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Human Gonad Developmental Cell Atlas

Project description

Cell atlas of human gonad development and sex determination

The ultimate goal of the EU-funded HUGODECA project is to describe cellular organisation and the development of human gonads for better understanding of the mechanisms that trigger differentiation and divergence during sex determination into testes in males and ovaries in females. The project consortium involves leading academic and industrial experts from five EU countries, including active contributors and executives of the Human Cell Atlas initiative. The research will implement novel tools and analytical and computational methods, including single-cell profiling, spatial transcriptomics, 2D mass cytometry and cyclic immunofluorescence, and 3D imaging of optically cleared gonads to process and integrate data across different platforms. The project will be focused on the development of healthy gonadal development in ex vivo culture models and will assess consequences of altering key signalling pathways mimicking disorders of sex development.

Call for proposal

H2020-SC1-BHC-2018-2020

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Sub call

H2020-SC1-2019-Single-Stage-RTD

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Net EU contribution
€ 1 886 998,00
Address
Rue De Tolbiac 101
75654 Paris
France

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,75

Participants (9)

KUNGLIGA TEKNISKA HOEGSKOLAN
Sweden
Net EU contribution
€ 204 952,00
Address
Brinellvagen 8
100 44 Stockholm

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Region
Östra Sverige Stockholm Stockholms län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,50
STOCKHOLMS UNIVERSITET
Sweden
Net EU contribution
€ 527 307,50
Address
Universitetsvagen 10
10691 Stockholm

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Region
Östra Sverige Stockholm Stockholms län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
REGION HOVEDSTADEN
Denmark
Net EU contribution
€ 402 800,00
Address
Kongens Vaenge 2
3400 Hillerod

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Region
Danmark Hovedstaden Nordsjælland
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,00
GENOME RESEARCH LIMITED
United Kingdom
Net EU contribution
€ 725 810,00
Address
The Gibbs Building, Euston Road 215
NW1 2BE London

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Region
London Inner London — West Camden and City of London
Activity type
Research Organisations
Non-EU contribution
€ 0,00
INSERM TRANSFERT SA
France
Net EU contribution
€ 309 200,00
Address
Rue Watt 7
75013 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
KEEN EYE TECHNOLOGIES
France
Net EU contribution
€ 488 750,00
Address
74 Rue Du Faubourg Saint Antoine Incubateur Instit De La Vision
75012 Paris

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Ile-de-France Ile-de-France Val-de-Marne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
CARTANA AB

Participation ended

Sweden
Net EU contribution
€ 33 567,50
Address
Nobels Vag 3
171 65 Solna

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Östra Sverige Stockholm Stockholms län
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
MILTENYI BIOTEC GMBH

Participation ended

Germany
Net EU contribution
€ 0,00
Address
Friedrich Ebert Strasse 68
51429 Bergish Gladbach

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Region
Nordrhein-Westfalen Köln Rheinisch-Bergischer Kreis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
MILTENYI BIOTEC BV & CO KG
Germany
Net EU contribution
€ 242 812,00
Address
Friedrich Ebert Strasse 68
51429 Bergisch Gladbach

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Region
Nordrhein-Westfalen Köln Rheinisch-Bergischer Kreis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,50