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CORDIS - EU research results
CORDIS

HUMAN UTERUS CELL ATLAS

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

High-resolution images (opens in new window)

Highresolution images of endometrial and myometrial sections immunohistochemically stained with cell typespecific markers

HUTER Workshop (opens in new window)
Virtual reality Microscopy tool. (opens in new window)

Virtual reality Microscopy tool

Deployment HUTER cloud infrastructure (opens in new window)

Deployment of HUTER cloud infrastructure

High-resolution spatial image maps (opens in new window)

Highresolution spatial image maps of different cell states in human endometrium and myometrium across lifespan

Spatial transcriptomics (opens in new window)

Dataset of spatial transcriptomics of endometrium and myometrium

HUTER collection completed (opens in new window)

HUTER collection completed with specimen storage for each donor and tissue type

Visual system & Digitalisation software (opens in new window)

Visual System implemented and Digitalisation software to transform images from research equipment under opensource standards

Cell type-specific protein expression patterns (opens in new window)

Dataset of cell typespecific protein expression patterns in human endometrium and myometrium across lifespan

Data access and DICOM visualization tools (opens in new window)

Final implementation of data access tools and DICOM visualization tool

Validated HUTER platform (opens in new window)

Validated HUTER platform accessible for use by the scientific community with activated measures to ensure its sustainability after projectend

SOP for tissue collection and processing (opens in new window)

Description of SOP for tissue collection and processing, agreed by all partners responsible for tissue procurement

DICOM implementation (opens in new window)

Report on the full DICOM implementation standard

Dissemination & Exploitation plan 2 (opens in new window)

Plan for the Dissemination Exploitation of Results Dissemination Toolkit 2 Industry consultations Record of dissemination and communication activities in year 1 and plan for year 2 project leaflets and posters audiovisual material Planning for the HUTER Workshop

Tissue specimens description (opens in new window)

Description of the tissue specimens used once the tissue procurement phase is finalised

Platform architecture design (opens in new window)

Platform architecture design, interconnectivity aspects and standards to use, fully aligned with the HCA guidelines

Final design of HUTER platform (opens in new window)

Final design of HUTER platform architecture

Record on the Dissemination, Exploitation, IPR (opens in new window)

Record on the Dissemination Exploitation and IPR activities in the project

Methylation atlas (opens in new window)

Generate a methylation atlas for normal endometrium and myometrium tissues cataloguing specific cell types

New cell states (opens in new window)

Report on identified new cell states and cell to cell communication mechanisms

Dissemination & Exploitation plan 1 (opens in new window)

Plan for the Dissemination Exploitation of Results Dissemination Toolkit 1 Industry consultations First year plan for dissemination and communication activities Website first industry consultations and dissemination toolkit 1

~1 mil scRNAseq for endometrium at reproductive age (opens in new window)

Data set of 1 mil scRNAseq for endometrium cells at reproductive age to assess variability among individuals

~1 mil scRNAseq for myometrium (opens in new window)

Data set of 1 mil scRNAseq for myometrium cells across the lifespan

Single-cell whole genome sequencing (opens in new window)

Whole genome sequencing for all healthy study population

~1 mil scRNAseq for endometrium (opens in new window)

Data set of 1 mil scRNAseq for endometrium cells across the lifespan

Publications

Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro (opens in new window)

Author(s): Luz Garcia-Alonso, Louis-François Handfield, Kenny Roberts, Konstantina Nikolakopoulou, Ridma C. Fernando, Lucy Gardner, Benjamin Woodhams, Anna Arutyunyan, Krzysztof Polanski, Regina Hoo, Carmen Sancho-Serra, Tong Li, Kwasi Kwakwa, Elizabeth Tuck, Valentina Lorenzi, Hassan Massalha, Martin Prete, Vitalii Kleshchevnikov, Aleksandra Tarkowska, Tarryn Porter, Cecilia Icoresi Mazzeo, Stijn van Donge
Published in: Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro, Issue Nat Genet 53 (2021), 2021, Page(s) 1698–1711, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-021-00972-2

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