New-generation cardiac therapeutic strategies directed to the activation of endogenous regenerative mechanisms

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Risultati finali

Dissemination Kit for conferences and events
Project Website

A new human in vitro cardiac injury model for the evaluation of endogenous repair mechanisms, cell competition and proproliferative interventions

A new human in vitro cardiac injury model for the evaluation of endogenous repairmechanisms cell competition and proproliferative interventions

Results on rhAg efficacy and safety in pig model of ischemia-reperfusion

Pubblicazioni

ERC-funded grant: cardiac regeneration

Autori: Cristina Villa del Campo, Inés Rivero-García, Miguel Torres
Pubblicato in: European Heart Journal, Numero 46, 2025, Pagina/e 887-889, ISSN 0195-668X
Editore: Oxford University Press
DOI: 10.1093/eurheartj/ehae873

The cellular and signaling dynamics of salamander limb regeneration

Autori: Elad Bassat, Elly M.Tanaka
Pubblicato in: Current Opinion in Cell Biology (COCEBI), Numero 78, 2021, Pagina/e Pages 117-123, ISSN 0955-0674
Editore: Elsevier BV
DOI: 10.1016/j.ceb.2021.07.010

ATF3’s shielding hand to counter ischemia-reperfusion injury in cardiac macrophages

Autori: Tim Koopmans, Alejandro Cardona-Monzonís, Eva van Rooij
Pubblicato in: Nature Cardiovascular Research, Numero 3, 2024, Pagina/e 15-17, ISSN 2731-0590
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s44161-023-00386-9

Gene editing for cardiomyopathy takes a step forward

Autori: M Giacca
Pubblicato in: Oxford Academic, 2022, ISSN 1348-0634
Editore: OUP
DOI: 10.1093/cvr/cvac164

Closed-Loop Vagus Nerve Stimulation for the Treatment of Cardiovascular Diseases: State of the Art and Future Directions

Autori: Matteo Maria Ottaviani, Fabio Vallone, Silvestro Micera, Fabio A. Recchia
Pubblicato in: Frontiers in Cardiovascular Medicine, Numero 9, 2022, ISSN 2297-055X
Editore: Frontiers Media SA
DOI: 10.3389/fcvm.2022.866957

The pathological maelstrom of COVID-19 and cardiovascular disease

Autori: Mauro Giacca and Ajay M. Shah
Pubblicato in: Nature Cardiovascular Research, Numero 1, 2022, Pagina/e March 2022 | 200–210, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s44161-022-00029-5

Repurposing of glatiramer acetate to treat cardiac ischemia in rodent models

Autori: Gal Aviel, Jacob Elkahal, Kfir Baruch Umansky, Hanna Bueno-Levy, Zachary Petrover, Yulia Kotlovski, Daria Lendengolts, David Kain, Tali Shalit, Lingling Zhang, Shoval Miyara, Matthias P. Kramer, Yifat Merbl, Stav Kozlovski, Ronen Alon, Rina Aharoni, Ruth Arnon, David Mishali, Uriel Katz, Dean Nachman, Rabea Asleh, Offer Amir, Eldad Tzahor, Rachel Sarig
Pubblicato in: Nature Cardiovascular Research, Numero 3, 2024, Pagina/e 1049-1066, ISSN 2731-0590
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s44161-024-00524-x

Transcriptomic data meta-analysis reveals common and injury model specific gene expression changes in the regenerating zebrafish heart

Autori: Marius Alexandru Botos; Prateek Arora; Panagiotis Chouvardas; Nadia Mercader
Pubblicato in: Botos, Marius Alexandru; Arora, Prateek; Chouvardas, Panagiotis; Mercader, Nadia (2023). Transcriptomic data meta-analysis reveals common and injury model specific gene expression changes in the regenerating zebrafish heart. Scientific Reports, 13(1), p. 5418. Nature Publishing Group 10.1038/s41598-023-32272-6 <http://dx.doi.org/10.1038/s41598-023-32272-6>, Numero 11, 2023, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-023-32272-6

Activation of an accessory pathway of glucose metabolism to treat dilated cardiomyopathy

