Dynamic longitudinal exposome trajectories in cardiovascular and metabolic non-communicable diseases

Livrables

Summary report of the first workshop connecting the scientific objectives of LONGITOOLS and the policy and regulation agendas

Findability catalogue

A publicly available metadata of LONGITOOLS cohorts - the metadata will be published on the LONGITOOLS website, the cluster website and CORDIS

Innovation platform

A public event to launch LONGITOOLS innovation platform organised alongside the second General Assembly of LONGITOOLS

LONGITOOLS website

LONGITOOLS website launched

Publications

Risk factors for positive and negative COVID-19 tests: a cautious and in- depth analysis of UK biobank data

Auteurs: Marc Chadeau-Hyam, Barbara Bodinier, Joshua Elliott, Matthew D Whitaker, Ioanna Tzoulaki, Roel Vermeulen, Michelle Kelly-Irving, Cyrille Delpierre, Paul Elliott
Publié dans: International Journal of Epidemiology, Numéro 49(5), 2020, Page(s) 1454-1467, ISSN 0300-5771
Éditeur: Oxford University Press
DOI: 10.1093/ije/dyaa134

Variant-specific symptoms of COVID-19 in a study of 1,542,510 adults in England

Auteurs: Whitaker M, Elliott J, Bodinier B, Barclay W, Ward H, Cooke G, Donnelly CA, Chadeau-Hyam M, Elliott P
Publié dans: Nature Communications, Numéro 13 (6856), 2022, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-022-34244-2

Maternal and infant prediction of the child BMI trajectories; studies across two generations of Northern Finland birth cohorts

Auteurs: Rozenn Nedelec, Jouko Miettunen, Minna Männikkö, Marjo-Riitta Järvelin, Sylvain Sebert
Publié dans: International Journal of Obesity, Numéro 45/2, 2021, Page(s) 404-414, ISSN 0307-0565
Éditeur: Nature Publishing Group
DOI: 10.1038/s41366-020-00695-0

Measurement invariance testing of the patient health questionnaire-9 (PHQ-9) across people with and without diabetes mellitus from the NHANES, EMHS and UK Biobank datasets

Auteurs: Arie Nouwen, Sonya S.Deschênes, Zhanna Balkhiyarova, Juan R.Albertorio-Díaz, Inga Prokopenko, Norbert Schmitz
Publié dans: Journal of Affective Disorders, Numéro 292, 2021, Page(s) 311-318, ISSN 0165-0327
Éditeur: Elsevier BV
DOI: 10.1016/j.jad.2021.05.031

Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes

Auteurs: Natalia Pervjakova; Gunn-Helen Moen; Maria-Carolina Borges; Teresa Ferreira; James P Cook; Catherine Allard; Robin N Beaumont; Mickaël Canouil; Gad Hatem; Anni Heiskala; Anni Joensuu; Ville Karhunen; Soo Heon Kwak; Frederick T J Lin; Jun Liu; Sheryl Rifas-Shiman; Claudia H Tam; Wing Hung Tam; Gudmar Thorleifsson; Toby Andrew; Juha Auvinen; Bishwajit Bhowmik; Amélie Bonnefond; Fabien Delahaye; Ay
Publié dans: Human Molecular Genetics, Numéro 31(19), 2022, Page(s) 3377-3391, ISSN 0964-6906
Éditeur: Oxford University Press
DOI: 10.1093/hmg/ddac050

Cord blood leptin level and a common variant of its receptor as determinants of the BMI trajectory: the EDEN mother-child cohort

Auteurs: Aminata H. Cissé, Marion Taine, Muriel Tafflet, Blandine de Lauzon-Guillain, Karine Clément, Olfa Khalfallah, Laetitia Davidovic, Sandrine Lioret, Marie A. Charles, Barbara Heude
Publié dans: Pediatric Obesity, 2022, ISSN 2047-6310
Éditeur: Wiley-Blackwell for the International Association for the Study of Obesity
DOI: 10.1111/ijpo.12955

Investigating childhood maltreatment as a modifier of genetic risk for cardiovascular diseases in the UK Biobank

Auteurs: Helena Urquijo, Ana Gonçalves Soares, Abigail Fraser, Laura D. Howe, Alice R. Carter
Publié dans: PLOS One, 2023, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0285258

Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

Auteurs: Thomas W. Winkler*, Humaira Rasheed, Lifelines Cohort Study, DiscovEHR/MyCode study, VA Million Veteran Program, Alexander Teumer, Mathias Gorski, Bryce X. Rowan, Kira J. Stanzick, Laurent F. Thomas, Adrienne Tin, Anselm Hoppmann, Audrey Y. Chu, Bamidele Tayo, Chris H.L. Thio, Daniele Cusi, Jin Fang Chai, Karsten B. Sieber, Katrin Horn, Man Li, Markus Scholz, Massimiliano Cocca, Matthias Wuttke, P
Publié dans: Communications Biology, Numéro 5(580), 2022, ISSN 2399-3642
Éditeur: Springer Nature
DOI: 10.1038/s42003-022-03448-z

Maternal Mediterranean diet in pregnancy and newborn DNA methylation: a meta-analysis in the PACE Consortium

Auteurs: Leanne K. Küpers; Sílvia Fernández-Barrés; Aayah Nounu; Chloe Friedman; Ruby Fore; Giulia Mancano; Dana Dabelea; Sheryl L. Rifas-Shiman; Rosa H. Mulder; Emily Oken; Laura Johnson; Mariona Bustamante; Vincent W.V. Jaddoe; Marie-France Hivert; Anne P. Starling; Jeanne H.M. de Vries; Gemma C. Sharp; Martine Vrijheid; Janine F. Felix
Publié dans: Epigenetics, 2022, Page(s) 1-13, ISSN 1559-2308
Éditeur: Taylor & Francis Group
DOI: 10.1080/15592294.2022.2038412

Paternal body mass index and offspring DNA methylation: findings from the PACE consortium

Auteurs: Gemma C Sharp, Rossella Alfano, Akram Ghantous, Jose Urquiza, Sheryl L Rifas-Shiman, Christian M Page, Jianping Jin, Silvia Fernández-Barrés, Gillian Santorelli, Gwen Tindula, Gemma C Sharp, Rossella Alfano, Akram Ghantous, Jose Urquiza, Sheryl L Rifas-Shiman, Christian M Page, Jianping Jin, Silvia Fernández-Barrés, Gillian Santorelli, Gwen Tindula, Paul Yousefi, Leanne Kupers, Carlos Ruiz-Are
Publié dans: International Journal of Epidemiology, 2021, ISSN 0300-5771
Éditeur: Oxford University Press
DOI: 10.1093/ije/dyaa267

