Investigating the function of P5 ATPase pumps in our cells
P-type ATP synthases or ATPases are a large group of evolutionarily related ion and lipid pumps that are found in bacteria, archaea and eukaryotes. Prominent examples include sodium–potassium and calcium pumps. Little is known about P5 ATPases, which are found only in eukaryotes and whose malfunctions have been linked to severe neurological diseases. The EU-funded hyP5 project plans to find out more about their substrate specificity and structure as well as their cellular interaction network using different methods, including native mass spectroscopy, cryo-electron microscopy and X-ray crystallography. The project's findings could help unravel the molecular mechanisms of neurodegenerative and cognitive disorders and guide the development of new drugs.
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