Autori: Thomas Eschenhagen
Pubblicato in: European Heart Journal, Numero 1-3, 2022, ISSN 0195-668X
Editore: Oxford University Press
DOI: 10.1093/eurheartj/ehac397

Cardioprotective factors against myocardial infarction selected in vivo from an AAV secretome library

Autori: Giulia Ruozi https://orcid.org/0000-0001-5005-6887, Francesca Bortolotti https://orcid.org/0000-0002-3014-6989, Antonio Mura https://orcid.org/0000-0002-3872-9118, Mateusz Tomczyk, Antonella Falcione, Valentina Martinelli, Simone Vodret, Luca Braga https://orcid.org/0000-0002-9827-6755, Matteo Dal Ferro https://orcid.org/0000-0002-2310-0448, Antonio Cannatà https://orcid.org/0000-0001-7609-6297,
Pubblicato in: Science Translational Medicine, 2022, ISSN 2673-8937
Editore: Science Translational Medicine
DOI: 10.1126/scitranslmed.abo0699

Redirecting glucose into anabolic pathways participates in the protective effects of NRF2 activation in the heart under stress

Autori: Thomas Eschenhagen
Pubblicato in: Cardiovascular Research, 2025, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvaf003

Cox7a1 controls skeletal muscle physiology and heart regeneration through complex IV dimerization

Autori: Carolina García-Poyatos, Prateek Arora, Enrique Calvo, Ines J. Marques, Nick Kirschke, Maria Galardi-Castilla, Carla Lembke, Marco Meer, Paula Fernández-Montes, Alexander Ernst, David Haberthür, Ruslan Hlushchuk, Jesús Vázquez, Peter Vermathen, José Antonio Enríquez, Nadia Mercader
Pubblicato in: Developmental Cell, Numero 59, 2024, Pagina/e 1824-1841.e10, ISSN 1534-5807
Editore: Cell Press
DOI: 10.1016/j.devcel.2024.04.012

Molecular and functional MRI enables detection of cardiac fibrosis and evaluation of treatment response after chordin-like 1 gene therapy in myocardial infarction

Autori: Konstantina Amoiradaki, Mateusz Tomczyk, Xiaoying Wang, Gastão Cruz, Carlos Velasco, Lorena Zentilin, Francesca Bortolotti, Claudia Prieto, René M. Botnar, Mauro Giacca, Alkystis Phinikaridou
Pubblicato in: Theranostics, Numero 15, 2025, Pagina/e 8706-8718, ISSN 1838-7640
Editore: Ivyspring International Publisher
DOI: 10.7150/thno.114459

RNA interference therapeutics for cardiac regeneration

Autori: Josef Huntington, Manendra Pachauri, Hashim Ali, MauroGiacca
Pubblicato in: Current Opinion in Genetics & Development, Numero 70, 2021, Pagina/e October 2021, Pages 48-53, ISSN 0959-437X
Editore: Elsevier BV
DOI: 10.1016/j.gde.2021.05.007

Cardiomyocyte proliferation is suppressed by ARID1A-mediated YAP inhibition during cardiac maturation

Autori: Cornelis J. Boogerd, Ilaria Perini, Eirini Kyriakopoulou, Su Ji Han, Phit La, Britt van der Swaan, Jari B. Berkhout, Danielle Versteeg, Jantine Monshouwer-Kloots & Eva van Rooij
Pubblicato in: Nature Communications, Numero 14(1):4716, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-40203-2

Cold and hot fibrosis define clinically distinct cardiac pathologies

Autori: Shoval Miyara,1,15 Miri Adler,2,14,15 Kfir B. Umansky,1 Daniel Haußler, € 3 Elad Bassat,4,13 Yalin Divinsky,1 Jacob Elkahal,1 David Kain,1 Daria Lendengolts,1 Ricardo O. Ramirez Flores,5 Hanna Bueno-Levy,1 Ofra Golani,6 Tali Shalit,7 Michael Gershovits,7 Eviatar Weizman,7 Alexander Genzelinakh,1 Danielle M. Kimchi,1 Avraham Shakked,1 Lingling Zhang,1 Jingkui Wang,4,13 Andrea Baehr,8,9 Zachary P
Pubblicato in: Cell Systems, 2025, ISSN 2405-4720
Editore: Elsevier

