Novel mechanistic insight into NK cell function
Natural killer (NK) cells are key components of the innate immune system that recognise HLA-I molecules present as a result of infected or cancer cells. Recent evidence indicates that the natural cytotoxicity receptor NKp44 also regulates NK cell function by interacting with HLA-II molecules. The EU-funded RegNK project aims to investigate this paradigm shift in NK cell function in human diseases. Using human organoid systems and proteomics technologies, scientists will study the interactions between NKp44 and HLA-II and determine their role in infection and inflammation. Results will pave the way for novel NK cell-based therapies against infectious and inflammatory diseases.
Call for proposal
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