Skip to main content

Early defects in the dynamic of the spinal sensorimotor network: is ALS a post-natal neurodevelopmental disorder ?

Project description

Investigating amyotrophic lateral sclerosis as a post-natal disorder

Amyotrophic lateral sclerosis (ALS) is a fatal and incurable neurodegenerative disorder with a midlife onset. Muscle weakness rapidly develops into a generalised paralysis and leads to death within 2–3 years. Despite the substantial knowledge available on adult subjects, successive clinical failures suggest that current treatment methods may not be pertinent. The EU-funded ADELE project therefore intends to explore ALS as a developmental disease that takes root during a person’s critical developmental stages. To this end, it will investigate the spatiotemporal network dynamics in ALS mouse neonates and conduct a behavioural study of proprioceptive integration. It will further identify activity-modulating drugs to influence the course of the disease. The project will provide valuable insight into the development and treatment of ALS.

Call for proposal

H2020-MSCA-IF-2019
See other projects for this call

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Address
Rue De Tolbiac 101
75654 Paris
France
Activity type
Research Organisations
EU contribution
€ 190 676,16

Partners (1)

FEDERAL STATE AUTONOMOUS EDUCATIONAL INSTITUTION OF HIGHER LEARNING KAZAN VOLGA REGION FEDERAL UNIVERSITY
Russia
Address
Kremlyovskaya 18
420008 Kazan
Activity type
Higher or Secondary Education Establishments