Abdominal obesity is a more important causal risk factor for pancreatic cancer than overall obesity

Auteurs: Jared G. Maina; Vincent Pascat; Liudmila Zudina; Anna Ulrich; Igor Pupko; Amélie Bonnefond; Zhanna Balkhiyarova; Marika Kaakinen; Philippe Froguel; Inga Prokopenko
Publié dans: European Journal of Human Genetics, Numéro 31, 2023, Page(s) 962-966, ISSN 1018-4813
Éditeur: Natue Publishing Group
DOI: 10.1038/s41431-023-01301-3

The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice

Auteurs: Francesca Forzano, Olga Antonova, Angus Clarke, Guido de Wert, Sabine Hentze, Yalda Jamshidi, Yves Moreau, Markus Perola, Inga Prokopenko, Andrew Read, Alexandre Reymond, Vigdis Stefansdottir, Carla van El & Maurizio Genuardi, on behalf of the Executive Committee of the European Society of Human Genetics & the Public and Professional Policy Committee of the European Society of Human Genetics
Publié dans: The European Journal of Human Genetics, 2021, ISSN 1018-4813
Éditeur: Natue Publishing Group
DOI: 10.1038/s41431-021-01000-x

Post-weight loss changes in fasting appetite- and energy balance-related hormone concentrations and the effect of the macronutrient content of a weight maintenance diet: a randomised controlled trial

Auteurs: Mari Näätänen, Marjukka Kolehmainen, David E. Laaksonen, Karl-Heinz Herzig, Kaisa Poutanen, Leila Karhunen
Publié dans: European Journal of Nutrition, 2020, ISSN 1436-6207
Éditeur: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00394-020-02438-3

Maternal plasma fatty acid patterns in mid-pregnancy and offspring epigenetic gestational age at birth

Auteurs: Giulietta S. Monasso, Trudy Voortman, Janine F. Felix
Publié dans: Epigenetics, 2022, ISSN 1559-2294
Éditeur: Landes Bioscience
DOI: 10.1080/15592294.2022.2076051

Cohort profile:46 years of follow-up of the Northern Finland Birth Cohort 1966 (NFBC1966)

Auteurs: Nordström, T. (Tanja); Miettunen, J. (Jouko); Auvinen, J. (Juha); Ala-Mursula, L. (Leena); Keinänen-Kiukaanniemi, S. (Sirkka); Veijola, J. (Juha); Järvelin, M.-R. (Marjo-Riitta); Sebert, S. (Sylvain); Männikkö, M. (Minna)
Publié dans: International Journal of Epidemiology, Numéro 50(6), 2021, Page(s) 1786-1787, ISSN 0300-5771
Éditeur: Oxford University Press
DOI: 10.1093/ije/dyab109

Cardiometabolic Risk Estimation Using Exposome Data and Machine Learning

Auteurs: Angélica Atehortúa; Polyxeni Gkontra; Marina Camacho; Oliver Diaz; Maria Bulgheroni; Valentina Simonetti; Marc Chadeau-Hyam; Janine F. Felix; Sylvain Sebert; Karim Lekadir
Publié dans: International Journal of Medical Informatics, Numéro 179, 2023, ISSN 1386-5056
Éditeur: Elsevier BV
DOI: 10.2139/ssrn.4367352

Identification and distribution of sterols, bile acids, and acylcarnitines by LC-MS/MS in humans, mice, and pigs – A qualitative analysis

Auteurs: Ambrin Farizah Babu, Ville Mikael Koistinen, Soile Turunen, Gloria Solano-Aguilar, Joseph F. Urban, Jr., Iman Zarei and Kati Hanhineva
Publié dans: Metabolites, Numéro 12(1), 2022, Page(s) 49, ISSN 2218-1989
Éditeur: MDPI
DOI: 10.3390/metabo12010049

Maternal iron status in early pregnancy and DNA methylation in offspring: an epigenome-wide meta-analysis

Auteurs: M. J. Taeubert, P. de Prado-Bert, M. L. Geurtsen, G. Mancano, M. J. Vermeulen, I. K. M. Reiss, D. Caramaschi, J. Sunyer, G. C. Sharp, J. Julvez, M. U. Muckenthaler & J. F. Felix
Publié dans: Clinical Epigenetics, Numéro 14(59), 2022, ISSN 1868-7083
Éditeur: BioMed Central
DOI: 10.1186/s13148-022-01276-w

Heterogeneous Effects of Calorie Content and Nutritional Components Underlie Dietary Influence on Pancreatic Cancer Susceptibility

Auteurs: James Dooley, Vasiliki Lagou, Jermaine Goveia, Anna Ulrich, Katerina Rohlenova, Nathalie Heirman, Tobias Karakach, Yulia Lampi, Shawez Khan, Jun Wang, Tom Dresselaers, Uwe Himmelreich, Marc J. Gunter, Inga Prokopenko, Peter Carmeliet, Adrian Liston
Publié dans: Cell Reports, Numéro 32/2, 2020, Page(s) 107880, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2020.107880

Epigenome-wide contributions to individual differences in childhood phenotypes: a GREML approach

Auteurs: Alexander Neumann, Jean-Baptiste Pingault, Janine F. Felix, Vincent W. V. Jaddoe, Henning Tiemeier, Charlotte Cecil & Esther Walton
Publié dans: Clinical Epigenetics, Numéro 14(1), 2022, Page(s) 53, ISSN 1868-7083
Éditeur: BioMed Central Ltd
DOI: 10.1186/s13148-022-01268-w

Relationship between glucose homeostasis and obesity in early life—a study of Italian children and adolescents

Auteurs: Zhanna Balkhiyarova, Rosa Luciano, Marika Kaakinen, Anna Ulrich, Aleksey Shmeliov, Marzia Bianchi, Laura Chioma, Bruno Dallapiccola, Inga Prokopenko, Melania Manco
Publié dans: Human Molecular Genetics, Numéro 09646906, 2022, Page(s) 816-826, ISSN 0964-6906
Éditeur: Oxford University Press
DOI: 10.1093/hmg/ddab287

DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures

Auteurs: Monica del C. Gomez-Alonso, Anja Kretschmer, Rory Wilson, Liliane Pfeiffer, Ville Karhunen, Ilkka Seppälä, Weihua Zhang, Kirstin Mittelstraß, Simone Wahl, Pamela R. Matias-Garcia, Holger Prokisch, Sacha Horn, Thomas Meitinger, Luis R. Serrano-Garcia, Sylvain Sebert, Olli Raitakari, Marie Loh, Wolfgang Rathmann, Martina Müller-Nurasyid, Christian Herder, Michael Roden, Mikko Hurme, Marjo-Riitta
Publié dans: Clinical Epigenetics, Numéro 13/1, 2021, ISSN 1868-7075
Éditeur: Springer Verlag
DOI: 10.1186/s13148-020-00957-8

