An analytical platform for organoid profiling
Organoids are emerging as promising tools for drug discovery and for studying disease pathogenesis. However, challenges associated with the capacity of organoids to recapitulate the complex structure and function of actual biological tissues and organs have limited their use. To address this, scientists of the EU-funded UltraRamanomics project propose to develop a bioanalytical platform for the phenotypic profiling of organoids derived from individual stem cells and human induced pluripotent stem cells. Using spectroscopy-based biochemical measurements, the platform will offer a direct comparison of different organoid models with great spatial resolution, filling a knowledge gap in stem cell organoid research.