New-generation cardiac therapeutic strategies directed to the activation of endogenous regenerative mechanisms

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A new human in vitro cardiac injury model for the evaluation of endogenous repair mechanisms, cell competition and proproliferative interventions

A new human in vitro cardiac injury model for the evaluation of endogenous repairmechanisms cell competition and proproliferative interventions

Results on rhAg efficacy and safety in pig model of ischemia-reperfusion

Publications

Gene editing for cardiomyopathy takes a step forward

Auteurs: M Giacca
Publié dans: Oxford Academic, 2022, ISSN 1348-0634
Éditeur: OUP
DOI: 10.1093/cvr/cvac164

Transcriptomic data meta-analysis reveals common and injury model specific gene expression changes in the regenerating zebrafish heart

Auteurs: Marius Alexandru Botos; Prateek Arora; Panagiotis Chouvardas; Nadia Mercader
Publié dans: Botos, Marius Alexandru; Arora, Prateek; Chouvardas, Panagiotis; Mercader, Nadia (2023). Transcriptomic data meta-analysis reveals common and injury model specific gene expression changes in the regenerating zebrafish heart. Scientific Reports, 13(1), p. 5418. Nature Publishing Group 10.1038/s41598-023-32272-6 <http://dx.doi.org/10.1038/s41598-023-32272-6>, Numéro 11, 2023, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-023-32272-6

Cardioprotective factors against myocardial infarction selected in vivo from an AAV secretome library

Auteurs: Giulia Ruozi https://orcid.org/0000-0001-5005-6887, Francesca Bortolotti https://orcid.org/0000-0002-3014-6989, Antonio Mura https://orcid.org/0000-0002-3872-9118, Mateusz Tomczyk, Antonella Falcione, Valentina Martinelli, Simone Vodret, Luca Braga https://orcid.org/0000-0002-9827-6755, Matteo Dal Ferro https://orcid.org/0000-0002-2310-0448, Antonio Cannatà https://orcid.org/0000-0001-7609-6297,
Publié dans: Science Translational Medicine, 2022, ISSN 2673-8937
Éditeur: Science Translational Medicine
DOI: 10.1126/scitranslmed.abo0699

Cardiomyocyte proliferation is suppressed by ARID1A-mediated YAP inhibition during cardiac maturation

Auteurs: Cornelis J. Boogerd, Ilaria Perini, Eirini Kyriakopoulou, Su Ji Han, Phit La, Britt van der Swaan, Jari B. Berkhout, Danielle Versteeg, Jantine Monshouwer-Kloots & Eva van Rooij
Publié dans: Nature Communications volume 14, Article number: 4716 (2023), 2023, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-023-40203-2

Regulation of endogenous cardiomyocyte proliferation: The known unknowns

Auteurs: Ilaria Secco, Mauro Giacca
Publié dans: Journal of Molecular and Cellular Cardiology, Numéro 179, 2023, Page(s) 80-89, ISSN 0022-2828
Éditeur: Academic Press
DOI: 10.1016/j.yjmcc.2023.04.001

High-throughput methods to help understand heart disease

Auteurs: Martijn Wehrens, Louk T. Timmer and Eva van Rooij
Publié dans: Nature Cardiovascular Research volume 1, pages 798–799 (2022), 2022, ISSN 2731-0590
Éditeur: Nature Cardiovascular Research
DOI: 10.1038/s44161-022-00126-5

Identification of FDA-approved drugs that induce heart regeneration in mammals

Auteurs: Mahmoud Salama Ahmed, Ngoc Uyen Nhi Nguyen, Yuji Nakada, Ching-Cheng Hsu, Ayman Farag, Nicholas T. Lam, Ping Wang, Suwannee Thet, Ivan Menendez-Montes, Waleed M. Elhelaly, Xi Lou, Ilaria Secco, Mateusz Tomczyk, Lorena Zentilin, Jimin Pei, Miao Cui, Matthieu Dos Santos, Xiaoye Liu, Yan Liu, David Zaha, Gregory Walcott, Diana R. Tomchick, Chao Xing, Cheng Cheng Zhang, Nick V. Grishin, Mauro Giacca,
Publié dans: Nature Cardiovascular, 2024, ISSN 2731-0590
Éditeur: Nature Cardiovascular Research
DOI: 10.1038/s44161-024-00450-y

Hypoxia to Stimulate Cardiomyocyte Proliferation After MI? A Word of Caution

Auteurs: Thomas Eschenhagen
Publié dans: Circulation Research, Numéro 132, 2023, Page(s) 741-743, ISSN 0009-7330
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.123.322553

P53 and BCL-2 family proteins PUMA and NOXA define competitive fitness in pluripotent cell competition

Auteurs: Jose A Valverde-Lopez 1, Lin Li-Bao 1, Rocío Sierra 1 2, Elisa Santos 3, Giovanna Giovinazzo 2 3, Covadonga Díaz-Díaz 1 2, Miguel Torres 1 2
Publié dans: Public Library of Science, 2024, ISSN 1553-7390
Éditeur: Public Library of Science
DOI: 10.1371/journal.pgen.1011193

Therapeutic efficacy of AAV-mediated restoration of PKP2 in arrhythmogenic cardiomyopathy

Auteurs: Eirini Kyriakopoulou, Danielle Versteeg, Hesther de Ruiter, Ilaria Perini, Fitzwilliam Seibertz, Yannic Döring, Lorena Zentilin, Hoyee Tsui, Sebastiaan J. van Kampen, Malte Tiburcy, Tim Meyer, Niels Voigt, van J. Peter Tintelen, Wolfram H. Zimmermann, Mauro Giacca & Eva van Rooij
Publié dans: Nature Cardiovascular, 2024, ISSN 2731-0590
Éditeur: Nature Cardiovascular Research
DOI: 10.1038/s44161-023-00378-9

SARS-CoV-2 infection boosts inflammation in atherosclerotic plaques

Auteurs: Mauro Giacca
Publié dans: Nature Cardiovascular Research, 2023, ISSN 2731-0590
Éditeur: Nature Cardiovascular Research
DOI: 10.1038/s44161-023-00358-z

Cardiomyocyte-Specific Wt1 Is Involved in Cardiac Metabolism and Response to Damage

Auteurs: Sandra Díaz del Moral; Maha Benaouicha; Cristina Villa del Campo; Miguel Torres; Nicole Wagner; Kay-Dietrich Wagner; Ramón Muñoz-Chápuli; Rita Carmona
Publié dans: Journal of Cardiovascular Development and Disease, Vol 10, Iss 5, p 211 (2023), Numéro 1, 2023, ISSN 2731-0590
Éditeur: Nature Cardiovascular
DOI: 10.3390/jcdd10050211

Fulfilling the Promise of RNA Therapies for Cardiac Repair and Regeneration

Auteurs: Mauro Giacca
Publié dans: Stem Cells Translational Medicine, Numéro 12(8), 2023, Page(s) 527-535, ISSN 2157-6564
Éditeur: AlphaMed Press
DOI: 10.1093/stcltm/szad038

CRISPR activation and interference as investigative tools in the cardiovascular system

Auteurs: Melissa S. Carroll, Mauro Giacca
Publié dans: The International Journal of Biochemistry & Cell Biology, Numéro 155, 2023, ISSN 1357-2725
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.biocel.2022.106348

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