Periodic Reporting for period 1 - ORIGAMI (cOmpRession of Genomic dAta to facilitate precision MedIcine)
Berichtszeitraum: 2019-08-01 bis 2020-01-31
This shift in the size of the genome sequenced is responsible for production of astronomical amount of numerical genomic data. With these volumes, transferring, storing, archiving and analyzing the data becomes an issue. To counteract these issues ENANCIO has developed LENA, an algorithm to compress genomic data and improve the entire genomic data workflow. ENANCIO aims to provide a solution to improve the speed of transfer and decrease the storage cost of those data, but also to improve speed and precision of data analysis.
Illumina, the leader sequencing instrument provider worldwide had launched new instruments to follow the whole exome, whole genome sequencing trend. The objective of this project was for ENANCIO to evaluate the performance of its compression technology on newest Illumina platforms, to study the market responsiveness of this algorithm, to establish new specifications that need to be implemented to facilitate its adoption and to refine its business plan.
The technical study has shown excellent performance results of LENA over data generated by latest sequencing instrument. Savings over storage can go as high as 75% and voluminous file transfers can be 5 times faster. Market survey also revealed performance were in line with customers expectations and highlighted further points that needed to be addressed depending on storage strategy.
The ORIGAMI projects allowed for a better understanding of main barriers for adoption, a better understanding of customer’s expectations according to which segment they belong to, a better positioning of LENA and led to a roadmap for future developments, and a commercial strategy to put in place.