Associations of Hair Cortisol Concentrations With Cardiometabolic Risk Factors in Childhood

Auteurs: Florianne O L Vehmeijer, Susana Santos, Yolanda B de Rijke, Erica L T van den Akker, Janine F Felix, Elisabeth F C van Rossum, Vincent W V Jaddoe
Publié dans: The Journal of Clinical Endocrinology & Metabolism, 2021, ISSN 0021-972X
Éditeur: The Endocrine Society
DOI: 10.1210/clinem/dgab379

Associations of green and blue space exposure in pregnancy with epigenetic gestational age acceleration

Auteurs: Marques I, Santos S, Monasso G, Fossati S, Vrijheid M, Nieuwenhuijsen M, Jaddoe VWV, Felix JF
Publié dans: Epigenetics, 2023, ISSN 1559-2308
Éditeur: Taylor & Francis
DOI: 10.1080/15592294.2023.2165321

Infant weight growth patterns, childhood BMI and arterial health at age 10 years

Auteurs: Giulietta S. Monasso, Carolina C.V. Silva, Susana Santos, Romy Goncalvez, Romy Gaillard, Janine F. Felix, Vincent W.V. Jaddoe
Publié dans: Obesity, Numéro 30(3), 2022, Page(s) 770-778, ISSN 1930-7381
Éditeur: Wiley-Blackwell
DOI: 10.1002/oby.23376

Defining the Scope of Exposome Studies and Research Needs from a Multidisciplinary Perspective.

Auteurs: Pei Zhang; Pei Zhang; Pei Zhang; Christopher Carlsten; Romanas Chaleckis; Romanas Chaleckis; Kati Hanhineva; Kati Hanhineva; Kati Hanhineva; Mengna Huang; Tomohiko Isobe; Ville M. Koistinen; Ville M. Koistinen; Isabel Meister; Isabel Meister; Stefano Papazian; Kalliroi Sdougkou; Hongyu Xie; Jonathan W. Martin; Stephen M. Rappaport; Hiroshi Tsugawa; Douglas I. Walker; Tracey J. Woodruff; Robert O.
Publié dans: Environmental Science & Technology Letters, Numéro 8(10), 2021, Page(s) 839-852, ISSN 2328-8930
Éditeur: ACS Publications
DOI: 10.1021/acs.estlett.1c00648

Body fat, pericardial fat, liver fat and arterial health at age 10 years

Auteurs: Giulietta S. Monasso, Susana Santos, Carolina C. V. Silva, Madelon L. Geurtsen, Edwin Oei, Romy Gaillard, Janine F. Felix, Vincent W. V. Jaddoe
Publié dans: Pediatric Obesity, 2022, ISSN 2047-6310
Éditeur: Wiley-Blackwell for the International Association for the Study of Obesity
DOI: 10.1111/ijpo.12926

Expression Quantitative Trait Locus Mapping in Pulmonary Arterial Hypertension

Auteurs: Anna Ulrich, Pablo Otero-Núñez, John Wharton, Emilia M. Swietlik, Stefan Gräf, Nicholas W. Morrell, Dennis Wang, Allan Lawrie, Martin R. Wilkins, Inga Prokopenko, Christopher J. Rhodes, UK PAH Cohort Study Consortium
Publié dans: Genes, Numéro 11/11, 2020, Page(s) 1247, ISSN 2073-4425
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes11111247

Longitudinal associations of DNA methylation and sleep in children: a meta-analysis

Auteurs: Sara Sammallahti, M. Elisabeth Koopman-Verhoeff, Anne-Claire Binter, Rosa H. Mulder, Alba Cabré-Riera, Tuomas Kvist, Anni L. K. Malmberg, Giancarlo Pesce, Sabine Plancoulaine, Jonathan A. Heiss, Sheryl L. Rifas-Shiman, Stefan W. Röder, Anne P. Starling, Rory Wilson, Kathrin Guerlich, Kristine L. Haftorn, Christian M. Page, Annemarie I. Luik, Henning Tiemeier, Janine F. Felix, Katri Raikkonen, Ja
Publié dans: Clinical Epigenetics, Numéro 14(83), 2022, ISSN 1868-7083
Éditeur: BioMed Central
DOI: 10.1186/s13148-022-01298-4

Dynamic longitudinal exposome trajectories in cardiovascular and metabolic noncommunicable diseases

Auteurs: Ronkainen, Justiina; Nedelec, Rozenn; Atehortua, Angelica; Balkhiyarova, Zhanna; Cascarano, Anna; Ngoc Dang, Vien; Elhakeem, Ahmed; van Enckevort, Esther; Goncalves Soares, Ana; Haakma, Sido; Halonen, Miia; Heil, Katharina F; Heiskala, Anni; Hyde, Eleanor; Jacquemin, Bénédicte; Keikkala, Elina; Kerckhoffs, Jules; Klåvus, Anton; Kopinska, Joanna A; Lepeule, Johanna; Marazzi, Francesca; Motoc, Ir
Publié dans: Environmental Epidemiology, Numéro 6(1), 2022, Page(s) e184, ISSN 2474-7882
Éditeur: Wolters Kluwer Health Inc
DOI: 10.1097/ee9.0000000000000184

Bifidobacterium Is Enriched in Gut Microbiome of Kashmiri Women with Polycystic Ovary Syndrome

Auteurs: Saqib Hassan, Marika A. Kaakinen, Harmen Draisma, Liudmila Zudina, Mohd A. Ganie, Aafia Rashid, Zhanna Balkhiyarova, George S. Kiran, Paris Vogazianos, Christos Shammas, Joseph Selvin, Athos Antoniades, Ayse Demirkan and Inga Prokopenko
Publié dans: Genes, Numéro 13(2), 2022, Page(s) 379, ISSN 2073-4425
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes13020379

Mediators of the association between childhood body mass index and educational attainment: Analysis of a UK prospective cohort study

Auteurs: Kirsty Bowman, Tim Cadman, Ana Goncalves Soares, Oliver Robinson, Amanda Hughes, Jon Heron, Alexa Blair Segal, Maria Carmen Huerta, Laura D. Howe
Publié dans: Pediatric Obesity, Numéro 18(5), 2023, Page(s) e13014, ISSN 2047-6310
Éditeur: Wiley-Blackwell for the International Association for the Study of Obesity
DOI: 10.1111/ijpo.13014

