The role of mucosal T cells in tissue repair
Mucosal associated invariant T (MAIT) cells are a specialised group of T cells that recognise specific microbial ligands in mucosal tissues. Intriguingly, these cells differentiate in the thymus during development through unknown mechanisms. Scientists of the EU-funded MAIT project will investigate how tissue and environmental cues drive this thymic differentiation and determine MAIT function. They will focus on the effector and protective role of MAIT cells in skin wound healing and flu infection. In addition to providing fundamental knowledge on this T cell population, results will lay the foundation for the use of MAIT cells in boosting tissue repair.
Funding SchemeERC-ADG - Advanced Grant
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