Engineering epithelial shape and mechanics: from synthetic morphogenesis to biohybrid devices

Información del proyecto

EpiFold

Identificador del acuerdo de subvención: 883739

DOI

10.3030/883739

Fecha de la firma de la CE 3 Junio 2020

Fecha de inicio 1 Enero 2021

Fecha de finalización 31 Diciembre 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 499 470,00

Aportación de la UE

€ 2 499 470,00

Coordinado por

FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA
Spain

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (21)

The force loading rate drives cell mechanosensing through both reinforcement and cytoskeletal softening

Autores: Andreu, I; Falcones, B; Hurst, S; Chahare, N; Quiroga, X; Le Roux, AL; Kechagia, Z; Beedle, AEM; Elosegui-Artola, A; Trepat, X; Farre, R; Betz, T; Almendros, I; Roca-Cusachs, P
Publicado en: Nature Communications, 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-24383-3

Digesting the mechanobiology of the intestinal epithelium

Autores: Pérez-González, Carlos; Ceada, Gerardo; Matejcic, Marija; Trepat, Xavier
Publicado en: Current Opinion In Genetics & Development, 2022, ISSN 0959-437X
Editor: Elsevier BV
DOI: 10.1016/j.gde.2021.10.005

A feedback loop between lamellipodial extension and HGF-ERK signaling specifies leader cells during collective cell migration

Autores: Naoya Hino, Kimiya Matsuda, Yuya Jikko, Gembu Maryu, Katsuya Sakai, Ryu Imamura, Shinya Tsukiji, Kazuhiro Aoki, Kenta Terai, Tsuyoshi Hirashima, Xavier Trepat, Michiyuki Matsuda
Publicado en: Developmental Cell, 2022, ISSN 1878-1551
Editor: Elsevier
DOI: 10.1016/j.devcel.2022.09.003

Optogenetic control of apical constriction induces synthetic morphogenesis in mammalian tissues

Autores: Guillermo Martínez-Ara, Núria Taberner, Mami Takayama, Elissavet Sandaltzopoulou, Casandra E. Villava, Miquel Bosch-Padrós, Nozomu Takata, Xavier Trepat, Mototsugu Eiraku, Miki Ebisuya
Publicado en: Nature communications, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-33115-0

Stiffness-dependent active wetting enables optimal collective cell durotaxis

Autores: Macià Esteve Pallarès, Irina Pi-Jaumà, Isabela Corina Fortunato, Valeria Grazu, Manuel Gómez-González, Pere Roca-Cusachs, Jesus M. de la Fuente, Ricard Alert, Raimon Sunyer, Jaume Casademunt, Xavier Trepat
Publicado en: Nature Physics, 2023, ISSN 1745-2473
Editor: Nature Publishing Group
DOI: 10.1038/s41567-022-01835-1

A mechanical G2 checkpoint controls epithelial cell division through E-cadherin-mediated regulation of Wee1-Cdk1

Autores: Lisa Donker, Ronja Houtekamer, Marjolein Vliem, François Sipieter, Helena Canever, Manuel Gómez-González, Miquel Bosch-Padrós, Willem-Jan Pannekoek, Xavier Trepat, Nicolas Borghi, Martijn Gloerich
Publicado en: Cell Reports, 2022, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2022.111475

Self-generated gradients steer collective migration on viscoelastic collagen networks

Autores: Andrew G. Clark, Ananyo Maitra, Cécile Jacques, Martin Bergert, Carlos Pérez-González, Anthony Simon, Luc Lederer, Alba Diz-Muñoz, Xavier Trepat, Raphaël Voituriez & Danijela Matic Vignjevic
Publicado en: Nature Materials, 2022, ISSN 1476-1122
Editor: Nature Publishing Group
DOI: 10.1038/s41563-022-01259-5

Caveolin-1 dolines form a distinct and rapid caveolae-independent mechanoadaptation system

Autores: Fidel-Nicolás Lolo, Nikhil Walani, Eric Seemann, Dobryna Zalvidea, Dácil María Pavón, Gheorghe Cojoc, Moreno Zamai, Christine Viaris de Lesegno, Fernando Martínez de Benito, Miguel Sánchez-Álvarez, Juan José Uriarte, Asier Echarri, Daniel Jiménez-Carretero, Joan-Carles Escolano, Susana A. Sánchez, Valeria R. Caiolfa, Daniel Navajas, Xavier Trepat, Jochen Guck, Christophe Lamaze, Pere Roc
Publicado en: Nature Cell Biology, 2022, ISSN 1465-7392
Editor: Nature Publishing Group
DOI: 10.1038/s41556-022-01034-3

Epithelial cell cluster size affects force distribution in response to EGF-induced collective contractility

Autores: Chiara Zambarda, Carlos Pérez González, Andreas Schoenit, Nisha Veits, Clara Schimmer, Raimund Jung, Dirk Ollech, Joel Christian, Pere Roca-Cusachs, Xavier Trepat, Elisabetta Ada Cavalcanti-Adam
Publicado en: European Journal of Cell Biology, 2022, ISSN 0171-9335
Editor: Elsevier BV
DOI: 10.1016/j.ejcb.2022.151274

Mechanobiological approaches to synthetic morphogenesis: learning by building

Autores: Marija Matejčić; Xavier Trepat
Publicado en: Trends in Cell Biology, 2022, ISSN 0962-8924
Editor: Elsevier BV
DOI: 10.1016/j.tcb.2022.06.013

Involvement of Mechanical Cues in the Migration of Cajal-Retzius Cells in the Marginal Zone During Neocortical Development