Egr1 regulates regenerative senescence and cardiac repair

Autori: Lingling Zhang, Jacob Elkahal, Tianzhen Wang, Racheli Rimmer, Alexander Genzelinakh, Elad Bassat, Jingkui Wang, Dahlia Perez, David Kain, Daria Lendengolts, Roni Winkler, Hanna Bueno-levy, Kfir Baruch Umansky, David Mishaly, Avraham Shakked, Shoval Miyara, Avital Sarusi-Portuguez, Naomi Goldfinger, Amir Prior, David Morgenstern, Yishai Levin, Yoseph Addadi, Baoguo Li, Varda Rotter, Uriel Katz, Ell
Pubblicato in: Nature Cardiovascular Research, Numero 3, 2024, Pagina/e 915-932, ISSN 2731-0590
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s44161-024-00493-1

A dualistic approach to heart repair through FGF10

Autori: Tim Koopmans, Eva van Rooij
Pubblicato in: Cardiovascular Research, Numero 118, 2023, Pagina/e 2564-2565, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvac123

Rocker or pump? Transcriptomic response of endothelial cells exposed to peristaltic pump-based unidirectional flow vs. rocker-induced bidirectional flow

Autori: Negar Vahdani, Prateek Arora, Lisette van Os, Denise Ackermann, Nadia Mercader, Olivier T. Guenat
Pubblicato in: Lab on a Chip, 2025, ISSN 1473-0197
Editore: Royal Society of Chemistry
DOI: 10.1039/d5lc00553a

Antagonism of miRNA in heart failure: first evidence in human.

Autori: Andrew H. Baker; Mauro Giacca; Mauro Giacca
Pubblicato in: European Heart Journal, Numero 5, 2021, Pagina/e Volume 42, Numero 2, 7 January 2021, Pages 189–191, ISSN 0195-668X
Editore: Oxford University Press
DOI: 10.1093/eurheartj/ehaa967

Non-coding RNA therapeutics for cardiac regeneration

Autori: Luca Braga, Hashim Ali, Ilaria Secco, Mauro Giacca
Pubblicato in: Cardiovascular Research, Numero 117/3, 2020, Pagina/e 674-693, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvaa071

BMP7 promotes cardiomyocyte regeneration in zebrafish and adult mice

Autori: Chiara Bongiovanni, Hanna Bueno-Levy, Denise Posadas Pena, Irene Del Bono, Carmen Miano, Stefano Boriati, Silvia Da Pra, Francesca Sacchi, Simone Redaelli, Max Bergen, Donatella Romaniello, Francesca Pontis, Riccardo Tassinari, Laura Kellerer, Ilaria Petraroia, Martina Mazzeschi, Mattia Lauriola, Carlo Ventura, Stephan Heermann, Gilbert Weidinger, Eldad Tzahor, Gabriele D’Uva
Pubblicato in: Cell Reports, Numero 43, 2025, Pagina/e 114162, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2024.114162

Fulfilling the Promise of RNA Therapies for Cardiac Repair and Regeneration

Autori: Mauro Giacca
Pubblicato in: Stem Cells Translational Medicine, Numero 12(8), 2023, Pagina/e 527-535, ISSN 2157-6564
Editore: AlphaMed Press
DOI: 10.1093/stcltm/szad038

Meis transcription factors regulate cardiac conduction system development and adult function

Autori: Noelia Muñoz-Martín, Ana Simon-Chica, Covadonga Díaz-Díaz, Vanessa Cadenas, Susana Temiño, Isaac Esteban, Andreas Ludwig, Barbara Schormair, Juliane Winkelmann, Veronika Olejnickova, David Sedmera, David Filgueiras-Rama, Miguel Torres
Pubblicato in: Cardiovascular Research, Numero 121, 2025, Pagina/e 311-323, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvae258

Regulation of endogenous cardiomyocyte proliferation: The known unknowns

Autori: Ilaria Secco, Mauro Giacca
Pubblicato in: Journal of Molecular and Cellular Cardiology, Numero 179, 2023, Pagina/e 80-89, ISSN 0022-2828
Editore: Academic Press
DOI: 10.1016/j.yjmcc.2023.04.001

