Skip to main content
Go to the home page of the European Commission (opens in new window)
English English
CORDIS - EU research results
CORDIS

Earth-Abundant Metals with Exclusively Achiral Ligands for Sustainable Chiral-at-Metal Catalysis

Project description

Chiral chemistry takes a leap forward with sustainable catalysts from earth-abundant metals

In the same way a glove fits a hand, molecules have the symmetry that controls their behaviour and interactions. Reversing the symmetry of molecules could mean the difference between effective and ineffective drugs, agricultural chemicals, flavours and fragrances. Chiral transition metal complexes – which are typically synthesised by combining metal salts or organometallic precursors with chiral ligands – are an important class of catalysts used in asymmetric catalysis. The EU-funded EARTHCAM project plans to design reactive chiral-at-metal catalysts based on earth-abundant metals. Researchers will extend a newly developed method that uses chiral-at-metal catalysts whose metal centre serves as both the stereogenic and the reactive centre for catalysis.

Objective

Asymmetric catalysis relies on the design of chiral catalysts and is dedicated to the economical generation of non-racemic chiral compounds, which are building blocks for the production of drugs, agricultural chemicals, flavors, fragrances, and materials. Chiral transition metal complexes constitute an important class of chiral catalysts and are typically synthesized by combining metal salts or organometallic precursors with chiral ligands. A neglected approach follows a different direction and exploits the generation of metal-centered chirality in the course of the assembly of achiral ligands around a central metal. Our group has pioneered the general use of such chiral-at-metal catalysts from noble metals, with the metal center both serving as the exclusive stereogenic center and at the same time acting as the reactive center for catalysis. The design of reactive chiral-at-metal catalysts based on earth-abundant metals, which have economical and environmental benefits, is the focus of this proposal. The design strategy appeals for its combination of sustainability (earth-abundant metals) and simplicity (achiral ligands). Furthermore, without the requirement for chiral motifs in the ligand sphere, untapped opportunities emerge for the design of chiral 3d metal complexes with distinct electronic properties and unique architectures. This unexplored chemical space for chiral catalysts will be applied to the challenging enantioselective functionalization of C(sp3)-H bonds with inexpensive and sustainable 3d metal catalysts.
The implementation of chiral-at-metal catalysts from earth-abundant metals will rely on taming the high lability of coordinative bonds of 3d metals to warrant a satisfactory configuration stability. This will be addressed by exploiting the chelate effect of tailored multidentate ligands in combination with strong-field ligands and attractive weak interactions between coordinated ligands.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

You need to log in or register to use this function

Keywords

Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)

Programme(s)

Multi-annual funding programmes that define the EU’s priorities for research and innovation.

Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

ERC-ADG - Advanced Grant

See all projects funded under this funding scheme

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) ERC-2019-ADG

See all projects funded under this call

Host institution

PHILIPPS UNIVERSITAET MARBURG
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 2 264 184,00
Address
BIEGENSTRASSE 10
35037 Marburg
Germany

See on map

Region
Hessen Gießen Marburg-Biedenkopf
Activity type
Higher or Secondary Education Establishments
Links
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 2 264 184,00

Beneficiaries (1)

My booklet 0 0