Autores: Ana López-Mengual, Miriam Segura-Feliu, Raimon Sunyer, Héctor Sanz-Fraile, Jorge Otero, Francina Mesquida-Veny, Vanessa Gil, Arnau Hervera, Isidre Ferrer, Jordi Soriano, Xavier Trepat, Ramon Farré, Daniel Navajas, José Antonio del Río
Publicado en: Frontiers in Cell and Developmental Biology, 2022, ISSN 2296-634X
Editor: Frontiers Media
DOI: 10.3389/fcell.2022.886110

A mechanosensing mechanism controls plasma membrane shape homeostasis at the nanoscale

Autores: Quiroga X, Walani N, Disanza A, Chavero A, Mittens A, Tebar F, Trepat X, Parton RG, Geli MI, Scita G, Arroyo M, Le Roux AL, Roca-Cusachs P
Publicado en: eLife, Edición 12, 2023, Página(s) e72316, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.72316

Metastatic recurrence in colorectal cancer arises from residual EMP1+ cells

Autores: Adrià Cañellas-Socias, Carme Cortina, Xavier Hernando-Momblona, Sergio Palomo-Ponce, Eoghan J. Mulholland, Gemma Turon, Lidia Mateo, Sefora Conti, Olga Roman, Marta Sevillano, Felipe Slebe, Diana Stork, Adrià Caballé-Mestres, Antonio Berenguer-Llergo, Adrián Álvarez-Varela, Nicola Fenderico, Laura Novellasdemunt, Laura Jiménez-Gracia, Tamara Sipka, Lidia Bardia, Patricia Lorden, Julien Colo
Publicado en: Nature, 2022, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-022-05402-9

Mapping mechanical stress in curved epithelia of designed size and shape

Autores: Ariadna Marín-Llauradó, Sohan Kale, Adam Ouzeri, Tom Golde, Raimon Sunyer, Alejandro Torres-Sánchez, Ernest Latorre, Manuel Gómez-González, Pere Roca-Cusachs, Marino Arroyo, Xavier Trepat
Publicado en: Nature Communications, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-38879-7

Mechanical control of the mammalian circadian clock via YAP/TAZ and TEAD

Autores: Juan F. Abenza, Leone Rossetti, Malèke Mouelhi, Javier Burgués, Ion Andreu, Keith Kennedy, Pere Roca-Cusachs, Santiago Marco, Jordi García-Ojalvo, Xavier Trepa
Publicado en: Journal of Cell Biology, 2023, ISSN 0021-9525
Editor: Rockefeller University Press
DOI: 10.1083/jcb.202209120

Cancer-associated fibroblasts actively compress cancer cells and modulate mechanotransduction

Autores: Barbazan J, Pérez-González C, Gómez-González M, Dedenon M, Richon S, Latorre E, Serra M, Mariani P, Descroix S, Sens P, Trepat X, Vignjevic DM
Publicado en: Nature Communicatios, Edición 14, 2023, Página(s) 6966, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-42382-4

Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina

Autores: Pedro Barbacena, Maria Dominguez-Cejudo, Catarina G. Fonseca, Manuel Gómez-González, Laura M. Faure, Georgia Zarkada, Andreia Pena, Anna Pezzarossa, Daniela Ramalho, Ylenia Giarratano, Marie Ouarné, David Barata, Isabela C. Fortunato, Lenka Henao Misikova, Ian Mauldin, Yulia Carvalho, Xavier Trepat, Pere Roca-Cusachs, Anne Eichmann, Miguel O. Bernabeu, Cláudio A. Franco
Publicado en: Developmental Cell, 2022, ISSN 1878-1551
Editor: Elsevier
DOI: 10.1016/j.devcel.2022.09.002

The laminin–keratin link shields the nucleus from mechanical deformation and signalling

Autores: Kechagia, Z; Sáez, P; Gómez-González, M; Canales, B; Viswanadha, S; Zamarbide, M; Andreu, I; Koorman, T; Beedle, AEM; Elosegui-Artola, A; Derksen, PWB; Trepat, X; Arroyo, M; Roca-Cusachs, P
Publicado en: Nature materials, Edición 22, 2023, Página(s) 1409-1420, ISSN 1476-1122
Editor: Nature Publishing Group
DOI: 10.1038/s41563-023-01657-3

Mechanical compartmentalization of the intestinal organoid enables crypt folding and collective cell migration

Autores: Pérez-González C; Ceada G; Greco F; Matejcic M; Gómez-González M; Castro N; Menendez A; Kale S; Krndija D; Clark AG; Gannavarapu VR; Álvarez-Varela A; Roca-Cusachs P; Batlle E; Vignjevic DM; Arroyo M; Trepat X
Publicado en: NATURE CELL BIOLOGY, 2021, ISSN 1465-7392
Editor: Nature Publishing Group
DOI: 10.1038/s41556-021-00699-6

Mechanical force application to the nucleus regulates nucleocytoplasmic transport

Autores: Ion Andreu, Ignasi Granero-Moya, Nimesh R. Chahare, Kessem Clein, Marc Molina-Jordán, Amy E. M. Beedle, Alberto Elosegui-Artola, Juan F. Abenza, Leone Rossetti, Xavier Trepat, Barak Raveh & Pere Roca-Cusachs
Publicado en: Nature Cell Biology, 2022, ISSN 1465-7392
Editor: Nature Publishing Group
DOI: 10.1038/s41556-022-00927-7

Dynamic mechanochemical feedback between curved membranes and BAR protein self-organization

Autores: Le Roux, Anabel-Lise; Tozzi, Caterina; Walani, Nikhil; Quiroga, Xarxa; Zalvidea, Dobryna; Trepat, Xavier; Staykova, Margarita; Arroyo, Marino; Roca-Cusachs, Pere
Publicado en: Nature Communications, 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-26591-3