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DISRUPTIVE GPCR LEAD DISCOVERY PLATFORM DELIVERING NEW AND SAFER THERAPEUTICS

Rezultaty

Website and social media profiles.

Links to project website and social media. Improve communication with potential customers and other stakeholders (Task 4.1).

Publikacje

Dopamine D2 Receptor Agonist Binding Kinetics—Role of a Conserved Serine Residue

Autorzy: Richard Ågren,Tomasz Maciej Stepniewski, Hugo Zeberg, Jana Selent and Kristoffer Sahlholm
Opublikowane w: Int. J. Mol. Sci., Numer 22 (8), 2021, Strona(/y) 4078, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22084078

Structural dynamics bridge the gap between the genetic and functional levels of GPCRs

Autorzy: MarionaTorrens-Fontanals, Tomasz M.Stepniewski, David E.Gloriam, JanaSelent
Opublikowane w: Current Opinion in Structural Biology, Numer 69, 2021, Strona(/y) 150-159, ISSN 0959-440X
Wydawca: Elsevier BV
DOI: 10.1016/j.sbi.2021.04.005

Distinct phosphorylation sites in a prototypical GPCR differently orchestrate β-arrestin interaction, trafficking, and signaling

Autorzy: Hemlata Dwivedi-Agnihotri, Madhu Chaturvedi, Mithu Baidya, Tomasz Maciej Stepniewski, Shubhi Pandey, Jagannath Maharana, Ashish Srivastava, Natarin Caengprasath, Aylin C. Hanyaloglu, Jana Selent, Arun K. Shukla
Opublikowane w: Science Advances, Numer 6/37, 2020, Strona(/y) eabb8368, ISSN 2375-2548
Wydawca: AAAS
DOI: 10.1126/sciadv.abb8368

Key phosphorylation sites in GPCR s orchestrate the contribution of β‐Arrestin 1 in ERK 1/2 activation

Autorzy: Mithu Baidya, Punita Kumari, Hemlata Dwivedi‐Agnihotri, Shubhi Pandey, Madhu Chaturvedi, Tomasz Maciej Stepniewski, Kouki Kawakami, Yubo Cao, Stéphane A Laporte, Jana Selent, Asuka Inoue, Arun K Shukla
Opublikowane w: EMBO reports, Numer 21/9, 2020, ISSN 1469-221X
Wydawca: Nature Publishing Group
DOI: 10.15252/embr.201949886

Ligand with Two Modes of Interaction with the Dopamine D2 Receptor−An Induced-Fit Mechanism of Insurmountable Antagonism

Autorzy: Richard Ågren, Hugo Zeberg, Tomasz Maciej Stępniewski, R. Benjamin Free, Sean W. Reilly, Robert R. Luedtke, Peter Århem, Francisco Ciruela, David R. Sibley, Robert H. Mach, Jana Selent, Johanna Nilsson, and Kristoffer Sahlholm
Opublikowane w: ACS Chemical Neuroscience, Numer 11, 2020, Strona(/y) 3130 - 3143, ISSN 1948-7193
Wydawca: American Chemical Society
DOI: 10.1021/acschemneuro.0c00477

A Focus on Unusual ECL2 Interactions Yields β 2 ‐Adrenergic Receptor Antagonists with Unprecedented Scaffolds

Autorzy: Magdalena M. Scharf, Mirjam Zimmermann, Florian Wilhelm, Raimond Stroe, Maria Waldhoer, Peter Kolb
Opublikowane w: ChemMedChem, Numer 15/10, 2020, Strona(/y) 882-890, ISSN 1860-7179
Wydawca: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.201900715

New Insights into Arrestin Recruitment to GPCRs

Autorzy: Martin Spillmann, Larissa Thurner, Nina Romantini, Mirjam Zimmermann, Benoit Meger, Martin Behe, Maria Waldhoer, Gebhard F. X. Schertler, Philipp Berger
Opublikowane w: International Journal of Molecular Sciences, Numer 21/14, 2020, Strona(/y) 4949, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21144949

GPCRmd uncovers the dynamics of the 3D-GPCRome

Autorzy: Ismael Rodríguez-Espigares, Mariona Torrens-Fontanals, Johanna K. S. Tiemann, David Aranda-García, Juan Manuel Ramírez-Anguita, Tomasz Maciej Stepniewski, Nathalie Worp, Alejandro Varela-Rial, Adrián Morales-Pastor, Brian Medel-Lacruz, Gáspár Pándy-Szekeres, Eduardo Mayol, Toni Giorgino, Jens Carlsson, Xavier Deupi, Slawomir Filipek, Marta Filizola, José Carlos Gómez-Tamayo, Angel Gonzale
Opublikowane w: Nature Methods, Numer 17/8, 2020, Strona(/y) 777-787, ISSN 1548-7091
Wydawca: Nature Publishing Group
DOI: 10.1038/s41592-020-0884-y

How Do Molecular Dynamics Data Complement Static Structural Data of GPCRs

Autorzy: Mariona Torrens-Fontanals, Tomasz Maciej Stepniewski, David Aranda-García, Adrián Morales-Pastor, Brian Medel-Lacruz and Jana Selent
Opublikowane w: Int. J. Mol. Sci., Numer 21(16), 2020, Strona(/y) 5933, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21165933

The European Research Network on Signal Transduction (ERNEST): Toward a Multidimensional Holistic Understanding of G Protein-Coupled Receptor Signaling

Autorzy: Martha E. Sommer, Jana Selent, Jens Carlsson, Chris De Graaf, David E. Gloriam, Gyorgy M. Keseru, Mickey Kosloff, Stefan Mordalski, Aurelien Rizk, Mette M. Rosenkilde, Eddy Sotelo, Johanna K. S. Tiemann, Andrew Tobin, Nina Vardjan, Maria Waldhoer, Peter Kolb
Opublikowane w: ACS Pharmacology & Translational Science, Numer 3/2, 2020, Strona(/y) 361-370, ISSN 2575-9108
Wydawca: Washington, DC : American Chemical Society
DOI: 10.1021/acsptsci.0c00024

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