Tissue repair functions of MAIT cells: integrating thymic pre-commitment and peripheral signals

Project description

The role of mucosal T cells in tissue repair

Mucosal associated invariant T (MAIT) cells are a specialised group of T cells that recognise specific microbial ligands in mucosal tissues. Intriguingly, these cells differentiate in the thymus during development through unknown mechanisms. Scientists of the EU-funded MAIT project will investigate how tissue and environmental cues drive this thymic differentiation and determine MAIT function. They will focus on the effector and protective role of MAIT cells in skin wound healing and flu infection. In addition to providing fundamental knowledge on this T cell population, results will lay the foundation for the use of MAIT cells in boosting tissue repair.

Host institution

INSTITUT CURIE

Net EU contribution

€ 2 499 500,00

Address

Rue D Ulm 26
75231 Paris
France

Region

Ile-de-France Ile-de-France Paris

Activity type

Research Organisations

Links

Contact the organisation Website

Participation in EU R&I programmes

HORIZON collaboration network

Other funding

€ 0,00

Beneficiaries (1)