High-throughput methods to help understand heart disease

Autori: Martijn Wehrens, Louk T. Timmer and Eva van Rooij
Pubblicato in: Nature Cardiovascular Research volume 1, pages 798–799 (2022), 2022, ISSN 2731-0590
Editore: Nature Cardiovascular Research
DOI: 10.1038/s44161-022-00126-5

Identification of FDA-approved drugs that induce heart regeneration in mammals

Autori: Mahmoud Salama Ahmed, Ngoc Uyen Nhi Nguyen, Yuji Nakada, Ching-Cheng Hsu, Ayman Farag, Nicholas T. Lam, Ping Wang, Suwannee Thet, Ivan Menendez-Montes, Waleed M. Elhelaly, Xi Lou, Ilaria Secco, Mateusz Tomczyk, Lorena Zentilin, Jimin Pei, Miao Cui, Matthieu Dos Santos, Xiaoye Liu, Yan Liu, David Zaha, Gregory Walcott, Diana R. Tomchick, Chao Xing, Cheng Cheng Zhang, Nick V. Grishin, Mauro Giacca,
Pubblicato in: Nature Cardiovascular, 2024, ISSN 2731-0590
Editore: Nature Cardiovascular Research
DOI: 10.1038/s44161-024-00450-y

ZebraReg—a novel platform for discovering regulators of cardiac regeneration using zebrafish

Autori: Kateřina Apolínová, Ferran Arqué Pérez, Sylvia Dyballa, Benedetta Coppe, Nadia Mercader Huber, Javier Terriente, Vincenzo Di Donato
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 12, 2024, ISSN 2296-634X
Editore: Frontiers Media SA
DOI: 10.3389/fcell.2024.1384423

Hypoxia to Stimulate Cardiomyocyte Proliferation After MI? A Word of Caution

Autori: Thomas Eschenhagen
Pubblicato in: Circulation Research, Numero 132, 2023, Pagina/e 741-743, ISSN 0009-7330
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.123.322553

P53 and BCL-2 family proteins PUMA and NOXA define competitive fitness in pluripotent cell competition

Autori: Jose A Valverde-Lopez 1, Lin Li-Bao 1, Rocío Sierra 1 2, Elisa Santos 3, Giovanna Giovinazzo 2 3, Covadonga Díaz-Díaz 1 2, Miguel Torres 1 2
Pubblicato in: Public Library of Science, 2024, ISSN 1553-7390
Editore: Public Library of Science
DOI: 10.1371/journal.pgen.1011193

Regulation of Myc transcription by an enhancer cluster dedicated to pluripotency and early embryonic expression

Autori: Lin Li-Bao, Covadonga Díaz-Díaz, Morena Raiola, Rocío Sierra, Susana Temiño, Francisco J. Moya, Sandra Rodriguez-Perales, Elisa Santos, Giovanna Giovinazzo, Tore Bleckwehl, Álvaro Rada-Iglesias, Francois Spitz, Miguel Torres
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-48258-5

Challenges and perspectives of heart repair with pluripotent stem cell-derived cardiomyocytes

Autori: Thomas Eschenhagen, Florian Weinberger
Pubblicato in: Nature Cardiovascular Research, Numero 3, 2024, Pagina/e 515-524, ISSN 2731-0590
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s44161-024-00472-6

Persistent <scp>SARS‐CoV</scp>‐2 infection in patients seemingly recovered from <scp>COVID</scp>‐19

Autori: Rossana Bussani, Lorena Zentilin, Ricardo Correa, Andrea Colliva, Furio Silvestri, Serena Zacchigna, Chiara Collesi, Mauro Giacca
Pubblicato in: The Journal of Pathology, Numero 259, 2023, Pagina/e 254-263, ISSN 0022-3417
Editore: John Wiley & Sons Inc.
DOI: 10.1002/path.6035

VEGF-B Gene Therapy for the Heart: Proceed with Caution

Autori: M Giacca, FA Recchia
Pubblicato in: Molecular Therapy, Numero 28(7), 2020, Pagina/e 1566-1568, ISSN 1525-0016
Editore: Nature Publishing Group
DOI: 10.1016/j.ymthe.2020.06.014

A coalition to heal—the impact of the cardiac microenvironment

Autori: Eldad Tzahor, Stefanie Dimmeler
Pubblicato in: Science, Numero 377, 2024, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.abm4443

