Human Gonad Developmental Cell Atlas

Livrables

Profiling with NanoString WTA technology

A data set containing spatial coordinates of germ and somatic cells

A 3D spatial map of gonadal cells in male and female human embryos

A data set containing gene expression matrices linked to their spatial positions within Hematoxylin and Eosin HE stained developmental gonad tissue sections

2D ISS gonad data set

A data set containing gene expression images in human developmental gonad tissue sections

3D integrated image data

3D image datasets integrated in 3D models of whole developmental gonads

2D gonad cell map

A 2D ultrahigh content cellular and protein expression map of gonadal cells in male and female human embryos

Imaging mass cytometry analysis of developing gonads

Imaging mass data of human gonads during sex determination

3D integrated spatial OMICS data

Spatial OMICS data sets integrated in 3D models of whole developmental gonads

ISS profiling in cleared tissues

Protocols for generating spatial ISS expression data in optically cleared tissues

Integration of spatial and scRNA/scATAC-seq data

Computational integration of spatial and scRNAATACseq datasets

ST profiling in cleared tissues

Protocols for generating ST expression data in optically cleared tissues

The HUGODECA web-portal

A centralized web-resource to provide access to multi-omics data from the HUGODECA project

Communication and Dissemination tools

This deliverable is composed of: the web site, the graphic charter, the project leaflet.

Final public symposium on sex determination differences, human reproduction and gender
Training courses on Spatial transcriptomics and 3D imaging/tissue clearing

Publications

Deciphering Sex-Specific Differentiation of Human Fetal Gonads: Insight From Experimental Models

Auteurs: Malene Lundgaard Riis, Anne Jørgensen
Publié dans: Frontiers in Cell and Developmental Biology, Numéro 2296634x, 2022, ISSN 2296-634x
Éditeur: Frontiers in Cell and Developmental Biology
DOI: 10.3389/fcell.2022.902082

Single-cell roadmap of human gonadal development

Auteurs: Luz Garcia-Alonso, Valentina Lorenzi, Cecilia Icoresi Mazzeo, João Pedro Alves-Lopes, Kenny Roberts, Carmen Sancho-Serra, Justin Engelbert, Magda Marečková, Wolfram H Gruhn, Rachel A Botting, Tong Li, Berta Crespo, Stijn van Dongen , Vladimir Kiselev, Elena Prigmore, Mary Herbert, Ashley Moffett, Alain Chedotal, Omer Ali Bayraktar, Azim Surani, Muzlifah Haniffa, Roser Vento-Tormo
Publié dans: Nature, Numéro 14764687, 2022, ISSN 1476-4687
Éditeur: Nature
DOI: 10.1038/s41586-022-04918-4

Livrables

Publications

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