Regulation of NK cell function

Project description

Novel mechanistic insight into NK cell function

Natural killer (NK) cells are key components of the innate immune system that recognise HLA-I molecules present as a result of infected or cancer cells. Recent evidence indicates that the natural cytotoxicity receptor NKp44 also regulates NK cell function by interacting with HLA-II molecules. The EU-funded RegNK project aims to investigate this paradigm shift in NK cell function in human diseases. Using human organoid systems and proteomics technologies, scientists will study the interactions between NKp44 and HLA-II and determine their role in infection and inflammation. Results will pave the way for novel NK cell-based therapies against infectious and inflammatory diseases.

Programme(s)

• H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)

Topic(s)

• ERC-2019-ADG - ERC Advanced Grant

Call for proposal

ERC-2019-ADG
See other projects for this call

Funding Scheme

ERC-ADG - Advanced Grant

Host institution

HEINRICH-PETTE INSTITUT LEIBNIZ INSTITUT FUER EXPERIMENTELLE VIROLOGIE

Address

Martinistrasse 52
20251 Hamburg
Germany

Activity type

Research Organisations

EU contribution

€ 2 497 500

Beneficiaries (1)

HEINRICH-PETTE INSTITUT LEIBNIZ INSTITUT FUER EXPERIMENTELLE VIROLOGIE

Germany

EU contribution

€ 2 497 500

Address

Martinistrasse 52
20251 Hamburg

Activity type

Research Organisations