Genetic tracing and topography of spontaneous and stimulated cardiac regeneration in mice

Autori: Ilaria Secco, Ana Backovic, Mateusz Tomczyk, Antonio Mura, Gang Li, Francesca Bortolotti, Simone Vodret, Matteo Dal Ferro, Elena Chiavacci, Lorena Zentilin, Gianfranco Sinagra, Serena Zacchigna, Miguel Mano, Mauro Giacca
Pubblicato in: Nature Cardiovascular Research, Numero 4, 2025, Pagina/e 397-411, ISSN 2731-0590
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s44161-025-00623-3

CRISPR activation and interference as investigative tools in the cardiovascular system

Autori: Melissa S. Carroll, Mauro Giacca
Pubblicato in: The International Journal of Biochemistry & Cell Biology, Numero 155, 2023, ISSN 1357-2725
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.biocel.2022.106348

Delayed miR-199a Administration After Myocardial Infarction Precludes Pro-Regenerative Effects

Autori: Gia Burjanadze, Nikoloz Gorgodze, Giovanni Donato Aquaro, Khatia Gabisonia, Lucia Carlucci, Manendra Pachauri, Federico Turreni, Ilaria Secco, Fabio Bernini, Lorena Zentilin, Mauro Giacca, Fabio A. Recchia
Pubblicato in: JACC: Basic to Translational Science, Numero 10, 2025, Pagina/e 634-649, ISSN 2452-302X
Editore: Elsevier BV
DOI: 10.1016/j.jacbts.2024.12.014

Deep generative models in single-cell omics

Autori: Inés Rivero-Garcia, Miguel Torres, Fátima Sánchez-Cabo
Pubblicato in: Computers in Biology and Medicine, Numero 176, 2024, Pagina/e 108561, ISSN 0010-4825
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2024.108561

Single-cell transcriptomics following ischemic injury identifies a role for B2M in cardiac repair

Autori: Bas Molenaar, Louk T. Timmer, Marjolein Droog, Ilaria Perini, Danielle Versteeg, Lieneke Kooijman, Jantine Monshouwer-Kloots, Hesther de Ruiter, Monika M. Gladka, Eva van Rooij
Pubblicato in: Communications Biology, Numero 4/1, 2021, ISSN 2399-3642
Editore: Communications Biology
DOI: 10.1038/s42003-020-01636-3

Immature human engineered heart tissues engraft in a guinea pig chronic injury model

Autori: Constantin von Bibra, Aya Shibamiya, Andrea Bähr, Birgit Geertz, Maria Köhne, Tim Stuedemann, Jutta Starbatty, Verena Horneffer-van der Sluis, Ulrich C. Klostermeier, Nadja Hornaschewitz, Xinghai Li, Eckhard Wolf, Nikolai Klymiuk, Markus Krane, Christian Kupatt, Bernhard Hiebl, Thomas Eschenhagen, Florian Weinberger
Pubblicato in: Disease Models & Mechanisms, Numero 16, 2023, ISSN 1754-8403
Editore: The Company of Biologists Ltd.
DOI: 10.1242/dmm.049834

Therapeutic efficacy of AAV-mediated restoration of PKP2 in arrhythmogenic cardiomyopathy

Autori: Eirini Kyriakopoulou, Danielle Versteeg, Hesther de Ruiter, Ilaria Perini, Fitzwilliam Seibertz, Yannic Döring, Lorena Zentilin, Hoyee Tsui, Sebastiaan J. van Kampen, Malte Tiburcy, Tim Meyer, Niels Voigt, van J. Peter Tintelen, Wolfram H. Zimmermann, Mauro Giacca & Eva van Rooij
Pubblicato in: Nature Cardiovascular, 2024, ISSN 2731-0590
Editore: Nature Cardiovascular Research
DOI: 10.1038/s44161-023-00378-9

