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Tissue repair functions of MAIT cells: integrating thymic pre-commitment and peripheral signals

Project description

The role of mucosal T cells in tissue repair

Mucosal associated invariant T (MAIT) cells are a specialised group of T cells that recognise specific microbial ligands in mucosal tissues. Intriguingly, these cells differentiate in the thymus during development through unknown mechanisms. Scientists of the EU-funded MAIT project will investigate how tissue and environmental cues drive this thymic differentiation and determine MAIT function. They will focus on the effector and protective role of MAIT cells in skin wound healing and flu infection. In addition to providing fundamental knowledge on this T cell population, results will lay the foundation for the use of MAIT cells in boosting tissue repair.

Host institution

INSTITUT CURIE
Net EU contribution
€ 2 499 500,00
Address
Rue D Ulm 26
75231 Paris
France

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 0,00

Beneficiaries (1)

INSTITUT CURIE
France
Net EU contribution
€ 2 499 500,00
Address
Rue D Ulm 26
75231 Paris

See on map

Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 0,00