Targeting the essentialome of radiotherapy-resistant cancer

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Meiotic Genes and DNA Double Strand Break Repair in Cancer

Autores: Lea Lingg, Sven Rottenberg, Paola Francica
Publicado en: Frontiers in Genetics, 2022, ISSN 1664-8021
Editor: Frontiers Media
DOI: 10.3389/fgene.2022.831620

Multi-omics analysis reveals distinct non-reversion mechanisms of PARPi resistance in BRCA1- versus BRCA2-deficient mammary tumors

Autores: Bhin J, Paes Dias M, Gogola E, Rolfs F, Piersma SR, de Bruijn R, de Ruiter JR, van den Broek B, Duarte AA, Sol W, van der Heijden I, Andronikou C, Kaiponen TS, Bakker L, Lieftink C, Morris B, Beijersbergen RL, van de Ven M, Jimenez CR, Wessels LFA, Rottenberg S, Jonkers J
Publicado en: Cell Reports, 2023, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2023.112538

LRP6 Is a Functional Receptor for Attenuated Canine Distemper Virus

Autores: Gradauskaite, Vaiva; Inglebert, Marine; Doench, John; Scherer, Melanie; Dettwiler, Martina; Wyss, Marianne; Shrestha, Neeta; Rottenberg, Sven; Plattet, Philippe
Publicado en: mBio, 2023, ISSN 2150-7511
Editor: American Society for Microbiology
DOI: 10.1128/mbio.03114-22

Persisting cancer cells are different from bacterial persisters

Autores: Decollogny, Morgane; Rottenberg, Sven
Publicado en: Trends in Cancer, Edición 10(5):393-406, 2024, ISSN 2405-8025
Editor: CellPress
DOI: 10.1016/j.trecan.2024.02.002

PARG-deficient tumor cells have an increased dependence on EXO1/FEN1-mediated DNA repair

Autores: Andronikou, Christina; Burdova, Kamila; Dibitetto, Diego; Lieftink, Cor; Malzer, Elke; Kuiken, Hendrik J; Gogola, Ewa; Ray Chaudhuri, Arnab; Beijersbergen, Roderick L; Hanzlikova, Hana; Jonkers, Jos; Rottenberg, Sven
Publicado en: The EMBO Journal, Edición 43(6):1015-1042, 2024, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.1038/s44318-024-00043-2

MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells

Autores: Zelceski A, Francica P, Lingg L, Mutlu M, Stok C, Liptay M, Alexander J, Baxter JS, Brough R, Gulati A, Haider S, Raghunandan M, Song F, Sridhar S, Forment JV, O'Connor MJ, Davies BR, van Vugt MATM, Krastev DB, Pettitt SJ, Tutt ANJ, Rottenberg S, Lord CJ
Publicado en: Cell Reports, 2023, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2023.112484

Loss of the Volume-regulated Anion Channel Components LRRC8A and LRRC8D Limits Platinum Drug Efficacy

Autores: Widmer CA, Klebic I, Domanitskaya N, Decollogny M, Howald D, Siffert M, Essers P, Nowicka Z, Stokar-Regenscheit N, van de Ven M, de Korte-Grimmerink R, Galván JA, Pritchard CEJ, Huijbers IJ, Fendler W, Vens C, Rottenberg S
Publicado en: Cancer Research Communications, 2022, ISSN 2767-9764
Editor: American Association for Cancer Research
DOI: 10.1158/2767-9764.crc-22-0208

H2AX promotes replication fork degradation and chemosensitivity in BRCA-deficient tumours

Autores: Diego Dibitetto; Martin Liptay; Francesca Vivalda; Ewa Gogola; Hulya Dogan; Martín G. Fernández; Alexandra Duarte; Jonas A. Schmid; Stephen T. Durant; Josep V. Forment; Ismar Klebic; Myriam Siffert; Roebi de Bruijn; Arne N. Kousholt; Nicole A. Marti; Martina Dettwiler; Claus S. Sørensen; Massimo Lopes; Alessandro A. Sartori; Jos Jonkers; Sven Rottenberg
Publicado en: Nature Communications, Edición 4430 (2024), 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1101/2023.05.22.541781

International multidisciplinary consensus on the integration of radiotherapy with new systemic treatments for breast cancer: European Society for Radiotherapy and Oncology (ESTRO)-endorsed recommendations

Autores: Meattini I, Becherini C, Caini S, Coles CE, Cortes J, Curigliano G, de Azambuja E, Isacke CM, Harbeck N, Kaidar-Person O, Marangoni E, Offersen BV, Rugo HS, Salvestrini V, Visani L, Morandi A, Lambertini M, Poortmans P, Livi L; Consensus Panellist Group
Publicado en: Lancet Oncology, Edición 25(2):e73-e83, 2024, ISSN 1470-2045
Editor: The Lancet Publishing Group
DOI: 10.1016/s1470-2045(23)00534-x

DNA-PKcs promotes fork reversal and chemoresistance

Autores: Dibitetto D, Marshall S, Sanchi A, Liptay M, Badar J, Lopes M, Rottenberg S, Smolka MB
Publicado en: Molecular Cell, 2022, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2022.08.028

Truncated FGFR2 is a clinically actionable oncogene in multiple cancers

Autores: Zingg D, Bhin J, Yemelyanenko J, Kas SM, Rolfs F, Lutz C, Lee JK, Klarenbeek S, Silverman IM, Annunziato S, Chan CS, Piersma SR, Eijkman T, Badoux M, Gogola E, Siteur B, Sprengers J, de Klein B, de Goeij-de Haas RR, Riedlinger GM, Ke H, Madison R, Drenth AP, van der Burg E, Schut E, Henneman L, van Miltenburg MH, Proost N, Zhen H, Wientjens E, de Bruijn R, de Ruiter JR, Boon U, de Korte-Grimmerink
Publicado en: Nature, 2022, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-022-05066-5

DNA repair, gap suppression, or fork protection: BRCA2 needs a break!

Autores: Diego Dibitetto, Sven Rottenberg
Publicado en: Molecular Cell, Edición 84(3):409-410, 2024, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2023.12.026

Functional genetic dropout screens and in vivo validation of candidate therapeutic targets using mouse mammary tumoroids

Autores: Paes Dias M, Rottenberg S, Jonkers J.
Publicado en: Star Protocols, 2022, ISSN 2666-1667
Editor: Elsevier
DOI: 10.1016/j.xpro.2022.101132

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