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Human Gonad Developmental Cell Atlas

Project description

Cell atlas of human gonad development and sex determination

The ultimate goal of the EU-funded HUGODECA project is to describe cellular organisation and the development of human gonads for better understanding of the mechanisms that trigger differentiation and divergence during sex determination into testes in males and ovaries in females. The project consortium involves leading academic and industrial experts from five EU countries, including active contributors and executives of the Human Cell Atlas initiative. The research will implement novel tools and analytical and computational methods, including single-cell profiling, spatial transcriptomics, 2D mass cytometry and cyclic immunofluorescence, and 3D imaging of optically cleared gonads to process and integrate data across different platforms. The project will be focused on the development of healthy gonadal development in ex vivo culture models and will assess consequences of altering key signalling pathways mimicking disorders of sex development.

Call for proposal

H2020-SC1-2019-Single-Stage-RTD
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Funding Scheme

RIA - Research and Innovation action

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Address
Rue De Tolbiac 101
75654 Paris
France
Activity type
Research Organisations
EU contribution
€ 1 820 748

Participants (9)

KUNGLIGA TEKNISKA HOEGSKOLAN
Sweden
EU contribution
€ 204 952
Address
Brinellvagen 8
100 44 Stockholm
Activity type
Higher or Secondary Education Establishments
STOCKHOLMS UNIVERSITET
Sweden
EU contribution
€ 354 625
Address
Universitetsvagen 10
10691 Stockholm
Activity type
Higher or Secondary Education Establishments
REGION HOVEDSTADEN
Denmark
EU contribution
€ 402 800
Address
Kongens Vaenge 2
3400 Hillerod
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
GENOME RESEARCH LIMITED
United Kingdom
EU contribution
€ 725 810
Address
The Gibbs Building, Euston Road 215
NW1 2BE London
Activity type
Research Organisations
INSERM TRANSFERT SA
France
EU contribution
€ 320 450
Address
Rue Watt 7
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
KEEN EYE TECHNOLOGIES
France
EU contribution
€ 543 750
Address
74 Rue Du Faubourg Saint Antoine Incubateur Instit De La Vision
75012 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CARTANA AB
Sweden
EU contribution
€ 206 250
Address
Nobels Vag 3
171 65 Solna
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MILTENYI BIOTEC GMBH

Participation ended

Germany
EU contribution
€ 0
Address
Friedrich Ebert Strasse 68
51429 Bergish Gladbach
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MILTENYI BIOTEC BV & CO KG
Germany
EU contribution
€ 242 812
Address
Friedrich Ebert Strasse 68
51429 Bergisch Gladbach
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)