Engineering epithelial shape and mechanics: from synthetic morphogenesis to biohybrid devices

Pubblicazioni

The force loading rate drives cell mechanosensing through both reinforcement and cytoskeletal softening

Autori: Andreu, I; Falcones, B; Hurst, S; Chahare, N; Quiroga, X; Le Roux, AL; Kechagia, Z; Beedle, AEM; Elosegui-Artola, A; Trepat, X; Farre, R; Betz, T; Almendros, I; Roca-Cusachs, P
Pubblicato in: Nature Communications, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-24383-3

Digesting the mechanobiology of the intestinal epithelium

Autori: Pérez-González, Carlos; Ceada, Gerardo; Matejcic, Marija; Trepat, Xavier
Pubblicato in: Current Opinion In Genetics & Development, 2022, ISSN 0959-437X
Editore: Elsevier BV
DOI: 10.1016/j.gde.2021.10.005

A feedback loop between lamellipodial extension and HGF-ERK signaling specifies leader cells during collective cell migration

Autori: Naoya Hino, Kimiya Matsuda, Yuya Jikko, Gembu Maryu, Katsuya Sakai, Ryu Imamura, Shinya Tsukiji, Kazuhiro Aoki, Kenta Terai, Tsuyoshi Hirashima, Xavier Trepat, Michiyuki Matsuda
Pubblicato in: Developmental Cell, 2022, ISSN 1878-1551
Editore: Elsevier
DOI: 10.1016/j.devcel.2022.09.003

Optogenetic control of apical constriction induces synthetic morphogenesis in mammalian tissues

Autori: Guillermo Martínez-Ara, Núria Taberner, Mami Takayama, Elissavet Sandaltzopoulou, Casandra E. Villava, Miquel Bosch-Padrós, Nozomu Takata, Xavier Trepat, Mototsugu Eiraku, Miki Ebisuya
Pubblicato in: Nature communications, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-33115-0

Stiffness-dependent active wetting enables optimal collective cell durotaxis

Autori: Macià Esteve Pallarès, Irina Pi-Jaumà, Isabela Corina Fortunato, Valeria Grazu, Manuel Gómez-González, Pere Roca-Cusachs, Jesus M. de la Fuente, Ricard Alert, Raimon Sunyer, Jaume Casademunt, Xavier Trepat
Pubblicato in: Nature Physics, 2023, ISSN 1745-2473
Editore: Nature Publishing Group
DOI: 10.1038/s41567-022-01835-1

A mechanical G2 checkpoint controls epithelial cell division through E-cadherin-mediated regulation of Wee1-Cdk1

Autori: Lisa Donker, Ronja Houtekamer, Marjolein Vliem, François Sipieter, Helena Canever, Manuel Gómez-González, Miquel Bosch-Padrós, Willem-Jan Pannekoek, Xavier Trepat, Nicolas Borghi, Martijn Gloerich
Pubblicato in: Cell Reports, 2022, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2022.111475

Self-generated gradients steer collective migration on viscoelastic collagen networks

Autori: Andrew G. Clark, Ananyo Maitra, Cécile Jacques, Martin Bergert, Carlos Pérez-González, Anthony Simon, Luc Lederer, Alba Diz-Muñoz, Xavier Trepat, Raphaël Voituriez & Danijela Matic Vignjevic
Pubblicato in: Nature Materials, 2022, ISSN 1476-1122
Editore: Nature Publishing Group
DOI: 10.1038/s41563-022-01259-5

Caveolin-1 dolines form a distinct and rapid caveolae-independent mechanoadaptation system

Autori: Fidel-Nicolás Lolo, Nikhil Walani, Eric Seemann, Dobryna Zalvidea, Dácil María Pavón, Gheorghe Cojoc, Moreno Zamai, Christine Viaris de Lesegno, Fernando Martínez de Benito, Miguel Sánchez-Álvarez, Juan José Uriarte, Asier Echarri, Daniel Jiménez-Carretero, Joan-Carles Escolano, Susana A. Sánchez, Valeria R. Caiolfa, Daniel Navajas, Xavier Trepat, Jochen Guck, Christophe Lamaze, Pere Roc
Pubblicato in: Nature Cell Biology, 2022, ISSN 1465-7392
Editore: Nature Publishing Group
DOI: 10.1038/s41556-022-01034-3

Epithelial cell cluster size affects force distribution in response to EGF-induced collective contractility

Autori: Chiara Zambarda, Carlos Pérez González, Andreas Schoenit, Nisha Veits, Clara Schimmer, Raimund Jung, Dirk Ollech, Joel Christian, Pere Roca-Cusachs, Xavier Trepat, Elisabetta Ada Cavalcanti-Adam
Pubblicato in: European Journal of Cell Biology, 2022, ISSN 0171-9335
Editore: Elsevier BV
DOI: 10.1016/j.ejcb.2022.151274

Mechanobiological approaches to synthetic morphogenesis: learning by building

Autori: Marija Matejčić; Xavier Trepat
Pubblicato in: Trends in Cell Biology, 2022, ISSN 0962-8924
Editore: Elsevier BV
DOI: 10.1016/j.tcb.2022.06.013

Involvement of Mechanical Cues in the Migration of Cajal-Retzius Cells in the Marginal Zone During Neocortical Development

Autori: Ana López-Mengual, Miriam Segura-Feliu, Raimon Sunyer, Héctor Sanz-Fraile, Jorge Otero, Francina Mesquida-Veny, Vanessa Gil, Arnau Hervera, Isidre Ferrer, Jordi Soriano, Xavier Trepat, Ramon Farré, Daniel Navajas, José Antonio del Río
Pubblicato in: Frontiers in Cell and Developmental Biology, 2022, ISSN 2296-634X
Editore: Frontiers Media
DOI: 10.3389/fcell.2022.886110

