Human Gonad Developmental Cell Atlas

Información del proyecto

HUGODECA

Identificador del acuerdo de subvención: 874741

DOI 10.3030/874741

Proyecto cerrado

Fecha de la firma de la CE 24 Noviembre 2019

Fecha de inicio 1 Enero 2020

Fecha de finalización 30 Junio 2022

Financiado con arreglo a

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coste total € 4 822 198,75

Aportación de la UE € 4 822 197,00

Coordinado por

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

Resultado final

Documents, reports (11)

Profiling with NanoString WTA technology

A data set containing spatial coordinates of germ and somatic cells

3D gonad cell maps

A 3D spatial map of gonadal cells in male and female human embryos

2D ST gonad data set

A data set containing gene expression matrices linked to their spatial positions within Hematoxylin and Eosin HE stained developmental gonad tissue sections

2D ISS gonad data set

A data set containing gene expression images in human developmental gonad tissue sections

3D integrated image data

3D image datasets integrated in 3D models of whole developmental gonads

2D gonad cell map

A 2D ultrahigh content cellular and protein expression map of gonadal cells in male and female human embryos

Imaging mass cytometry analysis of developing gonads

Imaging mass data of human gonads during sex determination

3D integrated spatial OMICS data

Spatial OMICS data sets integrated in 3D models of whole developmental gonads

ISS profiling in cleared tissues

Protocols for generating spatial ISS expression data in optically cleared tissues

Integration of spatial and scRNA/scATAC-seq data

Computational integration of spatial and scRNAATACseq datasets

ST profiling in cleared tissues

Protocols for generating ST expression data in optically cleared tissues

Websites, patent fillings, videos etc. (1)

The HUGODECA web-portal

A centralized web-resource to provide access to multi-omics data from the HUGODECA project

Other (3)

Communication and Dissemination tools

This deliverable is composed of: the web site, the graphic charter, the project leaflet.

Final public symposium on sex determination differences, human reproduction and gender
Training courses on Spatial transcriptomics and 3D imaging/tissue clearing

Publicaciones

Peer reviewed articles (2)

Deciphering Sex-Specific Differentiation of Human Fetal Gonads: Insight From Experimental Models

Autores: Malene Lundgaard Riis, Anne Jørgensen
Publicado en: Frontiers in Cell and Developmental Biology, Edición 2296634x, 2022, ISSN 2296-634x
Editor: Frontiers in Cell and Developmental Biology
DOI: 10.3389/fcell.2022.902082

Single-cell roadmap of human gonadal development

Autores: Luz Garcia-Alonso, Valentina Lorenzi, Cecilia Icoresi Mazzeo, João Pedro Alves-Lopes, Kenny Roberts, Carmen Sancho-Serra, Justin Engelbert, Magda Marečková, Wolfram H Gruhn, Rachel A Botting, Tong Li, Berta Crespo, Stijn van Dongen , Vladimir Kiselev, Elena Prigmore, Mary Herbert, Ashley Moffett, Alain Chedotal, Omer Ali Bayraktar, Azim Surani, Muzlifah Haniffa, Roser Vento-Tormo
Publicado en: Nature, Edición 14764687, 2022, ISSN 1476-4687
Editor: Nature
DOI: 10.1038/s41586-022-04918-4