Investigating amyotrophic lateral sclerosis as a post-natal disorder
Amyotrophic lateral sclerosis (ALS) is a fatal and incurable neurodegenerative disorder with a midlife onset. Muscle weakness rapidly develops into a generalised paralysis and leads to death within 2–3 years. Despite the substantial knowledge available on adult subjects, successive clinical failures suggest that current treatment methods may not be pertinent. The EU-funded ADELE project therefore intends to explore ALS as a developmental disease that takes root during a person’s critical developmental stages. To this end, it will investigate the spatiotemporal network dynamics in ALS mouse neonates and conduct a behavioural study of proprioceptive integration. It will further identify activity-modulating drugs to influence the course of the disease. The project will provide valuable insight into the development and treatment of ALS.
Fields of science
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Funding SchemeMSCA-IF-GF - Global Fellowships