Determining in vivo protein structures and understanding genetic interactions using deep mutagenesis

Project Information

MUTANOMICS

Grant agreement ID: 883742

DOI 10.3030/883742

EC signature date 23 July 2020

Start date 1 January 2021

End date 31 December 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 333 279,00

EU contribution € 2 333 279,00

Coordinated by

FUNDACIO CENTRE DE REGULACIO GENOMICA
Spain

Publications

Peer reviewed articles (5)

Neuronal perception of the social environment generates an inherited memory that controls the development and generation time of C. elegans

Author(s): Marcos Francisco Perez, Mehrnaz Shamalnasab, Alejandro Mata-Cabana, María Olmedo, Mirko Francesconi, Ben Lehner
Published in: Current Biology, 2021, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2021.07.031

The impact of rare germline variants on human somatic mutation processes

Author(s): Ben Lehner; Fran Supek; Mischan Vali Pour Jamnani
Published in: Crossref, Issue 1, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-31483-1

Mapping the energetic and allosteric landscapes of protein binding domains.

Author(s): Andre J. Faure; Júlia Domingo; Jörn M. Schmiedel; Cristina Hidalgo-Carcedo; Guillaume Diss; Ben Lehner
Published in: Crossref, Issue 1, 2022, ISSN 1476-4687
Publisher: Nature Research
DOI: 10.1038/s41586-022-04586-4

An atlas of amyloid aggregation: the impact of substitutions, insertions, deletions and truncations on amyloid beta fibril nucleation.

Author(s): Benedetta Bolognesi; Ben Lehner; Mireia Seuma
Published in: Crossref, Issue 1, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-34742-3

Higher order genetic interactions switch cancer genes from two-hit to one-hit drivers.

Author(s): Park, Solip; Supek, Fran; Lehner, Ben; park
Published in: Nature Communications, Issue 1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-27242-3