ERBB2 drives YAP activation and EMT-like processes during cardiac regeneration

Autori: Alla Aharonov, Avraham Shakked, Kfir Baruch Umansky, Alon Savidor, Alexander Genzelinakh, David Kain, Daria Lendengolts, Or-Yam Revach, Yuka Morikawa, Jixin Dong, Yishai Levin, Benjamin Geiger, James F. Martin, Eldad Tzahor
Pubblicato in: Nature Cell Biology, Numero 22/11, 2020, Pagina/e 1346-1356, ISSN 1465-7392
Editore: Nature Publishing Group
DOI: 10.1038/s41556-020-00588-4

Hypoxia-responsive zinc finger E-box-binding homeobox 2 (ZEB2) regulates a network of calcium-handling genes in the injured heart

Autori: Monika M Gladka, Arwa Kohela, Anne E de Leeuw, Bas Molenaar, Danielle Versteeg, Lieneke Kooijman, Mariska van Geldorp, Willem B van Ham, Rocco Caliandro, Jody J Haigh, Toon A B van Veen, Eva van Rooij
Pubblicato in: Cardiovascular Research, Numero 120, 2024, Pagina/e 1869-1883, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvae163

Neuromuscular and cardiac organoids and assembloids: Advanced platforms for drug testing

Autori: Lorenzo Fontanelli, Noemi Nisini, Sergio Pirola, Fabio A. Recchia
Pubblicato in: Pharmacology & Therapeutics, Numero 272, 2025, Pagina/e 108876, ISSN 0163-7258
Editore: Pergamon Press
DOI: 10.1016/j.pharmthera.2025.108876

Contractile Force of Transplanted Cardiomyocytes Actively Supports Heart Function After Injury

Autori: Tim Stüdemann, Judith Rössinger, Christoph Manthey, Birgit Geertz, Rajiven Srikantharajah, Constantin von Bibra, Aya Shibamiya, Maria Köhne, Antonius Wiehler, J. Simon Wiegert, Thomas Eschenhagen, Florian Weinberger
Pubblicato in: Circulation, Numero 146, 2024, Pagina/e 1159-1169, ISSN 0009-7322
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.122.060124

Health position paper and redox perspectives on reactive oxygen species as signals and targets of cardioprotection

Autori: Gerd Heusch, Ioanna Andreadou, Robert Bell, Edoardo Bertero, Hans-Erik Botker, Sean M. Davidson, James Downey, Philip Eaton, Peter Ferdinandy, Bernard J. Gersh, Mauro Giacca, Derek J. Hausenloy, Borja Ibanez, Thomas Krieg, Christoph Maack, Rainer Schulz, Frank Sellke, Ajay M. Shah, Holger Thiele, Derek M. Yellon, Fabio Di Lisa
Pubblicato in: Redox Biology, Numero 67, 2024, Pagina/e 102894, ISSN 2213-2317
Editore: Elsevier BV
DOI: 10.1016/j.redox.2023.102894

SARS-CoV-2 infection boosts inflammation in atherosclerotic plaques

Autori: Mauro Giacca
Pubblicato in: Nature Cardiovascular Research, 2023, ISSN 2731-0590
Editore: Nature Cardiovascular Research
DOI: 10.1038/s44161-023-00358-z

Small non-coding RNA therapeutics for cardiovascular disease

Autori: Ajay M Shah, Mauro Giacca
Pubblicato in: European Heart Journal, Numero 43, 2022, Pagina/e 4548-4561, ISSN 0195-668X
Editore: Oxford University Press
DOI: 10.1093/eurheartj/ehac463

Cardiomyocyte-Specific Wt1 Is Involved in Cardiac Metabolism and Response to Damage

Autori: Sandra Díaz del Moral; Maha Benaouicha; Cristina Villa del Campo; Miguel Torres; Nicole Wagner; Kay-Dietrich Wagner; Ramón Muñoz-Chápuli; Rita Carmona
Pubblicato in: Journal of Cardiovascular Development and Disease, Vol 10, Iss 5, p 211 (2023), Numero 1, 2023, ISSN 2731-0590
Editore: Nature Cardiovascular
DOI: 10.3390/jcdd10050211

Molecular gatekeepers of endogenous adult mammalian cardiomyocyte proliferation

Autori: Tim Koopmans, Eva van Rooij
Pubblicato in: Nature Reviews Cardiology, 2025, ISSN 1759-5002
Editore: Nature Publishing Group
DOI: 10.1038/s41569-025-01145-y

