, 2024, ISSN 1471-2288
Editore: BioMed Central
DOI: 10.1186/s12874-024-02419-8

Omega-3 fatty acids and individual variability in plasma triglyceride response: A mini-review

Autori: Amanda Rundblad, Viviana Sandoval, Kirsten B. Holven, José M. Ordovás, Stine M. Ulven
Pubblicato in: Redox Biology, Numero 63, 2023, Pagina/e 102370, ISSN 2213-2317
Editore: Elsevier BV
DOI: 10.1016/j.redox.2023.102730

Exposure to the Dutch Famine in Early Gestation and Cognitive Function and Decline in Older Age

Autori: Aline Marileen Wiegersma; Amber Boots; Tessa J. Roseboom; Susanne R. de Rooij
Pubblicato in: Nutrients, Numero 15(2), 2023, Pagina/e 293, ISSN 2072-6643
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu15020293

Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation

Autori: Olivia Solomon; Karen Huen; Paul Yousefi; Leanne K. Küpers; Juan R. González; Matthew Suderman; Sarah E. Reese; Christian M. Page; Olena Gruzieva; Peter Rzehak; Lu Gao; Kelly M. Bakulski; Alexei Novoloaca; Catherine Allard; Irene Pappa; Maria Llambrich; Marta Vives; Dereje D. Jima; Tuomas Kvist; Andrea Baccarelli; Cory White; Faisal I. Rezwan; Gemma C. Sharp; Gwen Tindula; Anna Bergström; Veit
Pubblicato in: Mutation Research/Reviews in Mutation Research, Numero 789, 2022, ISSN 1383-5742
Editore: Elsevier BV
DOI: 10.1016/j.mrrev.2022.108415

Lessons learned from 25 Years of Research into Long term Consequences of Prenatal Exposure to the Dutch famine 1944–45: The Dutch famine Birth Cohort

Autori: Susanne R. De Rooij, Laura S. Bleker, Rebecca C. Painter, Anita C. Ravelli, Tessa J. Roseboom
Pubblicato in: International Journal of Environmental Health Research, Numero 32, 2022, Pagina/e 1432-1446, ISSN 0960-3123
Editore: Chapman & Hall
DOI: 10.1080/09603123.2021.1888894

Mapping prenatal predictors and neurobehavioral outcomes of an epigenetic marker of neonatal inflammation – A longitudinal population-based study

Autori: Anna Suleri, Nicole Creasey, Esther Walton, Ryan Muetzel, Janine F. Felix, Liesbeth Duijts, Veerle Bergink, Charlotte A.M. Cecil
Pubblicato in: Brain, Behavior, and Immunity, Numero 122, 2024, Pagina/e 483-496, ISSN 0889-1591
Editore: Academic Press
DOI: 10.1016/j.bbi.2024.08.053

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