Targeting the essentialome of radiotherapy-resistant cancer

Publikacje

Meiotic Genes and DNA Double Strand Break Repair in Cancer

Autorzy: Lea Lingg, Sven Rottenberg, Paola Francica
Opublikowane w: Frontiers in Genetics, 2022, ISSN 1664-8021
Wydawca: Frontiers Media
DOI: 10.3389/fgene.2022.831620

Multi-omics analysis reveals distinct non-reversion mechanisms of PARPi resistance in BRCA1- versus BRCA2-deficient mammary tumors

Autorzy: Bhin J, Paes Dias M, Gogola E, Rolfs F, Piersma SR, de Bruijn R, de Ruiter JR, van den Broek B, Duarte AA, Sol W, van der Heijden I, Andronikou C, Kaiponen TS, Bakker L, Lieftink C, Morris B, Beijersbergen RL, van de Ven M, Jimenez CR, Wessels LFA, Rottenberg S, Jonkers J
Opublikowane w: Cell Reports, 2023, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2023.112538

LRP6 Is a Functional Receptor for Attenuated Canine Distemper Virus

Autorzy: Gradauskaite, Vaiva; Inglebert, Marine; Doench, John; Scherer, Melanie; Dettwiler, Martina; Wyss, Marianne; Shrestha, Neeta; Rottenberg, Sven; Plattet, Philippe
Opublikowane w: mBio, 2023, ISSN 2150-7511
Wydawca: American Society for Microbiology
DOI: 10.1128/mbio.03114-22

Persisting cancer cells are different from bacterial persisters

Autorzy: Decollogny, Morgane; Rottenberg, Sven
Opublikowane w: Trends in Cancer, Numer 10(5):393-406, 2024, ISSN 2405-8025
Wydawca: CellPress
DOI: 10.1016/j.trecan.2024.02.002

PARG-deficient tumor cells have an increased dependence on EXO1/FEN1-mediated DNA repair

Autorzy: Andronikou, Christina; Burdova, Kamila; Dibitetto, Diego; Lieftink, Cor; Malzer, Elke; Kuiken, Hendrik J; Gogola, Ewa; Ray Chaudhuri, Arnab; Beijersbergen, Roderick L; Hanzlikova, Hana; Jonkers, Jos; Rottenberg, Sven
Opublikowane w: The EMBO Journal, Numer 43(6):1015-1042, 2024, ISSN 0261-4189
Wydawca: Nature Publishing Group
DOI: 10.1038/s44318-024-00043-2

MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells

Autorzy: Zelceski A, Francica P, Lingg L, Mutlu M, Stok C, Liptay M, Alexander J, Baxter JS, Brough R, Gulati A, Haider S, Raghunandan M, Song F, Sridhar S, Forment JV, O'Connor MJ, Davies BR, van Vugt MATM, Krastev DB, Pettitt SJ, Tutt ANJ, Rottenberg S, Lord CJ
Opublikowane w: Cell Reports, 2023, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2023.112484

Loss of the Volume-regulated Anion Channel Components LRRC8A and LRRC8D Limits Platinum Drug Efficacy

Autorzy: Widmer CA, Klebic I, Domanitskaya N, Decollogny M, Howald D, Siffert M, Essers P, Nowicka Z, Stokar-Regenscheit N, van de Ven M, de Korte-Grimmerink R, Galván JA, Pritchard CEJ, Huijbers IJ, Fendler W, Vens C, Rottenberg S
Opublikowane w: Cancer Research Communications, 2022, ISSN 2767-9764
Wydawca: American Association for Cancer Research
DOI: 10.1158/2767-9764.crc-22-0208

H2AX promotes replication fork degradation and chemosensitivity in BRCA-deficient tumours

Autorzy: Diego Dibitetto; Martin Liptay; Francesca Vivalda; Ewa Gogola; Hulya Dogan; Martín G. Fernández; Alexandra Duarte; Jonas A. Schmid; Stephen T. Durant; Josep V. Forment; Ismar Klebic; Myriam Siffert; Roebi de Bruijn; Arne N. Kousholt; Nicole A. Marti; Martina Dettwiler; Claus S. Sørensen; Massimo Lopes; Alessandro A. Sartori; Jos Jonkers; Sven Rottenberg
Opublikowane w: Nature Communications, Numer 4430 (2024), 2024, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1101/2023.05.22.541781

International multidisciplinary consensus on the integration of radiotherapy with new systemic treatments for breast cancer: European Society for Radiotherapy and Oncology (ESTRO)-endorsed recommendations

Autorzy: Meattini I, Becherini C, Caini S, Coles CE, Cortes J, Curigliano G, de Azambuja E, Isacke CM, Harbeck N, Kaidar-Person O, Marangoni E, Offersen BV, Rugo HS, Salvestrini V, Visani L, Morandi A, Lambertini M, Poortmans P, Livi L; Consensus Panellist Group
Opublikowane w: Lancet Oncology, Numer 25(2):e73-e83, 2024, ISSN 1470-2045
Wydawca: The Lancet Publishing Group
DOI: 10.1016/s1470-2045(23)00534-x

DNA-PKcs promotes fork reversal and chemoresistance

Autorzy: Dibitetto D, Marshall S, Sanchi A, Liptay M, Badar J, Lopes M, Rottenberg S, Smolka MB
Opublikowane w: Molecular Cell, 2022, ISSN 1097-2765
Wydawca: Cell Press
DOI: 10.1016/j.molcel.2022.08.028

Truncated FGFR2 is a clinically actionable oncogene in multiple cancers

Autorzy: Zingg D, Bhin J, Yemelyanenko J, Kas SM, Rolfs F, Lutz C, Lee JK, Klarenbeek S, Silverman IM, Annunziato S, Chan CS, Piersma SR, Eijkman T, Badoux M, Gogola E, Siteur B, Sprengers J, de Klein B, de Goeij-de Haas RR, Riedlinger GM, Ke H, Madison R, Drenth AP, van der Burg E, Schut E, Henneman L, van Miltenburg MH, Proost N, Zhen H, Wientjens E, de Bruijn R, de Ruiter JR, Boon U, de Korte-Grimmerink
Opublikowane w: Nature, 2022, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/s41586-022-05066-5

DNA repair, gap suppression, or fork protection: BRCA2 needs a break!

Autorzy: Diego Dibitetto, Sven Rottenberg
Opublikowane w: Molecular Cell, Numer 84(3):409-410, 2024, ISSN 1097-2765
Wydawca: Cell Press
DOI: 10.1016/j.molcel.2023.12.026

Functional genetic dropout screens and in vivo validation of candidate therapeutic targets using mouse mammary tumoroids

Autorzy: Paes Dias M, Rottenberg S, Jonkers J.
Opublikowane w: Star Protocols, 2022, ISSN 2666-1667
Wydawca: Elsevier
DOI: 10.1016/j.xpro.2022.101132

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