Modulation of cardiomyocyte contractility and action potentials with chemogenetic chloride currents

Autori: Muhammed Sönmez, Tim Stüdemann, Christoph Manthey, Anita Covic, Nancy Shehata, Junsoo Im, Barbora Schwarzova, Judith Rössinger, Rajiven Srikantharajah, Aya Shibamiya, Edzard Schwedhelm, Thomas Eschenhagen, Torsten Christ, Florian Weinberger
Pubblicato in: The Journal of Physiology, Numero 603, 2025, Pagina/e 1399-1415, ISSN 0022-3751
Editore: Blackwell Publishing Inc.
DOI: 10.1113/jp286428

Cardiac Regeneration After Myocardial Infarction: an Approachable Goal

Autori: Mauro Giacca
Pubblicato in: Current Cardiology Reports, Numero 22/10, 2020, ISSN 1523-3782
Editore: Current Science Inc.
DOI: 10.1007/s11886-020-01361-7

Myocardium and endocardium of the early mammalian heart tube arise from independent multipotent lineages specified at the primitive streak

Autori: Miquel Sendra, Katie McDole, Juan de Dios Hourcade, Susana Temiño, Morena Raiola, Léo Guignard, Philipp J. Keller, Jorge N. Domínguez, Miguel Torres
Pubblicato in: Developmental Cell, 2025, ISSN 1534-5807
Editore: Cell Press
DOI: 10.1016/j.devcel.2025.05.002

Gene Therapy for the Heart Lessons Learned and Future Perspectives

Autori: Antonio Cannatà, Hashim Ali, Gianfranco Sinagra and Mauro Giacca
Pubblicato in: Circulation Research, Numero 126, 2020, Pagina/e Numero 10, 8 May 2020; Pages 1394-1414, ISSN 0009-7330
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.120.315855

Spns1-dependent endocardial lysosomal function drives valve morphogenesis through Notch1-signaling

Autori: Myra N. Chávez, Prateek Arora, Marco Meer, Ines J. Marques, Alexander Ernst, Rodrigo A. Morales Castro, Nadia Mercader
Pubblicato in: iScience, Numero 27, 2024, Pagina/e 111406, ISSN 2589-0042
Editore: Elsevier BV
DOI: 10.1016/j.isci.2024.111406

RIGENERAZIONE CARDIACA: UN TRAGUARDO POSSIBILE

Autori: MAURO GIACCA
Pubblicato in: Giornale Italiano dell'Arteriosclerosi, Numero 12 (3), 2021, Pagina/e 31-43, ISSN 2240-4821
Editore: societa' italiana per lo studio dell'aterosclerosi

Control of coronary lymphangiogenesis by epicardial VEGFC/D

Autori: Ester de la Cruz, Vanessa Cadenas, Susana Temiño, Guillermo Oliver, Miguel Torres
Pubblicato in: 2023
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.02.10.528007

Lower left ventricular ejection time inMYBPC3variant carriers with overt or subclinical hypertrophic cardiomyopathy

Autori: Isabell Yan, Zoe Möhring, Daniel Reichart, Julia Münch, Rixa Woitschach, Paulus Kirchhof, Lucie Carrier, Carolyn Y. Ho, Thomas Eschenhagen, Monica Patten
Pubblicato in: 2024
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.10.15.24315469

Epigenetic priming of embryonic lineages in the mammalian epiblast

Autori: Miquel Sendra, Katie McDole, Daniel Jimenez-Carretero, Juan de Dios Hourcade, Susana Temiño, Morena Raiola, Léo Guignard, Philipp J Keller, Fátima Sánchez-Cabo, Jorge N. Domínguez, Miguel Torres
Pubblicato in: 2024
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.01.11.575188

Immature human engineered heart tissues engraft in a guinea pig chronic injury model

Autori: Constantin von Bibra, Aya Shibamiya, Andrea Bähr, Birgit Geertz, Maria Köhne, Tim Stuedemann, Jutta Starbatty, Nadja Hornaschewitz, Xinghai Li, Eckhard Wolf, Nikolai Klymiuk, Markus Krane, Christian Kupatt, Bernhard Hiebl, Thomas Eschenhagen, Florian Weinberger
Pubblicato in: 2022
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.07.07.499077

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