A mechanosensing mechanism controls plasma membrane shape homeostasis at the nanoscale

Autori: Quiroga X, Walani N, Disanza A, Chavero A, Mittens A, Tebar F, Trepat X, Parton RG, Geli MI, Scita G, Arroyo M, Le Roux AL, Roca-Cusachs P
Pubblicato in: eLife, Numero 12, 2023, Pagina/e e72316, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.72316

Metastatic recurrence in colorectal cancer arises from residual EMP1+ cells

Autori: Adrià Cañellas-Socias, Carme Cortina, Xavier Hernando-Momblona, Sergio Palomo-Ponce, Eoghan J. Mulholland, Gemma Turon, Lidia Mateo, Sefora Conti, Olga Roman, Marta Sevillano, Felipe Slebe, Diana Stork, Adrià Caballé-Mestres, Antonio Berenguer-Llergo, Adrián Álvarez-Varela, Nicola Fenderico, Laura Novellasdemunt, Laura Jiménez-Gracia, Tamara Sipka, Lidia Bardia, Patricia Lorden, Julien Colo
Pubblicato in: Nature, 2022, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-022-05402-9

Mapping mechanical stress in curved epithelia of designed size and shape

Autori: Ariadna Marín-Llauradó, Sohan Kale, Adam Ouzeri, Tom Golde, Raimon Sunyer, Alejandro Torres-Sánchez, Ernest Latorre, Manuel Gómez-González, Pere Roca-Cusachs, Marino Arroyo, Xavier Trepat
Pubblicato in: Nature Communications, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-38879-7

Mechanical control of the mammalian circadian clock via YAP/TAZ and TEAD

Autori: Juan F. Abenza, Leone Rossetti, Malèke Mouelhi, Javier Burgués, Ion Andreu, Keith Kennedy, Pere Roca-Cusachs, Santiago Marco, Jordi García-Ojalvo, Xavier Trepa
Pubblicato in: Journal of Cell Biology, 2023, ISSN 0021-9525
Editore: Rockefeller University Press
DOI: 10.1083/jcb.202209120

Cancer-associated fibroblasts actively compress cancer cells and modulate mechanotransduction

Autori: Barbazan J, Pérez-González C, Gómez-González M, Dedenon M, Richon S, Latorre E, Serra M, Mariani P, Descroix S, Sens P, Trepat X, Vignjevic DM
Pubblicato in: Nature Communicatios, Numero 14, 2023, Pagina/e 6966, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-42382-4

Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina

Autori: Pedro Barbacena, Maria Dominguez-Cejudo, Catarina G. Fonseca, Manuel Gómez-González, Laura M. Faure, Georgia Zarkada, Andreia Pena, Anna Pezzarossa, Daniela Ramalho, Ylenia Giarratano, Marie Ouarné, David Barata, Isabela C. Fortunato, Lenka Henao Misikova, Ian Mauldin, Yulia Carvalho, Xavier Trepat, Pere Roca-Cusachs, Anne Eichmann, Miguel O. Bernabeu, Cláudio A. Franco
Pubblicato in: Developmental Cell, 2022, ISSN 1878-1551
Editore: Elsevier
DOI: 10.1016/j.devcel.2022.09.002

The laminin–keratin link shields the nucleus from mechanical deformation and signalling

Autori: Kechagia, Z; Sáez, P; Gómez-González, M; Canales, B; Viswanadha, S; Zamarbide, M; Andreu, I; Koorman, T; Beedle, AEM; Elosegui-Artola, A; Derksen, PWB; Trepat, X; Arroyo, M; Roca-Cusachs, P
Pubblicato in: Nature materials, Numero 22, 2023, Pagina/e 1409-1420, ISSN 1476-1122
Editore: Nature Publishing Group
DOI: 10.1038/s41563-023-01657-3

Mechanical compartmentalization of the intestinal organoid enables crypt folding and collective cell migration

Autori: Pérez-González C; Ceada G; Greco F; Matejcic M; Gómez-González M; Castro N; Menendez A; Kale S; Krndija D; Clark AG; Gannavarapu VR; Álvarez-Varela A; Roca-Cusachs P; Batlle E; Vignjevic DM; Arroyo M; Trepat X
Pubblicato in: NATURE CELL BIOLOGY, 2021, ISSN 1465-7392
Editore: Nature Publishing Group
DOI: 10.1038/s41556-021-00699-6

Mechanical force application to the nucleus regulates nucleocytoplasmic transport

Autori: Ion Andreu, Ignasi Granero-Moya, Nimesh R. Chahare, Kessem Clein, Marc Molina-Jordán, Amy E. M. Beedle, Alberto Elosegui-Artola, Juan F. Abenza, Leone Rossetti, Xavier Trepat, Barak Raveh & Pere Roca-Cusachs
Pubblicato in: Nature Cell Biology, 2022, ISSN 1465-7392
Editore: Nature Publishing Group
DOI: 10.1038/s41556-022-00927-7

Dynamic mechanochemical feedback between curved membranes and BAR protein self-organization

Autori: Le Roux, Anabel-Lise; Tozzi, Caterina; Walani, Nikhil; Quiroga, Xarxa; Zalvidea, Dobryna; Trepat, Xavier; Staykova, Margarita; Arroyo, Marino; Roca-Cusachs, Pere
Pubblicato in: Nature Communications, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-26591-3

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