Machine and deep learning for longitudinal biomedical data: a review of methods and applications

Auteurs: Cascarano, Anna; Mur-Petit, Jordi; Hernández-González, Jerónimo; Camacho, Marina; de Toro Eadie, Nina; Gkontra, Polyxeni; Chadeau-Hyam, Marc; Vitria, Jordi; Lekadir, Karim
Publié dans: Artificial Intelligence Review, Numéro 44, 2023, ISSN 1573-7462
Éditeur: Springer Nature
DOI: 10.1007/s10462-023-10561-w

Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence

Auteurs: Priyanka Choudhary, Giulietta S Monasso, Ville Karhunen, Justiina Ronkainen, Giulia Mancano, Caitlin G Howe, Zhongzheng Niu, Xuehuo Zeng, Weihua Guan, John Dou, Jason I. Feinberg, Charles Mordaunt, Giancarlo Pesce, Nour Baïz, Rossella Alfano, Dries S. Martens, Congrong Wang, Elena Isaevska, Elina Keikkala, Sanna Mustaniemi, Chris H.L. Thio, Eliza Fraszczyk, Elmar W. Tobi, Anne P. Starling, Marta
Publié dans: Molecular Pyschiatry, 2023, ISSN 1359-4184
Éditeur: Nature Publishing Group
DOI: 10.1038/s41380-023-02331-5

Automated calibration for stability selection in penalised regression and graphical models

Auteurs: Barbara Bodinier, Sarah Filippi, Therese Haugdahl Nøst, Julien Chiquet, Marc Chadeau-Hyam
Publié dans: Journal of the Royal Statistical Socety Series C: Applied Statistics, 2023, ISSN 0035-9254
Éditeur: Blackwell Publishing Inc.
DOI: 10.1093/jrsssc/qlad058

Effect of common pregnancy and perinatal complications on offspring metabolic traits across the life-course: a multi-cohort study

Auteurs: Ahmed Elhakeem, Justiina Roinkainen, Toby Mansell, Tuija Mikkola, Binisha Mishra, Rama Wahab, Tim Cadman, Tiffany Yang, David Burgner, Johan G. Eriksson, Marjo-Riitta Järvelin, Romy Gaillard, Vincent W V Jaddoe, Terho Lehtimäki, Olli T Raitakari, Richard Saffrey, Melissa Wake, John Wright, Sylvain P Sebert, Deborah A Lawlor
Publié dans: BMC Medicine, Numéro 21(23), 2023, ISSN 1741-7015
Éditeur: BioMed Central
DOI: 10.1101/2022.04.05.22273388

Depression, cardiometabolic disease, and their co-occurrence after childhood maltreatment: an individual participant data meta-analysis including over 200,000 participants

Auteurs: Camille Souama, Femke Lamers, Yuri Milaneschi, Christiaan H. Vinkers, Serena Defina, Linda Garvert, Frederike Stein, Tom Woofenden, Katharina Brosch, Udo Dannlowski, Henrike Galenkamp, Ron de Graaf, Vincent W. V. Jaddoe, Anja Lok, Bas B. van Rijn, Henry Völzke, Charlotte A. M. Cecil, Janine F. Felix, Hans J. Grabe, Tilo Kircher, Karim Lekadir, Margreet ten Have, Esther Walton & Brenda W. J. H. Pe
Publié dans: BMC Medicine, Numéro 21 (93), 2023, ISSN 1741-7015
Éditeur: BioMed Central
DOI: 10.1186/s12916-023-02769-y

Fetal and childhood exposure to parental tobacco smoking and arterial health at age 10 years

Auteurs: Giulietta S Monasso, Janine F Felix, Romy Gaillard, Vincent W V Jaddoe
Publié dans: American Journal of Hypertension, Numéro 35(10), 2022, Page(s) 867-874, ISSN 1941-7225
Éditeur: Oxford University Press
DOI: 10.1093/ajh/hpac084

Maternal Glycemic Dysregulation During Pregnancy and Neonatal Blood DNA Methylation: Meta-analyses of Epigenome-Wide Association Studies

Auteurs: Elmar W. Tobi; Diana L. Juvinao-Quintero; Justiina Ronkainen; Raffael Ott; Rossella Alfano; Mickaël Canouil; Madelon L. Geurtsen; Amna Khamis; Leanne K. Küpers; Ives Y. Lim; Patrice Perron; Giancarlo Pesce; Johanna Tuhkanen; Anne P. Starling; Toby Andrew; Elisabeth Binder; Robert Caiazzo; Jerry K.Y. Chan; Romy Gaillard; Peter D. Gluckman; Elina Keikkala; Neerja Karnani; Sanna Mustaniemi; Tim S.
Publié dans: Diabetes Care, Numéro 6, 2022, ISSN 0149-5992
Éditeur: American Diabetes Association
DOI: 10.2337/dc21-1701

Sex-specific effects of prenatal undernutrition on resting-state functional connectivity in the human brain at age 68

Auteurs: AmberBoot, Moriah E.Thomason, Claudia Espinoza-Heredia, Patrick J.Pruitt, Jessica S.Damoiseaux, Tessa J.Roseboom, Susanne R.de Rooij
Publié dans: Neurobiology of Aging, Numéro 112, 2022, Page(s) 129-138, ISSN 0197-4580
Éditeur: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2022.01.003

A framework for assessing selection and misclassification bias in Mendelian randomization studies: An illustrative example between body mass index and COVID-19

Auteurs: Gemma L Clayton, Ana Gonçalves Soares, Neil Goulding, Maria Carolina Borges, Michael V Holmes, George Davey Smith, Kate Tilling, Deborah A Lawlor, Alice R Carter
Publié dans: BMJ, Numéro 381:e072148, 2023, ISSN 2044-6055
Éditeur: BMJ Publishing Group
DOI: 10.1136/bmj-2022-072148

Maternal Dietary Glycemic Index and Glycemic Load in Pregnancy and Offspring Cord Blood DNA Methylation

Auteurs: Leanne K. Küpers; Sílvia Fernández-Barrés; Giulia Mancano; Laura Johnson; Raffael Ott; Jesus Vioque; Marco Colombo; Kathrin Landgraf; Elmar W. Tobi; Antje Körner; Romy Gaillard; Jeanne H.M. de Vries; Vincent W.V. Jaddoe; Martine Vrijheid; Gemma C. Sharp; Janine F. Felix
Publié dans: Diabetes Care, 2022, ISSN 0149-5992
Éditeur: American Diabetes Association
DOI: 10.2337/dc21-2662

Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

Auteurs: Vasiliki Lagou, Reedik Mägi, Jouke- Jan Hottenga, Harald Grallert, John R. B. Perry, Nabila Bouatia-Naji, Letizia Marullo, Denis Rybin, Rick Jansen, Josine L. Min, Antigone S. Dimas, Anna Ulrich, Liudmila Zudina, Jesper R. Gådin, Longda Jiang, Alessia Faggian, Amélie Bonnefond, Joao Fadista, Maria G. Stathopoulou, Aaron Isaacs, Sara M. Willems, Pau Navarro, Toshiko Tanaka, Anne U. Jackson, May
Publié dans: Nature Communications, Numéro 12/1, 2021, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-020-19366-9

Genetic Correlation and Causal Relationships between Cardio-Metabolic Traits and Lung Function Impairment

Auteurs: Matthias Wielscher; Andre F.S. Amaral; Diana A van der Plaat; Louise V. Wain; Louise V. Wain; Sylvain Sebert; David Mosen-Ansorena; Juha Auvinen; Karl-Heinz Herzig; Karl-Heinz Herzig; Karl-Heinz Herzig; Abbas Dehghan; Deborah Jarvis; Marjo-Riitta Järvelin
Publié dans: Genome Medicine, Numéro 13(104), 2021, ISSN 1756-994X
Éditeur: BioMed Central
DOI: 10.2139/ssrn.3566256

Early exposure to social disadvantages and later life body mass index beyond genetic predisposition in three generations of Finnish birth cohorts

Auteurs: Estelle Lowry, Nina Rautio, Niko Wasenius, Tom A. Bond, Jari Lahti, Ioanna Tzoulaki, Abbas Dehghan, Anni Heiskala, Leena Ala-Mursula, Jouko Miettunen, Johan Eriksson, Marjo-Riitta Järvelin, Sylvain Sebert
Publié dans: BMC Public Health, Numéro 20/1, 2020, ISSN 1471-2458
Éditeur: BioMed Central
DOI: 10.1186/s12889-020-08763-w

Vitamin B12, folate and homocysteine concentrations during pregnancy and early signs of atherosclerosis at school-age

Auteurs: Giulietta S. Monasso, Janine F. Felix, Sandra G. Heil, Yolanda B. de Rijke, Romy Gaillard, Vincent W.V. Jaddoe
Publié dans: Clinical Nutrition, Numéro 40(9), 2021, Page(s) 5133-5140, ISSN 0346-251X
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.clnu.2021.08.001

Machine Learning-Based DNA Methylation Score for Fetal Exposure to Maternal Smoking: Development and Validation in Samples Collected from Adolescents and Adults

Auteurs: Sebastian Rauschert, Phillip E. Melton, Anni Heiskala, Ville Karhunen, Graham Burdge, Jeffrey M. Craig, Keith M. Godfrey, Karen Lillycrop, Trevor A. Mori, Lawrence J. Beilin, Wendy H. Oddy, Craig Pennell, Marjo-Riitta Järvelin, Sylvain Sebert, Rae-Chi Huang
Publié dans: Environmental Health Perspectives, Numéro 128/9, 2020, Page(s) 097003, ISSN 0091-6765
Éditeur: US Department of Health and Human Services
DOI: 10.1289/ehp6076

Cardiovascular Health at Age 5 Years: Distribution, Determinants, and Association With Neurodevelopment

Auteurs: Rachel E. Climie*, Muriel Tafflet, Thomas van Sloten, Blandine de Lauzon-Guillain, Jonathan Y. Bernard, Patricia Dargent-Molina, Sabine Plancoulaine, Sandrine Lioret, Xavier Jouven, Marie-Alines Charles, Barbara Heude and Jean-Philippe Empana
Publié dans: Frontiers in Pediatrics, 2022, ISSN 2296-2360
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fped.2022.827525

Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight

Auteurs: NCD Risk Factor Collaboration (NCD-RisC); Iurilli, Maria LC; Zhou, Bin; Bennett, James E; Carrillo-Larco, Rodrigo M; Sophiea, Marisa K; Rodriguez-Martinez, Andrea; Bixby, Honor; Solomon, Bethlehem D; Taddei, Cristina; Danaei, Goodarz; Di Cesare, Mariachiara; Stevens, Gretchen A; Riley, Leanne M; Savin, Stefan; Cowan, Melanie J; Bovet, Pascal; Damasceno, Albertino; Chirita-Emandi, Adela; Hayes, Ali
Publié dans: "eLife, eLife Sciences Publication, 2021, 10, ⟨10.7554/elife.60060⟩", Numéro 2, 2021, ISSN 2050-084X
Éditeur: eLife Sciences Publications
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Cohort profile: the Dutch famine birth cohort (DFBC)- a prospective birth cohort study in the Netherlands.

Auteurs: Bleker, Laura S; de Rooij, Susanne R; Painter, Rebecca C; Ravelli, Anita CJ; Roseboom, Tessa J
Publié dans: BMJ Open, Numéro 6, 2021, ISSN 2044-6055
Éditeur: BMJ Publishing Group
DOI: 10.1136/bmjopen-2020-042078

Dynamics of competing SARS-CoV-2 variants during the Omicron epidemic in England

Auteurs: Eales, O Martins, LDO Page, AJ Wang, H Bodinier, B Tang, D Haw, D Jonnerby, J Atchison, C Ashby, D Barclay, W Taylor, G Cooke, G Ward, H Darzi, A Riley, S Elliott, P Donnelly, CA Chadeau-Hyam, M
Publié dans: Nature Communications, Numéro 13 (4375), 2022, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-022-32096-4

Dynamics of a national Omicron SARS-CoV-2 epidemic during January 2022 in England

Auteurs: Paul Elliott; Oliver Eales; Barbara Bodinier; David Tang; Haowei Wang; Jakob Jonnerby; David Haw; Joshua Elliott; Matthew Whitaker; Caroline E. Walters; Christina Atchison; Peter J. Diggle; Andrew J. Page; Alexander J. Trotter; Deborah Ashby; Wendy Barclay; Graham Taylor; Helen Ward; Ara Darzi; Graham S. Cooke; Marc Chadeau-Hyam; Christl A. Donnelly
Publié dans: Nature Communications, Numéro 13(4500), 2022, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-022-32121-6

Abuse in childhood and cardiometabolic health in early adulthood: evidence from the Avon Longitudinal Study of Parents and Children

Auteurs: Ana Luiza Goncalves Soares, Annie Zimmerman, Stanley Zammit, Anke Karl, Sarah L Halligan, Abi Fraser
Publié dans: Journal of the American Heart Association, Numéro 10(24), 2021, Page(s) e021701, ISSN 2047-9980
Éditeur: Wiley-Blackwell
DOI: 10.1161/jaha.121.021701

