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DISRUPTIVE GPCR LEAD DISCOVERY PLATFORM DELIVERING NEW AND SAFER THERAPEUTICS

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Publicaciones

Dopamine D2 Receptor Agonist Binding Kinetics—Role of a Conserved Serine Residue

Autores: Richard Ågren,Tomasz Maciej Stepniewski, Hugo Zeberg, Jana Selent and Kristoffer Sahlholm
Publicado en: Int. J. Mol. Sci., Edición 22 (8), 2021, Página(s) 4078, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22084078

Structural dynamics bridge the gap between the genetic and functional levels of GPCRs

Autores: MarionaTorrens-Fontanals, Tomasz M.Stepniewski, David E.Gloriam, JanaSelent
Publicado en: Current Opinion in Structural Biology, Edición 69, 2021, Página(s) 150-159, ISSN 0959-440X
Editor: Elsevier BV
DOI: 10.1016/j.sbi.2021.04.005

Distinct phosphorylation sites in a prototypical GPCR differently orchestrate β-arrestin interaction, trafficking, and signaling

Autores: Hemlata Dwivedi-Agnihotri, Madhu Chaturvedi, Mithu Baidya, Tomasz Maciej Stepniewski, Shubhi Pandey, Jagannath Maharana, Ashish Srivastava, Natarin Caengprasath, Aylin C. Hanyaloglu, Jana Selent, Arun K. Shukla
Publicado en: Science Advances, Edición 6/37, 2020, Página(s) eabb8368, ISSN 2375-2548
Editor: AAAS
DOI: 10.1126/sciadv.abb8368

Key phosphorylation sites in GPCR s orchestrate the contribution of β‐Arrestin 1 in ERK 1/2 activation

Autores: Mithu Baidya, Punita Kumari, Hemlata Dwivedi‐Agnihotri, Shubhi Pandey, Madhu Chaturvedi, Tomasz Maciej Stepniewski, Kouki Kawakami, Yubo Cao, Stéphane A Laporte, Jana Selent, Asuka Inoue, Arun K Shukla
Publicado en: EMBO reports, Edición 21/9, 2020, ISSN 1469-221X
Editor: Nature Publishing Group
DOI: 10.15252/embr.201949886

Ligand with Two Modes of Interaction with the Dopamine D2 Receptor−An Induced-Fit Mechanism of Insurmountable Antagonism

Autores: Richard Ågren, Hugo Zeberg, Tomasz Maciej Stępniewski, R. Benjamin Free, Sean W. Reilly, Robert R. Luedtke, Peter Århem, Francisco Ciruela, David R. Sibley, Robert H. Mach, Jana Selent, Johanna Nilsson, and Kristoffer Sahlholm
Publicado en: ACS Chemical Neuroscience, Edición 11, 2020, Página(s) 3130 - 3143, ISSN 1948-7193
Editor: American Chemical Society
DOI: 10.1021/acschemneuro.0c00477

A Focus on Unusual ECL2 Interactions Yields β 2 ‐Adrenergic Receptor Antagonists with Unprecedented Scaffolds

Autores: Magdalena M. Scharf, Mirjam Zimmermann, Florian Wilhelm, Raimond Stroe, Maria Waldhoer, Peter Kolb
Publicado en: ChemMedChem, Edición 15/10, 2020, Página(s) 882-890, ISSN 1860-7179
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.201900715

New Insights into Arrestin Recruitment to GPCRs

Autores: Martin Spillmann, Larissa Thurner, Nina Romantini, Mirjam Zimmermann, Benoit Meger, Martin Behe, Maria Waldhoer, Gebhard F. X. Schertler, Philipp Berger
Publicado en: International Journal of Molecular Sciences, Edición 21/14, 2020, Página(s) 4949, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21144949

GPCRmd uncovers the dynamics of the 3D-GPCRome

Autores: Ismael Rodríguez-Espigares, Mariona Torrens-Fontanals, Johanna K. S. Tiemann, David Aranda-García, Juan Manuel Ramírez-Anguita, Tomasz Maciej Stepniewski, Nathalie Worp, Alejandro Varela-Rial, Adrián Morales-Pastor, Brian Medel-Lacruz, Gáspár Pándy-Szekeres, Eduardo Mayol, Toni Giorgino, Jens Carlsson, Xavier Deupi, Slawomir Filipek, Marta Filizola, José Carlos Gómez-Tamayo, Angel Gonzale
Publicado en: Nature Methods, Edición 17/8, 2020, Página(s) 777-787, ISSN 1548-7091
Editor: Nature Publishing Group
DOI: 10.1038/s41592-020-0884-y

How Do Molecular Dynamics Data Complement Static Structural Data of GPCRs

Autores: Mariona Torrens-Fontanals, Tomasz Maciej Stepniewski, David Aranda-García, Adrián Morales-Pastor, Brian Medel-Lacruz and Jana Selent
Publicado en: Int. J. Mol. Sci., Edición 21(16), 2020, Página(s) 5933, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21165933

The European Research Network on Signal Transduction (ERNEST): Toward a Multidimensional Holistic Understanding of G Protein-Coupled Receptor Signaling

Autores: Martha E. Sommer, Jana Selent, Jens Carlsson, Chris De Graaf, David E. Gloriam, Gyorgy M. Keseru, Mickey Kosloff, Stefan Mordalski, Aurelien Rizk, Mette M. Rosenkilde, Eddy Sotelo, Johanna K. S. Tiemann, Andrew Tobin, Nina Vardjan, Maria Waldhoer, Peter Kolb
Publicado en: ACS Pharmacology & Translational Science, Edición 3/2, 2020, Página(s) 361-370, ISSN 2575-9108
Editor: Washington, DC : American Chemical Society
DOI: 10.1021/acsptsci.0c00024

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