Targeting the essentialome of radiotherapy-resistant cancer

Publications

Meiotic Genes and DNA Double Strand Break Repair in Cancer

Auteurs: Lea Lingg, Sven Rottenberg, Paola Francica
Publié dans: Frontiers in Genetics, 2022, ISSN 1664-8021
Éditeur: Frontiers Media
DOI: 10.3389/fgene.2022.831620

Multi-omics analysis reveals distinct non-reversion mechanisms of PARPi resistance in BRCA1- versus BRCA2-deficient mammary tumors

Auteurs: Bhin J, Paes Dias M, Gogola E, Rolfs F, Piersma SR, de Bruijn R, de Ruiter JR, van den Broek B, Duarte AA, Sol W, van der Heijden I, Andronikou C, Kaiponen TS, Bakker L, Lieftink C, Morris B, Beijersbergen RL, van de Ven M, Jimenez CR, Wessels LFA, Rottenberg S, Jonkers J
Publié dans: Cell Reports, 2023, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2023.112538

LRP6 Is a Functional Receptor for Attenuated Canine Distemper Virus

Auteurs: Gradauskaite, Vaiva; Inglebert, Marine; Doench, John; Scherer, Melanie; Dettwiler, Martina; Wyss, Marianne; Shrestha, Neeta; Rottenberg, Sven; Plattet, Philippe
Publié dans: mBio, 2023, ISSN 2150-7511
Éditeur: American Society for Microbiology
DOI: 10.1128/mbio.03114-22

Persisting cancer cells are different from bacterial persisters

Auteurs: Decollogny, Morgane; Rottenberg, Sven
Publié dans: Trends in Cancer, Numéro 10(5):393-406, 2024, ISSN 2405-8025
Éditeur: CellPress
DOI: 10.1016/j.trecan.2024.02.002

PARG-deficient tumor cells have an increased dependence on EXO1/FEN1-mediated DNA repair

Auteurs: Andronikou, Christina; Burdova, Kamila; Dibitetto, Diego; Lieftink, Cor; Malzer, Elke; Kuiken, Hendrik J; Gogola, Ewa; Ray Chaudhuri, Arnab; Beijersbergen, Roderick L; Hanzlikova, Hana; Jonkers, Jos; Rottenberg, Sven
Publié dans: The EMBO Journal, Numéro 43(6):1015-1042, 2024, ISSN 0261-4189
Éditeur: Nature Publishing Group
DOI: 10.1038/s44318-024-00043-2

MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells

Auteurs: Zelceski A, Francica P, Lingg L, Mutlu M, Stok C, Liptay M, Alexander J, Baxter JS, Brough R, Gulati A, Haider S, Raghunandan M, Song F, Sridhar S, Forment JV, O'Connor MJ, Davies BR, van Vugt MATM, Krastev DB, Pettitt SJ, Tutt ANJ, Rottenberg S, Lord CJ
Publié dans: Cell Reports, 2023, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2023.112484

Loss of the Volume-regulated Anion Channel Components LRRC8A and LRRC8D Limits Platinum Drug Efficacy

Auteurs: Widmer CA, Klebic I, Domanitskaya N, Decollogny M, Howald D, Siffert M, Essers P, Nowicka Z, Stokar-Regenscheit N, van de Ven M, de Korte-Grimmerink R, Galván JA, Pritchard CEJ, Huijbers IJ, Fendler W, Vens C, Rottenberg S
Publié dans: Cancer Research Communications, 2022, ISSN 2767-9764
Éditeur: American Association for Cancer Research
DOI: 10.1158/2767-9764.crc-22-0208

H2AX promotes replication fork degradation and chemosensitivity in BRCA-deficient tumours

Auteurs: Diego Dibitetto; Martin Liptay; Francesca Vivalda; Ewa Gogola; Hulya Dogan; Martín G. Fernández; Alexandra Duarte; Jonas A. Schmid; Stephen T. Durant; Josep V. Forment; Ismar Klebic; Myriam Siffert; Roebi de Bruijn; Arne N. Kousholt; Nicole A. Marti; Martina Dettwiler; Claus S. Sørensen; Massimo Lopes; Alessandro A. Sartori; Jos Jonkers; Sven Rottenberg
Publié dans: Nature Communications, Numéro 4430 (2024), 2024, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1101/2023.05.22.541781

International multidisciplinary consensus on the integration of radiotherapy with new systemic treatments for breast cancer: European Society for Radiotherapy and Oncology (ESTRO)-endorsed recommendations

Auteurs: Meattini I, Becherini C, Caini S, Coles CE, Cortes J, Curigliano G, de Azambuja E, Isacke CM, Harbeck N, Kaidar-Person O, Marangoni E, Offersen BV, Rugo HS, Salvestrini V, Visani L, Morandi A, Lambertini M, Poortmans P, Livi L; Consensus Panellist Group
Publié dans: Lancet Oncology, Numéro 25(2):e73-e83, 2024, ISSN 1470-2045
Éditeur: The Lancet Publishing Group
DOI: 10.1016/s1470-2045(23)00534-x

DNA-PKcs promotes fork reversal and chemoresistance

Auteurs: Dibitetto D, Marshall S, Sanchi A, Liptay M, Badar J, Lopes M, Rottenberg S, Smolka MB
Publié dans: Molecular Cell, 2022, ISSN 1097-2765
Éditeur: Cell Press
DOI: 10.1016/j.molcel.2022.08.028

Truncated FGFR2 is a clinically actionable oncogene in multiple cancers

Auteurs: Zingg D, Bhin J, Yemelyanenko J, Kas SM, Rolfs F, Lutz C, Lee JK, Klarenbeek S, Silverman IM, Annunziato S, Chan CS, Piersma SR, Eijkman T, Badoux M, Gogola E, Siteur B, Sprengers J, de Klein B, de Goeij-de Haas RR, Riedlinger GM, Ke H, Madison R, Drenth AP, van der Burg E, Schut E, Henneman L, van Miltenburg MH, Proost N, Zhen H, Wientjens E, de Bruijn R, de Ruiter JR, Boon U, de Korte-Grimmerink
Publié dans: Nature, 2022, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/s41586-022-05066-5

DNA repair, gap suppression, or fork protection: BRCA2 needs a break!

Auteurs: Diego Dibitetto, Sven Rottenberg
Publié dans: Molecular Cell, Numéro 84(3):409-410, 2024, ISSN 1097-2765
Éditeur: Cell Press
DOI: 10.1016/j.molcel.2023.12.026

Functional genetic dropout screens and in vivo validation of candidate therapeutic targets using mouse mammary tumoroids

Auteurs: Paes Dias M, Rottenberg S, Jonkers J.
Publié dans: Star Protocols, 2022, ISSN 2666-1667
Éditeur: Elsevier
DOI: 10.1016/j.xpro.2022.101132

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