How does childhood maltreatment influence cardiovascular disease? A sequential causal mediation analysis

Auteurs: Ana G Soares, Laura D Howe, Jon Heron, Gemma Hammerton, Janet Rich-Edwards, Maria C Magnus, Sarah L Halligan, Abigail Fraser
Publié dans: International Journal of Epidemiology, 2021, ISSN 0300-5771
Éditeur: Oxford University Press
DOI: 10.1093/ije/dyab085

Associations of circulating folate, vitamin B12 and homocysteine concentrations in early pregnancy and cord blood with epigenetic gestational age: the Generation R Study

Auteurs: Giulietta S. Monasso, Leanne K. Küpers, Vincent W. V. Jaddoe, Sandra G. Heil, Janine F. Felix
Publié dans: Clinical Epigenetics, Numéro 13/1, 2021, Page(s) 95, ISSN 1868-7075
Éditeur: Springer Verlag
DOI: 10.1186/s13148-021-01065-x

Omicron SARS-CoV-2 epidemic in England during February 2022: A series of cross-sectional community surveys

Auteurs: Chadeau-Hyam, M Tang, D Eales, O Bodinier, B Wang, H Jonnerby, J Whitaker, M Elliott, J Haw, D Walters, CE Atchison, C Diggle, PJ Page, AJ Ashby, D Barclay, W Taylor, G Cooke, G Ward, H Darzi, A Donnelly, CA Elliott, P
Publié dans: The Lancet Regional Health - Europe, Numéro 21, 2022, Page(s) 100462, ISSN 2666-7762
Éditeur: Elsevier Ltd
DOI: 10.1016/j.lanepe.2022.100462

Functional Effects In Silico Prediction for Androgen Receptor Ligand-Binding Domain Novel I836S Mutation

Auteurs: Alexey Rayevsky, Dmytro Sirokha, Dariia Samofalova, Dmytro Lozhko, Olexandra Gorodna, Inga Prokopenko, Liudmyla Livshits
Publié dans: Life, Numéro 11/7, 2021, Page(s) 659, ISSN 2075-1729
Éditeur: MDPI
DOI: 10.3390/life11070659

Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude

Auteurs: Latha Kadalayil, Md. Zahangir Alam, Cory Haley White, Akram Ghantous, Esther Walton, Olena Gruzieva, Simon Kebede Merid, Ashish Kumar, Ritu P. Roy, Olivia Solomon, Karen Huen, Brenda Eskenazi, Peter Rzehak, Veit Grote, Jean-Paul Langhendries, Elvira Verduci, Natalia Ferre, Darek Gruszfeld, Lu Gao, Weihua Guan, Xuehuo Zeng, Enrique F. Schisterman, John F. Dou, Kelly M. Bakulski, Jason I. Feinberg,
Publié dans: Clinical Epigenetics, Numéro 15(148), 2023, ISSN 1868-7083
Éditeur: BioMed Central Ltd
DOI: 10.1186/s13148-023-01542-5

Twin peaks: The Omicron SARS-CoV-2 BA.1 and BA.2 epidemics in England

Auteurs: PAUL ELLIOTT, OLIVER EALES, NICHOLAS STEYN, DAVID TANG, BARBARA BODINIER, HAOWEI WANG, JOSHUA ELLIOTT, MATTHEW WHITAKER, CHRISTINA ATCHISON, PETER J. DIGGLE, ANDREW J. PAGE, ALEXANDER J. TROTTER, DEBORAH ASHBY, WENDY BARCLAY, GRAHAM TAYLOR, HELEN WARD, ARA DARZI GRAHAM S. COOKE, CHRISTL A. DONNELLY, AND MARC CHADEAU-HYAM
Publié dans: Science, Numéro 376 (6600), 2022, ISSN 0036-8075
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/science.abq4411

Risk of Recurrent Pregnancy Loss in the Ukrainian Population Using a Combined Effect of Genetic Variants: A Case-Control Study

Auteurs: Eleni M. Loizidou, Anastasia Kucherenko, Pavlo Tatarskyy, Sergey Chernushyn, Ganna Livshyts, Roman Gulkovskyi, Iryna Vorobiova, Yurii Antipkin, Oleksandra Gorodna, Marika A. Kaakinen, Inga Prokopenko, Ludmila Livshits
Publié dans: Genes, Numéro 12/1, 2021, Page(s) 64, ISSN 2073-4425
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes12010064

MC3R links nutritional state to childhood growth and the timing of puberty

Auteurs: B. Y. H. Lam, A. Williamson, S. Finer, F. R. Day, J. A. Tadross, A. Gonçalves Soares, K. Wade, P. Sweeney, M. N. Bedenbaugh, D. T. Porter, A. Melvin, K. L. J. Ellacott, R. N. Lippert, S. Buller, J. Rosmaninho-Salgado, G. K. C. Dowsett, K. E. Ridley, Z. Xu, I. Cimino, D. Rimmington, K. Rainbow, K. Duckett, S. Holmqvist, A. Khan, Genes & Health Research Team, S. O’Rahilly
Publié dans: Nature, Numéro 599, 2021, Page(s) 436-441, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/s41586-021-04088-9

Bi-directional Mendelian randomization and multi-phenotype GWAS show causality and shared pathophysiology between depression and type 2 diabetes

Auteurs: Jared G Maina; Zhanna Balkhiyarova; Arie Nouwen; Igor Pupko; Anna Ulrich; Mathilde Boissel; Amélie Bonnefond; Philippe Froguel; Amna Khamis; Inga Prokopenko; Marika Kaakinen
Publié dans: Diabetes Care, Numéro 46(9), 2023, Page(s) 1707–1714, ISSN 0149-5992
Éditeur: American Diabetes Association
DOI: 10.1101/2022.12.06.22283143

Associations of PFAS-related plasma metabolites with cholesterol and triglyceride concentrations

Auteurs: T. Schillemans; I.A. Bergdahl; K. Hanhineva; L. Shi; C. Donat-Vargas; J. Koponen; H. Kiviranta; R. Landberg; A. Åkesson; C. Brunius
Publié dans: Environmental Research (0013-9351) vol.216(2023), Numéro 216(2), 2023, Page(s) 114570, ISSN 0013-9351
Éditeur: Academic Press
DOI: 10.1016/j.envres.2022.114570

COVID-19 mortality in the UK Biobank cohort: revisiting and evaluating risk factors

