DISRUPTIVE GPCR LEAD DISCOVERY PLATFORM DELIVERING NEW AND SAFER THERAPEUTICS

Project Information

PICARD

Grant agreement ID: 880322

DOI 10.3030/880322

Project closed

EC signature date 20 September 2019

Start date 1 October 2019

End date 31 May 2021

Funded under

• INDUSTRIAL LEADERSHIP - Innovation In SMEs

Total cost € 2 493 167,50

EU contribution € 1 745 217,25

Coordinated by

INTERAX BIOTECH AG
Switzerland

Deliverables

Websites, patent fillings, videos etc. (1)

Website and social media profiles.

Links to project website and social media. Improve communication with potential customers and other stakeholders (Task 4.1).

Publications

Peer reviewed articles (10)

Dopamine D2 Receptor Agonist Binding Kinetics—Role of a Conserved Serine Residue

Author(s): Richard Ågren,Tomasz Maciej Stepniewski, Hugo Zeberg, Jana Selent and Kristoffer Sahlholm
Published in: Int. J. Mol. Sci., Issue 22 (8), 2021, Page(s) 4078, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22084078

Structural dynamics bridge the gap between the genetic and functional levels of GPCRs

Author(s): MarionaTorrens-Fontanals, Tomasz M.Stepniewski, David E.Gloriam, JanaSelent
Published in: Current Opinion in Structural Biology, Issue 69, 2021, Page(s) 150-159, ISSN 0959-440X
Publisher: Elsevier BV
DOI: 10.1016/j.sbi.2021.04.005

Distinct phosphorylation sites in a prototypical GPCR differently orchestrate β-arrestin interaction, trafficking, and signaling

Author(s): Hemlata Dwivedi-Agnihotri, Madhu Chaturvedi, Mithu Baidya, Tomasz Maciej Stepniewski, Shubhi Pandey, Jagannath Maharana, Ashish Srivastava, Natarin Caengprasath, Aylin C. Hanyaloglu, Jana Selent, Arun K. Shukla
Published in: Science Advances, Issue 6/37, 2020, Page(s) eabb8368, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.abb8368

Key phosphorylation sites in GPCR s orchestrate the contribution of β‐Arrestin 1 in ERK 1/2 activation

Author(s): Mithu Baidya, Punita Kumari, Hemlata Dwivedi‐Agnihotri, Shubhi Pandey, Madhu Chaturvedi, Tomasz Maciej Stepniewski, Kouki Kawakami, Yubo Cao, Stéphane A Laporte, Jana Selent, Asuka Inoue, Arun K Shukla
Published in: EMBO reports, Issue 21/9, 2020, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.201949886

Ligand with Two Modes of Interaction with the Dopamine D2 Receptor−An Induced-Fit Mechanism of Insurmountable Antagonism

Author(s): Richard Ågren, Hugo Zeberg, Tomasz Maciej Stępniewski, R. Benjamin Free, Sean W. Reilly, Robert R. Luedtke, Peter Århem, Francisco Ciruela, David R. Sibley, Robert H. Mach, Jana Selent, Johanna Nilsson, and Kristoffer Sahlholm
Published in: ACS Chemical Neuroscience, Issue 11, 2020, Page(s) 3130 - 3143, ISSN 1948-7193
Publisher: American Chemical Society
DOI: 10.1021/acschemneuro.0c00477

A Focus on Unusual ECL2 Interactions Yields β 2 ‐Adrenergic Receptor Antagonists with Unprecedented Scaffolds

Author(s): Magdalena M. Scharf, Mirjam Zimmermann, Florian Wilhelm, Raimond Stroe, Maria Waldhoer, Peter Kolb
Published in: ChemMedChem, Issue 15/10, 2020, Page(s) 882-890, ISSN 1860-7179
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.201900715

New Insights into Arrestin Recruitment to GPCRs

Author(s): Martin Spillmann, Larissa Thurner, Nina Romantini, Mirjam Zimmermann, Benoit Meger, Martin Behe, Maria Waldhoer, Gebhard F. X. Schertler, Philipp Berger
Published in: International Journal of Molecular Sciences, Issue 21/14, 2020, Page(s) 4949, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21144949

GPCRmd uncovers the dynamics of the 3D-GPCRome

Author(s): Ismael Rodríguez-Espigares, Mariona Torrens-Fontanals, Johanna K. S. Tiemann, David Aranda-García, Juan Manuel Ramírez-Anguita, Tomasz Maciej Stepniewski, Nathalie Worp, Alejandro Varela-Rial, Adrián Morales-Pastor, Brian Medel-Lacruz, Gáspár Pándy-Szekeres, Eduardo Mayol, Toni Giorgino, Jens Carlsson, Xavier Deupi, Slawomir Filipek, Marta Filizola, José Carlos Gómez-Tamayo, Angel Gonzale
Published in: Nature Methods, Issue 17/8, 2020, Page(s) 777-787, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/s41592-020-0884-y

How Do Molecular Dynamics Data Complement Static Structural Data of GPCRs

Author(s): Mariona Torrens-Fontanals, Tomasz Maciej Stepniewski, David Aranda-García, Adrián Morales-Pastor, Brian Medel-Lacruz and Jana Selent
Published in: Int. J. Mol. Sci., Issue 21(16), 2020, Page(s) 5933, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21165933

The European Research Network on Signal Transduction (ERNEST): Toward a Multidimensional Holistic Understanding of G Protein-Coupled Receptor Signaling

Author(s): Martha E. Sommer, Jana Selent, Jens Carlsson, Chris De Graaf, David E. Gloriam, Gyorgy M. Keseru, Mickey Kosloff, Stefan Mordalski, Aurelien Rizk, Mette M. Rosenkilde, Eddy Sotelo, Johanna K. S. Tiemann, Andrew Tobin, Nina Vardjan, Maria Waldhoer, Peter Kolb
Published in: ACS Pharmacology & Translational Science, Issue 3/2, 2020, Page(s) 361-370, ISSN 2575-9108
Publisher: Washington, DC : American Chemical Society
DOI: 10.1021/acsptsci.0c00024