Resultado final
Highresolution images of endometrial and myometrial sections immunohistochemically stained with cell typespecific markers
HUTER WorkshopVirtual reality Microscopy tool.
Virtual reality Microscopy tool
Deployment HUTER cloud infrastructureDeployment of HUTER cloud infrastructure
High-resolution spatial image mapsHighresolution spatial image maps of different cell states in human endometrium and myometrium across lifespan
Spatial transcriptomicsDataset of spatial transcriptomics of endometrium and myometrium
HUTER collection completedHUTER collection completed with specimen storage for each donor and tissue type
Visual system & Digitalisation softwareVisual System implemented and Digitalisation software to transform images from research equipment under opensource standards
Cell type-specific protein expression patternsDataset of cell typespecific protein expression patterns in human endometrium and myometrium across lifespan
Data access and DICOM visualization toolsFinal implementation of data access tools and DICOM visualization tool
Validated HUTER platformValidated HUTER platform accessible for use by the scientific community with activated measures to ensure its sustainability after projectend
Description of SOP for tissue collection and processing, agreed by all partners responsible for tissue procurement
DICOM implementationReport on the full DICOM implementation standard
Dissemination & Exploitation plan 2Plan for the Dissemination Exploitation of Results Dissemination Toolkit 2 Industry consultations Record of dissemination and communication activities in year 1 and plan for year 2 project leaflets and posters audiovisual material Planning for the HUTER Workshop
Tissue specimens descriptionDescription of the tissue specimens used once the tissue procurement phase is finalised
Platform architecture designPlatform architecture design, interconnectivity aspects and standards to use, fully aligned with the HCA guidelines
Final design of HUTER platformFinal design of HUTER platform architecture
Record on the Dissemination, Exploitation, IPRRecord on the Dissemination Exploitation and IPR activities in the project
Methylation atlasGenerate a methylation atlas for normal endometrium and myometrium tissues cataloguing specific cell types
New cell statesReport on identified new cell states and cell to cell communication mechanisms
Dissemination & Exploitation plan 1Plan for the Dissemination Exploitation of Results Dissemination Toolkit 1 Industry consultations First year plan for dissemination and communication activities Website first industry consultations and dissemination toolkit 1
Data set of 1 mil scRNAseq for endometrium cells at reproductive age to assess variability among individuals
~1 mil scRNAseq for myometriumData set of 1 mil scRNAseq for myometrium cells across the lifespan
Single-cell whole genome sequencingWhole genome sequencing for all healthy study population
~1 mil scRNAseq for endometriumData set of 1 mil scRNAseq for endometrium cells across the lifespan
Publicaciones
Autores:
Luz Garcia-Alonso, Louis-François Handfield, Kenny Roberts, Konstantina Nikolakopoulou, Ridma C. Fernando, Lucy Gardner, Benjamin Woodhams, Anna Arutyunyan, Krzysztof Polanski, Regina Hoo, Carmen Sancho-Serra, Tong Li, Kwasi Kwakwa, Elizabeth Tuck, Valentina Lorenzi, Hassan Massalha, Martin Prete, Vitalii Kleshchevnikov, Aleksandra Tarkowska, Tarryn Porter, Cecilia Icoresi Mazzeo, Stijn van Donge
Publicado en:
Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro, Edición Nat Genet 53 (2021), 2021, Página(s) 1698–1711, ISSN 1061-4036
Editor:
Nature Publishing Group
DOI:
10.1038/s41588-021-00972-2
Buscando datos de OpenAIRE...
Se ha producido un error en la búsqueda de datos de OpenAIRE
No hay resultados disponibles