Auteurs: Joshua Elliott, Barbara Bodinier, Matthew Whitaker, Cyrille Delpierre, Roel Vermeulen, Ioanna Tzoulaki, Paul Elliott, Marc Chadeau-Hyam
Publié dans: European Journal of Epidemiology, Numéro 36/3, 2021, Page(s) 299-309, ISSN 0393-2990
Éditeur: Kluwer Academic Publishers
DOI: 10.1007/s10654-021-00722-y

Prenatal exposure to the Dutch famine is associated with more self-perceived cognitive problems at 72 years of age

Auteurs: Aline Marileen Wiegersma, Amber Boots, Tessa J. Roseboom & Susanne R. de Rooij
Publié dans: BMC Geriatrics, Numéro 22, 2022, Page(s) 176, ISSN 1471-2318
Éditeur: BioMed Central
DOI: 10.1186/s12877-022-02820-2

The determinants and longitudinal changes in vitamin D status in middle-age: a Northern Finland Birth Cohort 1966 study

Auteurs: Helmi Ikonen; Johanna Lumme; Jussi Seppälä; Jussi Seppälä; Paula Pesonen; Terhi Piltonen; Terhi Piltonen; Marjo-Riitta Järvelin; Karl-Heinz Herzig; Jouko Miettunen; Jouko Miettunen; Maarit Niinimäki; Maarit Niinimäki; Saranya Palaniswamy; Saranya Palaniswamy; Sylvain Sebert; Marja Ojaniemi; Marja Ojaniemi
Publié dans: European Journal of Nutrition, Numéro 60, 2021, Page(s) 4541–4553, ISSN 1436-6207
Éditeur: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00394-021-02606-z

Using linear and natural cubic splines, SITAR, and latent trajectory models to characterise nonlinear longitudinal growth trajectories in cohort studies

Auteurs: Ahmed Elhakeem; Rachael A. Hughes; Kate Tilling; Diana L. Cousminer; Diana L. Cousminer; Jackowski S; Jackowski S; Tim J Cole; Kwong Asf; Kwong Asf; Li Z; Li Z; Struan F.A. Grant; Baxter-Jones A; Babette S. Zemel; Babette S. Zemel; Debbie A Lawlor
Publié dans: BMC Medical Research Methodology, Numéro 68, 2022, ISSN 1471-2288
Éditeur: BioMed Central
DOI: 10.1186/s12874-022-01542-8

Epigenome-wide change and variation in DNA methylation in childhood: trajectories from birth to late adolescence

Auteurs: Rosa H Mulder, Alexander Neumann, Charlotte A M Cecil, Esther Walton, Lotte C Houtepen, Andrew J Simpkin, Jolien Rijlaarsdam, Bastiaan T Heijmans, Tom R Gaunt, Janine F Felix, Vincent W V Jaddoe, Marian J Bakermans-Kranenburg, Henning Tiemeier, Caroline L Relton, Marinus H van IJzendoorn, Matthew Suderman
Publié dans: Human Molecular Genetics, Numéro 30/1, 2021, Page(s) 119-134, ISSN 0964-6906
Éditeur: Oxford University Press
DOI: 10.1093/hmg/ddaa280

Effects of Pre- and Postnatal Early-Life Stress on Internalizing, Adiposity and Their Comorbidity

Auteurs: Serena Defina, MSc Tom Woofenden, MSc Vilte Baltramonaityte, MSc Carmine M. Pariante, MD, PhD Karim Lekadir, PhD Vincent W.V. Jaddoe, PhD Fadila Serdarevic, MD, PhD Henning Tiemeier, MD, PhD Esther Walton, PhD Janine F. Felix, PhD Charlotte A.M. Cecil, PhD on behalf of theEarlyCause Consortium
Publié dans: Journal of the American Academy of Child & Adolescent Psychiatry, 2023, ISSN 0890-8567
Éditeur: Elsevier BV
DOI: 10.1016/j.jaac.2023.05.034

Epigenome-wide meta-analysis of prenatal maternal stressful life events and newborn DNA methylation

Auteurs: Anna Kotsakis Ruehlmann, Sara Sammallahti, Andrea P. Cortés Hidalgo, Kelly M. Bakulski, Elisabeth B. Binder, Megan Loraine Campbell, Doretta Caramaschi, Charlotte A.M. Cecil, Elena Colicino, Cristiana Cruceanu, Darina Czamara, Linda Dieckmann, John Dou, Janine F. Felix, Josef Frank, Siri E. Håberg, Gunda Herberth, Thanh T. Hoang, Lotte C. Houtepen, Anke HülsNastassja Koen, Stephanie J. London,
Publié dans: Molecular Psychiatry, 2023, ISSN 1359-4184
Éditeur: Nature Publishing Group
DOI: 10.1038/s41380-023-02010-5

Epigenetic age acceleration and cardiovascular outcomes in school-age children: The Generation R Study.

Auteurs: Giulietta S Monasso; Vincent W. V. Jaddoe; Leanne K. Küpers; Leanne K. Küpers; Janine F. Felix
Publié dans: Clinical Epigenetics, Numéro 13(1), 2021, Page(s) 205, ISSN 1868-7083
Éditeur: BioMed Central Ltd
DOI: 10.1186/s13148-021-01193-4

Polycystic ovary syndrome and leukocyte telomere length:cross-sectional and longitudinal changes

Auteurs: Pölönen, J. (Johanna); Pinola, P. (Pekka); Ronkainen, J. (Justiina); Blakemore, A. I. (Alex I.); Buxton, J. L. (Jessica L.); Tapanainen, J. S. (Juha S.); Franks, S. (Stephen); Piltonen, T. T. (Terhi T.); Sebert, S. (Sylvain); Morin-Papunen, L. (Laure)
Publié dans: European Journal of Endocrinology, Numéro 187(5), 2022, Page(s) 651-661, ISSN 0804-4643
Éditeur: BioScientifica Ltd.
DOI: 10.1530/eje-22-0462

Plasma metabolites associated with exposure to perfluoroalkyl substances and risk of type 2 diabetes – A nested case-control study

Auteurs: Tessa Schillemans, Lin Shi, Carolina Donat-Vargas, Kati Hanhineva, Andreas Tornevi, Ingegerd Johansson, Jani Koponen, Hannu Kiviranta, Olov Rolandsson, Ingvar A. Bergdahl, Rikard Landberg, Agneta Åkesson, Carl Brunius
Publié dans: Environment International, Numéro 146, 2021, Page(s) 106180, ISSN 0160-4120
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2020.106180

Harnessing Microbes for Sustainable Development: Food Fermentation as a Tool for Improving the Nutritional Quality of Alternative Protein Sources

