Project description
Vector–virus interaction in tick-transmitted severe fever with thrombocytopenia syndrome virus
Ticks are transmitters of many types of arboviruses, including the recently discovered severe fever with thrombocytopenia syndrome virus (SFTSV), a phenuivirus emerging in some Asian countries. Ripicephalus microplus ticks serve as vectors of deadly SFTSV, and there are no basic genomic data for these non-model arthropods. Funded by the Marie Skłodowska-Curie Actions programme, the TICKITS project aims to develop an innovative approach, acquiring combined transcriptomics and proteomics data from tick cells during infection. This complex study of the host response will provide information about potential targets that can be further investigated to determine their impact on viral infection.
Objective
Among hematophagous arthropods ticks transmit a large variety of pathogens with public health and veterinary importance. Tick transmit several emergent and re-emergent arboviruses across the world. In 2010, scientists discovered severe fever with thrombocytopenia syndrome virus (SFTSV), an emergent Banyangvirus (Phenuivirus) transmitted by ticks in Asian countries. SFTSV infection causes severe symptoms and can lead to the death in infected individuals. Novel vector-based control strategies require a more detailed understanding of the vector-virus interaction and the vector response to infection.
Ripicephalius microplus ticks are vectors of SFTSV and as for many non-model arthropods we are missing basic genomic data, which makes tick-arbovirus interaction studies difficult. To overcome these limitations, the TICKITS (TICK cell Interactions with SFTSV) project aims to develop an innovative approach coupling transcriptomic and proteomics data from R. microplus cells during infection. This systematic approach will characterize SFTSV infections in their natural tick vector and will generate information on changes in vector cells both at transcriptome and proteome level. This integrative view of the host response will give us insights on targets that can be investigated using gene silencing approaches to determine their impact on viral infection. I choose to work with the Kohl and Brennan laboratories at the MRC-University of Glasgow Centre for Virus Research (CVR) in Glasgow, UK. Both laboratories excel in tick/arthropod biology and arbovirus infection studies and have all the tools necessary to carry out this work. By adding my molecular and omics expertise we aim to develop novel angles in tick research. Moreover, the data generated will provide a solid base for other projects to build on and develop comparative projects across species.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences public health
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences biological sciences microbiology virology
- natural sciences biological sciences genetics RNA transcriptomes
- natural sciences biological sciences zoology invertebrate zoology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2019
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
G12 8QQ Glasgow
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.