Auteurs: Anna Kårlund, Carlos Gómez-Gallego, Jenni Korhonen, Outi-Maaria Palo-oja, Hani El-Nezami, Marjukka Kolehmainen
Publié dans: Nutrients, Numéro 12/4, 2020, Page(s) 1020, ISSN 2072-6643
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu12041020

Keeping it in the family: Consanguinity reveals P4HTM as a novel syndromic obesity gene

Auteurs: Janine F. Felix and Struan F.A. Grant
Publié dans: Diabetes, Numéro 72(9), 2023, Page(s) 1184–1186, ISSN 0012-1797
Éditeur: American Diabetes Association
DOI: 10.2337/dbi23-0010

Fetal exposure to phthalates and bisphenols and DNA methylation at birth: the Generation R Study

Auteurs: Chalana M. Sol, Abigail Gaylord, Susana Santos, Vincent W. V. Jaddoe, Janine F. Felix & Leonardo Trasande
Publié dans: Clinical Epigenetics, Numéro 14(125), 2022, ISSN 1868-7083
Éditeur: BioMed Central
DOI: 10.1186/s13148-022-01345-0

A meta-analysis of epigenome-wide association studies on pregnancy vitamin B12 concentrations and offspring DNA methylation

Auteurs: Giulietta S. Monasso,Thanh T. Hoang, Giulia Mancano, Sílvia Fernández-Barrés,John Dou, Vincent W.V. Jaddoe, Christian M. Page,Laura Johnson, Mariona Bustamante, Kelly M. Bakulski, Siri E. Håberg, Per M. Ueland, Thomas Battram, Simon K. Merid, Erik Melén, Doretta Caramaschi, Leanne K. Küpers, Jordi Sunyer, Wenche Nystad, Sandra G. Heil, Rebecca J. Schmidt, Martine Vrijheid, Gemma C. Sharp,Ste
Publié dans: Epigenetics, 2023, ISSN 1559-2308
Éditeur: Taylor & Francis
DOI: 10.1080/15592294.2023.2202835

Metabolic profiles of socio-economic position: a multi-cohort analysis

Auteurs: Oliver Robinson; Alice R Carter; Mika Ala-Korpela; Juan P Casas; Juan P Casas; Nishi Chaturvedi; Jorgen Engmann; Laura D Howe; Alun D. Hughes; Marjo-Riitta Järvelin; Mika Kähönen; Ville Karhunen; Diana Kuh; Tina Shah; Yoav Ben-Shlomo; Reecha Sofat; Chung-Ho E Lau; Terho Lehtimäki; Usha Menon; Olli T. Raitakari; Olli T. Raitakari; Andy Ryan; Rui Providência; Stephanie Smith; Julie Taylor; Ther
Publié dans: Robinson , O , Carter , A R , Ala-Korpela , M , Casas , J P , Chaturvedi , N , Engmann , J , Howe , L D , Hughes , A D , Järvelin , M-R , Kähönen , M , Karhunen , V , Kuh , D , Shah , T , Ben-Shlomo , Y , Sofat , R , Lau , C-H E , Lehtimäki , T , Menon , U , Raitakari , O , Ryan , A , Providencia , R , Smith , S , Taylor , J , Tillin , T , Viikari , J , Wong , A , Hingorani , A D , Kivimaki ,, Numéro 50(3), 2021, Page(s) 768-782, ISSN 0300-5771
Éditeur: Oxford University Press
DOI: 10.1093/ije/dyaa188

Epigenome-Wide Association Study Reveals Methylation Loci Associated With Offspring Gestational Diabetes Mellitus Exposure and Maternal Methylome

Auteurs: Mickaël Canouil; Amna Khamis; Elina Keikkala; Sandra Hummel; Stephane Lobbens; Amélie Bonnefond; Fabien Delahaye; Evangelia Tzala; Sanna Mustaniemi; Marja Vääräsmäki; Marjo-Riitta Jarvelin; Sylvain Sebert; Eero Kajantie; Philippe Froguel; Toby Andrew
Publié dans: Diabetes Care, Numéro 44(9), 2021, Page(s) 1992-1999, ISSN 0149-5992
Éditeur: American Diabetes Association
DOI: 10.2337/dc20-2960

The relationship of life-course patterns of adiposity with type 2 diabetes, depression, and their comorbidity in the Northern Finland Birth Cohort 1966

Auteurs: Priyanka Choudhary; Justiina Ronkainen; Rozenn Nedelec; Mimmi Tolvanen; Estelle Lowry; Jouko Miettunen; Marjo-Riitta Jarvelin; Sylvain Sebert
Publié dans: Choudhary , P , Ronkainen , J , Nedelec , R , Tolvanen , M , Lowry , E , Jarvelin , M-R & Sebert , S 2022 , ' The relationship of life-course patterns of adiposity with type 2 diabetes, depression, and their comorbidity in the Northern Finland Birth Cohort 1966 ' , International Journal of Obesity . https://doi.org/10.1038/s41366-022-01134-y, Numéro 4, 2022, ISSN 0307-0565
Éditeur: Nature Publishing Group
DOI: 10.1038/s41366-022-01134-y

Towards early risk biomarkers:serum metabolic signature in childhood predicts cardio-metabolic risk in adulthood

Auteurs: Ojanen, X. (Xiaowei); Cheng, R. (Runtan); Törmäkangas, T. (Timo); Rappaport, N. (Noa); Wilmanski, T. (Tomasz); Wu, N. (Na); Fung, E. (Erik); Nedelec, R. (Rozenn); Sebert, S. (Sylvain); Vlachopoulos, D. (Dimitris); Yan, W. (Wei); Price, N. D. (Nathan D.); Cheng, S. (Sulin); Wiklund, P. (Petri)
Publié dans: eBioMedicine, Numéro 72(103611), 2021, ISSN 2352-3964
Éditeur: Elsevier BV
DOI: 10.1016/j.ebiom.2021.103611

Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation

Auteurs: Olivia Solomon; Karen Huen; Paul Yousefi; Leanne K. Küpers; Juan R. González; Matthew Suderman; Sarah E. Reese; Christian M. Page; Olena Gruzieva; Peter Rzehak; Lu Gao; Kelly M. Bakulski; Alexei Novoloaca; Catherine Allard; Irene Pappa; Maria Llambrich; Marta Vives; Dereje D. Jima; Tuomas Kvist; Andrea Baccarelli; Cory White; Faisal I. Rezwan; Gemma C. Sharp; Gwen Tindula; Anna Bergström; Veit
Publié dans: Mutation Research/Reviews in Mutation Research, Numéro 789, 2022, ISSN 1383-5742
Éditeur: Elsevier BV
DOI: 10.1016/j.mrrev.2022.108415

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